{"id":66275,"date":"2026-10-22T09:07:43","date_gmt":"2026-10-22T01:07:43","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=66275"},"modified":"2026-10-22T09:07:43","modified_gmt":"2026-10-22T01:07:43","slug":"deepvariant-1-10-gpu-server-resource-planning","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/deepvariant-1-10-gpu-server-resource-planning\/","title":{"rendered":"DeepVariant 1.10 \u5df2\u652f\u6301 RNA-seq\uff1a16 GB \u663e\u5b58\u591f\u4e86\uff0c\u4e3a\u4ec0\u4e48\u670d\u52a1\u5668\u4ecd\u4f1a\u62d6\u6162\uff1f"},"content":{"rendered":"<div id=\"articleContent\" style=\"max-width:860px;margin:0 auto;color:#1f2937;font-size:17px;line-height:1.85;\">\n<p>2026 \u5e74 3 \u6708\u53d1\u5e03\u7684 DeepVariant 1.10\uff0c\u628a RNA-seq \u6a21\u578b\u6b63\u5f0f\u5217\u5165\u652f\u6301\u8303\u56f4\uff0c\u8fd8\u4e3a PacBio \u4e0e ONT \u957f\u8bfb\u957f\u52a0\u5165\u8fde\u7eed\u5b9a\u76f8\u8f93\u51fa\u3002\u5f88\u591a\u4eba\u770b\u5230\u201cGPU \u7248\u201d\u540e\uff0c\u7b2c\u4e00\u53cd\u5e94\u662f\uff1a\u627e\u4e00\u5f20\u663e\u5361\uff0c\u53d8\u5f02\u68c0\u6d4b\u5c31\u80fd\u5f88\u5feb\u8dd1\u5b8c\u3002<\/p>\n<p>\u4f46 DeepVariant \u4e0d\u662f\u4e00\u4e2a\u4ece\u5934\u5230\u5c3e\u90fd\u7531 GPU \u63a5\u7ba1\u7684\u9ed1\u76d2\u3002\u5b83\u81f3\u5c11\u5305\u542b <code>make_examples<\/code>\u3001<code>call_variants<\/code> \u548c <code>postprocess_variants<\/code> \u4e09\u4e2a\u9636\u6bb5\uff0cCPU\u3001\u663e\u5b58\u3001\u5185\u5b58\u548c\u5b58\u50a8\u5206\u522b\u5361\u5728\u4e0d\u540c\u4f4d\u7f6e\u3002\u53ea\u76ef\u663e\u5361\u578b\u53f7\uff0c\u5e38\u89c1\u7ed3\u679c\u662f GPU \u5728\u7b49\u6570\u636e\uff0cCPU \u5728\u62c6\u5206\u533a\u95f4\uff0c\u6700\u540e\u4e00\u6b65\u53c8\u56e0\u5185\u5b58\u4e0d\u8db3\u4e2d\u65ad\u3002<\/p>\n<figure style=\"margin:28px 0;\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/10\/daily-bio-blog-20261022-deepvariant-gpu-deepvariant-gpu-poster.png?ssl=1\" alt=\"DeepVariant 1.10 \u670d\u52a1\u5668\u8d44\u6e90\u89c4\u5212\u6d77\u62a5\" style=\"display:block;width:100%;height:auto;border-radius:14px;\"><figcaption style=\"margin-top:8px;color:#64748b;font-size:14px;text-align:center;\">DeepVariant 1.10 \u8d44\u6e90\u89c4\u5212\uff1aCPU \u5206\u7247\u3001\u5355\u5361\u63a8\u7406\u3001\u5185\u5b58\u5cf0\u503c\u548c NVMe \u5fc5\u987b\u4e00\u8d77\u8ba1\u7b97\u3002<\/figcaption><\/figure>\n<h2 style=\"margin-top:34px;color:#12314a;\">\u5148\u770b\u7ed3\u8bba\uff1a16 GB \u662f\u663e\u5b58\u5360\u7528\uff0c\u4e0d\u662f\u6574\u673a\u914d\u7f6e<\/h2>\n<p>DeepVariant \u5b98\u65b9 FAQ \u8868\u793a\uff0cKeras \u6a21\u578b\u5728\u6d4b\u8bd5\u4e2d\u5360\u7528\u7ea6 <strong>16 GB GPU \u663e\u5b58<\/strong>\uff1b\u540c\u65f6\uff0c\u5f53\u524d <code>call_variants<\/code> \u7684 GPU \u63a8\u7406\u6700\u591a\u53ea\u4f7f\u7528 <strong>1 \u5f20 GPU<\/strong>\u3002\u56e0\u6b64\uff0c\u628a\u9884\u7b97\u5806\u5230\u591a\u5361\u673a\u5668\u4e0a\uff0c\u5e76\u4e0d\u4f1a\u81ea\u52a8\u7f29\u77ed\u5355\u4e2a\u6837\u672c\u7684\u63a8\u7406\u65f6\u95f4\u3002<\/p>\n<p>\u66f4\u5173\u952e\u7684\u662f\uff0c<code>make_examples<\/code> \u4e3b\u8981\u4f9d\u8d56 CPU\uff0c\u53ef\u6309\u57fa\u56e0\u7ec4\u533a\u95f4\u5206\u7247\uff1b<code>postprocess_variants<\/code> \u5219\u8981\u6c47\u603b\u3001\u6392\u5e8f\u5168\u90e8\u4e2d\u95f4\u7ed3\u679c\u3002\u5b98\u65b9\u6587\u6863\u7ed9\u51fa\u7684\u7ecf\u9a8c\u662f\uff0c\u5e76\u884c\u540e\u5904\u7406\u53ef\u80fd\u9700\u8981\u6bcf\u4e2a CPU \u6838\u7ea6 <strong>2\u20143 GB \u5185\u5b58<\/strong>\uff1b\u82e5\u5173\u95ed\u5e76\u884c\uff0c\u6574\u4f53\u4ecd\u53ef\u80fd\u9700\u8981 <strong>20\u201450 GB \u5185\u5b58<\/strong>\u3002\u8fd9\u610f\u5473\u7740\u4e00\u5f20 16 GB \u663e\u5b58\u7684 GPU\uff0c\u5e76\u4e0d\u80fd\u66ff\u4ee3 64 GB\u3001128 GB \u751a\u81f3\u66f4\u9ad8\u7684\u7cfb\u7edf\u5185\u5b58\u89c4\u5212\u3002<\/p>\n<div style=\"overflow-x:auto;margin:18px 0 26px;\">\n<table style=\"width:100%;border-collapse:collapse;min-width:720px;font-size:15px;\">\n<thead style=\"background:#0e5b68;color:#fff;\">\n<tr>\n<th style=\"padding:12px;border:1px solid #d6e2e5;text-align:left;\">\u9636\u6bb5<\/th>\n<th style=\"padding:12px;border:1px solid #d6e2e5;text-align:left;\">\u4e3b\u8981\u74f6\u9888<\/th>\n<th style=\"padding:12px;border:1px solid #d6e2e5;text-align:left;\">\u5b98\u65b9\u4fe1\u606f\u4e0e\u5de5\u7a0b\u5224\u65ad<\/th>\n<th style=\"padding:12px;border:1px solid #d6e2e5;text-align:left;\">\u914d\u7f6e\u91cd\u70b9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\"><code>make_examples<\/code><\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">CPU\u3001\u968f\u673a\u8bfb\u5199<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u5355\u8fdb\u7a0b\u53ef\u6309\u533a\u95f4\u5206\u7247\uff1b\u5206\u7247\u6570\u901a\u5e38\u4e0e\u53ef\u7528 CPU \u6838\u5339\u914d<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u8db3\u591f CPU \u6838\u3001\u672c\u5730\u9ad8\u901f\u76d8\u3001\u5408\u7406\u5206\u7247<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\"><code>call_variants<\/code><\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">GPU \u663e\u5b58\u4e0e\u63a8\u7406<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">Keras \u6a21\u578b\u6d4b\u8bd5\u5360\u7528\u7ea6 16 GB\uff1b\u5355\u6837\u672c\u6700\u591a\u4f7f\u7528 1 \u5f20 GPU<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u5355\u5361\u663e\u5b58\u7559\u4f59\u91cf\uff0c\u522b\u4e3a\u5355\u6837\u672c\u76f2\u76ee\u5806\u591a\u5361<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\"><code>postprocess_variants<\/code><\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u7cfb\u7edf\u5185\u5b58\u3001\u6392\u5e8f<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u5e76\u884c\u65f6\u7ea6 2\u20143 GB\/\u6838\uff1b\u4e32\u884c\u6a21\u5f0f\u603b\u5185\u5b58\u4ecd\u53ef\u80fd\u8fbe 20\u201450 GB<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u63a7\u5236 CPU \u6570\u4e0e <code>num_partitions<\/code>\uff0c\u4fdd\u7559\u5185\u5b58\u4f59\u91cf<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u8f93\u5165\u4e0e\u4e2d\u95f4\u6587\u4ef6<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u5bb9\u91cf\u3001\u541e\u5410<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u5b98\u65b9\u793a\u4f8b\u4e2d 30\u00d7 WGS\uff1aBAM 66.99 GB\uff0cCRAM 37.85 GB\uff1bCRAM \u8fd0\u884c\u66f4\u6162<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">NVMe \u6682\u5b58\uff0c\u5bb9\u91cf\u6309\u8f93\u5165\u3001\u4e2d\u95f4\u6587\u4ef6\u548c\u7ed3\u679c\u5171\u540c\u8ba1\u7b97<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h2 style=\"margin-top:34px;color:#12314a;\">\u4e3a\u4ec0\u4e48\u201cGPU \u4f7f\u7528\u7387\u4e0d\u9ad8\u201d\u4e0d\u4e00\u5b9a\u662f\u6545\u969c<\/h2>\n<p>\u5b98\u65b9\u7684 fast pipeline \u53ef\u4ee5\u8ba9 CPU \u751f\u6210\u6837\u672c\u56fe\u50cf\u65f6\uff0cGPU \u540c\u65f6\u6267\u884c <code>call_variants<\/code>\u3002\u8fd9\u7c7b\u6d41\u6c34\u7ebf\u53ea\u6709\u5728\u4e24\u7aef\u901f\u5ea6\u63a5\u8fd1\u65f6\u624d\u6709\u6548\uff1aCPU \u5206\u7247\u592a\u5c11\u3001BAM \u4f4d\u4e8e\u7f51\u7edc\u76d8\u3001\u5bb9\u5668\u6302\u8f7d\u76ee\u5f55\u541e\u5410\u4e0d\u7a33\uff0c\u90fd\u53ef\u80fd\u8ba9 GPU \u95f4\u6b47\u7a7a\u8f6c\u3002<\/p>\n<p>\u5b98\u65b9\u6587\u6863\u8fd8\u7ed9\u51fa\u4e00\u4e2a\u76f4\u89c2\u5bf9\u6bd4\uff1a\u540c\u4e00\u4efd 30\u00d7 \u5168\u57fa\u56e0\u7ec4\u6570\u636e\uff0cBAM \u7ea6 66.99 GB\uff0c\u5355\u4e2a <code>make_examples<\/code> \u4f5c\u4e1a\u7ea6 79 \u5206 47 \u79d2\uff1bCRAM \u7ea6 37.85 GB\uff0c\u5374\u8fd0\u884c\u7ea6 96 \u5206 53 \u79d2\u3002CRAM \u8282\u7701\u4e86\u7ea6 43.5% \u5bb9\u91cf\uff0c\u4f46\u8be5\u6d4b\u8bd5\u4e2d\u8017\u65f6\u589e\u52a0\u7ea6 21%\u3002\u8fd9\u4e0d\u662f\u8bf4 CRAM \u4e00\u5b9a\u6162\uff0c\u800c\u662f\u63d0\u9192\u6211\u4eec\uff1a\u538b\u7f29\u7387\u3001\u89e3\u7801\u5f00\u9500\u3001\u5b58\u50a8\u541e\u5410\u5fc5\u987b\u4e00\u8d77\u8bc4\u4f30\u3002<\/p>\n<h2 style=\"margin-top:34px;color:#12314a;\">\u4e00\u5957\u66f4\u7a33\u7684\u8d44\u6e90\u89c4\u5212\u65b9\u6cd5<\/h2>\n<p>\u5982\u679c\u662f\u5355\u4e2a WES \u6216\u5c0f\u533a\u57df\u9a8c\u8bc1\uff0c\u53ef\u5148\u5728\u8f83\u5c11 CPU \u6838\u4e0a\u8dd1\u901a\u5bb9\u5668\u3001\u53c2\u8003\u57fa\u56e0\u7ec4\u548c\u6a21\u578b\u7248\u672c\uff1b\u5982\u679c\u662f 30\u00d7 WGS\u3001\u957f\u8bfb\u957f\u6216\u6279\u91cf\u6837\u672c\uff0c\u518d\u628a\u8d44\u6e90\u62c6\u6210\u56db\u4e2a\u95ee\u9898\u3002<\/p>\n<ol>\n<li><strong>\u8f93\u5165\u89c4\u6a21<\/strong>\uff1a\u8bb0\u5f55 BAM\/CRAM \u5927\u5c0f\u3001\u8986\u76d6\u6df1\u5ea6\u3001\u53c2\u8003\u7248\u672c\u548c\u6837\u672c\u6570\uff0c\u800c\u4e0d\u662f\u53ea\u5199\u201c\u4e00\u4e2a\u5168\u57fa\u56e0\u7ec4\u201d\u3002<\/li>\n<li><strong>\u5e76\u884c\u7b56\u7565<\/strong>\uff1a<code>--num_shards<\/code> \u51b3\u5b9a <code>make_examples<\/code> \u5e76\u884c\u5ea6\u3002\u6838\u6570\u589e\u52a0\u4f1a\u653e\u5927\u5185\u5b58\u548c I\/O \u538b\u529b\uff0c\u4e0d\u80fd\u53ea\u6309 CPU \u603b\u6570\u62c9\u6ee1\u3002<\/li>\n<li><strong>\u663e\u5361\u8fb9\u754c<\/strong>\uff1a\u5b98\u65b9\u8bb0\u5f55\u7ea6 16 GB \u663e\u5b58\u5360\u7528\uff0c\u5b9e\u9645\u90e8\u7f72\u5e94\u4e3a\u9a71\u52a8\u3001\u5bb9\u5668\u548c\u5cf0\u503c\u4fdd\u7559\u4f59\u91cf\uff1b\u5f53\u524d\u5355\u6837\u672c\u591a\u5361\u6ca1\u6709\u6536\u76ca\u3002<\/li>\n<li><strong>\u78c1\u76d8\u9884\u7b97<\/strong>\uff1a\u81f3\u5c11\u540c\u65f6\u5bb9\u7eb3\u8f93\u5165\u3001\u53c2\u8003\u6587\u4ef6\u3001\u5bb9\u5668\u955c\u50cf\u3001\u4e2d\u95f4 TFRecord\u3001VCF\/gVCF \u4e0e\u65e5\u5fd7\u3002\u6279\u91cf\u4efb\u52a1\u8981\u8bbe\u7f6e\u6309\u6837\u672c\u6e05\u7406\u548c\u5f52\u6863\u89c4\u5219\u3002<\/li>\n<\/ol>\n<p>\u771f\u6b63\u5f00\u59cb\u6269\u5bb9\u524d\uff0c\u5efa\u8bae\u5148\u7528\u4e00\u4e2a\u6709\u4ee3\u8868\u6027\u7684\u6837\u672c\u505a\u57fa\u7ebf\u6d4b\u8bd5\uff0c\u5e76\u540c\u65f6\u8bb0\u5f55\u56db\u7c7b\u6307\u6807\uff1aCPU \u5229\u7528\u7387\u3001GPU \u5229\u7528\u7387\u4e0e\u663e\u5b58\u3001\u5cf0\u503c\u7cfb\u7edf\u5185\u5b58\u3001\u78c1\u76d8\u541e\u5410\u4e0e\u7b49\u5f85\u65f6\u95f4\u3002\u5982\u679c