{"id":65835,"date":"2026-10-10T14:00:37","date_gmt":"2026-10-10T06:00:37","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?post_type=ftc_question&#038;p=65835"},"modified":"2026-10-10T14:00:37","modified_gmt":"2026-10-10T06:00:37","slug":"what-is-ferroptosis-transcriptomic-evidence","status":"publish","type":"ftc_question","link":"https:\/\/www.biocloudservice.com\/wordpress\/ferroptosis\/questions\/what-is-ferroptosis-transcriptomic-evidence\/","title":{"rendered":"\u94c1\u6b7b\u4ea1\u662f\u4ec0\u4e48\uff1f\u8f6c\u5f55\u7ec4\u7ed3\u679c\u80fd\u8bc1\u660e\u94c1\u6b7b\u4ea1\u53d1\u751f\u5417\uff1f"},"content":{"rendered":"<p class=\"ftc-answer-first\"><strong>\u5148\u770b\u7ed3\u8bba\uff1a<\/strong>\u94c1\u6b7b\u4ea1\u662f\u4e00\u7c7b\u4e0e\u94c1\u4f9d\u8d56\u6027\u8102\u8d28\u8fc7\u6c27\u5316\u6709\u5173\u7684\u8c03\u63a7\u6027\u7ec6\u80de\u6b7b\u4ea1\u3002\u8868\u8fbe\u5dee\u5f02\u3001\u5bcc\u96c6\u6216\u7b7e\u540d\u8bc4\u5206\u53ef\u4ee5\u63d0\u51fa\u94c1\u6b7b\u4ea1\u76f8\u5173\u5047\u8bbe\uff0c\u4f46\u4e0d\u80fd\u5355\u72ec\u786e\u8ba4\u7ec6\u80de\u6b63\u5728\u53d1\u751f\u94c1\u6b7b\u4ea1\u3002\u5e94\u5148\u533a\u5206\u7814\u7a76\u662f\u5728\u62a5\u544a\u8f6c\u5f55\u5173\u8054\u3001\u5b9a\u4f4d\u7ec6\u80de\u6765\u6e90\uff0c\u8fd8\u662f\u8981\u8bc1\u660e\u6b7b\u4ea1\u673a\u5236\uff0c\u518d\u9009\u62e9\u5bf9\u5e94\u8bc1\u636e\u3002<\/p>\n<h2>\u9002\u7528\u60c5\u51b5<\/h2>\n<p>\u53ea\u6709 bulk\u3001\u82af\u7247\u6216\u5355\u7ec6\u80de\u8868\u8fbe\u6570\u636e\uff0c\u6216\u8005\u5df2\u7ecf\u5f97\u5230 GPX4\u3001SLC7A11 \u7b49\u57fa\u56e0\u53d8\u5316\uff0c\u6b63\u5728\u51b3\u5b9a\u8bba\u6587\u7ed3\u8bba\u5e94\u5199\u5230\u54ea\u4e00\u5c42\u3002<\/p>\n<h2>\u5efa\u8bae\u6309\u8fd9\u4e2a\u987a\u5e8f\u68c0\u67e5<\/h2>\n<ol>\n<li>\u628a\u62df\u5199\u7ed3\u8bba\u62c6\u6210\u53ef\u68c0\u9a8c\u9648\u8ff0\uff1a\u76f8\u5173\u8f6c\u5f55\u6a21\u5f0f\u53d8\u5316\u3001\u7ec6\u80de\u529f\u80fd\u6539\u53d8\u3001\u94c1\u6b7b\u4ea1\u53c2\u4e0e\u673a\u5236\uff0c\u4e09\u8005\u5206\u522b\u5217\u8bc1\u636e\u3002<\/li>\n<li>\u4fdd\u7559\u57fa\u56e0\u96c6\u6765\u6e90\u3001\u6d4b\u5230\u7684\u57fa\u56e0\u548c\u4e3b\u8981\u8bc4\u5206\u65b9\u6cd5\uff0c\u68c0\u67e5\u5206\u7ec4\u3001\u7ec6\u80de\u7ec4\u6210\u4e0e\u4f9b\u4f53\u91cd\u590d\u3002<\/li>\n