{"id":66294,"date":"2026-10-26T09:05:49","date_gmt":"2026-10-26T01:05:49","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=66294"},"modified":"2026-10-26T09:05:49","modified_gmt":"2026-10-26T01:05:49","slug":"foldseek-afdb50-memory-server-planning","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/foldseek-afdb50-memory-server-planning\/","title":{"rendered":"Foldseek \u5feb\uff0c\u4e0d\u7b49\u4e8e\u666e\u901a\u7535\u8111\u5c31\u591f\uff1a5400 \u4e07\u7ed3\u6784\u9ed8\u8ba4\u8981 151 GB \u5185\u5b58"},"content":{"rendered":"<div id=\"articleContent\" style=\"max-width:860px;margin:0 auto;color:#1f2937;font-size:17px;line-height:1.85;\">\n<p>AlphaFold \u628a\u201c\u6ca1\u6709\u7ed3\u6784\u53ef\u67e5\u201d\u53d8\u6210\u4e86\u201c\u7ed3\u6784\u591a\u5230\u67e5\u4e0d\u52a8\u201d\u3002AlphaFold DB \u5f53\u524d\u9875\u9762\u5217\u51fa <strong>261,552,403<\/strong> \u4e2a\u9884\u6d4b\u6a21\u578b\uff1b\u9762\u5bf9\u8fd9\u6837\u7684\u7ed3\u6784\u6d77\u6d0b\uff0c\u9010\u4e2a\u4e0b\u8f7d\u3001\u9010\u4e2a\u6bd4\u5bf9\u5df2\u7ecf\u4e0d\u53ef\u884c\u3002Foldseek \u628a\u4e09\u7ef4\u5c40\u90e8\u76f8\u4e92\u4f5c\u7528\u7f16\u7801\u6210 3Di \u5e8f\u5217\uff0c\u8bba\u6587\u62a5\u544a\u5b83\u53ef\u628a\u7ed3\u6784\u68c0\u7d22\u65f6\u95f4\u7f29\u77ed <strong>4\uff5e5 \u4e2a\u6570\u91cf\u7ea7<\/strong>\uff0c\u5728 AlphaFoldDB \u57fa\u51c6\u4e2d\u76f8\u5bf9 Dali \u548c TM-align \u5206\u522b\u5feb\u7ea6 <strong>184,600 \u500d<\/strong>\u4e0e <strong>23,000 \u500d<\/strong>\u3002<\/p>\n<p>\u4f46\u201c\u7b97\u6cd5\u5feb\u201d\u4e0d\u7b49\u4e8e\u201c\u968f\u4fbf\u4e00\u53f0\u7535\u8111\u90fd\u80fd\u8dd1\u201d\u3002Foldseek \u5b98\u65b9\u7ed9\u51fa\u7684 AFDB50 \u6570\u636e\u5e93\u7ea6\u6709 <strong>5400 \u4e07\u6761\u76ee<\/strong>\uff1a\u9ed8\u8ba4\u4fdd\u7559 C\u03b1 \u4fe1\u606f\u65f6\u9700\u8981 <strong>151 GB RAM<\/strong>\uff1b\u5173\u95ed\u7ed3\u6784\u4f4d\u6392\u5e8f\u540e\u53ef\u964d\u5230 <strong>35 GB<\/strong>\uff0c\u5374\u4f1a\u6539\u53d8\u547d\u4e2d\u6392\u5e8f\u548c\u6700\u7ec8\u5206\u6570\u3002\u771f\u6b63\u8981\u89c4\u5212\u7684\uff0c\u662f\u6570\u636e\u5e93\u89c4\u6a21\u3001\u67e5\u8be2\u65b9\u5f0f\u3001\u5185\u5b58\u3001\u7d22\u5f15\u3001\u4e34\u65f6\u76d8\u4e0e\u5e76\u53d1\uff0c\u800c\u4e0d\u53ea\u662f