{"id":61723,"date":"2024-11-19T15:30:09","date_gmt":"2024-11-19T07:30:09","guid":{"rendered":"http:\/\/www.biocloudservice.com\/wordpress\/?p=61723"},"modified":"2024-11-19T15:30:09","modified_gmt":"2024-11-19T07:30:09","slug":"%e5%b9%b2%e8%b4%a7%ef%bc%81%e5%bf%ab%e8%bf%9b%e6%9d%a5%e7%9c%8b%e7%9c%8b%ef%bc%81motifstack%e5%8c%85%ef%bc%8c%e5%ba%8f%e5%88%97logo%e5%ae%9a%e5%88%b6%e7%9a%84%e8%89%ba%e6%9c%af%e5%a4%a7%e5%b8%88","status":"publish","type":"post","link":"http:\/\/www.biocloudservice.com\/wordpress\/?p=61723","title":{"rendered":"\u5e72\u8d27\uff01\u5feb\u8fdb\u6765\u770b\u770b\uff01motifStack\u5305\uff0c\u5e8f\u5217logo\u5b9a\u5236\u7684\u827a\u672f\u5927\u5e08\uff01\uff01\u4f53\u9a8c\u79d1\u5b66\u7814\u7a76\u7684\u89c6\u89c9\u76db\u5bb4\uff01"},"content":{"rendered":"\n

<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u5927\u5bb6\u597d\uff0c\u5c0f\u679c\u6765\u5566\uff0c\u5f88\u9ad8\u5174\u53c8\u548c\u5927\u5bb6\u89c1\u9762\u4e86\uff01\u4eca\u5929\u6211\u4eec\u8981\u5b66\u4e60\u7684\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u7528\u7684R\u5305\u2014\u2014motifStack\u3002motifStack\u5305\u4e13\u95e8\u7528\u4e8e\u7ed8\u5236\u548c\u53ef\u89c6\u5316DNA\u3001RNA\u548c\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u57fa\u5e8f\uff0c\u901a\u8fc7\u5b83\u6211\u4eec\u53ef\u4ee5\u751f\u6210\u9ad8\u8d28\u91cf\u7684\u5e8f\u5217logo\u56fe\uff0c\u5e2e\u52a9\u6211\u4eec\u76f4\u89c2\u5730\u5c55\u793a\u5e8f\u5217\u4e2d\u5404\u4e2a\u4f4d\u7f6e\u7684\u78b1\u57fa\u6216\u6c28\u57fa\u9178\u7684\u4fdd\u5b88\u6027\u548c\u9891\u7387\u5206\u5e03\u3002\u6ca1\u6709\u4efb\u4f55\u751f\u4fe1\u5206\u6790\u80fd\u96be\u5012<\/strong>\u751f\u4fe1\u9ad8\u624b<\/strong>\u5c0f\u679c\uff0c\u8981\u662f<\/strong>\u540c\u5b66\u4eec<\/strong>\u6709\u81ea\u5df1\u505a\u4e0d\u4e86\u7684\u751f\u4fe1\u5206\u6790\uff0c<\/strong>\u6b22\u8fce\u968f\u65f6<\/strong>\u8054\u7cfb\u6211<\/strong>\uff01\uff01\uff01<\/strong><\/strong><\/p>\n\n\n\n

\u5728\u4eca\u5929\u7684\u8bfe\u7a0b\u4e2d\uff0c\u6211\u5c06\u8be6\u7ec6\u8bb2\u89e3\u5982\u4f55\u5b89\u88c5motifStack\u5305\uff0c\u5e76\u6f14\u793a\u5982\u4f55\u4f7f\u7528\u5b83\u6765\u7ed8\u5236\u4e30\u5bcc\u591a\u5f69\u7684DNA\u5e8f\u5217logo\u3002\u6211\u4eec\u4f1a\u4ece\u5305\u7684\u57fa\u672c\u5b89\u88c5\u5f00\u59cb\uff0c\u9010\u6b65\u4ecb\u7ecd\u5982\u4f55\u8f7d\u5165\u6570\u636e\u3001\u7ed8\u5236\u5e8f\u5217logo\uff0c\u5e76\u5c55\u793a\u5982\u4f55\u8c03\u6574\u7ed8\u56fe\u53c2\u6570\u4ee5\u53ca\u6dfb\u52a0\u6ce8\u91ca\u6807\u8bb0\uff0c\u4f7f\u5f97\u56fe\u5f62\u66f4\u52a0\u7f8e\u89c2\u548c\u4fe1\u606f\u4e30\u5bcc\u3002\u76f8\u4fe1\u901a\u8fc7\u4eca\u5929\u7684\u5b66\u4e60\uff0c\u5927\u5bb6\u4e00\u5b9a\u80fd\u591f\u638c\u63e1motifStack\u5305\u7684\u57fa\u672c\u7528\u6cd5\uff0c\u5e76\u5728\u81ea\u5df1\u7684\u7814\u7a76\u4e2d\u7075\u6d3b\u5e94\u7528\u3002\u90a3\u5c31\u8ba9\u6211\u4eec\u6b63\u5f0f\u5f00\u542fmotifStack\u5305\u7684\u5b66\u4e60\u4e4b\u65c5\u5427\uff01<\/p>\n\n\n\n

