{"id":65903,"date":"2026-10-13T09:00:00","date_gmt":"2026-10-13T01:00:00","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=65903"},"modified":"2026-10-10T16:15:28","modified_gmt":"2026-10-10T08:15:28","slug":"gwas-eqtl-single-cell-prioritize-target-gene-case","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/gwas-eqtl-single-cell-prioritize-target-gene-case\/","title":{"rendered":"\u7528 GWAS\u3001eQTL \u548c\u5355\u7ec6\u80de\u5206\u6790\uff0c\u89e3\u51b3\u201c\u4f4d\u70b9\u9644\u8fd1\u591a\u4e2a\u57fa\u56e0\uff0c\u5148\u9a8c\u8bc1\u8c01\u201d\u7684\u95ee\u9898"},"content":{"rendered":"<style>\n.ysx-case-intro{margin:22px 0 30px;padding:20px 22px;border-radius:16px;background:linear-gradient(135deg,#f2f7ff,#f8f4ff);border:1px solid #dfe8f6}.ysx-case-intro strong{color:#234ec4}.ysx-figure{margin:30px 0}.ysx-figure:before{display:none}.ysx-figure img{display:block;width:100%;height:auto;border-radius:16px;border:1px solid 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8px;color:#61758f;font-size:13px}.ysx-figure img{width:820px;max-width:none;border-radius:10px}.ysx-figure figcaption{width:100%;min-width:0}}\n<\/style>\n<div class=\"ysx-case-intro\"><strong>\u6848\u4f8b\u8bf4\u660e\uff1a<\/strong>\u672c\u6587\u662f\u4e00\u4e2a\u8131\u654f\u7684\u65b9\u6cd5\u578b\u6848\u4f8b\uff0c\u4fdd\u7559\u4e86\u771f\u5b9e\u9879\u76ee\u4e2d\u5e38\u89c1\u7684\u51b3\u7b56\u77db\u76fe\u4e0e\u5b8c\u6574\u5206\u6790\u8def\u5f84\uff0c\u4f46\u4e0d\u62ab\u9732\u5177\u4f53\u75be\u75c5\u3001\u5ba2\u6237\u5355\u4f4d\u3001\u4f4d\u70b9\u3001\u57fa\u56e0\u540d\u548c\u672a\u516c\u5f00\u7ed3\u679c\u3002\u56fe\u4e2d\u5019\u9009\u4e0e\u8bc1\u636e\u5f3a\u5f31\u5747\u4e3a\u7ed3\u6784\u5316\u793a\u610f\uff0c\u4e0d\u6784\u6210\u4e34\u5e8a\u7ed3\u8bba\u3002<\/div>\n<p>\u4e00\u4e2a\u56e2\u961f\u62ff\u5230 GWAS 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\u8d44\u6e90\u3001\u5355\u7ec6\u80de\u8868\u8fbe\u77e9\u9635\uff0c\u4ee5\u53ca\u82e5\u5e72\u5df2\u7ecf\u6574\u7406\u8fc7\u7684\u5019\u9009\u57fa\u56e0\u3002\u771f\u6b63\u7684\u56f0\u96be\u662f\uff0c\u73b0\u6709\u7ed3\u679c\u505c\u7559\u5728\u201c\u4f4d\u70b9\u9644\u8fd1\u6709\u4ec0\u4e48\u201d\uff0c\u8fd8\u6ca1\u6709\u53d8\u6210\u201c\u54ea\u6761\u8bc1\u636e\u652f\u6301\u54ea\u4e2a\u5019\u9009\u3001\u5b83\u53ef\u80fd\u5728\u54ea\u79cd\u7ec6\u80de\u72b6\u6001\u4e2d\u53d1\u6325\u4f5c\u7528\u3001\u5148\u505a\u54ea\u4e00\u6b65\u9a8c\u8bc1\u201d\u3002<\/p>\n<h2>\u95ee\u9898\u5e76\u4e0d\u662f\u5019\u9009\u592a\u5c11\uff0c\u800c\u662f\u6bcf\u4e2a\u5019\u9009\u90fd\u50cf\u201c\u6709\u9053\u7406\u201d<\/h2>\n<p>\u6700\u9760\u8fd1 