{"id":65847,"date":"2026-10-10T14:00:37","date_gmt":"2026-10-10T06:00:37","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?post_type=ftc_question&#038;p=65847"},"modified":"2026-10-10T14:00:37","modified_gmt":"2026-10-10T06:00:37","slug":"ferroptosis-immune-infiltration-tme-evidence","status":"publish","type":"ftc_question","link":"https:\/\/www.biocloudservice.com\/wordpress\/ferroptosis\/questions\/ferroptosis-immune-infiltration-tme-evidence\/","title":{"rendered":"\u94c1\u6b7b\u4ea1\u4e0e\u514d\u75ab\u6d78\u6da6\u3001\u80bf\u7624\u5fae\u73af\u5883\u5e94\u8be5\u600e\u6837\u8fde\u63a5\uff0c\u624d\u4e0d\u662f\u7b80\u5355\u62fc\u63a5\uff1f"},"content":{"rendered":"<p class=\"ftc-answer-first\"><strong>\u5148\u770b\u7ed3\u8bba\uff1a<\/strong>\u5148\u63d0\u51fa\u4e00\u4e2a\u80fd\u4e32\u8d77\u7ec6\u80de\u6765\u6e90\u548c\u4f5c\u7528\u65b9\u5411\u7684\u95ee\u9898\uff0c\u518d\u5b89\u6392\u514d\u75ab\u6d78\u6da6\u3001\u5355\u7ec6\u80de\u5b9a\u4f4d\u6216\u901a\u4fe1\u5206\u6790\u3002bulk \u94c1\u6b7b\u4ea1\u8bc4\u5206\u4e0e\u514d\u75ab\u5206\u6570\u76f8\u5173\u53ef\u80fd\u6765\u81ea\u7ec6\u80de\u6bd4\u4f8b\u5171\u540c\u53d8\u5316\uff0c\u4e0d\u80fd\u76f4\u63a5\u89e3\u91ca\u4e3a\u80bf\u7624\u7ec6\u80de\u901a\u8fc7\u94c1\u6b7b\u4ea1\u8c03\u63a7\u514d\u75ab\u3002\u9700\u8981\u533a\u5206\u7ec4\u6210\u6548\u5e94\u3001\u7ec6\u80de\u5185\u72b6\u6001\u548c\u673a\u5236\u5e72\u9884\u3002<\/p>\n<h2>\u9002\u7528\u60c5\u51b5<\/h2>\n<p>\u5df2\u6709\u94c1\u6b7b\u4ea1\u8bc4\u5206\uff0c\u51c6\u5907\u8ffd\u52a0\u514d\u75ab\u6d78\u6da6\u3001CellChat\u3001\u80bf\u7624\u5fae\u73af\u5883\u6216\u514d\u75ab\u6cbb\u7597\u76f8\u5173\u5206\u6790\u3002<\/p>\n<h2>\u5efa\u8bae\u6309\u8fd9\u4e2a\u987a\u5e8f\u68c0\u67e5<\/h2>\n<ol>\n<li>\u5199\u6e05\u4f5c\u7528\u4e3b\u4f53\u548c\u65b9\u5411\uff0c\u4f8b\u5982\u80bf\u7624\u7ec6\u80de\u7684\u67d0\u72b6\u6001\u662f\u5426\u4e0e CD8 T \u7ec6\u80de\u72b6\u6001\u76f8\u5173\uff0c\u907f\u514d\u53ea\u63d0\u51fa\u201c\u4e8c\u8005\u6709\u5173\u201d\u3002<\/li>\n<li>\u68c0\u67e5\u8bc4\u5206\u57fa\u56e0\u662f\u5426\u4e3b\u8981\u6765\u81ea\u514d\u75ab\u6216\u57fa\u8d28\u7ec6\u80de\uff0c\u4ee5\u53ca\u4e24\u4e2a\u5206\u6570\u662f\u5426\u5171\u4eab\u5927\u91cf\u57fa\u56e0\u3002<\/li>\n<li>bulk \u4e2d\u8bc4\u4f30\u7ec6\u80de\u6bd4\u4f8b\u3001\u80bf\u7624\u7eaf\u5ea6\u548c\u53ef\u7528\u534f\u53d8\u91cf\uff1b\u5355\u7ec6\u80de\u4e2d\u5728\u5339\u914d\u7ec6\u80de\u7c7b\u578b\u5185\u4fdd\u7559\u4f9b\u4f53\u5c42\u91cd\u590d\u3002<\/li>\n<li>\u901a\u4fe1\u5de5\u5177\u8f93\u51fa\u4f5c\u4e3a\u5019\u9009\u76f8\u4e92\u4f5c\u7528\uff0c\u68c0\u67e5\u914d\u4f53\u53d7\u4f53\u8868\u8fbe\u548c\u80cc\u666f\uff0c\u4e0d\u76f4\u63a5\u5199\u6210\u5df2\u53d1\u751f\u7684\u529f\u80fd\u4f20\u9012\u3002<\/li>\n<li>\u6839\u636e\u4e3b\u5f20\u5bfb\u627e\u72ec\u7acb\u961f\u5217\u3001\u7a7a\u95f4\u90bb\u8fd1\u6216\u529f\u80fd\u5e72\u9884\u8bc1\u636e\uff0c\u5e76\u8bf4\u660e\u6bcf\u79cd\u65b0\u589e\u6750\u6599\u89e3\u51b3\u54ea\u4e00\u4e2a\u66ff\u4ee3\u89e3\u91ca\u3002<\/li>\n<\/ol>\n<h2>\u628a\u4e09\u79cd\u89e3\u91ca\u5206\u5f00\u68c0\u9a8c<\/h2>\n<div class=\"ftc-table-wrap\" role=\"region\" tabindex=\"0\" aria-label=\"\u628a\u4e09\u79cd\u89e3\u91ca\u5206\u5f00\u68c0\u9a8c\">\n<table>\n<thead>\n<tr>\n<th scope=\"col\">\u89c2\u5bdf\u5230\u7684\u5173\u7cfb<\/th>\n<th scope=\"col\">\u53ef\u80fd\u7684\u89e3\u91ca<\/th>\n<th scope=\"col\">\u68c0\u67e5\u65b9\u6cd5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>bulk \u4e24\u4e2a\u5206\u6570\u90fd\u5347\u9ad8<\/td>\n<td>\u540c\u4e00\u7c7b\u7ec6\u80de\u53d8\u591a<\/td>\n<td>\u68c0\u67e5\u7ec6\u80de\u6bd4\u4f8b\u53ca\u7b7e\u540d\u57fa\u56e0\u6765\u6e90<\/td>\n<\/tr>\n<tr>\n<td>\u67d0\u7ec6\u80de\u7c7b\u578b\u5185\u8bc4\u5206\u6539\u53d8<\/td>\n<td>\u7ec6\u80de\u5185\u72b6\u6001\u6539\u53d8\u6216\u6d4b\u91cf\u56e0\u7d20<\/td>\n<td>\u4f9b\u4f53\u6c47\u603b\u3001\u6d4b\u5e8f\u6df1\u5ea6\u548c\u6279\u6b21\u68c0\u67e5<\/td>\n<\/tr>\n<tr>\n<td>\u901a\u4fe1\u5f97\u5206\u4e0e\u7b7e\u540d\u76f8\u5173<\/td>\n<td>\u5019\u9009\u7ec6\u80de\u95f4\u5173\u7cfb<\/td>\n<td>\u8868\u8fbe\u3001\u7a7a\u95f4\u6216\u72ec\u7acb\u529f\u80fd\u8bc1\u636e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p class=\"ftc-inline-sources\">\u4f9d\u636e\uff1a<a href=\"https:\/\/tisch.compbio.cn\/home\/\" target=\"_blank\" rel=\"noopener noreferrer\">TISCH2\uff1a\u80bf\u7624\u5fae\u73af\u5883\u5355\u7ec6\u80de\u6570\u636e\u5e93<\/a> \u00b7 <a href=\"https:\/\/github.com\/jinworks\/CellChat\" target=\"_blank\" rel=\"noopener noreferrer\">CellChat \u5b98\u65b9\u4ee3\u7801\u3001\u7248\u672c\u8bf4\u660e\u4e0e\u6559\u7a0b<\/a><\/p>\n<h2>\u539f\u59cb\u673a\u5236\u8bba\u6587\u80fd\u63d0\u4f9b\u4ec0\u4e48\u542f\u53d1<\/h2>\n<p>Wang \u7b49 2019 \u5e74\u7684\u7814\u7a76\u901a\u8fc7\u5b9e\u9a8c\u63a2\u8ba8\u4e86 CD8 T \u7ec6\u80de\u6765\u6e90 IFN\u03b3 \u4e0e\u80bf\u7624\u7ec6\u80de\u8102\u8d28\u8fc7\u6c27\u5316\u3001\u94c1\u6b7b\u4ea1\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u8fd9\u662f\u4e00\u4e2a\u5177\u4f53\u4f53\u7cfb\u4e2d\u7684\u673a\u5236\u793a\u4f8b\uff0c\u53ef\u4ee5\u5e2e\u52a9\u63d0\u51fa\u95ee\u9898\uff1b\u4e0d\u80fd\u4f5c\u4e3a\u6240\u6709\u764c\u79cd\u76f8\u5173\u6027\u5206\u6790\u7684\u901a\u7528\u7ed3\u8bba\u3002<\/p>\n<p>\u5982\u679c\u81ea\u5df1\u7684\u6570\u636e\u53ea\u6709\u6d78\u6da6\u5206\u6570\u76f8\u5173\uff0c\u5e94\u5199\u6210\u89c2\u5bdf\u6027\u5173\u8054\u3002\u8981\u6cbf\u7528\u7c7b\u4f3c\u673a\u5236\u4e3b\u5f20\uff0c\u8fd8\u9700\u8bc1\u660e\u672c\u4f53\u7cfb\u4e2d\u7684\u7ec6\u80de\u6765\u6e90\u3001\u5019\u9009\u73af\u8282\u548c\u5e72\u9884\u540e\u679c\uff0c\u4e0d\u80fd\u7528\u8be5\u8bba\u6587\u66ff\u4ee3\u81ea\u5df1\u7684\u9a8c\u8bc1\u3002<\/p>\n<p class=\"ftc-inline-sources\">\u4f9d\u636e\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1170-y\" target=\"_blank\" rel=\"noopener noreferrer\">Wang \u7b49\uff1aCD8 T \u7ec6\u80de\u4e0e\u80bf\u7624\u94c1\u6b7b\u4ea1\u7684\u5b9e\u9a8c\u7814\u7a76<\/a><\/p>\n<h2>\u4e00\u4e2a\u6700\u5c0f\u5206\u6790\u4efb\u52a1\u5355<\/h2>\n<p>\u793a\u610f\u4efb\u52a1\uff1a\u5148\u5728 bulk \u961f\u5217\u68c0\u67e5\u94c1\u6b7b\u4ea1\u76f8\u5173\u5206\u6570\u4e0e CD8 \u6307\u6807\u7684\u5173\u8054\uff0c\u518d\u5728\u5355\u7ec6\u80de\u4e2d\u5206\u522b\u770b\u80bf\u7624\u7ec6\u80de\u548c T \u7ec6\u80de\u7684\u8868\u8fbe\uff0c\u6700\u540e\u9009\u4e00\u4e2a\u6709\u660e\u786e\u8bc1\u636e\u7684\u5173\u7cfb\u8fdb\u5165\u5b9e\u9a8c\u3002\u6bcf\u4e00\u6b65\u90fd\u4fdd\u5b58\u6837\u672c\u5355\u4f4d\u3001\u534f\u53d8\u91cf\u548c\u9884\u8bbe\u6bd4\u8f83\u3002<\/p>\n<p>\u82e5\u63a7\u5236\u7ec4\u6210\u5dee\u5f02\u540e\u5173\u8054\u6d88\u5931\uff0c\u5e94\u5c06\u5176\u4f5c\u4e3a\u6709\u4ef7\u503c\u7ed3\u679c\u62a5\u544a\uff1a\u539f\u5173\u8054\u53ef\u80fd\u4e3b\u8981\u53cd\u6620\u7ec4\u6210\uff0c\u800c\u975e\u7ec6\u80de\u5185\u673a\u5236\u3002\u662f\u5426\u8ffd\u52a0 CellChat \u6216\u5176\u4ed6\u5de5\u5177\uff0c\u5e94\u7531\u5177\u4f53\u95ee\u9898\u51b3\u5b9a\uff0c\u4e0d\u4ee5\u56fe\u7684\u6570\u91cf\u51b3\u5b9a\u3002<\/p>\n<h2>\u4e0d\u80fd\u4ece\u5f53\u524d\u7ed3\u679c\u76f4\u63a5\u5f97\u51fa\u4ec0\u4e48<\/h2>\n<p>\u53bb\u5377\u79ef\u5f97\u5230\u7684\u6bd4\u4f8b\u6216\u5206\u6570\u4e0d\u662f\u76f4\u63a5\u7ec6\u80de\u8ba1\u6570\uff0c\u901a\u4fe1\u7f51\u7edc\u4e0d\u662f\u5df2\u8bc1\u5b9e\u7684\u4fe1\u53f7\u4f20\u9012\uff0c\u62df\u65f6\u5e8f\u4e5f\u4e0d\u80fd\u8865\u5145\u771f\u5b9e\u7684\u65f6\u95f4\u56e0\u679c\u3002\u76f8\u5173\u6027\u7ed3\u679c\u4e0d\u80fd\u7528\u4e8e\u4e2a\u4f53\u514d\u75ab\u6cbb\u7597\u51b3\u7b56\u3002<\/p>\n<h2>\u4f9d\u636e\u4e0e\u7248\u672c<\/h2>\n<ul class=\"ftc-source-list\">\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1170-y\" target=\"_blank\" rel=\"noopener noreferrer\">Wang \u7b49\uff1aCD8 T \u7ec6\u80de\u4e0e\u80bf\u7624\u94c1\u6b7b\u4ea1\u7684\u5b9e\u9a8c\u7814\u7a76<\/a><span>Nature\uff0c2019\uff1bDOI 10.1038\/s41586-019-1170-y<\/span><\/li>\n<li><a href=\"https:\/\/tisch.compbio.cn\/home\/\" target=\"_blank\" rel=\"noopener noreferrer\">TISCH2\uff1a\u80bf\u7624\u5fae\u73af\u5883\u5355\u7ec6\u80de\u6570\u636e\u5e93<\/a><span>TISCH2\uff1b2026-10-10 \u6838\u5bf9<\/span><\/li>\n<li><a href=\"https:\/\/github.com\/jinworks\/CellChat\" target=\"_blank\" rel=\"noopener noreferrer\">CellChat \u5b98\u65b9\u4ee3\u7801\u3001\u7248\u672c\u8bf4\u660e\u4e0e\u6559\u7a0b<\/a><span>v1\/v2 \u4ed3\u5e93\uff1b\u9875\u9762\u53e6\u5217 Spatial CellChat v3 \u5165\u53e3<\/span><\/li>\n<\/ul>\n<p class=\"ftc-verification\">\u6700\u540e\u6838\u9a8c\uff1a2026-10-10\uff5c\u8d44\u6599\u6838\u9a8c\uff1aAI \u7f16\u5199\u4e0e\u516c\u5f00\u6765\u6e90\u6838\u5bf9\uff1b\u672a\u7ecf\u4eba\u5de5\u4e13\u5bb6\u5ba1\u9605<\/p>\n<p class=\"ftc-verification\">\u4f9d\u636e\u516c\u5f00\u6765\u6e90\u6838\u5bf9\u6982\u5ff5\u3001\u8f93\u5165\u3001\u8bc1\u636e\u8fb9\u754c\u4e0e\u7248\u672c\u53e3\u5f84\uff1b\u793a\u610f\u6570\u636e\u4e0d\u4ee3\u8868\u771f\u5b9e\u7814\u7a76\u7ed3\u679c\u3002\u4ec5\u6807\u660e\u7684\u5c0f\u578b\u4ee3\u7801\u793a\u4f8b\u7ecf\u8fc7\u8fd0\u884c\u68c0\u67e5\uff0c\u4e0d\u4ee3\u8868\u5b8c\u6574\u751f\u7269\u4fe1\u606f\u6d41\u7a0b\u6216\u539f\u8bba\u6587\u5df2\u590d\u73b0\u3002<\/p>\n<h2>\u7ee7\u7eed\u89e3\u51b3\u76f8\u5173\u95ee\u9898<\/h2>\n<ul