\u672c\u6b21\u4ecb\u7ecd\u7684<\/strong>R\u5305<\/strong>\u9700\u8981\u8f83\u591a\u7684\u786c\u4ef6\u8d44\u6e90\uff0c\u5728<\/strong>\u670d\u52a1\u5668<\/strong>\u53ef\u4ee5\u66f4\u52a0\u6d41\u7545<\/strong>\u8fd0\u884c\uff0c<\/strong>\u540c\u5b66\u4eec<\/strong>\u5982\u679c\u6ca1\u6709\u81ea\u5df1\u7684\u670d\u52a1\u5668\u6b22\u8fce\u8054\u7cfb\u6211\u4eec<\/strong>\u8fdb\u884c<\/strong>\u670d\u52a1\u5668\u79df\u8d41~<\/strong><\/strong><\/p>\n\n\n\n

motifStack\u4ecb\u7ecd<\/p>\n\n\n\n

motifStack\u662f\u4e00\u4e2a\u4e13\u95e8\u7528\u4e8e\u7ed8\u5236\u548c\u53ef\u89c6\u5316DNA\u3001RNA\u548c\u86cb\u767d\u8d28\u5e8f\u5217\u57fa\u5e8f\u7684R\u5305\u3002\u5b83\u80fd\u591f\u751f\u6210\u9ad8\u8d28\u91cf\u7684\u5e8f\u5217logo\u56fe\uff0c\u8fd9\u4e9b\u56fe\u53ef\u4ee5\u5e2e\u52a9\u540c\u5b66\u4eec\u76f4\u89c2\u5730\u5c55\u793a\u5e8f\u5217\u4e2d\u5404\u4e2a\u4f4d\u7f6e\u7684\u78b1\u57fa\u6216\u6c28\u57fa\u9178\u7684\u4fdd\u5b88\u6027\u548c\u9891\u7387\u5206\u5e03\u3002motifStack\u5305\u652f\u6301\u591a\u79cd\u914d\u8272\u65b9\u6848\u548c\u5b57\u4f53\uff0c\u7528\u6237\u53ef\u4ee5\u6839\u636e\u9700\u8981\u81ea\u5b9a\u4e49\u56fe\u5f62\u7684\u5916\u89c2\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u63d0\u4f9b\u4e86\u6dfb\u52a0\u6ce8\u91ca\u6807\u8bb0\u7684\u529f\u80fd\uff0c\u4f7f\u5f97\u5e8f\u5217logo\u56fe\u66f4\u5177\u4fe1\u606f\u6027\u548c\u53ef\u8bfb\u6027\u3002\u901a\u8fc7motifStack\u5305\uff0c\u7814\u7a76\u4eba\u5458\u80fd\u591f\u66f4\u52a0\u65b9\u4fbf\u5730\u8fdb\u884c\u5e8f\u5217\u5206\u6790\u548c\u7ed3\u679c\u5c55\u793a\uff0c\u63d0\u5347\u6570\u636e\u53ef\u89c6\u5316\u7684\u6548\u679c\u548c\u7814\u7a76\u7684\u76f4\u89c2\u6027\u3002<\/p>\n\n\n\n

motifStack\u5305\u7684\u5b89\u88c5<\/p>\n\n\n\n

\u9700\u8981R\u8bed\u8a00\u7248\u672c\u4e3a4.3\uff0c\u5728\u63a7\u5236\u53f0\u4e2d\u8f93\u5165\u4ee5\u4e0b\u547d\u4ee4\uff1a<\/p>\n\n\n\n

if (!require(“BiocManager”, quietly = TRUE))<\/p>\n\n\n\n

    install.packages(“BiocManager “)<\/p>\n\n\n\n

BiocManager::install(“motifStack”) # \u5728BiocManager\u73af\u5883\u4e0b\u5b89\u88c5motifStack<\/p>\n\n\n\n

