{"id":60634,"date":"2024-06-17T11:38:29","date_gmt":"2024-06-17T03:38:29","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=60634"},"modified":"2026-09-11T23:07:49","modified_gmt":"2026-09-11T15:07:49","slug":"%e8%b6%85%e8%af%a6%e7%bb%86%ef%bc%81%e4%b8%80%e6%96%87%e5%b8%a6%e4%bd%a0%e8%af%bb%e6%87%82%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e7%bb%93%e6%9e%9c-2","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/%e8%b6%85%e8%af%a6%e7%bb%86%ef%bc%81%e4%b8%80%e6%96%87%e5%b8%a6%e4%bd%a0%e8%af%bb%e6%87%82%e5%ad%9f%e5%be%b7%e5%b0%94%e9%9a%8f%e6%9c%ba%e5%8c%96%e7%bb%93%e6%9e%9c-2\/","title":{"rendered":"\u8d85\u8be6\u7ec6\uff01\u4e00\u6587\u5e26\u4f60\u8bfb\u61c2\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7ed3\u679c"},"content":{"rendered":"<aside class=\"ysx-source-note\"><span>\u6765\u6e90<\/span><\/p>\n<p>\u516c\u4f17\u53f7\u300c\u751f\u4fe1\u56fe\u300d\u5386\u53f2\u5185\u5bb9\uff1b\u672c\u6587\u4fdd\u7559\u539f\u6709\u6280\u672f\u4fe1\u606f\u5e76\u4f18\u5316\u7f51\u9875\u6392\u7248\u3002 <a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&amp;mid=2247486043&amp;idx=1&amp;sn=dac41add614c51a950f68d7cd5591a13\" target=\"_blank\" rel=\"noopener noreferrer nofollow\">\u67e5\u770b\u539f\u6587<\/a><\/p>\n<\/aside>\n<p>\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\uff08Mendelian Randomization, MR\uff09\u662f\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u4e2d\u8bc4\u4f30\u75c5\u56e0\u63a8\u65ad\u7684\u6570\u636e\u5206\u6790\u6280\u5de7\uff0c\u5b83\u662f\u5229\u7528\u4e0e\u66b4\u9732\u56e0\u7d20\u5177\u6709\u5f3a\u76f8\u5173\u7684\u9057\u4f20\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\uff0c\u6765\u8bc4\u4f30\u66b4\u9732\u56e0\u7d20\u4e0e\u7ed3\u5c40\u4e4b\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u3002\u5728\u524d\u51e0\u671f\u7684\u63a8\u6587\u5185\u5bb9\u4e2d\uff0c\u5c0f\u679c\u4e2a\u5927\u5bb6\u4ecb\u7ecd\u4e86\uff0c\u5982\u4f55\u5229\u7528\u516c\u5171\u6570\u636e\u5e93\u67e5\u8be2\u5e76\u4e0b\u8f7dGWAS summary\u6570\u636e\u3001\u5982\u4f55\u8bfb\u53d6\u66b4\u9732\u6570\u636e\u8fdb\u884c\u5de5\u5177\u53d8\u91cf\u7684\u7b5b\u9009\u3001\u8fdb\u884cMR\u5206\u6790\uff0c\u4ee5\u53ca\u5bf9MR\u5206\u6790\u7ed3\u679c\u8fdb\u884c\u7a33\u5065\u6027\u68c0\u9a8c\u3002<\/p>\n<p>\u90a3\u4e48\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7ed3\u679c\u600e\u4e48\u770b\uff0c\u5728MR\u5206\u6790\u4e2d\u5e38\u89c1\u7684\u6709\u4ee5\u4e0b\u56db\u5f20\u56fe<\/p>\n<p>\u90a3\u5c0f\u679c\u4e00\u5f20\u5f20\u6765\u7ed9\u5927\u5bb6\u8fdb\u884c\u89e3\u8bfb<\/p>\n<p>\u4eca\u5929\u6211\u4eec\u7684\u66b4\u9732\u56e0\u7d20\u662f\u7761\u7720\u65f6\u95f4\uff0c\u7ed3\u5c40\u662f\u51a0\u5fc3\u75c5<\/p>\n<figure><img