CPU \u6838\u6570\u3002<\/p>\n<figure style=\"margin:28px 0;\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/10\/daily-bio-blog-20261026-foldseek-search-foldseek-poster.png?ssl=1\" alt=\"Foldseek \u86cb\u767d\u7ed3\u6784\u6570\u636e\u5e93\u68c0\u7d22\u4e0e\u670d\u52a1\u5668\u8d44\u6e90\u89c4\u5212\u6d77\u62a5\" style=\"display:block;width:100%;height:auto;border-radius:14px;\"><figcaption style=\"margin-top:8px;color:#64748b;font-size:14px;text-align:center;\">Foldseek \u8d44\u6e90\u89c4\u5212\uff1a\u6570\u636e\u5e93\u89c4\u6a21\u3001\u67e5\u8be2\u65b9\u5f0f\u3001\u5185\u5b58\u3001\u7d22\u5f15\u3001\u4e34\u65f6\u76d8\u4e0e\u5e76\u53d1\u5fc5\u987b\u4e00\u8d77\u8ba1\u7b97\u3002<\/figcaption><\/figure>\n<h2 style=\"margin-top:34px;color:#12314a;\">\u5148\u7b97\u5185\u5b58\uff1a\u4e0d\u662f\u201c\u88c5\u4e0a Foldseek\u201d\u5c31\u7ed3\u675f<\/h2>\n<p>\u5b98\u65b9\u7ed9\u51fa\u7684\u9ed8\u8ba4\u5185\u5b58\u4f30\u7b97\u5f0f\u662f\uff1a<code>(6 bytes C\u03b1 + 1 byte 3Di + 1 byte AA) \u00d7 \u6570\u636e\u5e93\u6b8b\u57fa\u6570<\/code>\u3002\u8fd9\u610f\u5473\u7740\u5185\u5b58\u968f\u6570\u636e\u5e93\u603b\u6b8b\u57fa\u6570\u589e\u957f\uff0c\u800c\u4e0d\u662f\u53ea\u770b\u7ed3\u6784\u6587\u4ef6\u6570\u91cf\u3002\u957f\u86cb\u767d\u3001\u5168\u86cb\u767d\u7ec4\u3001\u591a\u4e2a\u7248\u672c\u5e76\u5b58\uff0c\u90fd\u53ef\u80fd\u628a\u540c\u6837\u7684\u201c\u51e0\u5343\u4e07\u6761\u7ed3\u6784\u201d\u63a8\u5230\u4e0d\u540c\u8d44\u6e90\u6863\u4f4d\u3002<\/p>\n<div style=\"overflow-x:auto;margin:18px 0 26px;\">\n<table style=\"width:100%;border-collapse:collapse;min-width:720px;font-size:15px;\">\n<thead style=\"background:#0e5b68;color:#fff;\">\n<tr>\n<th style=\"padding:12px;border:1px solid #d6e2e5;text-align:left;\">\u573a\u666f<\/th>\n<th style=\"text-align: right;\">\u5b98\u65b9\u6216\u53ef\u8ba1\u7b97\u6570\u5b57<\/th>\n<th style=\"padding:12px;border:1px solid #d6e2e5;text-align:left;\">\u8d44\u6e90\u5224\u65ad<\/th>\n<th style=\"padding:12px;border:1px solid #d6e2e5;text-align:left;\">\u9002\u5408\u505a\u6cd5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">AFDB50 \u9ed8\u8ba4\u641c\u7d22<\/td>\n<td style=\"text-align: right;\">5400 \u4e07\u6761\u76ee\u3001151 GB