<li>\u82e5\u8981\u8ba8\u8bba\u7ec6\u80de\u6b7b\u4ea1\uff0c\u589e\u52a0\u4e0e\u6b7b\u4ea1\u6216\u5b58\u6d3b\u76f4\u63a5\u76f8\u5173\u7684\u89c2\u6d4b\uff0c\u5e76\u533a\u5206\u589e\u6b96\u53d8\u6162\u548c\u7ec6\u80de\u6b7b\u4ea1\u3002<\/li>\n<li>\u82e5\u8981\u5f52\u56e0\u4e8e\u94c1\u6b7b\u4ea1\uff0c\u8bbe\u8ba1\u8102\u8d28\u8fc7\u6c27\u5316\u3001\u94c1\u4f9d\u8d56\u6027\u548c\u6709\u9002\u5f53\u5bf9\u7167\u7684\u6551\u63f4\u8bc1\u636e\uff1b\u5177\u4f53\u5b9e\u9a8c\u7531\u7814\u7a76\u4f53\u7cfb\u51b3\u5b9a\u3002<\/li>\n<li>\u68c0\u67e5\u5176\u4ed6\u6b7b\u4ea1\u9014\u5f84\u548c\u975e\u7279\u5f02\u6bd2\u6027\u7b49\u89e3\u91ca\uff0c\u6700\u540e\u628a\u7ed3\u8bba\u9650\u5236\u5728\u5df2\u6709\u8bc1\u636e\u8986\u76d6\u7684\u8303\u56f4\u3002<\/li>\n<\/ol>\n<h2>\u628a\u73b0\u6709\u7ed3\u679c\u653e\u8fdb\u8bc1\u636e\u8868<\/h2>\n<p>\u4e0b\u9762\u662f\u7528\u4e8e\u6574\u7406\u6750\u6599\u7684\u5de5\u4f5c\u8868\uff0c\u4e0d\u662f\u89c4\u5b9a\u6240\u6709\u9879\u76ee\u5fc5\u987b\u5b8c\u6210\u540c\u4e00\u7ec4\u5b9e\u9a8c\u3002\u673a\u5236\u5b9a\u4e49\u6765\u81ea\u7ec6\u80de\u6b7b\u4ea1\u7814\u7a76\uff1b\u4ece\u8bc1\u636e\u7f3a\u53e3\u5b89\u6392\u4e0b\u4e00\u6b65\uff0c\u662f\u672c\u4e13\u9898\u7684\u7814\u7a76\u8bbe\u8ba1\u5efa\u8bae\u3002<\/p>\n<div class=\"ftc-table-wrap\" role=\"region\" tabindex=\"0\" aria-label=\"\u628a\u73b0\u6709\u7ed3\u679c\u653e\u8fdb\u8bc1\u636e\u8868\">\n<table>\n<thead>\n<tr>\n<th scope=\"col\">\u4f60\u624b\u91cc\u7684\u7ed3\u679c<\/th>\n<th scope=\"col\">\u76ee\u524d\u53ef\u652f\u6301<\/th>\n<th scope=\"col\">\u4ecd\u9700\u68c0\u67e5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u94c1\u6b7b\u4ea1\u76f8\u5173\u57fa\u56e0\u8868\u8fbe\u6216\u8bc4\u5206\u6709\u5dee\u5f02<\/td>\n<td>\u76f8\u5173\u8f6c\u5f55\u6a21\u5f0f\u53d8\u5316<\/td>\n<td>\u57fa\u56e0\u96c6\u65b9\u5411\u3001\u6279\u6b21\u3001\u7ec6\u80de\u6bd4\u4f8b<\/td>\n<\/tr>\n<tr>\n<td>\u8102\u8d28\u6c27\u5316\u8bfb\u6570\u5347\u9ad8<\/td>\n<td>\u5b58\u5728\u8102\u8d28\u6c27\u5316\u76f8\u5173\u53d8\u5316<\/td>\n<td>\u63a2\u9488\u80cc\u666f\u3001\u65f6\u95f4\u987a\u5e8f\u3001\u662f\u5426\u4f34\u968f\u6b7b\u4ea1<\/td>\n<\/tr>\n<tr>\n<td>\u5e72\u9884\u540e\u6b7b\u4ea1\u51cf\u5c11\u4e14\u76f8\u5173\u8868\u578b\u6062\u590d<\/td>\n<td>\u7279\u5b9a\u673a\u5236\u53c2\u4e0e\u7684\u652f\u6301\u589e\u5f3a<\/td>\n<td>\u5e72\u9884\u7279\u5f02\u6027\u3001\u5bf9\u7167\u548c\u5176\u4ed6\u6b7b\u4ea1\u9014\u5f84<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"ftc-inline-sources\">\u4f9d\u636e\uff1a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22632970\/\" target=\"_blank\" rel=\"noopener