\u67e5\u770b\u662f\u5426\u5b89\u88c5\u6210\u529f<\/p>\n\n\n\n

packageVersion(“motifStack”) # \u67e5\u770bmotifStack\u7248\u672c<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u663e\u793a\u4e3a1.46.0\u7248\u672c\uff0c\u5219\u8868\u793a\u5df2\u7ecf\u5b89\u88c5\u4e86motifStack\u5305\u3002<\/p>\n\n\n\n

\u6210\u529f\u5b89\u88c5motifStack\u5305\u540e\uff0c\u6211\u4eec\u63a5\u4e0b\u6765\u5c06\u6f14\u793a\u5982\u4f55\u4f7f\u7528motifStack\u5305\u6765\u7ed8\u5236\u4e30\u5bcc\u591a\u5f69\u7684\u5e8f\u5217LOGO(sequence logo)\uff0c\u5c0f\u679c\u4f1a\u8bb2\u7684\u5f88\u4ed4\u7ec6\uff0c\u540c\u5b66\u4eec\u53ef\u8981\u8ba4\u771f\u542c\u8bb2\u54e6\u3002<\/p>\n\n\n\n

\u4f7f\u7528motifStack\u5305\u7ed8\u5236DNA\u5e8f\u5217logo\u793a\u4f8b<\/p>\n\n\n\n

\u5305\u548c\u6570\u636e\u8f7d\u5165\uff1a<\/strong><\/strong><\/p>\n\n\n\n

\u8fdb\u884cDNA\u5e8f\u5217logo\u7ed8\u5236\uff0c\u6211\u4eec\u9996\u5148\u9700\u8981\u8f7d\u5165\u9700\u8981\u7528\u5230\u7684\u5305\u548c\u6570\u636e\uff0c\u672c\u7bc7\u6587\u7ae0\u6f14\u793a\u4e3a\u4e86\u8ba9\u540c\u5b66\u4eec\u66f4\u5bb9\u6613\u7406\u89e3\uff0c\u5c06\u53ea\u91c7\u7528motifStack\u5305\u81ea\u5e26\u7684\u6570\u636e\u96c6\uff0c\u540c\u5b66\u4eec\u5982\u679c\u9700\u8981\u5b8c\u6210\u81ea\u5df1\u6570\u636eDNA\u5e8f\u5217logo\u7ed8\u5236\uff0c\u8fdb\u884c\u5bf9\u5e94\u7684\u66ff\u6362\u5373\u53ef\uff0c\u76f8\u5173\u547d\u4ee4\u5982\u4e0b\uff1a<\/p>\n\n\n\n

# \u5bfc\u5165motifStack\u5305\uff0c\u8be5\u5e93\u7528\u4e8e\u64cd\u4f5c\u548c\u53ef\u89c6\u5316\u57fa\u5e8f\uff08motif\uff09<\/p>\n\n\n\n

library(motifStack)<\/p>\n\n\n\n

# \u8bfb\u53d6\u5305\u542b\u4f4d\u7f6e\u6743\u91cd\u77e9\u9635\uff08position count matrix\uff0cPCM\uff09\u7684\u6587\u672c\u6587\u4ef6<\/p>\n\n\n\n

