{"id":65388,"date":"2026-09-11T14:39:20","date_gmt":"2026-09-11T06:39:20","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/matrix-stiffness-gene-set\/"},"modified":"2026-09-11T14:39:20","modified_gmt":"2026-09-11T06:39:20","slug":"matrix-stiffness-gene-set","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/matrix-stiffness-gene-set\/","title":{"rendered":"\u57fa\u8d28\u521a\u5ea6\u76f8\u5173\u57fa\u56e0\u96c6\u6574\u7406\uff1a1,400+\u5019\u9009\u57fa\u56e0\uff0c\u9002\u7528\u4e8e\u8f6c\u5f55\u7ec4\u4e0e\u5355\u7ec6\u80de\u5206\u6790"},"content":{"rendered":"<p>\u7ec4\u7ec7\u548c\u7ec6\u80de\u6240\u5904\u7684\u529b\u5b66\u73af\u5883\uff0c\u4f1a\u76f4\u63a5\u5f71\u54cd\u9ecf\u9644\u3001\u8fc1\u79fb\u3001\u589e\u6b96\u3001\u5206\u5316\u4ee5\u53ca\u7ec6\u80de\u5916\u57fa\u8d28\u91cd\u5851\u3002\u5bf9\u4e8e\u80bf\u7624\u3001\u7ea4\u7ef4\u5316\u3001\u9aa8\u4e0e\u8f6f\u9aa8\u3001\u751f\u7269\u6750\u6599\u548c\u7ec4\u7ec7\u5de5\u7a0b\u7b49\u7814\u7a76\u6765\u8bf4\uff0c\u57fa\u8d28\u521a\u5ea6\uff08matrix stiffness\uff09\u5df2\u7ecf\u6210\u4e3a\u4e00\u4e2a\u8d8a\u6765\u8d8a\u5e38\u89c1\u7684\u5206\u6790\u65b9\u5411\u3002<\/p>\n<p>\u4e3a\u4e86\u65b9\u4fbf\u5927\u5bb6\u5f00\u5c55\u8f6c\u5f55\u7ec4\u548c\u5355\u7ec6\u80de\u6570\u636e\u5206\u6790\uff0c\u6211\u4eec\u6574\u7406\u4e86\u4e00\u4efd<strong>\u57fa\u8d28\u521a\u5ea6\u76f8\u5173\u5019\u9009\u57fa\u56e0\u96c6<\/strong>\u3002\u8868\u683c\u5305\u542b 1,418 \u6761\u57fa\u56e0\u8bb0\u5f55\uff0c\u6309\u539f\u59cb\u7b26\u53f7\u53bb\u91cd\u540e\u4e3a 1,417 \u4e2a\u5019\u9009\u57fa\u56e0\uff0c\u53ef\u4f5c\u4e3a\u540e\u7eed\u7b5b\u9009\u548c\u529f\u80fd\u5206\u6790\u7684\u8d77\u70b9\u3002<\/p>\n<h2>\u8fd9\u4efd\u57fa\u56e0\u96c6\u5305\u542b\u54ea\u4e9b\u65b9\u5411\uff1f<\/h2>\n<p>\u57fa\u56e0\u96c6\u8986\u76d6\u4e86\u591a\u7c7b\u4e0e\u7ec6\u80de\u529b\u5b66\u54cd\u5e94\u76f8\u5173\u7684\u5206\u5b50\uff0c\u4f8b\u5982\u7ec6\u80de\u5916\u57fa\u8d28\u4e0e\u80f6\u539f\u5bb6\u65cf\u3001\u6574\u5408\u7d20\u4e0e\u9ecf\u9644\u6591\u4fe1\u53f7\u3001\u808c\u52a8\u86cb\u767d\u9aa8\u67b6\u8c03\u63a7\u3001\u57fa\u8d28\u964d\u89e3\u4e0e\u91cd\u5851\u3001TGF-\u03b2 \u4fe1\u53f7\u3001\u673a\u68b0\u654f\u611f\u79bb\u5b50\u901a\u9053\uff0c\u4ee5\u53ca\u708e\u75c7\u548c\u7ec6\u80de\u8fc1\u79fb\u76f8\u5173\u5206\u5b50\u3002\u8868\u683c\u4e2d\u53ef\u89c1 COL\u3001LAMA\u3001ITGA\/ITGB\u3001MMP\u3001LOX\/LOXL\u3001TGFB\u3001PTK2\u3001ROCK\u3001PIEZO1 \u7b49\u4ee3\u8868\u6027\u57fa\u56e0\u6216\u5bb6\u65cf\u3002<\/p>\n<h2>\u53ef\u4ee5\u600e\u4e48\u7528\uff1f<\/h2>\n<ul>\n<li><strong>Bulk RNA-seq\uff1a<\/strong>\u4f7f\u7528 GSVA\u3001ssGSEA \u7b49\u65b9\u6cd5\u8ba1\u7b97\u6837\u672c\u7684\u57fa\u8d28\u521a\u5ea6\u76f8\u5173\u8bc4\u5206\uff0c\u5e76\u6bd4\u8f83\u4e0d\u540c\u5206\u7ec4\u3002<\/li>\n<li><strong>\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\uff1a<\/strong>\u4f7f\u7528 UCell\u3001AUCell \u6216 AddModuleScore\uff0c\u89c2\u5bdf\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u53ca\u7ec6\u80de\u4e9a\u7fa4\u7684\u529b\u5b66\u54cd\u5e94\u5dee\u5f02\u3002<\/li>\n<li><strong>\u5dee\u5f02\u57fa\u56e0\u7b5b\u9009\uff1a<\/strong>\u5c06\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u4e0e\u672c\u57fa\u56e0\u96c6\u53d6\u4ea4\u96c6\uff0c\u518d\u7ed3\u5408 GO\u3001KEGG\u3001PPI \u7b49\u7ed3\u679c\u7f29\u5c0f\u5019\u9009\u8303\u56f4\u3002<\/li>\n<li><strong>\u8bfe\u9898\u8bbe\u8ba1\uff1a<\/strong>\u56f4\u7ed5\u7ec6\u80de\u5916\u57fa\u8d28\u91cd\u5851\u3001\u673a\u68b0\u8f6c\u5bfc\u3001\u8fc1\u79fb\u4fb5\u88ad\u6216\u7ea4\u7ef4\u5316\u7b49\u65b9\u5411\u6784\u5efa\u5206\u6790\u7ebf\u7d22\u3002<\/li>\n<\/ul>\n<h2>\u4f7f\u7528\u524d\u9700\u8981\u6ce8\u610f<\/h2>\n<p>\u8fd9\u662f\u4e00\u4efd\u7528\u4e8e\u7814\u7a76\u63a2\u7d22\u7684\u5019\u9009\u57fa\u56e0\u96c6\u5408\uff0c\u4e0d\u7b49\u540c\u4e8e\u5df2\u7ecf\u5728\u6240\u6709\u7ec4\u7ec7\u3001\u75be\u75c5\u548c\u5b9e\u9a8c\u6761\u4ef6\u4e2d\u9a8c\u8bc1\u8fc7\u7684\u56fa\u5b9a\u6807\u5fd7\u7269\u3002\u57fa\u8d28\u521a\u5ea6\u7684\u751f\u7269\u5b66\u6548\u5e94\u5177\u6709\u660e\u663e\u7684\u7ec4\u7ec7\u3001\u7ec6\u80de\u7c7b\u578b\u548c\u75be\u75c5\u80cc\u666f\u5dee\u5f02\u3002\u6b63\u5f0f\u5206\u6790\u524d\uff0c\u5efa\u8bae\u6839\u636e\u7814\u7a76\u7269\u79cd\u7edf\u4e00\u57fa\u56e0\u7b26\u53f7\u3001\u53bb\u91cd\uff0c\u5e76\u7ed3\u5408\u5dee\u5f02\u8868\u8fbe\u3001\u901a\u8def\u5bcc\u96c6\u548c\u6587\u732e\u8bc1\u636e\u8fdb\u4e00\u6b65\u7b5b\u9009\u3002<\/p>\n<p><strong>\u57fa\u56e0\u96c6\u4e0b\u8f7d\uff1a<\/strong><a href=\"https:\/\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/09\/matrix-stiffness-gene-set.xlsx\">\u70b9\u51fb\u4e0b\u8f7d\u57fa\u8d28\u521a\u5ea6\u76f8\u5173\u5019\u9009\u57fa\u56e0\u96c6\uff08Excel\uff09<\/a><\/p>\n<hr>\n<p><strong>\u9700\u8981\u8fdb\u4e00\u6b65\u5206\u6790\uff1f<\/strong><\/p>\n<p>\u5982\u679c\u4f60\u5e0c\u671b\u628a\u8fd9\u4efd\u57fa\u56e0\u96c6\u7528\u4e8e Bulk RNA-seq\u3001\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u3001\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u3001\u5bcc\u96c6\u5206\u6790\u6216\u673a\u5668\u5b66\u4e60\u7b5b\u9009\uff0c\u53ef\u4ee5\u628a\u7814\u7a76\u65b9\u5411\u3001\u7269\u79cd\u548c\u6570\u636e\u7c7b\u578b\u53d1\u7ed9\u6211\u4eec\u3002\u6211\u4eec\u53ef\u4ee5\u534f\u52a9\u5b8c\u6210\u57fa\u56e0\u7b26\u53f7\u6574\u7406\u3001\u8bc4\u5206\u5206\u6790\u3001\u5206\u7ec4\u6bd4\u8f83\u3001\u7ed3\u679c\u53ef\u89c6\u5316\u548c\u5206\u6790\u65b9\u6848\u8bbe\u8ba1\u3002<\/p>\n<p><a href=\"https:\/\/work.weixin.qq.com\/kfid\/kfcb05492f29d4d6064\" target=\"_blank\" rel=\"noopener\">\u8054\u7cfb\u4f01\u4e1a\u5fae\u4fe1\u5ba2\u670d\uff0c\u6c9f\u901a\u4f60\u7684\u7814\u7a76\u9700\u6c42<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6574\u7406\u4e86\u4e00\u4efd\u5305\u542b1,400\u591a\u4e2a\u5019\u9009\u57fa\u56e0\u7684\u57fa\u8d28\u521a\u5ea6\u76f8\u5173\u57fa\u56e0\u96c6\uff0c\u53ef\u7528\u4e8eBulk RNA-seq\u3001\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u3001\u5bcc\u96c6\u5206\u6790\u4e0e\u7814\u7a76\u7ebf\u7d22\u7b5b\u9009\uff0c\u5e76\u63d0\u4f9bExcel\u8868\u683c\u4e0b\u8f7d\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":""},"categories":[71,73,72],"tags":[81,80,79,78,77,82],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/65388"}],"collection":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/comments?post=65388"}],"version-history":[{"count":0,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/65388\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media?parent=65388"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/categories?post=65388"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/tags?post=65388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}