noreferrer\">Dixon \u7b49\uff1aFerroptosis \u539f\u59cb\u7814\u7a76<\/a> \u00b7 <a href=\"https:\/\/www.nature.com\/articles\/s41418-017-0012-4\" target=\"_blank\" rel=\"noopener noreferrer\">NCCD\uff1a\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236\u5b9a\u4e49\u4e0e\u8bc1\u636e\u89e3\u91ca<\/a><\/p>\n<h2>\u4e00\u4e2a\u5bb9\u6613\u5199\u8fc7\u5934\u7684\u4f8b\u5b50<\/h2>\n<p>\u793a\u610f\u60c5\u5883\uff1a\u80bf\u7624\u7ec4\u7684\u4e00\u4e2a\u94c1\u6b7b\u4ea1\u7b7e\u540d\u5206\u6570\u66f4\u9ad8\uff0c\u540c\u65f6 GPX4 \u8f6c\u5f55\u672c\u4e0a\u8c03\u3002\u5408\u7406\u7684\u521d\u6b65\u8868\u8ff0\u662f\u201c\u89c2\u5bdf\u5230\u94c1\u6b7b\u4ea1\u76f8\u5173\u8f6c\u5f55\u7a0b\u5e8f\u5dee\u5f02\uff0c\u53ef\u80fd\u5305\u542b\u5e94\u6fc0\u9002\u5e94\u201d\u3002\u4e0d\u80fd\u636e\u6b64\u8ba4\u5b9a\u6b7b\u4ea1\u66f4\u591a\uff0c\u4e5f\u4e0d\u80fd\u4ec5\u56e0 GPX4 \u4e0a\u8c03\u5c31\u8ba4\u5b9a\u8be5\u6837\u672c\u5b8c\u5168\u62b5\u6297\u94c1\u6b7b\u4ea1\u3002<\/p>\n<p>\u4e0b\u4e00\u6b65\u5148\u68c0\u67e5\u5347\u9ad8\u7684\u4fe1\u53f7\u6765\u81ea\u80bf\u7624\u7ec6\u80de\u8fd8\u662f\u6d78\u6da6\u7ec6\u80de\uff0c\u5e76\u6838\u5bf9\u7b7e\u540d\u4e2d\u4e0d\u540c\u8c03\u63a7\u89d2\u8272\u3002\u82e5\u8bfe\u9898\u76ee\u6807\u53ea\u662f\u63cf\u8ff0\u8868\u8fbe\u5173\u8054\uff0c\u5e94\u628a\u8fb9\u754c\u5199\u6e05\uff1b\u82e5\u76ee\u6807\u662f\u673a\u5236\uff0c\u5c31\u9700\u9884\u7559\u5e72\u9884\u548c\u529f\u80fd\u9a8c\u8bc1\u3002\u6b64\u4f8b\u6ca1\u6709\u5bf9\u5e94\u771f\u5b9e\u961f\u5217\u7ed3\u679c\u3002<\/p>\n<h2>\u4ea4\u7ed9\u5408\u4f5c\u8005\u7684\u6700\u5c0f\u6750\u6599<\/h2>\n<p>\u51c6\u5907\u4e00\u9875\u201c\u4e3b\u5f20\u2014\u5df2\u6709\u8bc1\u636e\u2014\u66ff\u4ee3\u89e3\u91ca\u2014\u62df\u8865\u8bc1\u636e\u201d\u8868\uff0c\u9644\u6570\u636e\u7c7b\u578b\u3001\u5206\u7ec4\u8868\u548c\u4e3b\u8981\u56fe\u3002\u4e0d\u5fc5\u5148\u5806\u66f4\u591a\u7b97\u6cd5\uff1b\u5148\u786e\u8ba4\u65b0\u589e\u5206\u6790\u662f\u5426\u80fd\u89e3\u51b3\u5f53\u524d\u8bc1\u636e\u7f3a\u53e3\u3002<\/p>\n<h2>\u4e0d\u80fd\u4ece\u5f53\u524d\u7ed3\u679c\u76f4\u63a5\u5f97\u51fa\u4ec0\u4e48<\/h2>\n<p>\u5355\u4e2a