lead SNP \u7684\u57fa\u56e0\uff0c\u672a\u5fc5\u662f\u9057\u4f20\u6548\u5e94\u771f\u6b63\u5f71\u54cd\u7684\u57fa\u56e0\u3002\u4e00\u4e2a\u975e\u7f16\u7801\u53d8\u5f02\u53ef\u80fd\u901a\u8fc7\u8fdc\u7aef\u8c03\u63a7\u6539\u53d8\u53e6\u4e00\u4e2a\u57fa\u56e0\u7684\u8868\u8fbe\uff1b\u4e00\u4e2a\u4f4d\u70b9\u4e5f\u53ef\u80fd\u5305\u542b\u591a\u4e2a\u76f8\u4e92\u72ec\u7acb\u7684\u9057\u4f20\u4fe1\u53f7\u3002\u5982\u679c\u76f4\u63a5\u6309\u7269\u7406\u8ddd\u79bb\u3001\u6700\u5c0f P \u503c\u6216\u6587\u732e\u70ed\u5ea6\u6392\u5e8f\uff0c\u5f97\u5230\u7684\u901a\u5e38\u662f\u4e00\u5f20\u5f88\u957f\u7684\u540d\u5355\uff0c\u800c\u4e0d\u662f\u4e00\u4e2a\u53ef\u4ee5\u6267\u884c\u7684\u7814\u7a76\u8ba1\u5212\u3002<\/p>\n<p>\u6211\u4eec\u5148\u628a\u9879\u76ee\u95ee\u9898\u6536\u7a84\u4e3a\u4e00\u53e5\u8bdd\uff1a<strong>\u54ea\u4e9b\u5019\u9009\u540c\u65f6\u83b7\u5f97\u9057\u4f20\u5b9a\u4f4d\u3001\u5206\u5b50\u8c03\u63a7\u548c\u75be\u75c5\u76f8\u5173\u7ec6\u80de\u573a\u666f\u7684\u652f\u6301\uff0c\u5e76\u4e14\u80fd\u88ab\u8bbe\u8ba1\u6210\u4e0b\u4e00\u6b65\u53ef\u68c0\u9a8c\u7684\u5b9e\u9a8c\uff1f<\/strong><\/p>\n<figure class=\"ysx-figure\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/10\/gwas-qtl-single-cell-analysis-workflow-20261010.png?ssl=1\" alt=\"GWAS\u3001QTL\u4e0e\u5355\u7ec6\u80de\u8054\u5408\u5206\u6790\u4ece\u6570\u636e\u7edf\u4e00\u3001\u7cbe\u7ec6\u5b9a\u4f4d\u3001\u5171\u5b9a\u4f4d\u3001\u7ec6\u80de\u5b9a\u4f4d\u5230\u5b9e\u9a8c\u9a8c\u8bc1\u7684\u6d41\u7a0b\u56fe\" loading=\"lazy\"><figcaption>\u56fe 1\uff5c\u5206\u6790\u4e0d\u662f\u628a\u4e09\u7c7b\u6570\u636e\u7b80\u5355\u6c42\u4ea4\u96c6\uff0c\u800c\u662f\u8ba9\u6bcf\u4e00\u5c42\u8bc1\u636e\u56de\u7b54\u4e0d\u540c\u95ee\u9898\uff1a\u9057\u4f20\u4fe1\u53f7\u5728\u54ea\u91cc\u3001\u53ef\u80fd\u5f71\u54cd\u54ea\u4e2a\u5206\u5b50\u3001\u53c8\u53ef\u80fd\u5728\u54ea\u7c7b\u7ec6\u80de\u4e2d\u53d1\u751f\u3002<\/figcaption><\/figure>\n<h2>\u7b2c\u4e00\u6b65\uff1a\u5148\u628a\u9057\u4f20\u4fe1\u53f7\u672c\u8eab\u505a\u5bf9<\/h2>\n<p>\u6211\u4eec\u9996\u5148\u7edf\u4e00\u57fa\u56e0\u7ec4\u7248\u672c\u3001\u67d3\u8272\u4f53\u4f4d\u7f6e\u3001\u53c2\u8003\/\u66ff\u4ee3\u7b49\u4f4d\u57fa\u56e0\u548c\u6548\u5e94\u65b9\u5411\uff0c\u5e76\u68c0\u67e5 GWAS\u3001QTL \u4e0e LD \u53c2\u8003\u4e4b\u95f4\u662f\u5426\u4e00\u81f4\u3002A\/T\u3001C\/G \u8fd9\u7c7b\u56de\u6587\u4f4d\u70b9\u82e5\u7f3a\u5c11\u53ef\u9760\u9891\u7387\u4fe1\u606f\uff0c\u9700\u8981\u8c28\u614e\u5904\u7406\uff1bLD \u53c2\u8003\u8fd8\u5e94\u5c3d\u91cf\u5339\u914d\u7814\u7a76\u4eba\u7fa4\u7956\u6e90\u3002\u5426\u5219\uff0c\u540e\u9762\u7684\u5171\u5b9a\u4f4d\u56fe\u5373\u4f7f\u201c\u770b\u8d77\u6765\u5f88\u50cf\u201d\uff0c\u4e5f\u53ef\u80fd\u53ea\u662f\u7b49\u4f4d\u57fa\u56e0\u7ffb\u8f6c\u6216 LD \u7ed3\u6784\u4e0d\u5339\u914d\u9020\u6210\u7684\u5047\u8c61\u3002<\/p>\n<p>\u968f\u540e\u5728\u6bcf\u4e2a\u91cd\u70b9\u533a\u57df\u8bc6\u522b\u6761\u4ef6\u72ec\u7acb\u4fe1\u53f7\uff0c\u5e76\u4f7f\u7528\u80fd\u591f\u5904\u7406\u591a\u4fe1\u53f7\u7684\u7cbe\u7ec6\u5b9a\u4f4d\u6846\u67b6\u3002\u4ee5 SuSiE-RSS \u4e3a\u4f8b\uff0c\u5b83\u53ef\u4ee5\u57fa\u4e8e\u6c47\u603b\u7edf\u8ba1\u548c LD \u4f30\u8ba1\u6bcf\u4e2a\u53d8\u5f02\u7684\u540e\u9a8c\u7eb3\u5165\u6982\u7387\uff08PIP\uff09\uff0c\u5e76\u5f62\u6210\u53ef\u4fe1\u96c6\u3002\u8fd9\u91cc\u7684\u76ee\u6807\u4e0d\u662f\u6b66\u65ad\u5730\u5ba3\u5e03\u67d0\u4e00\u4e2a SNP \u5c31\u662f\u56e0\u679c\u53d8\u5f02\uff0c\u800c\u662f<strong>\u628a\u4e0d\u786e\u5b9a\u6027\u4ece\u201c\u6574\u4e2a\u4f4d\u70b9\u201d\u6536\u655b\u5230\u82e5\u5e72\u6709\u6982\u7387\u89e3\u91ca\u7684\u53d8\u5f02\u96c6\u5408<\/strong>\u3002<\/p>\n<div class=\"ysx-key\"><strong>\u5173\u952e\u68c0\u67e5\uff1a<\/strong>\u53ef\u4fe1\u96c6\u5927\u5c0f\u3001\u7eaf\u5ea6\u548c\u7a33\u5b9a\u6027\u8981\u548c LD \u53c2\u8003\u3001\u6837\u672c\u91cf\u3001\u533a\u57df\u8fb9\u754c\u4e00\u8d77\u89e3\u91ca\u3002lead SNP \u7684 P \u503c\u6700\u5c0f\uff0c\u4e0d\u7b49\u4e8e\u5b83\u5728\u591a\u53d8\u91cf\u6761\u4ef6\u4e0b\u62e5\u6709\u6700\u9ad8\u7684\u56e0\u679c\u540e\u9a8c\u6982\u7387\u3002<\/div>\n<h2>\u7b2c\u4e8c\u6b65\uff1a\u7528\u5171\u5b9a\u4f4d\u5224\u65ad\u201c\u540c\u4e00\u533a\u57df\u201d\u662f\u4e0d\u662f\u201c\u540c\u4e00\u4fe1\u53f7\u201d<\/h2>\n<p>\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u628a\u75be\u75c5 GWAS \u4e0e\u76f8\u5173\u7ec4\u7ec7\u7684 eQTL\u3001\u5fc5\u8981\u65f6\u7684 pQTL \u653e\u5728\u540c\u4e00\u4f4d\u70b9\u6bd4\u8f83\u3002\u8fd9\u91cc\u4e0d\u80fd\u53ea\u770b\u201cGWAS \u663e\u8457\u3001eQTL 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\u8d44\u6e90\u201d\u5199\u8fdb\u8bc1\u636e\u7f3a\u53e3\u3002<\/p>\n<h2>\u7b2c\u4e09\u6b65\uff1a\u628a\u5019\u9009\u653e\u56de\u5177\u4f53\u7ec6\u80de\u4e0e\u72b6\u6001<\/h2>\n<p>\u5355\u7ec6\u80de\u6570\u636e\u7684\u4f5c\u7528\uff0c\u4e0d\u53ea\u662f\u7ed9\u5019\u9009\u57fa\u56e0\u753b\u4e00\u5f20 