CPU \u957f\u65f6\u95f4\u6ee1\u8f7d\u800c GPU \u65ad\u65ad\u7eed\u7eed\uff0c\u4f18\u5148\u68c0\u67e5\u5206\u7247\u751f\u6210\u901f\u5ea6\u548c\u8f93\u5165\u76d8\uff1b\u5982\u679c GPU \u663e\u5b58\u63a5\u8fd1\u4e0a\u9650\u4f46\u7cfb\u7edf\u5185\u5b58\u5f88\u7a7a\uff0c\u624d\u9700\u8981\u8003\u8651\u66f4\u5927\u663e\u5b58\uff1b\u5982\u679c\u6700\u540e\u5408\u5e76\u9636\u6bb5\u7a81\u7136\u88ab\u7cfb\u7edf\u6740\u6b7b\uff0c\u95ee\u9898\u591a\u534a\u4e0d\u5728\u6a21\u578b\u63a8\u7406\uff0c\u800c\u5728\u540e\u5904\u7406\u5e76\u884c\u5ea6\u4e0e\u5185\u5b58\u5cf0\u503c\u3002\u53ea\u770b\u603b\u8fd0\u884c\u65f6\u95f4\uff0c\u65e0\u6cd5\u5b9a\u4f4d\u8be5\u628a\u9884\u7b97\u82b1\u5728\u54ea\u91cc\u3002<\/p>\n<p>\u591a\u6837\u672c\u4efb\u52a1\u8fd8\u8981\u533a\u5206\u201c\u5355\u6837\u672c\u52a0\u901f\u201d\u548c\u201c\u6837\u672c\u7ea7\u5e76\u53d1\u201d\u3002\u7531\u4e8e\u5f53\u524d <code>call_variants<\/code> \u5355\u4e2a\u6837\u672c\u6700\u591a\u4f7f\u7528\u4e00\u5f20 GPU\uff0c\u591a\u5361\u670d\u52a1\u5668\u66f4\u9002\u5408\u8ba9\u4e0d\u540c\u6837\u672c\u5206\u522b\u5360\u7528\u4e0d\u540c GPU\uff0c\u800c\u4e0d\u662f\u8ba9\u4e00\u4e2a\u6837\u672c\u8de8\u5361\u8fd0\u884c\u3002\u6b64\u65f6 CPU \u6838\u3001\u5185\u5b58\u3001NVMe \u5e26\u5bbd\u4e5f\u8981\u6309\u5e76\u53d1\u6837\u672c\u6570\u540c\u6b65\u589e\u52a0\uff1b\u5426\u5219\u4e24\u5f20 GPU \u540c\u65f6\u8bfb\u5199\u4e00\u4e2a\u62e5\u5835\u7684\u7f51\u7edc\u76d8\uff0c\u5229\u7528\u7387\u53cd\u800c\u53ef\u80fd\u4e0b\u964d\u3002\u961f\u5217\u7cfb\u7edf\u5e94\u4e3a\u6bcf\u4e2a\u4efb\u52a1\u660e\u786e\u7533\u8bf7 CPU\u3001\u5185\u5b58\u3001GPU \u548c\u4e34\u65f6\u76d8\uff0c\u5e76\u9650\u5236\u540c\u4e00\u8282\u70b9\u540c\u65f6\u8fd0\u884c\u7684\u6837\u672c\u6570\u3002<\/p>\n<p>\u8fd8\u6709\u4e00\u4e2a\u5bb9\u6613\u88ab\u5ffd\u7565\u7684\u53d8\u91cf\u662f\u4e2d\u95f4\u76ee\u5f55\u3002\u82e5 <code>intermediate_results_dir<\/code> \u6307\u5411\u5bb9\u91cf\u8f83\u5c0f\u7684\u7cfb\u7edf\u76d8\uff0c\u4efb\u52a1\u53ef\u80fd\u5728\u8fd0\u884c\u6570\u5c0f\u65f6\u540e\u624d\u56e0\u7a7a\u95f4\u8017\u5c3d\u5931\u8d25\uff1b\u82e5\u6307\u5411\u5171\u4eab\u5b58\u50a8\uff0c\u6210\u5343\u4e0a\u4e07\u4e2a\u5206\u7247\u6587\u4ef6\u53c8\u4f1a\u653e\u5927\u5143\u6570\u636e\u8bbf\u95ee\u5ef6\u8fdf\u3002\u66f4\u7a33\u59a5\u7684\u505a\u6cd5\u662f\u628a\u4e2d\u95f4\u7ed3\u679c\u653e\u5728\u8282\u70b9\u672c\u5730 NVMe\uff0c\u5b8c\u6210\u540e\u53ea\u56de\u4f20 