RAM<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u666e\u901a 64\/128 GB \u5de5\u4f5c\u7ad9\u4e0d\u8db3<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u9009\u62e9 192\/256 GB \u4ee5\u4e0a\u5355\u8282\u70b9\u5e76\u7559\u7cfb\u7edf\u4f59\u91cf<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">AFDB50 \u4e0d\u4fdd\u7559 C\u03b1 \u6392\u5e8f<\/td>\n<td style=\"text-align: right;\">\u7ea6 35 GB RAM<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u7701\u5185\u5b58\uff0c\u4f46\u6392\u5e8f\u548c\u6700\u7ec8\u5206\u6570\u4f1a\u53d8\u5316<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u4ec5\u5728\u786e\u8ba4\u8f93\u51fa\u5f71\u54cd\u53ef\u63a5\u53d7\u65f6\u4f7f\u7528<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u5355\u6761\u6216\u5c11\u91cf\u67e5\u8be2<\/td>\n<td style=\"text-align: right;\"><code>--prefilter-mode 1<\/code> \u4e0d\u53d7\u6574\u5e93\u9a7b\u7559\u5185\u5b58\u9650\u5236<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u8ba1\u7b97\u65b9\u5f0f\u53d8\u5316\uff0c\u9002\u5408\u5355\u67e5\u8be2<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u5148\u5c0f\u89c4\u6a21\u9a8c\u8bc1\u7075\u654f\u5ea6\u4e0e\u8f93\u51fa\u5b57\u6bb5<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">GPU \u641c\u7d22<\/td>\n<td style=\"text-align: right;\">Ampere \u6216\u66f4\u65b0\u67b6\u6784\u53ef\u83b7\u5f97\u5b8c\u6574\u901f\u5ea6<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u6570\u636e\u5e93\u8fd8\u9700 padding\uff0c\u663e\u5b58\u4e0d\u662f\u552f\u4e00\u7ea6\u675f<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u5148\u505a <code>makepaddedseqdb<\/code>\uff0c\u518d\u6d4b\u541e\u5410<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u81ea\u5efa\u7ed3\u6784\u5e93\u53cd\u590d\u68c0\u7d22<\/td>\n<td style=\"text-align: right;\">\u5148 <code>createdb<\/code>\uff0c\u53ef\u9009 <code>createindex<\/code><\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u9996\u6b21\u9884\u5904\u7406\u8017\u65f6\uff0c\u4e4b\u540e\u53ef\u590d\u7528<\/td>\n<td style=\"padding:11px;border:1px solid #d6e2e5;vertical-align:top;\">\u6570\u636e\u5e93\u3001\u7d22\u5f15\u3001\u7248\u672c\u548c\u53c2\u6570\u4e00\u8d77\u5f52\u6863<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>151 GB \u4e0d\u662f\u670d\u52a1\u5668\u5e94\u914d\u7f6e\u7684\u603b\u5185\u5b58\u3002\u7cfb\u7edf\u3001\u6587\u4ef6\u7f13\u5b58\u3001\u4e34\u65f6\u6570\u636e\u5e93\u3001\u67e5\u8be2\u96c6\u5408\u548c\u5e76\u53d1\u4efb\u52a1\u90fd\u8981\u5360\u7a7a\u95f4\uff1b\u82e5\u8282\u70b9\u603b\u5185\u5b58\u6b63\u597d\u7b49\u4e8e\u7406\u8bba\u503c\uff0c\u5e38\u89c1\u7ed3\u679c\u662f\u641c\u7d22\u521a\u8fdb\u5165\u5cf0\u503c\u5c31\u88ab OOM kill\u3002\u5b9e\u9645\u914d\u7f6e\u5e94\u5728\u4ee3\u8868\u6027\u6570\u636e\u4e0a\u8bb0\u5f55\u5cf0\u503c RSS\uff0c\u518d\u51b3\u5b9a\u5b89\u5168\u4f59\u91cf\u3002<\/p>\n<h2 style=\"margin-top:34px;color:#12314a;\">\u4e09\u79cd\u7701\u8d44\u6e90\u65b9\u6cd5\uff0c\u4ee3\u4ef7\u5e76\u4e0d\u76f8\u540c<\/h2>\n<p>\u7b2c\u4e00\u79cd\u662f\u5173\u95ed\u7ed3\u6784\u4f4d\u6392\u5e8f\uff1a<\/p>\n<pre style=\"overflow-x:auto;padding:18px;background:#102f47;color:#f8fafc;border-radius:12px;line-height:1.55;\"><code class=\"language-bash\">foldseek easy-search query.pdb afdb50 result.m8 tmp \\\r\n  --sort-by-structure-bits 0\r\n<\/code><\/pre>\n<p>\u5b83\u628a AFDB50 \u7684\u5185\u5b58\u9700\u6c42\u4ece 151 GB \u964d\u5230\u7ea6 35 GB\uff0c\u4f46\u5b98\u65b9\u660e\u786e\u8bf4\u660e\u547d\u4e2d\u6392\u540d\u548c\u6700\u7ec8\u5206\u6570\u4f1a\u53d8\u5316\uff0cE-value \u4e0d\u53d8\u3002\u82e5\u4efb\u52a1\u662f\u5019\u9009\u4f18\u5148\u7ea7\u6392\u5e8f\u3001\u8fdc\u7f18\u540c\u6e90\u53d1\u73b0\u6216\u540e\u7eed\u53ea\u53d6 Top hits\uff0c\u4e0d\u80fd\u53ea\u770b\u5230\u201c\u7701\u4e86 116 GB\u201d\uff0c\u8fd8\u8981\u9a8c\u8bc1\u6392\u5e8f\u53d8\u5316\u662f\u5426\u5f71\u54cd\u7ed3\u8bba\u3002<\/p>\n<p>\u7b2c\u4e8c\u79cd\u662f\u5bf9\u5355\u6761\u67e5\u8be2\u4f7f\u7528 <code>--prefilter-mode 1<\/code>\u3002\u8be5\u6a21\u5f0f\u8ba1\u7b97\u5168\u90e8\u6700\u4f18\u65e0\u7f3a\u53e3\u6bd4\u5bf9\uff0c\u4e0d\u53d7\u6574\u5e93\u9a7b\u7559\u5185\u5b58\u9650\u5236\uff0c\u4e5f\u80fd\u4f7f\u7528 GPU\uff1b\u4f46\u5b83\u66f4\u9002\u5408\u5c11\u91cf\u67e5\u8be2\u3002\u628a\u6210\u5343\u4e0a\u4e07\u6761\u7ed3\u6784\u9010\u6761\u8fd9\u6837\u8dd1\uff0c\u53ef\u80fd\u4ece\u201c\u5185\u5b58\u74f6\u9888\u201d\u53d8\u6210\u201c\u603b\u8ba1\u7b97\u91cf\u74f6\u9888\u201d\u3002<\/p>\n<p>\u7b2c\u4e09\u79cd\u662f\u7f29\u5c0f\u6570\u636e\u5e93\uff0c\u4f8b\u5982\u53ea\u68c0\u7d22 