# \u4f7f\u7528find.package\u51fd\u6570\u627e\u5230motifStack\u5305\u7684\u5b89\u88c5\u8def\u5f84\uff0c\u5e76\u6784\u5efa\u6587\u4ef6\u8def\u5f84<\/p>\n\n\n\n

pcm <- read.table(file.path(find.package(“motifStack”),<\/p>\n\n\n\n

                            “extdata”, “bin_SOLEXA.pcm”))<\/p>\n\n\n\n

# \u53bb\u9664\u6570\u636e\u6846\u7684\u524d\u4e24\u5217\uff0c\u53ea\u4fdd\u7559\u7b2c\u4e09\u5217\u53ca\u5176\u540e\u7684\u5217<\/p>\n\n\n\n

pcm <- pcm[,3:ncol(pcm)]<\/p>\n\n\n\n

# \u8bbe\u7f6e\u6570\u636e\u6846\u7684\u884c\u540d\uff0c\u4ee3\u8868\u78b1\u57faA\u3001C\u3001G\u3001T<\/p>\n\n\n\n

rownames(pcm) <- c(“A”,”C”,”G”,”T”)<\/p>\n\n\n\n

# \u67e5\u770b\u5904\u7406\u4e4b\u540e\u7684pcm\u6570\u636e\u6846<\/p>\n\n\n\n

pcm<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u7ed3\u679c\u663e\u793a\u5982\u4e0a\u56fe\uff0c\u53ef\u77e5\u5171\u67091068\u4e2a\u5e8f\u5217\u7684\u4e03\u4e2a\u4f4d\u70b9\u4fe1\u606f\uff0c\u5176\u4e2d\u5217\u4e3a\u5e8f\u5217\u4e2d\u7684DNA\u4f4d\u70b9\uff0c\u884c\u4e3a\u78b1\u57fa\uff0c\u5355\u5143\u683c\u4e3a\u8be5\u78b1\u57fa\u5728\u5bf9\u5e94\u4f4d\u70b9\u51fa\u73b0\u7684\u6b21\u6570\u3002\u63a5\u4e0b\u6765\u6211\u4eec\u53ef\u4ee5\u6784\u5efa\u4e00\u4e2apcm\uff08position count matrix\uff0c\u4f4d\u7f6e\u6743\u91cd\u77e9\u9635\uff09\u5bf9\u8c61\u6765\u7ed8\u5236\u5bf9\u5e94\u5e8f\u5217\u7684logo\uff0c\u76f8\u5173\u547d\u4ee4\u5982\u4e0b\uff1a<\/p>\n\n\n\n

# \u521b\u5efa\u4e00\u4e2a\u65b0\u7684pcm\u5bf9\u8c61\uff0c\u4f7f\u7528as.matrix\u5c06\u6570\u636e\u6846\u8f6c\u6362\u4e3a\u77e9\u9635<\/p>\n\n\n\n

# \u5c06\u77e9\u9635\u5b58\u50a8\u5728motif\u5bf9\u8c61\u7684mat\u5c5e\u6027\u4e2d\uff0c\u5e76\u8bbe\u7f6emotif\u5bf9\u8c61\u7684\u540d\u79f0\u4e3a”bin_SOLEXA”<\/p>\n\n\n\n

motif <- new(“pcm”, mat=as.matrix(pcm), name=”bin_SOLEXA”)<\/p>\n\n\n\n

# \u7ed8\u5236motif\u5bf9\u8c61<\/p>\n\n\n\n

plot(motif)<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u663e\u793a\u5982\u4e0a\u56fe\uff0c\u5373\u6210\u529f\u7ed8\u5236\u4e86\u793a\u4f8b\u6570\u636eDNA\u7684\u5e8f\u5217logo\uff0c\u4ece\u56fe\u4e2d\u6211\u4eec\u53ef\u77e52-7\u53f7\u4f4d\u70b9\u76f8\u5bf9\u4fdd\u5b88\uff0c\u53ef\u80fd\u662f\u4e0eDNA\u529f\u80fd\u76f8\u5173\u7684\u4e00\u4e9b\u91cd\u8981\u4f4d\u70b9\u3002\u63a5\u4e0b\u6765\u6211\u4eec\u8fd8\u53ef\u4ee5\u5bf9\u7ed8\u5236\u5e8f\u5217logo\u7684\u53c2\u6570\u8fdb\u884c\u8c03\u6574\uff0c\u8ba9\u56fe\u50cf\u66f4\u52a0\u7f8e\u89c2\uff0c\u6ee1\u8db3\u4e0d\u540c\u7814\u7a76\u7684\u9700\u6c42\u3002<\/p>\n\n\n\n