FeaturePlot\u3002\u6211\u4eec\u4f1a\u5148\u68c0\u67e5\u7ec6\u80de\u6ce8\u91ca\u4f9d\u636e\u3001\u60a3\u8005\u7ec4\u6210\u3001\u75be\u75c5\u72b6\u6001\u548c\u6279\u6b21\uff0c\u518d\u56de\u7b54\u4e09\u4e2a\u5c42\u6b21\u7684\u95ee\u9898\uff1a<\/p>\n<ol>\n<li><strong>\u8868\u8fbe\u5b9a\u4f4d\uff1a<\/strong>\u5019\u9009\u4e3b\u8981\u5728\u54ea\u4e9b\u7ec6\u80de\u7c7b\u578b\u6216\u4e9a\u7fa4\u4e2d\u8868\u8fbe\uff1f<\/li>\n<li><strong>\u72b6\u6001\u5173\u8054\uff1a<\/strong>\u5728\u75be\u75c5\u76f8\u5173\u72b6\u6001\u3001\u523a\u6fc0\u6761\u4ef6\u6216\u8fdb\u5c55\u9636\u6bb5\u4e2d\uff0c\u8868\u8fbe\u6216\u57fa\u56e0\u7a0b\u5e8f\u662f\u5426\u53d1\u751f\u4e00\u81f4\u53d8\u5316\uff1f<\/li>\n<li><strong>\u60a3\u8005\u5c42\u7ea7\u590d\u6838\uff1a<\/strong>\u8fd9\u79cd\u53d8\u5316\u80fd\u5426\u5728\u591a\u4e2a\u4f9b\u4f53\u4e2d\u91cd\u590d\uff0c\u800c\u4e0d\u662f\u7531\u67d0\u4e00\u4e2a\u6837\u672c\u6216\u7ec6\u80de\u6570\u91cf\u5dee\u5f02\u9a71\u52a8\uff1f<\/li>\n<\/ol>\n<p>\u6d89\u53ca\u7ec4\u95f4\u6bd4\u8f83\u65f6\uff0c\u6211\u4eec\u628a\u4f9b\u4f53\u89c6\u4e3a\u7edf\u8ba1\u91cd\u590d\uff0c\u6309\u7ec6\u80de\u7c7b\u578b\u8fdb\u884c pseudobulk \u6c47\u603b\u6216\u91c7\u7528\u9002\u5408\u91cd\u590d\u6d4b\u91cf\u7684\u6a21\u578b\uff0c\u907f\u514d\u628a\u540c\u4e00\u4e2a\u60a3\u8005\u7684\u4e0a\u5343\u4e2a\u7ec6\u80de\u8bef\u5f53\u4f5c\u4e0a\u5343\u4e2a\u72ec\u7acb\u6837\u672c\u3002\u82e5\u53ea\u6709\u8868\u8fbe\u5b9a\u4f4d\u3001\u6ca1\u6709\u7ec6\u80de\u7279\u5f02 QTL \u6216\u8c03\u63a7\u8bc1\u636e\uff0c\u6211\u4eec\u4f1a\u660e\u786e\u5199\u6210\u201c\u7ec6\u80de\u573a\u666f\u652f\u6301\u201d\uff0c\u800c\u4e0d\u662f\u201c\u7ec6\u80de\u56e0\u679c\u8bc1\u636e\u201d\u3002<\/p>\n<figure class=\"ysx-figure\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/10\/candidate-gene-evidence-matrix-20261010.png?ssl=1\" alt=\"\u5019\u9009\u57fa\u56e0\u5728\u9057\u4f20\u5b9a\u4f4d\u3001QTL\u5171\u5b9a\u4f4d\u3001\u7ec6\u80de\u573a\u666f\u3001\u8de8\u6570\u636e\u590d\u6838\u548c\u5b9e\u9a8c\u53ef\u9a8c\u8bc1\u6027\u4e94\u6761\u8bc1\u636e\u8f74\u4e0a\u7684\u5206\u5c42\u77e9\u9635\" loading=\"lazy\"><figcaption>\u56fe 2\uff5c\u5019\u9009\u6392\u5e8f\u4e0d\u662f\u4e00\u4e2a\u795e\u79d8\u7684\u7efc\u5408\u5206\u6570\u3002\u628a\u8bc1\u636e\u62c6\u5f00\u540e\uff0c\u56e2\u961f\u80fd\u770b\u5230\u5019\u9009\u4e3a\u4ec0\u4e48\u4f18\u5148\u3001\u8fd8\u7f3a\u4ec0\u4e48\u3001\u4e0b\u4e00\u6b65\u600e\u6837\u8865\u8bc1\u636e\u3002<\/figcaption><\/figure>\n<h2>\u7b2c\u56db\u6b65\uff1a\u628a\u201c\u6392\u540d\u201d\u6539\u9020\u6210\u201c\u9a8c\u8bc1\u8def\u7ebf\u201d<\/h2>\n<p>\u8fd9\u4e2a\u6848\u4f8b\u6700\u7ec8\u6ca1\u6709\u4ea4\u4ed8\u4e00\u5f20\u4ece 1 \u6392\u5230 N \u7684\u57fa\u56e0\u8868\uff0c\u800c\u662f\u5f62\u6210\u4e09\u5c42\u5019\u9009\u8def\u7ebf\uff1a<\/p>\n<ul>\n<li><strong>\u4f18\u5148\u5019\u9009\uff1a<\/strong>\u9057\u4f20\u7cbe\u7ec6\u5b9a\u4f4d\u3001\u76f8\u5173\u7ec4\u7ec7 