PDB\u3001Swiss-Prot \u6216\u6307\u5b9a\u7269\u79cd\u86cb\u767d\u7ec4\u3002\u8fd9\u6837\u6700\u7701\u8d44\u6e90\uff0c\u4e5f\u6700\u5bb9\u6613\u89e3\u91ca\uff1b\u4ee3\u4ef7\u662f\u641c\u7d22\u7a7a\u95f4\u53d8\u7a84\uff0c\u53ef\u80fd\u6f0f\u6389\u6765\u81ea\u975e\u6a21\u5f0f\u7269\u79cd\u3001\u5b8f\u57fa\u56e0\u7ec4\u6216\u672a\u4eba\u5de5\u5ba1\u6821\u6761\u76ee\u7684\u8fdc\u7f18\u7ed3\u6784\u3002\u6570\u636e\u5e93\u8303\u56f4\u5fc5\u987b\u7531\u7814\u7a76\u95ee\u9898\u51b3\u5b9a\uff0c\u4e0d\u80fd\u7531\u673a\u5668\u914d\u7f6e\u5012\u63a8\u3002<\/p>\n<h2 style=\"margin-top:34px;color:#12314a;\">CPU\u3001GPU\u4e0e\u78c1\u76d8\uff1a\u522b\u8ba9\u5feb\u7b97\u6cd5\u5835\u5728\u6570\u636e\u51c6\u5907\u4e0a<\/h2>\n<p>Foldseek \u7684 CPU \u7248\u672c\u5df2\u7ecf\u652f\u6301\u591a\u7ebf\u7a0b\u548c SIMD\u3002GPU \u641c\u7d22\u8981\u6c42\u5148\u628a\u6570\u636e\u5e93\u8f6c\u6362\u4e3a padded \u683c\u5f0f\uff1a<\/p>\n<pre style=\"overflow-x:auto;padding:18px;background:#102f47;color:#f8fafc;border-radius:12px;line-height:1.55;\"><code class=\"language-bash\">foldseek makepaddedseqdb targetDB targetDB_pad\r\nfoldseek search queryDB targetDB_pad resultDB tmp --gpu 1\r\n<\/code><\/pre>\n<p>\u5b98\u65b9\u8bf4\u660e Ampere \u53ca\u66f4\u65b0 NVIDIA GPU \u53ef\u83b7\u5f97\u5b8c\u6574\u901f\u5ea6\uff0cTuring \u53ef\u7528\u4f46\u901f\u5ea6\u964d\u4f4e\uff0cVolta\/Pascal \u4e0d\u53d7\u9884\u7f16\u8bd1\u5305\u652f\u6301\u3002\u8fd9\u91cc\u7684\u5173\u952e\u4e0d\u662f\u201c\u6709 GPU \u5c31\u5feb\u201d\uff0c\u800c\u662f GPU \u67b6\u6784\u3001\u6570\u636e\u5e93\u683c\u5f0f\u3001\u663e\u5b58\u4f20\u8f93\u3001CPU \u89e3\u538b\u548c\u672c\u5730\u76d8\u541e\u5410\u8981\u914d\u5957\u3002\u82e5 padded \u6570\u636e\u5e93\u653e\u5728\u62e5\u5835\u7684\u7f51\u7edc\u76d8\uff0c\u591a\u5757 GPU \u4e5f\u53ef\u80fd\u7b49 I\/O\u3002<\/p>\n<p>\u81ea\u5efa\u5e93\u53cd\u590d\u4f7f\u7528\u65f6\uff0c<code>createdb<\/code> \u548c\u53ef\u9009\u7684 <code>createindex<\/code> \u5e94\u53ea\u505a\u4e00\u6b21\uff0c\u5e76\u56fa\u5b9a Foldseek \u7248\u672c\u3001\u6e90\u7ed3\u6784\u6e05\u5355\u3001\u6570\u636e\u5e93\u751f\u6210\u547d\u4ee4\u548c\u6821\u9a8c\u503c\u3002\u4e34\u65f6\u76ee\u5f55\u4f18\u5148\u653e\u9ad8\u901f\u672c\u5730 