marker\u3001\u5355\u6b21 ROS \u68c0\u6d4b\u3001\u5355\u5f20\u7535\u955c\u56fe\u6216\u4e00\u6b21\u836f\u7269\u6551\u63f4\u90fd\u4e0d\u5b9c\u8131\u79bb\u5b9e\u9a8c\u8bbe\u8ba1\u72ec\u7acb\u627f\u62c5\u5b8c\u6574\u673a\u5236\u7ed3\u8bba\u3002\u672c\u6587\u63d0\u4f9b\u7814\u7a76\u8bc1\u636e\u6574\u7406\u65b9\u6cd5\uff0c\u4e0d\u7ed9\u51fa\u4e34\u5e8a\u8bca\u65ad\u6216\u6cbb\u7597\u5efa\u8bae\u3002<\/p>\n<h2>\u4f9d\u636e\u4e0e\u7248\u672c<\/h2>\n<ul class=\"ftc-source-list\">\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22632970\/\" target=\"_blank\" rel=\"noopener noreferrer\">Dixon \u7b49\uff1aFerroptosis \u539f\u59cb\u7814\u7a76<\/a><span>Cell\uff0c2012\uff1bPMID 22632970<\/span><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41418-017-0012-4\" target=\"_blank\" rel=\"noopener noreferrer\">NCCD\uff1a\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236\u5b9a\u4e49\u4e0e\u8bc1\u636e\u89e3\u91ca<\/a><span>Cell Death &amp; Differentiation\uff0c2018\uff1b\u673a\u5236\u5b9a\u4e49\u53c2\u8003<\/span><\/li>\n<li><a href=\"https:\/\/www.zhounan.org\/ferrdb\/v3\/pages\/help.html\" target=\"_blank\" rel=\"noopener noreferrer\">FerrDb V3 \u5b98\u65b9\u5e2e\u52a9\uff1a\u5206\u7c7b\u3001\u7f6e\u4fe1\u7b49\u7ea7\u4e0e\u6570\u636e\u7248\u672c<\/a><span>FerrDb V3\uff1b2026-10-10 \u6838\u5bf9<\/span><\/li>\n<\/ul>\n<p class=\"ftc-verification\">\u6700\u540e\u6838\u9a8c\uff1a2026-10-10\uff5c\u8d44\u6599\u6838\u9a8c\uff1aAI \u7f16\u5199\u4e0e\u516c\u5f00\u6765\u6e90\u6838\u5bf9\uff1b\u672a\u7ecf\u4eba\u5de5\u4e13\u5bb6\u5ba1\u9605<\/p>\n<p class=\"ftc-verification\">\u4f9d\u636e\u516c\u5f00\u6765\u6e90\u6838\u5bf9\u6982\u5ff5\u3001\u8f93\u5165\u3001\u8bc1\u636e\u8fb9\u754c\u4e0e\u7248\u672c\u53e3\u5f84\uff1b\u793a\u610f\u6570\u636e\u4e0d\u4ee3\u8868\u771f\u5b9e\u7814\u7a76\u7ed3\u679c\u3002\u4ec5\u6807\u660e\u7684\u5c0f\u578b\u4ee3\u7801\u793a\u4f8b\u7ecf\u8fc7\u8fd0\u884c\u68c0\u67e5\uff0c\u4e0d\u4ee3\u8868\u5b8c\u6574\u751f\u7269\u4fe1\u606f\u6d41\u7a0b\u6216\u539f\u8bba\u6587\u5df2\u590d\u73b0\u3002<\/p>\n<h2>\u7ee7\u7eed\u89e3\u51b3\u76f8\u5173\u95ee\u9898<\/h2>\n<ul