{"id":65822,"date":"2026-11-14T14:00:00","date_gmt":"2026-11-14T06:00:00","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=65822"},"modified":"2026-10-10T12:33:56","modified_gmt":"2026-10-10T04:33:56","slug":"mixed-model-gwas-server-lowmem-guide","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/mixed-model-gwas-server-lowmem-guide\/","title":{"rendered":"\u6df7\u5408\u6a21\u578b GWAS \u4e3a\u4ec0\u4e48\u8981\u5355\u72ec\u8bc4\u4f30\u670d\u52a1\u5668\uff1f"},"content":{"rendered":"<p>\u540c\u6837\u53eb GWAS\uff0c\u7528 PLINK \u505a\u5e38\u89c4\u56de\u5f52\uff0c\u548c\u7528 REGENIE \u7b49\u5de5\u5177\u5904\u7406\u5927\u6837\u672c\u3001\u76f8\u5173\u4e2a\u4f53\u6216\u591a\u4e2a\u8868\u578b\uff0c\u670d\u52a1\u5668\u9700\u6c42\u53ef\u80fd\u5b8c\u5168\u4e0d\u540c\u3002<\/p>\n<p>\u6df7\u5408\u6a21\u578b\u6216\u4e24\u9636\u6bb5 GWAS \u4e0d\u53ea\u662f\u201c\u591a\u8dd1\u4e00\u4e2a\u547d\u4ee4\u201d\u3002\u5168\u57fa\u56e0\u7ec4\u9884\u6d4b\u3001\u5173\u8054\u68c0\u9a8c\u3001\u67d3\u8272\u4f53\u5206\u533a\u3001\u591a\u8868\u578b\u8f93\u51fa\u548c\u4e34\u65f6\u6587\u4ef6\uff0c\u4f1a\u628a\u5185\u5b58\u3001CPU \u4e0e\u5de5\u4f5c\u76d8\u7ed1\u5728\u4e00\u8d77\u3002<\/p>\n<p><strong>\u5c24\u5176\u5f53\u4f60\u542f\u7528\u4f4e\u5185\u5b58\u6a21\u5f0f\u65f6\uff0c\u95ee\u9898\u5e76\u6ca1\u6709\u6d88\u5931\uff0c\u800c\u662f\u4ece\u5185\u5b58\u8f6c\u79fb\u5230\u4e86\u78c1\u76d8\u3002<\/strong><\/p>\n<h2>\u4e3a\u4ec0\u4e48\u6df7\u5408\u6a21\u578b\u9700\u8981\u5355\u72ec\u8bc4\u4f30\u8d44\u6e90\uff1f<\/h2>\n<p>\u666e\u901a\u8fb9\u9645\u56de\u5f52\u901a\u5e38\u9010\u4e2a\u4f4d\u70b9\u68c0\u9a8c\u3002\u5927\u6837\u672c\u6216\u5b58\u5728\u4eb2\u7f18\u5173\u7cfb\u3001\u7fa4\u4f53\u7ed3\u6784\u65f6\uff0c\u7814\u7a76\u8005\u53ef\u80fd\u4f7f\u7528\u5168\u57fa\u56e0\u7ec4\u9884\u6d4b\u6216\u6df7\u5408\u6a21\u578b\uff0c\u5148\u4f30\u8ba1\u80cc\u666f\u9057\u4f20\u6548\u5e94\uff0c\u518d\u505a\u9010\u4f4d\u70b9\u5173\u8054\u3002<\/p>\n<p>\u4ee5 REGENIE \u4e3a\u4f8b\uff0c\u6d41\u7a0b\u5206\u4e3a\u4e24\u4e2a\u4e3b\u8981\u6b65\u9aa4\uff1a<\/p>\n<ol>\n<li><strong>Step 1\uff1a<\/strong>\u4f7f\u7528\u4e00\u7ec4\u57fa\u56e0\u578b\u6784\u5efa\u5168\u57fa\u56e0\u7ec4\u9884\u6d4b\uff1b<\/li>\n<li><strong>Step 2\uff1a<\/strong>\u7ed3\u5408\u9884\u6d4b\u7ed3\u679c\uff0c\u5bf9\u76ee\u6807\u53d8\u5f02\u548c\u8868\u578b\u6267\u884c\u5173\u8054\u68c0\u9a8c\u3002<\/li>\n<\/ol>\n<p>\u6837\u672c\u6570\u3001SNP \u6570\u3001block size\u3001ridge \u53c2\u6570\u548c\u8868\u578b\u6570\u91cf\uff0c\u90fd\u4f1a\u6539\u53d8 Step 1 \u7684\u5185\u5b58\u4e0e\u4e34\u65f6\u6587\u4ef6\u538b\u529b\u3002Step 2 \u53c8\u53ef\u80fd\u6309\u67d3\u8272\u4f53\u3001\u8868\u578b\u6216\u5206\u533a\u5e76\u884c\u3002<\/p>\n<figure class=\"wp-block-image size-full\"><img data-recalc-dims=\"1\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/10\/cellranger-gwas-series-20261010-gwas-mixed-model-poster.png?ssl=1\" alt=\"\u6df7\u5408\u6a21\u578b GWAS \u4e24\u9636\u6bb5\u5206\u6790\uff1a\u4f4e\u5185\u5b58\u6a21\u5f0f\u4f1a\u51cf\u5c11\u5185\u5b58\u5e76\u589e\u52a0\u4e34\u65f6\u78c1\u76d8\u4f7f\u7528\" loading=\"lazy\" decoding=\"async\"><figcaption>\u4f4e\u5185\u5b58\u6a21\u5f0f\u662f\u4e00\u79cd\u8d44\u6e90\u4ea4\u6362\uff1a\u51cf\u5c11\u5185\u5b58\u5360\u7528\uff0c\u4f46\u9700\u8981\u66f4\u5927\u7684\u9ad8\u901f\u5de5\u4f5c\u76d8\u548c\u66f4\u6e05\u695a\u7684\u4e34\u65f6\u6587\u4ef6\u7ba1\u7406\u3002<\/figcaption><\/figure>\n<h2>\u591a\u4e00\u4e2a\u8868\u578b\uff0c\u53ef\u80fd\u4e0d\u53ea\u662f\u591a\u4e00\u4efd\u7ed3\u679c<\/h2>\n<p><a href=\"https:\/\/rgcgithub.github.io\/regenie\/install\/\" target=\"_blank\" rel=\"noopener noreferrer\">REGENIE \u5b98\u65b9\u8ba1\u7b97\u8981\u6c42<\/a>\u8bf4\u660e\uff0c\u9ed8\u8ba4\u6a21\u5f0f\u4f1a\u5728\u5185\u5b58\u4e2d\u4fdd\u5b58\u9884\u6d4b\u6570\u636e\u3002\u6587\u6863\u7ed9\u51fa\u7684\u793a\u4f8b\u4e2d\uff0c\u5f53\u6837\u672c\u3001SNP\u3001block size \u548c ridge \u53c2\u6570\u56fa\u5b9a\u65f6\uff0c\u5355\u4e2a\u8868\u578b\u53ef\u5360\u7528\u7ea6 8 GB\uff0c25 \u4e2a\u8868\u578b\u5408\u8ba1\u53ef\u8fbe\u5230\u7ea6 200 GB\u3002<\/p>\n<p>\u8fd9\u4e0d\u662f\u6240\u6709\u9879\u76ee\u7684\u901a\u7528\u6570\u5b57\uff0c\u5374\u63ed\u793a\u4e86\u4e00\u4e2a\u91cd\u8981\u89c4\u5f8b\uff1a<strong>\u8868\u578b\u6570\u91cf\u4e5f\u4f1a\u6210\u4e3a\u5185\u5b58\u7ef4\u5ea6\u3002<\/strong><\/p>\n<p>\u5982\u679c\u53ea\u6309\u6837\u672c\u6570\u548c\u4f4d\u70b9\u6570\u914d\u7f6e\u670d\u52a1\u5668\uff0c\u800c\u5ffd\u7565\u8868\u578b\u6570\u91cf\uff0c\u5355\u8868\u578b\u6d4b\u8bd5\u53ef\u80fd\u987a\u5229\uff0c\u591a\u8868\u578b\u6b63\u5f0f\u8fd0\u884c\u5374\u4f1a\u7a81\u7136\u8d8a\u8fc7\u5185\u5b58\u4e0a\u9650\u3002<\/p>\n<h2>\u4f4e\u5185\u5b58\u6a21\u5f0f\uff1a\u5c11\u5360\u5185\u5b58\uff0c\u591a\u7528\u78c1\u76d8<\/h2>\n<p>REGENIE \u7684 <code>--lowmem<\/code> \u4f1a\u628a\u90e8\u5206\u9884\u6d4b\u7ed3\u679c\u5199\u5230\u4e34\u65f6\u6587\u4ef6\uff0c\u907f\u514d\u5168\u90e8\u4fdd\u5b58\u5728\u5185\u5b58\u4e2d\u3002\u8fd9\u6837\u53ef\u4ee5\u964d\u4f4e RAM \u538b\u529b\uff0c\u4f46\u4e34\u65f6\u76d8\u5bb9\u91cf\u3001\u5199\u5165\u901f\u5ea6\u548c\u76ee\u5f55\u7ba1\u7406\u5c31\u53d8\u5f97\u66f4\u91cd\u8981\u3002<\/p>\n<p>\u5982\u679c\u628a\u4e34\u65f6\u76ee\u5f55\u653e\u5728\u5bb9\u91cf\u4e0d\u8db3\u6216\u901f\u5ea6\u8f83\u6162\u7684\u78c1\u76d8\u4e0a\uff0c\u4f4e\u5185\u5b58\u6a21\u5f0f\u53ef\u80fd\u4ece\u201cOOM\u201d\u53d8\u6210\u201c\u78c1\u76d8\u7206\u6ee1\u201d\u6216\u201cI\/O \u7b49\u5f85\u201d\u3002\u56e0\u6b64\uff0c\u9009\u62e9 lowmem \u4e0d\u80fd\u53ea\u770b\u5185\u5b58\u6570\u5b57\uff0c\u8fd8\u8981\u540c\u65f6\u89c4\u5212\uff1a<\/p>\n<ul>\n<li>\u4e34\u65f6\u6587\u4ef6\u653e\u5728\u54ea\u5757\u76d8\uff1b<\/li>\n<li>\u591a\u4e2a\u8868\u578b\u4f1a\u751f\u6210\u591a\u5c11\u4e34\u65f6\u6570\u636e\uff1b<\/li>\n<li>\u4efb\u52a1\u4e2d\u65ad\u540e\u662f\u5426\u4fdd\u7559\u6216\u6e05\u7406\u4e34\u65f6\u76ee\u5f55\uff1b<\/li>\n<li>\u5e76\u884c\u5206\u533a\u662f\u5426\u540c\u65f6\u5199\u5165\u540c\u4e00\u5b58\u50a8\uff1b<\/li>\n<li>\u6700\u7ec8\u7ed3\u679c\u548c\u4e2d\u95f4\u9884\u6d4b\u6587\u4ef6\u5982\u4f55\u5f52\u6863\u3002<\/li>\n<\/ul>\n<h2>\u7ebf\u7a0b\u8d8a\u591a\uff0c\u4e5f\u8981\u770b\u4efb\u52a1\u600e\u4e48\u62c6<\/h2>\n<p>REGENIE \u652f\u6301\u901a\u8fc7 <code>--threads<\/code> \u4f7f\u7528\u591a\u4e2a\u6838\u5fc3\u3002\u5b98\u65b9\u5efa\u8bae\u5728\u5408\u9002\u573a\u666f\u4e2d\u4f7f\u7528\u591a\u7ebf\u7a0b\uff0c\u540c\u65f6\u4e5f\u6307\u51fa\u67d0\u4e9b gene-based tests \u66f4\u9002\u5408\u9650\u5236\u5355\u4efb\u52a1\u7ebf\u7a0b\uff0c\u518d\u6309\u57fa\u56e0\u7ec4\u5206\u533a\u5e76\u884c\u3002<\/p>\n<p>\u8fd9\u8bf4\u660e\u201c\u7ed9\u4e00\u4e2a\u4efb\u52a1\u5168\u90e8\u6838\u5fc3\u201d\u5e76\u4e0d\u603b\u662f\u6700\u4f73\u7b56\u7565\u3002\u5927\u6837\u672c GWAS \u5e38\u5e38\u66f4\u9700\u8981\u628a\u67d3\u8272\u4f53\u3001\u8868\u578b\u3001\u5206\u533a\u548c\u4efb\u52a1\u961f\u5217\u4e00\u8d77\u89c4\u5212\uff0c\u8ba9\u6bcf\u4e2a\u4efb\u52a1\u6709\u6e05\u695a\u7684\u5185\u5b58\u4e0e\u8f93\u51fa\u8fb9\u754c\u3002<\/p>\n<h2>\u4e0d\u540c\u8fd0\u884c\u65b9\u5f0f\uff0c\u8d44\u6e90\u538b\u529b\u843d\u70b9\u4e0d\u540c<\/h2>\n<figure class=\"wp-block-table\">\n<table style=\"display:table;width:100%;min-width:0;table-layout:fixed\">\n<thead>\n<tr>\n<th