SSD\uff1b\u7ed3\u679c\u3001\u65e5\u5fd7\u548c\u53ef\u590d\u73b0\u5143\u6570\u636e\u518d\u56de\u4f20\u5171\u4eab\u5b58\u50a8\u3002\u8fd9\u6837\u65e2\u51cf\u5c11\u91cd\u590d\u9884\u5904\u7406\uff0c\u4e5f\u907f\u514d\u591a\u4eba\u5404\u5efa\u4e00\u4efd\u6570\u636e\u5e93\u628a\u5bb9\u91cf\u8fc5\u901f\u5403\u6ee1\u3002<\/p>\n<p>\u6570\u636e\u5e93\u66f4\u65b0\u4e5f\u8981\u6309\u201c\u65b0\u7248\u672c\u91cd\u65b0\u5efa\u5e93\u201d\u7ba1\u7406\uff0c\u800c\u4e0d\u662f\u76f4\u63a5\u8986\u76d6\u65e7\u76ee\u5f55\u3002AlphaFold DB \u7684\u6570\u91cf\u4f1a\u968f UniProt \u540c\u6b65\u53d1\u751f\u65b0\u589e\u3001\u79fb\u9664\u4e0e\u5e8f\u5217\u53d8\u5316\uff1a\u5b98\u65b9 v6 \u53d1\u5e03\u8bf4\u660e\u8bb0\u5f55\u4e86 <strong>241,070,489<\/strong> \u4e2a\u6a21\u578b\uff0c\u800c\u5f53\u524d FAQ \u9875\u9762\u5df2\u7ecf\u5217\u51fa 261,552,403 \u4e2a\u9884\u6d4b\u6a21\u578b\u3002\u4e24\u4e2a\u6570\u5b57\u5bf9\u5e94\u4e0d\u540c\u53d1\u5e03\u72b6\u6001\uff0c\u4e0d\u80fd\u6df7\u7528\u3002\u8bba\u6587\u590d\u73b0\u65f6\u5e94\u5199\u660e\u6570\u636e\u5e93\u540d\u79f0\u3001\u4e0b\u8f7d\u65e5\u671f\u6216\u7248\u672c\uff0c\u4ee5\u53ca\u662f\u5426\u4f7f\u7528 UniProt50 \u805a\u7c7b\u5e93\uff1b\u5426\u5219\u540c\u4e00\u6761\u67e5\u8be2\u5728\u534a\u5e74\u540e\u91cd\u8dd1\uff0c\u5019\u9009\u6570\u91cf\u548c\u6392\u540d\u90fd\u53ef\u80fd\u4e0d\u540c\u3002<\/p>\n<p>\u5bb9\u91cf\u4f30\u7b97\u8fd8\u5e94\u628a\u539f\u59cb PDB\/mmCIF\u3001Foldseek \u6570\u636e\u5e93\u3001\u7d22\u5f15\u3001GPU padded \u526f\u672c\u3001\u4e34\u65f6\u6587\u4ef6\u4e0e\u7ed3\u679c\u5206\u5f00\u8ba1\u7b97\u3002\u5982\u679c\u540c\u65f6\u4fdd\u7559 CPU \u5e93\u548c GPU \u5e93\uff0c\u78c1\u76d8\u5e76\u4e0d\u662f\u201c\u4e0b\u8f7d\u5305\u5927\u5c0f\u201d\u90a3\u4e48\u7b80\u5355\u3002\u5efa\u8bae\u5148\u5728\u76ee\u6807\u6587\u4ef6\u7cfb\u7edf\u5b8c\u6574\u5efa\u4e00\u6b21\u5e93\uff0c\u7528 <code>du<\/code> \u8bb0\u5f55\u5404\u9636\u6bb5\u5cf0\u503c\uff0c\u518d\u6309\u6570\u636e\u5e93\u66f4\u65b0\u9891\u7387\u548c\u4fdd\u7559\u7248\u672c\u6570\u6838\u7b97\u5bb9\u91cf\u3002\u591a\u4eba\u5171\u4eab\u65f6\u7ed9\u6570\u636e\u5e93\u53ea\u8bfb\u6743\u9650\uff0c\u6bcf\u4e2a\u4efb\u52a1\u4f7f\u7528\u72ec\u7acb\u4e34\u65f6\u76ee\u5f55\uff0c\u80fd\u51cf\u5c11\u8bef\u5220\u3001\u9501\u51b2\u7a81\u4e0e\u7ed3\u679c\u4e92\u76f8\u8986\u76d6\u3002<\/p>\n<h2 