\u7ed8\u5236\u53c2\u6570\u8c03\u6574<\/strong><\/strong><\/p>\n\n\n\n

\u6211\u4eec\u53ef\u4ee5\u5bf9plot\u7684\u53c2\u6570\u8fdb\u884c\u76f8\u5e94\u7684\u8c03\u6574\uff0c\u6765\u83b7\u5f97\u6211\u4eec\u60f3\u8981\u7684\u6548\u679c\uff0c\u4f8b\u5982\u8ba9y\u8f74\u6807\u4e3a\u78b1\u57fa\u7684\u6982\u7387\u5206\u5e03\uff0c\u4ee3\u7801\u5982\u4e0b\uff1a<\/p>\n\n\n\n

#\u7ed8\u5236\u78b1\u57fa\u6982\u7387\u5206\u5e03\u7684DNA\u5e8f\u5217logo<\/p>\n\n\n\n

plot(motif, ic.scale=FALSE, ylab=”probability”)<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u6539\u53d8x\u8f74\u4e3a\u81ea\u5b9a\u4e49\u523b\u5ea6\uff0c\u4ee3\u7801\u5982\u4e0b\uff1a<\/p>\n\n\n\n

#\u7ed8\u5236\u81ea\u52a8x\u8f74\u523b\u5ea6\u7684DNA\u5e8f\u5217logo<\/p>\n\n\n\n

plot(motif, xaxis=paste0(“pos”, seq.int(7)+10))<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u81ea\u5b9a\u4e49\u914d\u8272\u65b9\u6848\u548c\u5b57\u4f53\uff0c\u4ee3\u7801\u5982\u4e0b\uff1a<\/p>\n\n\n\n

#\u7ed8\u5236\u6307\u5b9a\u914d\u8272\u65b9\u6848\u548c\u5b57\u4f53\u7684DNA\u5e8f\u5217logo<\/p>\n\n\n\n

motif@color <- colorset(colorScheme=’basepairing’)<\/p>\n\n\n\n

plot(motif,font=”serif”)<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u5bf9\u4e8eDNA \u548c RNA\u53ef\u7528\u7684\u914d\u8272\u65b9\u6848\u6709’auto’, ‘basepairing’, or ‘blindnessSafe’\uff0c\u53ef\u7528\u7684\u5b57\u4f53\u6709’sans’\uff0c’serif’\uff0c’mono’\uff0c’Helvetica’ \u7b49\u7ed8\u56fe\u5e38\u7528\u5b57\u4f53\u3002<\/p>\n\n\n\n

\u6dfb\u52a0\u6ce8\u91ca\u6807\u8bb0<\/strong><\/strong><\/p>\n\n\n\n

\u60f3\u8981\u8ba9DNA\u5e8f\u5217logo\u66f4\u52a0\u76f4\u89c2\u6613\u61c2\uff0c\u9664\u4e86\u5bf9\u4e8eplot()\u51fd\u6570\u7684\u57fa\u7840\u53c2\u6570\u8c03\u6574\u5916\uff0c\u6211\u4eec\u8fd8\u53ef\u4ee5\u76f4\u63a5\u5728logo\u56fe\u4e0a\u6dfb\u52a0marker\u6807\u8bb0\uff0c\u76f8\u5173\u4ee3\u7801\u5982\u4e0b\uff1a<\/p>\n\n\n\n

# \u521b\u5efa\u4e00\u4e2a\u77e9\u5f62\u6807\u8bb0\u5bf9\u8c61\uff0c\u6807\u8bb0\u4ece\u7b2c6\u5230\u7b2c7\u4f4d\uff0c\u8bbe\u7f6e\u4e3a\u865a\u7ebf\u8fb9\u6846\uff0c\u6a59\u8272\uff0c\u65e0\u586b\u5145<\/p>\n\n\n\n

markerRect <- new(“marker”, type=”rect”, start=6, stop=7, gp=gpar(lty=2, fill=NA, col=”orange”))<\/p>\n\n\n\n

# \u521b\u5efa\u4e00\u4e2a\u7ebf\u6761\u6807\u8bb0\u5bf9\u8c61\uff0c\u6807\u8bb0\u4ece\u7b2c2\u5230\u7b2c7\u4f4d\uff0c\u8bbe\u7f6e\u4e3a\u7ea2\u8272\uff0c\u7ebf\u5bbd\u4e3a2<\/p>\n\n\n\n

markerLine <- new(“marker”, type=”line”, start=2, stop=7, gp=gpar(lwd=2, col=”red”))<\/p>\n\n\n\n