QTL \u5171\u5b9a\u4f4d\u548c\u75be\u75c5\u76f8\u5173\u7ec6\u80de\u72b6\u6001\u4e09\u5c42\u8bc1\u636e\u65b9\u5411\u4e00\u81f4\uff0c\u53ef\u76f4\u63a5\u8fdb\u5165\u9488\u5bf9\u6027\u9a8c\u8bc1\u8bbe\u8ba1\uff1b<\/li>\n<li><strong>\u5907\u9009\u5019\u9009\uff1a<\/strong>\u5176\u4e2d\u4e24\u5c42\u652f\u6301\u8f83\u5f3a\uff0c\u4f46\u5b58\u5728\u7ec4\u7ec7\u4e0d\u5339\u914d\u3001\u8de8\u961f\u5217\u4e0d\u7a33\u5b9a\u6216\u591a\u4fe1\u53f7\u96be\u4ee5\u533a\u5206\u7684\u95ee\u9898\uff0c\u5148\u8865\u4e00\u9879\u5173\u952e\u8bc1\u636e\uff1b<\/li>\n<li><strong>\u6682\u7f13\u5019\u9009\uff1a<\/strong>\u4e3b\u8981\u4f9d\u636e\u6765\u81ea\u7269\u7406\u8ddd\u79bb\u3001\u6587\u732e\u70ed\u5ea6\u6216\u5355\u4e00\u6570\u636e\u96c6\u8868\u8fbe\u5dee\u5f02\uff0c\u76ee\u524d\u4e0d\u8db3\u4ee5\u5360\u7528\u9996\u8f6e\u5b9e\u9a8c\u8d44\u6e90\u3002<\/li>\n<\/ul>\n<p>\u5bf9\u6bcf\u4e2a\u4f18\u5148\u5019\u9009\uff0c\u6211\u4eec\u7ee7\u7eed\u5199\u6e05\u4e09\u4ef6\u4e8b\uff1a\u5efa\u8bae\u4f7f\u7528\u54ea\u7c7b\u7ec6\u80de\u6a21\u578b\u6216\u7ec4\u7ec7\u573a\u666f\uff0c\u5e72\u9884\u540e\u89c2\u5bdf\u4ec0\u4e48\u5206\u5b50\u6216\u8868\u578b\u8bfb\u51fa\uff0c\u4ee5\u53ca\u4ec0\u4e48\u7ed3\u679c\u4f1a\u652f\u6301\u6216\u53cd\u9a73\u5f53\u524d\u5047\u8bbe\u3002\u8fd9\u6837\uff0c\u751f\u4fe1\u5206\u6790\u7684\u7ec8\u70b9\u4e0d\u518d\u662f\u201c\u56fe\u753b\u5b8c\u4e86\u201d\uff0c\u800c\u662f\u4e0b\u4e00\u6b65\u5b9e\u9a8c\u53ef\u4ee5\u636e\u6b64\u6392\u987a\u5e8f\u3002<\/p>\n<h2>\u4ea4\u4ed8\u7269\u4e3a\u4ec0\u4e48\u4e0d\u53ea\u662f\u51e0\u5f20\u56fe<\/h2>\n<figure class=\"wp-block-table\">\n<table style=\"display:table;width:100%;min-width:720px;table-layout:fixed\">\n<thead>\n<tr>\n<th>\u4ea4\u4ed8\u6a21\u5757<\/th>\n<th>\u56de\u7b54\u7684\u95ee\u9898<\/th>\n<th>\u5173\u952e\u6280\u672f\u7ec6\u8282<\/th>\n<th>\u53ef\u7528\u4e8e\u4ec0\u4e48\u51b3\u7b56<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u4f4d\u70b9\u4e0e\u53ef\u4fe1\u96c6\u62a5\u544a<\/td>\n<td>\u9057\u4f20\u4fe1\u53f7\u7a76\u7adf\u96c6\u4e2d\u5728\u54ea\u91cc\uff1f<\/td>\n<td>\u7b49\u4f4d\u57fa\u56e0\u534f\u8c03\u3001LD \u5339\u914d\u3001\u72ec\u7acb\u4fe1\u53f7\u3001PIP \u4e0e\u53ef\u4fe1\u96c6<\/td>\n<td>\u907f\u514d\u53ea\u8ffd lead SNP \u6216\u6700\u8fd1\u57fa\u56e0<\/td>\n<\/tr>\n<tr>\n<td>QTL \u5171\u5b9a\u4f4d\u8bc1\u636e\u8868<\/td>\n<td>\u75be\u75c5\u4e0e\u8868\u8fbe\/\u86cb\u767d\u662f\u5426\u53ef\u80fd\u5171\u4eab\u4fe1\u53f7\uff1f<\/td>\n<td>\u591a\u4fe1\u53f7\u5efa\u6a21\u3001H3\/H4 \u6bd4\u8f83\u3001\u5148\u9a8c\u548c\u7ec4\u7ec7\u654f\u611f\u6027<\/td>\n<td>\u533a\u5206\u5171\u4eab\u8c03\u63a7\u4e0e\u533a\u57df\u91cd\u53e0<\/td>\n<\/tr>\n<tr>\n<td>\u7ec6\u80de\u573a\u666f\u56fe\u8c31<\/td>\n<td>\u5019\u9009\u53ef\u80fd\u5728\u54ea\u7c7b\u7ec6\u80de\u548c\u72b6\u6001\u4e2d\u8d77\u4f5c\u7528\uff1f<\/td>\n<td>\u6ce8\u91ca\u590d\u6838\u3001\u4f9b\u4f53\u5c42\u7ea7\u6bd4\u8f83\u3001pseudobulk\u3001\u8de8\u961f\u5217\u590d\u6838<\/td>\n<td>\u9009\u62e9\u6a21\u578b\u4e0e\u5b9e\u9a8c\u6750\u6599<\/td>\n<\/tr>\n<tr>\n<td>\u5019\u9009\u5206\u5c42\u4e0e\u9a8c\u8bc1\u6e05\u5355<\/td>\n<td>\u5148\u9a8c\u8bc1\u8c01\u3001\u4e3a\u4ec0\u4e48\u3001\u6d4b\u4ec0\u4e48\uff1f<\/td>\n<td>\u652f\u6301\u3001\u51b2\u7a81\u3001\u7f3a\u53e3\u4e0e\u53ef\u9a8c\u8bc1\u6027\u5206\u9879\u5448\u73b0<\/td>\n<td>\u5b89\u6392\u9996\u8f6e\u5b9e\u9a8c\u548c\u8865\u6570\u636e\u987a\u5e8f<\/td>\n<\/tr>\n<\/tbody>\n<\/table><figcaption>\u8868 1\uff5c\u6570\u636e\u548c\u75be\u75c5\u4e0d\u540c\uff0c\u5177\u4f53\u65b9\u6cd5\u4f1a\u8c03\u6574\uff0c\u4f46\u201c\u6bcf\u4e2a\u7ed3\u679c\u5fc5\u987b\u670d\u52a1\u4e8e\u4e00\u4e2a\u51b3\u7b56\u201d\u8fd9\u4e00\u4ea4\u4ed8\u539f\u5219\u4e0d\u53d8\u3002<\/figcaption><\/figure>\n<h2>\u54ea\u4e9b\u505a\u6cd5\u770b\u8d77\u6765\u5feb\uff0c\u5b9e\u9645\u5bb9\u6613\u628a\u9879\u76ee\u5e26\u504f<\/h2>\n<ul>\n<li>\u628a lead SNP \u6700\u8fd1\u7684\u57fa\u56e0\u76f4\u63a5\u5f53\u6210\u9776\u57fa\u56e0\uff1b<\/li>\n<li>\u53ea\u8981 GWAS \u548c eQTL \u7684\u663e\u8457\u5cf0\u91cd\u53e0\uff0c\u5c31\u5ba3\u5e03\u5171\u5b9a\u4f4d\uff1b<\/li>\n<li>\u5728\u5b58\u5728\u591a\u4e2a\u72ec\u7acb\u4fe1\u53f7\u65f6\uff0c\u4ecd\u5957\u7528\u5355\u4e00\u56e0\u679c\u53d8\u5f02\u5047\u8bbe\uff1b<\/li>\n<li>\u53ea\u51ed\u67d0\u4e2a\u57fa\u56e0\u5728\u4e00\u79cd\u7ec6\u80de\u91cc\u9ad8\u8868\u8fbe\uff0c\u5c31\u628a\u5b83\u89e3\u91ca\u6210\u75be\u75c5\u9a71\u52a8\u7ec6\u80de\uff1b<\/li>\n<li>\u628a\u6bcf\u4e2a\u7ec6\u80de\u5f53\u72ec\u7acb\u6837\u672c\u505a\u7ec4\u95f4\u68c0\u9a8c\uff0c\u5ffd\u7565\u4f9b\u4f53\u5c42\u7ea7\u91cd\u590d\uff1b<\/li>\n<li>\u7528\u4e00\u4e2a\u7efc\u5408\u5206\u6570\u906e\u4f4f\u8bc1\u636e\u51b2\u7a81\uff0c\u8ba9\u6392\u540d\u65e0\u6cd5\u590d\u6838\u3002<\/li>\n<\/ul>\n<div class=\"ysx-scope-note\"><strong>\u7ed3\u8bba\u8fb9\u754c\uff1a<\/strong>\u7cbe\u7ec6\u5b9a\u4f4d\u7ed9\u51fa\u7684\u662f\u6982\u7387\u5316\u5019\u9009\u96c6\u5408\uff1b\u5171\u5b9a\u4f4d\u652f\u6301\u5171\u4eab\u9057\u4f20\u4fe1\u53f7\uff0c\u4e0d\u76f4\u63a5\u8bc1\u660e\u67d0\u57fa\u56e0\u4ecb\u5bfc\u75be\u75c5\uff1b\u5355\u7ec6\u80de\u8868\u8fbe\u5b9a\u4f4d\u4e0d\u7b49\u4e8e\u7ec6\u80de\u7279\u5f