style=\"margin-top:34px;color:#12314a;\">\u4e00\u5957\u53ef\u6267\u884c\u7684\u4e0a\u7ebf\u6d41\u7a0b<\/h2>\n<p>\u5148\u7528 50\uff5e100 \u6761\u6709\u5df2\u77e5\u5173\u7cfb\u7684\u67e5\u8be2\u505a\u57fa\u7ebf\uff0c\u5206\u522b\u8bb0\u5f55\u641c\u7d22\u5899\u949f\u65f6\u95f4\u3001\u5cf0\u503c\u5185\u5b58\u3001\u4e34\u65f6\u76d8\u5cf0\u503c\u3001\u7ed3\u679c\u6761\u6570\u548c Top hits \u7a33\u5b9a\u6027\u3002\u518d\u9010\u6b65\u63d0\u9ad8\u67e5\u8be2\u6570\u4e0e\u5e76\u53d1\uff0c\u4e0d\u8981\u4e00\u5f00\u59cb\u5c31\u63d0\u4ea4\u5168\u5e93\u4efb\u52a1\u3002<\/p>\n<p>\u7ed3\u679c\u8fc7\u6ee4\u81f3\u5c11\u540c\u65f6\u770b E-value\u3001\u6bd4\u5bf9\u8986\u76d6\u5ea6\u548c TM-score\/LDDT \u7b49\u7ed3\u6784\u8d28\u91cf\u6307\u6807\u3002Foldseek \u8bba\u6587\u4e5f\u6307\u51fa\uff0c\u591a\u7ed3\u6784\u57df\u86cb\u767d\u7684\u76f8\u5bf9\u53d6\u5411\u3001\u4f4e\u7f6e\u4fe1\u5ea6\u533a\u57df\u548c\u9ad8\u5206\u5047\u9633\u6027\u9700\u8981\u8fdb\u4e00\u6b65\u6838\u67e5\uff1b\u201c\u901f\u5ea6\u5feb\u201d\u5e76\u4e0d\u53d6\u6d88\u751f\u7269\u5b66\u89e3\u91ca\u4e0e\u4eba\u5de5\u590d\u6838\u3002<\/p>\n<p>\u6700\u540e\u628a\u67e5\u8be2\u3001\u76ee\u6807\u5e93\u7248\u672c\u3001\u53c2\u6570\u3001\u8f93\u51fa\u683c\u5f0f\u4e0e\u4e0b\u6e38\u811a\u672c\u5199\u8fdb\u5de5\u4f5c\u6d41\u3002\u5bf9\u6570\u767e\u5230\u6570\u5343\u4e2a\u67e5\u8be2\uff0c\u4efb\u52a1\u6570\u7ec4\u901a\u5e38\u6bd4\u4e00\u5473\u589e\u52a0\u5355\u4efb\u52a1\u7ebf\u7a0b\u66f4\u4fbf\u4e8e\u5931\u8d25\u91cd\u8dd1\uff1b\u5bf9\u5171\u4eab\u6570\u636e\u5e93\uff0c\u9650\u5236\u5e76\u53d1\u548c\u4e34\u65f6\u76ee\u5f55\uff0c\u624d\u80fd\u907f\u514d\u591a\u4eba\u540c\u65f6\u628a\u5185\u5b58\u4e0e I\/O \u6253\u6ee1\u3002<\/p>\n<p>\u5e38\u89c1\u6545\u969c\u4e5f\u5e94\u63d0\u524d\u7eb3\u5165\u9a8c\u6536\uff1a\u8fdb\u7a0b\u88ab\u7cfb\u7edf\u6740\u6b7b\u591a\u534a\u8981\u5148\u67e5\u5cf0\u503c\u5185\u5b58\uff1b\u901f\u5ea6\u968f\u5e76\u53d1\u4e0a\u5347\u53cd\u800c\u4e0b\u964d\uff0c\u901a\u5e38\u8981\u67e5\u5171\u4eab\u76d8\u541e\u5410\u548c page cache\uff1b\u540c\u4e00\u67e5\u8be2\u5728 CPU\/GPU \u8def\u5f84\u7ed3\u679c\u4e0d\u4e00\u81f4\uff0c\u5219\u8981\u6838\u5bf9\u6570\u636e\u5e93\u662f\u5426\u6765\u81ea\u540c\u4e00\u6e90\u3001\u662f\u5426\u5b8c\u6210 