# \u521b\u5efa\u4e00\u4e2a\u6587\u672c\u6807\u8bb0\u5bf9\u8c61\uff0c\u6807\u8bb0\u7b2c1\u548c\u7b2c5\u4f4d\uff0c\u8bbe\u7f6e\u4e3a\u7ea2\u8272\uff0c\u5b57\u4f53\u5927\u5c0f\u4e3a2\uff0c\u6587\u672c\u6807\u7b7e\u4e3a\u201c*\u201d\u548c\u201ccore\u201d<\/p>\n\n\n\n

markerText <- new(“marker”, type=”text”, start=c(1, 5),<\/p>\n\n\n\n

                  label=c(“*”, “core”), gp=gpar(cex=2, col=”red”))<\/p>\n\n\n\n

# \u6784\u5efa\u4e00\u4e2a\u65b0\u7684pcm\u5bf9\u8c61\uff0c\u5e76\u4e14\u6dfb\u52a0markerRect, markerLine, markerText\u4e09\u4e2a\u6ce8\u91ca\u3002<\/p>\n\n\n\n

motif <- new(“pcm”, mat=as.matrix(pcm), name=”bin_SOLEXA”,<\/p>\n\n\n\n

             markers=c(markerRect, markerLine, markerText))<\/p>\n\n\n\n

#\u7ed8\u5236motif\u5bf9\u8c61<\/p>\n\n\n\n

plot(motif)<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u5728\u6570\u636e\u53ef\u89c6\u5316\u4e2d\uff0c\u5c24\u5176\u662f\u751f\u7269\u4fe1\u606f\u5b66\u4e2d\u7684\u5e8f\u5217logo\u7ed8\u5236\u65f6\uff0c\u6dfb\u52a0\u6ce8\u91ca\u6807\u8bb0\u80fd\u591f\u6781\u5927\u5730\u63d0\u5347\u56fe\u5f62\u7684\u76f4\u89c2\u6027\u548c\u4fe1\u606f\u91cf\u3002\u5982\u56fe\u6240\u793a\uff0c\u4ee3\u7801\u5206\u522b\u521b\u5efa\u4e86\u4e00\u4e2a\u77e9\u5f62\u6807\u8bb0\u5bf9\u8c61\uff0c\u6807\u8bb0\u4ece\u7b2c6\u5230\u7b2c7\u4f4d\uff0c\u8bbe\u7f6e\u4e3a\u865a\u7ebf\u8fb9\u6846\uff0c\u77e9\u5f62\u6807\u8bb0\u5e38\u7528\u4e8e\u5f3a\u8c03\u67d0\u4e9b\u5173\u952e\u533a\u57df\uff0c\u6bd4\u5982\u5728DNA\u5e8f\u5217\u4e2d\u6807\u6ce8\u91cd\u8981\u7684\u4fdd\u5b88\u533a\u57df\u3001\u529f\u80fd\u57df\u6216\u7ed3\u6784\u57df\u3002\u4e00\u4e2a\u7ebf\u6761\u6807\u8bb0\u5bf9\u8c61\uff0c\u6807\u8bb0\u4ece\u7b2c2\u5230\u7b2c7\u4f4d\uff0c\u8bbe\u7f6e\u4e3a\u7ea2\u8272\uff0c\u7ebf\u5bbd\u4e3a2\uff0c\u7ebf\u6761\u6807\u8bb0\u53ef\u4ee5\u7528\u6765\u8868\u793a\u67d0\u4e9b\u529f\u80fd\u5143\u4ef6\u7684\u8303\u56f4\uff0c\u6bd4\u5982\u57fa\u56e0\u8c03\u63a7\u5143\u4ef6\u3001\u86cb\u767d\u8d28\u7ed3\u5408\u4f4d\u70b9\u7b49\u3002\u4e00\u4e2a\u6587\u672c\u6807\u8bb0\u5bf9\u8c61\uff0c\u6807\u8bb0\u7b2c1\u548c\u7b2c5\u4f4d\uff0c\u8bbe\u7f6e\u4e3a\u7ea2\u8272\uff0c\u5b57\u4f53\u5927\u5c0f\u4e3a2\uff0c\u6587\u672c\u6807\u7b7e\u4e3a\u201c*\u201d\u548c\u201ccore\u201d\uff0c\u6587\u672c\u6807\u8bb0\u53ef\u4ee5\u7528\u4e8e\u6807\u6ce8\u5173\u952e\u4f4d\u70b9\uff0c\u6bd4\u5982\u7a81\u53d8\u4f4d\u70b9\u3001\u7ed3\u5408\u4f4d\u70b9\u7b49\uff0c\u63d0\u4f9b\u8be6\u7ec6\u7684\u6ce8\u91ca\u4fe1\u606f\u3002\u901a\u8fc7\u5c06\u77e9\u5f62\u6807\u8bb0\u3001\u7ebf\u6761\u6807\u8bb0\u548c\u6587\u672c\u6807\u8bb0\u6dfb\u52a0\u5230\u7ed8\u5236\u7684DNA \u5e8f\u5217logo\u4e0a\uff0c\u53ef\u4ee5\u663e\u8457\u63d0\u5347\u5e8f\u5217logo\u7684\u76f4\u89c2\u6027\u548c\u4fe1\u606f\u4e30\u5bcc\u5ea6\u3002\u8fd9\u4e9b\u6807\u8bb0\u4e0d\u4ec5\u80fd\u591f\u5f3a\u8c03\u91cd\u8981\u533a\u57df\u548c\u4f4d\u70b9\uff0c\u8fd8\u80fd\u901a\u8fc7\u8be6\u7ec6\u7684\u6ce8\u91ca\u4f7f\u5f97\u56fe\u8868\u66f4\u52a0\u6613\u4e8e\u7406\u89e3\u548c\u89e3\u91ca\uff0c\u5bf9\u4e8e\u540c\u5b66\u4eec\u8fdb\u884c\u79d1\u5b66\u7814\u7a76\u548c\u6210\u679c\u5c55\u793a\u6709\u7740\u91cd\u8981\u7684\u610f\u4e49\u3002<\/p>\n\n\n\n