VCF\u3001gVCF\u3001\u7edf\u8ba1\u62a5\u544a\u548c\u5fc5\u8981\u65e5\u5fd7\uff0c\u5e76\u5728\u786e\u8ba4\u7ed3\u679c\u5b8c\u6574\u540e\u518d\u6e05\u7406\u4e34\u65f6\u6587\u4ef6\u3002\u8fd9\u6837\u65e2\u80fd\u51cf\u5c11\u7f51\u7edc\u76d8\u538b\u529b\uff0c\u4e5f\u65b9\u4fbf\u6309\u6837\u672c\u590d\u67e5\u5931\u8d25\u9636\u6bb5\u3002<\/p>\n<p>\u7248\u672c\u590d\u73b0\u540c\u6837\u91cd\u8981\u3002DeepVariant 1.10 \u7684\u6a21\u578b\u4f1a\u901a\u8fc7 <code>model.example_info.json<\/code> \u643a\u5e26\u4e0e\u8bad\u7ec3\u76f8\u5339\u914d\u7684\u8f93\u5165\u53c2\u6570\uff1b\u81ea\u5b9a\u4e49\u6a21\u578b\u6216\u62c6\u5f00\u8fd0\u884c\u4e09\u4e2a\u9636\u6bb5\u65f6\uff0c\u6a21\u578b\u6587\u4ef6\u4e0e\u8be5\u5143\u6570\u636e\u5e94\u4e00\u540c\u4fdd\u5b58\u3002\u5bb9\u5668\u6807\u7b7e\u3001\u53c2\u8003 FASTA\u3001\u7d22\u5f15\u6587\u4ef6\u3001BAM\/CRAM \u548c\u547d\u4ee4\u884c\u53c2\u6570\u4e5f\u5e94\u8fdb\u5165\u4efb\u52a1\u6e05\u5355\u3002\u4ec5\u8bb0\u5f55\u201c\u7528\u4e86 DeepVariant\u201d\uff0c\u4e0d\u8db3\u4ee5\u652f\u6301\u540e\u7eed\u590d\u8dd1\u6216\u5ba1\u7a3f\u6838\u5bf9\u3002<\/p>\n<p>\u4e0b\u9762\u8fd9\u7c7b\u547d\u4ee4\u9002\u5408\u5148\u505a\u5355\u6837\u672c\u57fa\u7ebf\uff0c\u518d\u6839\u636e\u76d1\u63a7\u7ed3\u679c\u8c03\u6574\u5206\u7247\u3002\u7248\u672c\u3001\u6a21\u578b\u7c7b\u578b\u3001\u53c2\u8003\u57fa\u56e0\u7ec4\u5fc5\u987b\u4e0e\u6570\u636e\u4e00\u81f4\uff1a<\/p>\n<pre style=\"overflow-x:auto;padding:18px;background:#102f47;color:#f8fafc;border-radius:12px;line-height:1.55;\"><code class=\"language-bash\">docker run --gpus 1 \\\r\n  -v \/data\/input:\/input \\\r\n  -v \/data\/output:\/output \\\r\n  google\/deepvariant:1.10.0-gpu \\\r\n  \/opt\/deepvariant\/bin\/run_deepvariant \\\r\n  --model_type=WGS \\\r\n  --ref=\/input\/GRCh38.fa \\\r\n  --reads=\/input\/sample.bam \\\r\n  --output_vcf=\/output\/sample.vcf.gz \\\r\n  --output_gvcf=\/output\/sample.g.vcf.gz \\\r\n  --num_shards=16\r\n<\/code><\/pre>\n<h2 style=\"margin-top:34px;color:#12314a;\">RNA-seq \u6a21\u578b\u4e0a\u7ebf\uff0c\u4e0d\u7b49\u4e8e RNA \u53d8\u5f02\u53ef\u4ee5\u76f4\u63a5\u4e0b\u7ed3\u8bba<\/h2>\n<p>DeepVariant 1.10 \u7684 RNA-seq \u652f\u6301\u6269\u5927\u4e86\u5de5\u5177\u9002\u7528\u8303\u56f4\uff0c\u4f46 RNA \u6570\u636e\u53d7\u8868\u8fbe\u91cf\u3001\u53ef\u53d8\u526a\u63a5\u3001\u7b49\u4f4d\u57fa\u56e0\u7279\u5f02\u8868\u8fbe\u3001\u6bd4\u5bf9\u7b56\u7565\u548c RNA \u7f16\u8f91\u5f71\u54cd\u3002\u4f4e\u8868\u8fbe\u4f4d\u70b9\u6ca1\u6709\u8db3\u591f\u8986\u76d6\uff0c\u5e76\u4e0d\u7b49\u540c\u4e8e\u57fa\u56e0\u7ec4\u4e2d\u4e0d\u5b58\u5728\u53d8\u5f02\uff1bRNA \u4e2d\u89c2\u5bdf\u5230\u7684\u5dee\u5f02\uff0c\u4e5f\u4e0d\u80fd\u76f4\u63a5\u66ff\u4ee3 DNA \u5c42\u9762\u7684\u751f\u6b96\u7cfb\u6216\u4f53\u7ec6\u80de\u9a8c\u8bc1\u3002<\/p>\n<p>\u56e0\u6b64\uff0cRNA-seq \u53d8\u5f02\u68c0\u6d4b\u66f4\u9002\u5408\u5728\u660e\u786e\u7814\u7a76\u76ee\u6807\u548c\u8fc7\u6ee4\u89c4\u5219\u4e0b\u4f5c\u4e3a\u8865\u5145\u8bc1\u636e\u3002\u82e5\u7814\u7a76\u7ed3\u8bba\u6d89\u53ca\u4e34\u5e8a\u5224\u65ad\u6216\u5173\u952e\u5019\u9009\u9a8c\u8bc1\uff0c\u5e94\u7ed3\u5408 DNA \u6570\u636e\u3001\u6b63\u4ea4\u5b9e\u9a8c\u548c\u76f8\u5e94\u89c4\u8303\uff0c\u800c\u4e0d\u662f\u628a\u6a21\u578b\u8f93\u51fa\u5f53\u4f5c\u6700\u7ec8\u8bc1\u636e\u3002<\/p>\n<h2 style=\"margin-top:34px;color:#12314a;\">\u4ec0\u4e48\u65f6\u5019\u670d\u52a1\u5668\u6bd4\u672c\u5730\u5de5\u4f5c\u7ad9\u66f4\u5408\u9002<\/h2>\n<p>\u5f53\u4efb\u52a1\u5305\u542b 30\u00d7 WGS\u3001\u591a\u6837\u672c\u5e76\u53d1\u3001\u957f\u8bfb\u957f\u3001gVCF \u8f93\u51fa\u6216\u9700\u8981\u4fdd\u7559\u5b8c\u6574\u4e2d\u95f4\u6587\u4ef6\u65f6\uff0c\u670d\u52a1\u5668\u7684\u4ef7\u503c\u4e0d\u53ea\u662f\u201c\u6709 GPU\u201d\uff0c\u800c\u662f\u80fd\u628a CPU \u5206\u7247\u3001\u5355\u5361\u63a8\u7406\u3001\u5185\u5b58\u5cf0\u503c\u3001\u672c\u5730 NVMe \u548c\u5bb9\u5668\u7248\u672c\u7edf\u4e00\u7ba1\u7406\u3002\u8fd9\u6837\u66f4\u5bb9\u6613\u590d\u73b0\u5931\u8d25\u6b65\u9aa4\uff0c\u4e5f\u907f\u514d\u4e2a\u4eba\u7535\u8111\u88ab\u957f\u671f\u5360\u7528\u3002<\/p>\n<p>\u5982\u679c\u4f60\u7684 DeepVariant \u4efb\u52a1\u51fa\u73b0 GPU \u7a7a\u8f6c\u3001\u540e\u5904\u7406\u7206\u5185\u5b58\u3001\u5bb9\u5668\u4e0e CUDA \u4e0d\u517c\u5bb9\uff0c\u6216\u4e0d\u786e\u5b9a 64 GB \/ 128 GB \u5185\u5b58\u3001\u5355\u5361 GPU \u4e0e NVMe \u5bb9\u91cf\u8be5\u600e\u6837\u642d\u914d\uff0c\u53ef\u4ee5\u51c6\u5907\u8f6f\u4ef6\u7248\u672c\u3001\u6570\u636e\u7c7b\u578b\u3001\u6837\u672c\u6570\u3001\u5355\u6837\u672c\u5927\u5c0f\u3001\u5f53\u524d\u62a5\u9519\u548c\u671f\u671b\u65f6\u95f4\u3002\u4e91\u751f\u4fe1\u4f1a\u5148\u5224\u65ad\u74f6\u9888\u4f4d\u4e8e CPU\u3001GPU\u3001\u5185\u5b58\u8fd8\u662f\u5b58\u50a8\uff0c\u518d\u786e\u8ba4\u662f\u79df\u7528\u73af\u5883\u81ea\u884c\u8fd0\u884c\u3001\u90e8\u7f72\u5e76\u4ea4\u63a5\u73af\u5883\uff0c\u8fd8\u662f\u59d4\u6258\u5206\u6790\u66f4\u5408\u9002\u3002<\/p>\n<p><a href=\"https:\/\/work.weixin.qq.com\/kfid\/kfcb05492f29d4d6064\" data-ysx-event=\"contact_click\" style=\"display:inline-block;padding:13px 