02\u56e0\u679c\u3002\u9057\u4f20\u6548\u5e94\u65b9\u5411\u4e5f\u4e0d\u80fd\u76f4\u63a5\u66ff\u4ee3\u836f\u7269\u5e72\u9884\u65b9\u5411\u3002\u771f\u6b63\u7684\u56e0\u679c\u4e0e\u529f\u80fd\u7ed3\u8bba\u4ecd\u9700\u8981\u9002\u5f53\u7684\u5b9e\u9a8c\u6216\u72ec\u7acb\u7814\u7a76\u8bbe\u8ba1\u9a8c\u8bc1\u3002<\/div>\n<h2>\u8fd9\u7c7b\u8054\u5408\u5206\u6790\uff0c\u4ec0\u4e48\u60c5\u51b5\u4e0b\u6700\u503c\u5f97\u505a<\/h2>\n<p>\u5982\u679c\u4f60\u5df2\u7ecf\u6709 GWAS \u4f4d\u70b9\u3001\u5019\u9009\u57fa\u56e0\u6216 MR \u7ed3\u679c\uff0c\u4f46\u5361\u5728\u201c\u5019\u9009\u592a\u591a\u201d\u201c\u4e0d\u77e5\u9053\u653e\u5728\u54ea\u7c7b\u7ec6\u80de\u9a8c\u8bc1\u201d\u201c\u4e0d\u540c\u8bc1\u636e\u4e92\u76f8\u51b2\u7a81\u201d\uff0c\u8fd9\u7c7b\u5206\u6790\u6bd4\u7ee7\u7eed\u5806\u66f4\u591a\u76f8\u5173\u6027\u56fe\u66f4\u6709\u4ef7\u503c\u3002\u5b83\u4e5f\u9002\u5408\u51c6\u5907\u529f\u80fd\u5b9e\u9a8c\u3001\u7533\u8bf7\u8bfe\u9898\u3001\u6574\u7406\u6587\u7ae0\u4e3b\u7ebf\uff0c\u6216\u8005\u9700\u8981\u5224\u65ad\u73b0\u6709\u516c\u5f00\u6570\u636e\u80fd\u5426\u652f\u6491\u4e0b\u4e00\u6b65\u7814\u7a76\u7684\u95ee\u9898\u3002<\/p>\n<div class=\"ysx-consult-card\">\n<h2>\u628a\u4e00\u4e2a\u4f4d\u70b9\u53d1\u6765\uff0c\u6211\u4eec\u5148\u5224\u65ad\u8bc1\u636e\u80fd\u4e0d\u80fd\u63a5\u8d77\u6765<\/h2>\n<p>\u8bf7\u51c6\u5907\uff1a\u7814\u7a76\u75be\u75c5\u6216\u6027\u72b6\u3001\u5019\u9009\u4f4d\u70b9\/\u57fa\u56e0\u3001GWAS \u6570\u636e\u6765\u6e90\u3001\u5df2\u6709 QTL \u6216\u5355\u7ec6\u80de\u6570\u636e\u3001\u76ee\u6807\u7ec4\u7ec7\uff0c\u4ee5\u53ca\u4f60\u6700\u60f3\u56de\u7b54\u7684\u5b9e\u9a8c\u95ee\u9898\u3002\u6211\u4eec\u4f1a\u5148\u8bc4\u4f30\u6570\u636e\u7248\u672c\u3001\u7956\u6e90\u3001\u6837\u672c\u6761\u4ef6\u548c\u53ef\u7528\u516c\u5f00\u8d44\u6e90\uff0c\u518d\u8bf4\u660e\u80fd\u8fde\u63a5\u5230\u54ea\u4e00\u5c42\u8bc1\u636e\u3001\u54ea\u4e9b\u7ed3\u8bba\u76ee\u524d\u4e0d\u80fd\u505a\u3002<\/p>\n<p><a class=\"button\" href=\"https:\/\/work.weixin.qq.com\/kfid\/kfcb05492f29d4d6064\" target=\"_blank\" rel=\"noopener noreferrer\" data-ysx-event=\"contact_click\">\u5728\u7ebf\u6c9f\u901a\u9057\u4f20\u4e0e\u5355\u7ec6\u80de\u8054\u5408\u5206\u6790\u9700\u6c42 \u2197<\/a><\/p>\n<\/div>\n<h2>\u65b9\u6cd5\u4e0e\u8d44\u6e90\u53c2\u8003<\/h2>\n<ol class=\"ysx-ref-list\">\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9337707\/\" target=\"_blank\" rel=\"noopener noreferrer\">SuSiE-RSS\uff1a\u57fa\u4e8e\u6c47\u603b\u7edf\u8ba1\u548c LD \u7684\u9057\u4f20\u7cbe\u7ec6\u5b9a\u4f4d<\/a><\/li>\n<li><a href=\"https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1009440\" target=\"_blank\" rel=\"noopener noreferrer\">coloc + SuSiE\uff1a\u5141\u8bb8\u4f4d\u70b9\u5b58\u5728\u591a\u4e2a\u56e0\u679c\u53d8\u5f02\u7684\u5171\u5b9a\u4f4d\u6846\u67b6<\/a><\/li>\n<li><a href=\"https:\/\/www.gtexportal.