class=\"ftc-related-reading\">\n<li><a href=\"https:\/\/www.biocloudservice.com\/wordpress\/ferroptosis\/questions\/bulk-single-cell-ferroptosis-evidence-chain\/\">bulk RNA-seq \u4e0e\u5355\u7ec6\u80de\u5982\u4f55\u7ec4\u6210\u94c1\u6b7b\u4ea1\u8bc1\u636e\u94fe\uff1f<\/a><\/li>\n<li><a href=\"https:\/\/www.biocloudservice.com\/wordpress\/ferroptosis\/questions\/ferrdb-geo-tcga-tisch2-resource-selection\/\">FerrDb\u3001GEO\u3001TCGA\u3001TISCH2 \u5404\u9002\u5408\u89e3\u51b3\u4ec0\u4e48\u95ee\u9898\uff1f<\/a><\/li>\n<li><a href=\"https:\/\/www.biocloudservice.com\/wordpress\/ferroptosis\/questions\/ferroptosis-external-single-cell-experimental-validation\/\">\u94c1\u6b7b\u4ea1\u7ed3\u679c\u81f3\u5c11\u9700\u8981\u54ea\u4e9b\u5916\u90e8\u961f\u5217\u3001\u5355\u7ec6\u80de\u6216\u5b9e\u9a8c\u9a8c\u8bc1\uff1f<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u5148\u63d0\u51fa\u4e00\u4e2a\u80fd\u4e32\u8d77\u7ec6\u80de\u6765\u6e90\u548c\u4f5c\u7528\u65b9\u5411\u7684\u95ee\u9898\uff0c\u518d\u5b89\u6392\u514d\u75ab\u6d78\u6da6\u3001\u5355\u7ec6\u80de\u5b9a\u4f4d\u6216\u901a\u4fe1\u5206\u6790\u3002bulk \u94c1\u6b7b\u4ea1\u8bc4\u5206\u4e0e\u514d\u75ab\u5206\u6570\u76f8\u5173\u53ef\u80fd\u6765\u81ea\u7ec6\u80de\u6bd4\u4f8b\u5171\u540c\u53d8\u5316\uff0c\u4e0d\u80fd\u76f4\u63a5\u89e3\u91ca\u4e3a\u80bf\u7624\u7ec6\u80de\u901a\u8fc7\u94c1\u6b7b\u4ea1\u8c03\u63a7\u514d\u75ab\u3002\u9700\u8981\u533a\u5206\u7ec4\u6210\u6548\u5e94\u3001\u7ec6\u80de\u5185\u72b6\u6001\u548c\u673a\u5236\u5e72\u9884\u3002<\/p>\n","protected":false},"template":"","class_list":["post-65847","ftc_question","type-ftc_question","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/ftc_question\/65847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/ftc_question"}],"about":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/types\/ftc_question"}],"version-history":[{"count":1,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/ftc_question\/65847\/revisions"}],"predecessor-version":[{"id":65867,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/ftc_question\/65847\/revisions\/65867"}],"wp:attachment":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media?parent=65847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}