20px;border-radius:10px;background:#e36e2e;color:#fff;text-decoration:none;font-weight:800;\">\u8054\u7cfb\u4e91\u751f\u4fe1\uff0c\u54a8\u8be2 DeepVariant \u670d\u52a1\u5668\u4e0e\u5206\u6790\u65b9\u6848<\/a><\/p>\n<h2 style=\"margin-top:34px;color:#12314a;\">\u53c2\u8003\u8d44\u6599<\/h2>\n<ul>\n<li><a href=\"https:\/\/github.com\/google\/deepvariant\/releases\/tag\/v1.10.0\">DeepVariant 1.10.0 \u5b98\u65b9\u53d1\u5e03\u8bf4\u660e<\/a><\/li>\n<li><a href=\"https:\/\/github.com\/google\/deepvariant\/blob\/r1.10\/docs\/FAQ.md\">DeepVariant \u5b98\u65b9 FAQ\uff1aGPU \u663e\u5b58\u4e0e\u591a GPU \u8fb9\u754c<\/a><\/li>\n<li><a href=\"https:\/\/github.com\/google\/deepvariant\/blob\/r1.10\/docs\/deepvariant-details.md\">DeepVariant \u5b98\u65b9\u8be6\u7ec6\u8bf4\u660e\uff1a\u5206\u7247\u3001\u5185\u5b58\u4e0e BAM\/CRAM \u6570\u636e<\/a><\/li>\n<li><a href=\"https:\/\/github.com\/google\/deepvariant\/blob\/r1.10\/docs\/deepvariant-quick-start.md\">DeepVariant \u5b98\u65b9\u5feb\u901f\u5f00\u59cb<\/a><\/li>\n<\/ul>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>DeepVariant 1.10 \u65b0\u589e RNA-seq \u6a21\u578b\uff0c\u4f46\u5355\u770b GPU \u4ecd\u53ef\u80fd\u914d\u7f6e\u5931\u8861\u3002\u672c\u6587\u62c6\u89e3 make_examples\u3001call_variants\u3001postprocess_variants \u7684 CPU\u3001\u663e\u5b58\u3001\u5185\u5b58\u4e0e\u5b58\u50a8\u74f6\u9888\u3002<\/p>\n","protected":false},"author":1,"featured_media":66274,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1,75],"tags":[406,340,80,408,407,275,409,352],"class_list":["post-66275","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-part","category-compute-environment","tag-deepvariant","tag-gpu","tag-rna-seq","tag-wgs","tag-407","tag-275","tag-ai","tag-352"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/10\/daily-bio-blog-20261022-deepvariant-gpu-deepvariant-gpu-poster.png?fit=1080%2C1350&ssl=1","_links":{"self":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/comments?post=66275"}],"version-history":[{"count":1,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66275\/revisions"}],"predecessor-version":[{"id":66276,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66275\/revisions\/66276"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media\/66274"}],"wp:attachment":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media?parent=66275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/categories?post=66275"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/tags?post=66275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}