data-recalc-dims=\"1\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/mr-result-figure-01.png?ssl=1\" loading=\"lazy\" decoding=\"async\" alt=\"\"><\/figure>\n<h2>1. SNP \u68ee\u6797\u56fe<\/h2>\n<p>\u9996\u5148\u8fd9\u5f20\u56fe\u662f\u5de5\u5177\u53d8\u91cf\uff0c\u4e5f\u5c31\u662fSNP\u7684\u68ee\u6797\u56fe\u3002\u6bcf\u4e00\u6761\u6c34\u5e73\u5b9e\u7ebf\u53cd\u5e94\u7684\u662f\u5355\u4e2aSNP\uff0c\u5229\u7528Wald ratio\u65b9\u6cd5\u4f30\u8ba1\u51fa\u6765\u7684\u7ed3\u679c\uff0c\u5b9e\u7ebf\u5b8c\u5168\u57280\u5de6\u8fb9\uff0c\u8bf4\u660e\u7531\u8fd9\u4e2aSNP\u4f30\u8ba1\u51fa\u6765\u7684\u7ed3\u679c\uff0c\u662f\u7761\u7720\u65f6\u95f4\u589e\u52a0\uff0c\u80fd\u964d\u4f4e\u51a0\u5fc3\u75c5\u7684\u53d1\u75c5\u98ce\u9669\uff0c\u5b9e\u7ebf\u5b8c\u5168\u57280\u53f3\u8fb9\uff0c\u8bf4\u660e\u7531\u8fd9\u4e2aSNP\u4f30\u8ba1\u51fa\u6765\u7684\u7ed3\u679c\u662f\u7761\u7720\u65f6\u95f4\u589e\u52a0\u80fd\u589e\u52a0\u51a0\u5fc3\u75c5\u7684\u53d1\u75c5\u98ce\u9669\uff0c\u90a3\u4e9b\u8de8\u8fc70\u7684\u7ed3\u679c\u8bf4\u660e\u4e0d\u660e\u663e\uff0c\u4f46\u662f\u5355\u4e2aSNP\u7684\u7ed3\u679c\u5e76\u4e0d\u7a33\u5065\uff0c\u56e0\u4e3a\u8fd9\u91cc\u7684\u7761\u7720\u65f6\u95f4\u662f\u7531\u591a\u4e2aSNP\u5f71\u54cd\u7684\uff0c\u6240\u4ee5\u9700\u8981\u628a\u7ed3\u679c\u7efc\u5408\u8d77\u6765\u770b\uff0c\u4e5f\u5c31\u662f\u6700\u5e95\u4e0b\u7684\u7ea2\u7ebf\uff0c\u4e0b\u65b9\u7ea2\u7ebf\u53ef\u770b\u51fa\uff0c\u7761\u7720\u65f6\u95f4\u7684\u5347\u9ad8\uff0c\u53ef\u4ee5\u964d\u4f4e\u51a0\u5fc3\u75c5\u7684\u53d1\u75c5\u98ce\u9669<\/p>\n<figure><img data-recalc-dims=\"1\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/mr-result-figure-02.png?ssl=1\" loading=\"lazy\" decoding=\"async\" alt=\"\"><\/figure>\n<p>\uff08\u6ce8\uff1ax\u8f74\u4ee3\u8868SNP\u5bf9\u66b4\u9732\u7684\u5f71\u54cd\uff0cy\u8f74\u4ee3\u8868SNP\u5bf9\u7ed3\u5c40\u7684\u5f71\u54cd\u3002\u659c\u7387\u5c0f\u4e8e0\uff0c\u4ee3\u8868\u66b4\u9732\u56e0\u7d20\u662f\u7ed3\u5c40\u7684\u6709\u5229\u56e0\u7d20\uff09<\/p>\n<h2>2. \u6563\u70b9\u56fe\u4e0e\u56e0\u679c\u65b9\u5411<\/h2>\n<p>\u8fd9\u5f20\u56fe\u8868\u793a\u7684\u662f\u66b4\u9732\u56e0\u7d20\u4e0e\u7ed3\