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">GTEx Portal\uff1a\u7ec4\u7ec7\u8868\u8fbe\u4e0e QTL \u516c\u5171\u8d44\u6e90<\/a><\/li>\n<li><a href=\"https:\/\/www.ebi.ac.uk\/gwas\/docs\/summary-statistics\/\" target=\"_blank\" rel=\"noopener noreferrer\">NHGRI-EBI GWAS Catalog\uff1aGWAS \u6c47\u603b\u7edf\u8ba1\u8bf4\u660e\u4e0e\u83b7\u53d6<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41467-021-21038-1\" target=\"_blank\" rel=\"noopener noreferrer\">\u5355\u7ec6\u80de\u7814\u7a76\u4e2d\u7684 pseudoreplication \u4e0e\u4f9b\u4f53\u5c42\u7ea7\u5206\u6790<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>GWAS \u627e\u5230\u663e\u8457\u4f4d\u70b9\u540e\uff0c\u6700\u8fd1\u7684\u57fa\u56e0\u672a\u5fc5\u6700\u503c\u5f97\u5148\u9a8c\u8bc1\u3002\u8fd9\u4e2a\u8131\u654f\u6848\u4f8b\u5c55\u793a\u5982\u4f55\u7ed3\u5408\u9057\u4f20\u7cbe\u7ec6\u5b9a\u4f4d\u3001eQTL\/pQTL \u5171\u5b9a\u4f4d\u548c\u5355\u7ec6\u80de\u573a\u666f\uff0c\u628a\u5019\u9009\u5217\u8868\u6536\u655b\u6210\u53ef\u8ffd\u6eaf\u3001\u53ef\u9a8c\u8bc1\u7684\u7814\u7a76\u8def\u7ebf\u3002<\/p>\n","protected":false},"author":1,"featured_media":65900,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1,71,64],"tags":[318,300,319,322,321,90,83,320],"class_list":["post-65903","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-part","category-single-cell","category-mr","tag-eqtl","tag-gwas","tag-pqtl","tag-322","tag-321","tag-90","tag-83","tag-320"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/10\/gwas-eqtl-single-cell-target-prioritization-featured-20261010.png?fit=1672%2C941&ssl=1","_links":{"self":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/65903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/comments?post=65903"}],"version-history":[{"count":2,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/65903\/revisions"}],"predecessor-version":[{"id":65911,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/65903\/revisions\/65911"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media\/65900"}],"wp:attachment":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media?parent=65903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/categories?post=65903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/tags?post=65903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}