style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u8fd0\u884c\u65b9\u5f0f<\/th>\n<th style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u4e3b\u8981\u538b\u529b<\/th>\n<th style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u914d\u7f6e\u91cd\u70b9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u9ed8\u8ba4 Step 1<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u9884\u6d4b\u6570\u636e\u9a7b\u7559\u5185\u5b58<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u6309\u6837\u672c\u3001SNP \u548c\u8868\u578b\u8bc4\u4f30 RAM<\/td>\n<\/tr>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">Step 1 + lowmem<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u4e34\u65f6\u6587\u4ef6\u5199\u76d8<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u9ad8\u901f\u5de5\u4f5c\u76d8\u3001\u5bb9\u91cf\u548c\u6e05\u7406\u89c4\u5219<\/td>\n<\/tr>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u591a\u8868\u578b\u540c\u65f6\u8fd0\u884c<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u5185\u5b58\u6216\u4e34\u65f6\u6587\u4ef6\u6210\u500d\u589e\u52a0<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u5206\u6279\u3001\u9650\u5236\u5e76\u53d1\u3001\u72ec\u7acb\u8f93\u51fa<\/td>\n<\/tr>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u6309\u67d3\u8272\u4f53\u6216\u5206\u533a\u5e76\u884c<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">CPU\u3001I\/O \u4e0e\u6587\u4ef6\u6570\u91cf<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;padding:10px 8px;vertical-align:top;font-size:15px;line-height:1.65\">\u4efb\u52a1\u961f\u5217\u3001\u547d\u540d\u4e0e\u5408\u5e76\u68c0\u67e5<\/td>\n<\/tr>\n<\/tbody>\n<\/table><figcaption>\u4f4e\u5185\u5b58\u3001\u5e76\u53d1\u548c\u5206\u533a\u90fd\u662f\u8d44\u6e90\u7b56\u7565\uff0c\u4e0d\u4f1a\u66ff\u4ee3\u5bf9\u8868\u578b\u3001\u534f\u53d8\u91cf\u548c\u6a21\u578b\u9002\u7528\u6027\u7684\u68c0\u67e5\u3002<\/figcaption><\/figure>\n<h2>\u4ec0\u4e48\u65f6\u5019\u9700\u8981\u9ad8\u5185\u5b58\uff0c\u4ec0\u4e48\u65f6\u5019\u66f4\u9700\u8981\u9ad8\u901f\u5de5\u4f5c\u76d8\uff1f<\/h2>\n<p>\u5982\u679c\u8868\u578b\u8f83\u5c11\u3001\u6837\u672c\u548c\u4f4d\u70b9\u89c4\u6a21\u53ef\u63a7\uff0c\u6807\u51c6\u6a21\u5f0f\u53ef\u80fd\u66f4\u76f4\u63a5\uff1b\u5982\u679c\u8868\u578b\u591a\u6216\u5185\u5b58\u6709\u9650\uff0clowmem \u53ef\u4ee5\u964d\u4f4e RAM \u538b\u529b\uff0c\u4f46\u9700\u8981\u66f4\u5927\u7684\u9ad8\u901f\u78c1\u76d8\u3002<\/p>\n<p>\u51fa\u73b0\u4ee5\u4e0b\u60c5\u51b5\u65f6\uff0c\u5efa\u8bae\u5355\u72ec\u505a\u670d\u52a1\u5668\u8bc4\u4f30\uff1a<\/p>\n<ul>\n<li>\u5927\u6837\u672c\u6216 imputation \u6570\u636e\uff0c\u9700\u8981\u4e24\u9636\u6bb5\u6216\u6df7\u5408\u6a21\u578b GWAS\uff1b<\/li>\n<li>\u591a\u4e2a\u8868\u578b\u3001\u4e9a\u7ec4\u6216\u6a21\u578b\u9700\u8981\u6279\u91cf\u8fd0\u884c\uff1b<\/li>\n<li>Step 1 \u5cf0\u503c\u5185\u5b58\u63a5\u8fd1\u73b0\u6709\u673a\u5668\u4e0a\u9650\uff1b<\/li>\n<li>\u51c6\u5907\u4f7f\u7528 lowmem\uff0c\u5374\u6ca1\u6709\u8db3\u591f\u9ad8\u901f\u4e34\u65f6\u76d8\uff1b<\/li>\n<li>\u9700\u8981\u6309\u67d3\u8272\u4f53\u3001\u8868\u578b\u6216\u5206\u533a\u5e76\u884c\uff0c\u5e76\u7edf\u4e00\u5408\u5e76\u7ed3\u679c\uff1b<\/li>\n<li>\u9700\u8981\u5b8c\u6574\u4fdd\u7559\u9884\u6d4b\u6587\u4ef6\u3001\u65e5\u5fd7\u3001\u7248\u672c\u548c\u53c2\u6570\u4ee5\u4fbf\u590d\u73b0\u3002<\/li>\n<\/ul>\n<h2>\u914d\u7f6e\u524d\u9700\u8981\u8bf4\u660e\u7684 8 \u9879\u4fe1\u606f<\/h2>\n<ol>\n<li>\u6837\u672c\u6570\u4e0e\u4f4d\u70b9\u6570\uff1b<\/li>\n<li>\u57fa\u56e0\u578b\u683c\u5f0f\u548c\u6587\u4ef6\u603b\u5927\u5c0f\uff1b<\/li>\n<li>\u5b9a\u91cf\u6216\u4e8c\u5206\u7c7b\u8868\u578b\u6570\u91cf\uff1b<\/li>\n<li>\u534f\u53d8\u91cf\u6570\u91cf\u548c\u7f3a\u5931\u60c5\u51b5\uff1b<\/li>\n<li>\u51c6\u5907\u4f7f\u7528\u7684\u6a21\u578b\u4e0e\u8f6f\u4ef6\u7248\u672c\uff1b<\/li>\n<li>\u662f\u5426\u4f7f\u7528 lowmem\u3001Firth \u6216 gene-based tests\uff1b<\/li>\n<li>\u6309\u67d3\u8272\u4f53\u3001\u8868\u578b\u6216\u5206\u533a\u7684\u5e76\u884c\u8ba1\u5212\uff1b<\/li>\n<li>\u671f\u671b\u5b8c\u6210\u65f6\u95f4\u548c\u9700\u8981\u4fdd\u7559\u7684\u4e2d\u95f4\u6587\u4ef6\u3002<\/li>\n<\/ol>\n<h2>\u628a\u6a21\u578b\u548c\u6570\u636e\u89c4\u6a21\u53d1\u6765\uff0c\u5148\u83b7\u5f97\u8fd0\u884c\u65b9\u6848<\/h2>\n<p>\u5982\u679c\u6df7\u5408\u6a21\u578b GWAS \u5df2\u7ecf\u5361\u5728\u5185\u5b58\u5cf0\u503c\u3001\u4e34\u65f6\u76d8\u6216\u591a\u8868\u578b\u6392\u961f\uff0c\u53ef\u4ee5\u8054\u7cfb\u4e91\u751f\u4fe1\u4f01\u4e1a\u5fae\u4fe1\u5ba2\u670d\uff0c\u53d1\u9001<strong>\u201c\u6df7\u5408\u6a21\u578b GWAS\u201d<\/strong>\u3002<\/p>\n<p>\u8bf7\u51c6\u5907\u6837\u672c\u6570\u3001\u4f4d\u70b9\u6570\u3001\u8868\u578b\u6570\u3001\u8f93\u5165\u683c\u5f0f\u3001\u8f6f\u4ef6\u4e0e\u6a21\u578b\u3001\u662f\u5426\u4f7f\u7528 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