u5c40\u56e0\u7d20\u4e4b\u95f4\u7684MR\u5206\u6790\u7ed3\u679c\uff0c\u6bcf\u4e00\u4e2a\u70b9\u4ee3\u8868\u4e86\u4e00\u4e2a\u5de5\u5177\u53d8\u91cfSNP\u6bcf\u4e2a\u70b9\u4e0a\u7684\u7ebf\uff0c\u5b9e\u9645\u53cd\u5e94\u7684\u662f95%\u7684\u7f6e\u4fe1\u533a\u95f4\uff0c\u6a2a\u5750\u6807\u662fSNP\u5bf9\u66b4\u9732\u56e0\u7d20\uff08\u7761\u7720\u65f6\u95f4\uff09\u7684\u6548\u5e94\uff1b\u7eb5\u5750\u6807\u662fSNP\u5bf9\u7ed3\u5c40\u56e0\u7d20\uff08\u51a0\u5fc3\u75c5\uff09\u7684\u6548\u5e94\uff0c\u4e24\u4e2a\u6548\u5e94\u505a\u6bd4\u503c\uff0c\u5373\u66b4\u9732\u5bf9\u7ed3\u5c40\u7684\u6548\u5e94\uff0c\u4e5f\u5c31\u662f\u4e0a\u56fe\u4e2d\u5f69\u8272\u7ebf\u7684\u659c\u7387\uff0c\u4e0d\u540c\u989c\u8272\u7684\u7ebf\u8868\u793a\u7684\u662f\u4e0d\u540c\u7684\u7b97\u6cd5\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4e0d\u540c\u7b97\u6cd5\u7684\u7ebf\u603b\u4f53\u662f\u659c\u5411\u4e0b\u7684\uff0c\u8fd9\u5c31\u610f\u5473\u7740\u968f\u7740\u7761\u7720\u65f6\u95f4\u7684\u5347\u9ad8\uff0c\u51a0\u5fc3\u75c5\u7684\u53d1\u75c5\u98ce\u9669\u5728\u964d\u4f4e\u3002<\/p>\n<figure><img data-recalc-dims=\"1\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/mr-result-figure-03.png?ssl=1\" loading=\"lazy\" decoding=\"async\" alt=\"\"><\/figure>\n<p>\uff08\u6ce8\uff1a\u5224\u65ad\u6bcf\u4e2aSNP\u5bf9\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u5206\u6790\u7ed3\u679c\u7684\u5f71\u54cd\uff0c\u5982\u679c\u6709\u79bb\u7fa4\u503c\u9700\u8981\u53bb\u6389\u540e\u91cd\u65b0\u5206\u6790\uff09<\/p>\n<h2>3. \u9010\u4e2a\u5254\u9664\u56fe<\/h2>\n<p>MR\u7ed3\u679c\u5206\u6790\u4e4b\u540e\u9700\u8981\u8fdb\u884c\u654f\u611f\u6027\u5206\u6790\u6765\u68c0\u9a8c\u5206\u6790\u7ed3\u679c\u7684\u53ef\u9760\u6027\u4e0e\u7a33\u5b9a\u6027\uff0c\u9010\u4e2a\u5254\u9664\u68c0\u9a8c\u5c31\u662f\u5176\u4e2d\u7684\u4e00\u4e2d\u3002\u9010\u4e2a\u5254\u9664\u68c0\u9a8c\uff0c\u6307\u7684\u662f\u9010\u6b65\u5254\u9664\u6bcf\u4e2aSNP\uff0c\u8ba1\u7b97\u5269\u4f59SNP\u7684meta\u6548\u5e94\uff0c\u89c2\u5bdf\u5254\u9664\u6bcf\u4e2aSNP\u540e\u7ed3\u679c\u662f\u5426\u53d1\u751f\u53d8\u5316\uff0c\u5982\u679c\u5254\u9664\u4e86\u67d0\u4e00\u4e2aSNP\u540e\uff0c\u7ed3\u679c\u6539\u53d8\u5f88\u5927\uff0c\u8bf4\u660e\u5b58\u5728\u67d0\u4e00\u4e2aSNP\u5bf9\u7ed3\u679c\u5f71\u54cd\u5f88\u5927\uff0c\u6709\u5f02\u5e38\u503c\u9700\u8981\u5254\u9664\u6389\uff0c\u5982\u4e0a\u56fe\u6240\u793a\uff0c\u5254\u9664\u6bcf\u4e2aSNP\u540e\uff0c\u603b\u4f53\u7684\u8bef\u5dee \u7ebf\u53d8\u5316\u4e0d\u5927\uff0c\u4e5f\u5c31\u662f\u6240\u6709\u7684\u8bef\u5dee\u7ebf\u5747\u57280\u7684\u53f3\u4fa7\uff0c\u6216\u8005\u6240\u6709\u7684\u8bef\u5dee\u7ebf\u90fd\u57280\u7684\u5de6\u4fa7\uff0c\u8bf4\u660e\u7ed3\u679c\u662f\u53ef\u9760\u7684\u3002<\/p>\n<figure><img data-recalc-dims=\"1\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2024\/06\/mr-result-figure-04.png?ssl=1\" loading=\"lazy\" decoding=\"async\" alt=\"\"><\/figure>\n<h2>4. \u6f0f\u6597\u56fe<\/h2>\n<p>\u6f0f\u6597\u56fe\u53ef\u4ee5\u770bSNP\u7684\u5f02\u8d28\u6027\uff0c\u4e0emeta\u5206\u6790\u4e2d\u7684\u6f0f\u6597\u56fe\u7c7b\u4f3c\uff0c\u4e3b\u8981\u5173\u6ce8IVW\u7ebf\u7684\u5de6\u53f3\u4e24\u8fb9\u7684\u70b9\u662f\u5426\u5927\u81f4\u5bf9\u79f0\uff0c\u5982\u679c\u6709\u7279\u522b\u79bb\u7fa4\u7684\u70b9\u8bf4\u660e\u6709\u79bb\u7fa4\u503c\uff0c\u53ef\u4ee5\u53bb\u9664\u540e\u518d\u6b21\u8fdb\u884cMR\u5206\u6790\u3002<\/p>\n<p>\u81f3\u6b64\u4eca\u5929\u7684\u5206\u4eab\u5230\u8fd9\u91cc\u5c31\u7ed3\u675f\u4e86\uff0c\u540e\u9762\u5c0f\u679c\u4f1a\u7ee7\u7eed\u4e3a\u5927\u5bb6\u5206\u4eab\u6bcf\u4e2a\u6b65\u9aa4\u7684\u5177\u4f53\u64cd\u4f5c\u548c\u4e00\u4e9b\u6ce8\u610f\u4e8b\u9879\uff0c\u6b22\u8fce\u5927\u5bb6\u7ee7\u7eed\u5173\u6ce8\u54e6\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8d85\u8be6\u7ec6\uff01\u4e00\u6587\u5e26\u4f60\u8bfb\u61c2\u5b5f\u5fb7\u5c14\u968f\u673a\u5316\u7ed3\u679c \u5c0f\u56fe \u751f\u4fe1\u679c 2024-01-11 19:00:44 \u8f6c\u81ea\u516c\u4f17\u53f7\uff1a\u751f\u4fe1\u56fehttp:\/\/mp.weixin.qq.com\/s?__biz=MzkxODUxNDgzNA==&#038;mid=2247486043&#038;idx=1&#038;sn=dac41\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-60634","post","type-post","status-publish","format-standard","hentry","category-part"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/60634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/comments?post=60634"}],"version-history":[{"count":2,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/60634\/revisions"}],"predecessor-version":[{"id":65425,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/60634\/revisions\/65425"}],"wp:attachment":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media?parent=60634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/categories?post=60634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/tags?post=60634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}