\u4ee5\u4e0a\uff0c\u5c31\u662f\u5bf9motifStack\u5305\u7684\u5168\u90e8\u4ecb\u7ecd\u4e86\u3002\u5c0f\u679c\u5e0c\u671b\u540c\u5b66\u4eec\u901a\u8fc7\u672c\u6587\u7684\u5b66\u4e60\uff0c\u80fd\u591f\u638c\u63e1motifStack\u5305\u7684\u57fa\u672c\u7528\u6cd5\uff0c\u5e76\u80fd\u5728\u81ea\u5df1\u7684\u7814\u7a76\u4e2d\u7075\u6d3b\u5e94\u7528\uff0c\u7ee7\u7eed\u63a2\u7d22\u548c\u5b66\u4e60\u66f4\u9ad8\u7ea7\u7684\u529f\u80fd\uff0c\u63d0\u5347\u81ea\u5df1\u7684\u6570\u636e\u53ef\u89c6\u5316\u80fd\u529b\u3002\u5982\u679c\u9700\u8981\u66f4\u591a\u5e2e\u52a9\u6216\u786c\u4ef6\u652f\u6301\uff0c\u6b22\u8fce\u8054\u7cfb\u6211\u4eec\u3002\u795d\u540c\u5b66\u4eec\u5b66\u4e60\u6109\u5feb\uff01<\/p>\n\n\n\n

\u540c\u5b66\u4eec\u5982\u679c\u89c9\u5f97\u81ea\u5df1\u5199\u4ee3\u7801\u9ebb\u70e6\uff0c\u53ef\u4ee5\u4f53\u9a8c\u4e00\u4e0b\u6211\u4eec\u7684\u4e91\u751f\u4fe1\u5c0f\u5de5\u5177\uff0c\u53ea\u9700\u8f93\u5165\u6570\u636e\uff0c\u5373\u53ef\u8f7b\u677e\u751f\u6210\u6240\u9700\u56fe\u8868\u3002\u7acb\u5373\u8bbf\u95ee\u4e91\u751f\u4fe1\uff08<\/a><\/strong>http:\/\/www.biocloudservice.com\/home.html<\/u><\/a>\uff09\uff0c\u5f00\u542f\u4fbf\u6377\u7684\u751f\u4fe1\u4e4b\u65c5\uff01<\/strong><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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