class=\"ftc-related-reading\">\n<li><a href=\"https:\/\/www.biocloudservice.com\/wordpress\/ferroptosis\/questions\/ferrdb-driver-suppressor-marker-unclassified\/\">FerrDb \u7684 driver\u3001suppressor\u3001marker \u548c unclassified \u6709\u4ec0\u4e48\u533a\u522b\uff1f<\/a><\/li>\n<li><a href=\"https:\/\/www.biocloudservice.com\/wordpress\/ferroptosis\/questions\/ferroptosis-oxidative-stress-apoptosis-autophagy\/\">\u94c1\u6b7b\u4ea1\u3001\u6c27\u5316\u5e94\u6fc0\u3001\u51cb\u4ea1\u548c\u81ea\u566c\u7ed3\u679c\u600e\u6837\u533a\u5206\uff1f<\/a><\/li>\n<li><a href=\"https:\/\/www.biocloudservice.com\/wordpress\/ferroptosis\/questions\/reviewer-asks-ferroptosis-validation\/\">\u5ba1\u7a3f\u4eba\u8981\u6c42\u8865\u94c1\u6b7b\u4ea1\u9a8c\u8bc1\uff0c\u6700\u4f4e\u5e94\u5148\u8865\u54ea\u4e9b\u8bc1\u636e\uff1f<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u94c1\u6b7b\u4ea1\u662f\u4e00\u7c7b\u4e0e\u94c1\u4f9d\u8d56\u6027\u8102\u8d28\u8fc7\u6c27\u5316\u6709\u5173\u7684\u8c03\u63a7\u6027\u7ec6\u80de\u6b7b\u4ea1\u3002\u8868\u8fbe\u5dee\u5f02\u3001\u5bcc\u96c6\u6216\u7b7e\u540d\u8bc4\u5206\u53ef\u4ee5\u63d0\u51fa\u94c1\u6b7b\u4ea1\u76f8\u5173\u5047\u8bbe\uff0c\u4f46\u4e0d\u80fd\u5355\u72ec\u786e\u8ba4\u7ec6\u80de\u6b63\u5728\u53d1\u751f\u94c1\u6b7b\u4ea1\u3002\u5e94\u5148\u533a\u5206\u7814\u7a76\u662f\u5728\u62a5\u544a\u8f6c\u5f55\u5173\u8054\u3001\u5b9a\u4f4d\u7ec6\u80de\u6765\u6e90\uff0c\u8fd8\u662f\u8981\u8bc1\u660e\u6b7b\u4ea1\u673a\u5236\uff0c\u518d\u9009\u62e9\u5bf9\u5e94\u8bc1\u636e\u3002<\/p>\n","protected":false},"template":"","class_list":["post-65835","ftc_question","type-ftc_question","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/ftc_question\/65835","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/ftc_question"}],"about":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/types\/ftc_question"}],"version-history":[{"count":1,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/ftc_question\/65835\/revisions"}],"predecessor-version":[{"id":65855,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/ftc_question\/65835\/revisions\/65855"}],"wp:attachment":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media?parent=65835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}