padding\u3001\u53c2\u6570\u4e0e\u8f6f\u4ef6\u7248\u672c\u662f\u5426\u4e00\u81f4\u3002\u628a\u8fd9\u4e9b\u68c0\u67e5\u5199\u6210\u81ea\u52a8\u5316\u65e5\u5fd7\uff0c\u6bd4\u4efb\u52a1\u5931\u8d25\u540e\u53ea\u4fdd\u5b58\u4e00\u5f20\u62a5\u9519\u622a\u56fe\u66f4\u6709\u4ef7\u503c\u3002<\/p>\n<p>\u5982\u679c\u4f60\u7684\u4efb\u52a1\u5361\u5728 35\/151\/256 GB \u5185\u5b58\u9009\u62e9\u3001AFDB\/PDB\/\u81ea\u5efa\u5e93\u8303\u56f4\u3001CPU \u4e0e GPU \u53d6\u820d\u3001\u7d22\u5f15\u590d\u7528\u6216\u6279\u91cf\u5e76\u53d1\uff0c\u53ef\u4ee5\u51c6\u5907\u67e5\u8be2\u6570\u91cf\u4e0e\u683c\u5f0f\u3001\u76ee\u6807\u6570\u636e\u5e93\u3001\u671f\u671b\u8f93\u51fa\u3001\u670d\u52a1\u5668\u914d\u7f6e\u548c\u5b8c\u6210\u65f6\u95f4\u3002\u4e91\u751f\u4fe1\u53ef\u5148\u505a\u8d44\u6e90\u6d4b\u7b97\u4e0e\u5c0f\u6837\u672c\u57fa\u7ebf\uff0c\u518d\u786e\u8ba4\u79df\u7528\u73af\u5883\u81ea\u884c\u8fd0\u884c\u3001\u670d\u52a1\u5668\u90e8\u7f72\u4ea4\u63a5\u6216\u59d4\u6258\u5206\u6790\u7684\u8fb9\u754c\u3002<\/p>\n<p><a href=\"https:\/\/work.weixin.qq.com\/kfid\/kfcb05492f29d4d6064\" data-ysx-event=\"contact_click\" style=\"display:inline-block;padding:13px 20px;border-radius:10px;background:#e36e2e;color:#fff;text-decoration:none;font-weight:800;\">\u8054\u7cfb\u4e91\u751f\u4fe1\uff0c\u54a8\u8be2 Foldseek \u7ed3\u6784\u68c0\u7d22\u670d\u52a1\u5668\u4e0e\u5206\u6790\u65b9\u6848<\/a><\/p>\n<h2 style=\"margin-top:34px;color:#12314a;\">\u53c2\u8003\u8d44\u6599<\/h2>\n<ul>\n<li><a href=\"https:\/\/github.com\/steineggerlab\/foldseek\">Foldseek \u5b98\u65b9 GitHub \u4e0e\u5185\u5b58\u3001GPU\u8bf4\u660e<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41587-023-01773-0\">Foldseek \u539f\u59cb\u8bba\u6587\uff1aFast and accurate protein structure search<\/a><\/li>\n<li><a href=\"https:\/\/alphafold.ebi.ac.uk\/faq\">AlphaFold DB \u5b98\u65b9 FAQ<\/a><\/li>\n<li><a href=\"https:\/\/www.ebi.ac.uk\/pdbe\/news\/alphafold-database-release-notes\">AlphaFold DB v6 \u53d1\u5e03\u8bf4\u660e<\/a><\/li>\n<\/ul>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Foldseek \u53ef\u5c06\u7ed3\u6784\u641c\u7d22\u52a0\u901f4\u81f35\u4e2a\u6570\u91cf\u7ea7\uff0c\u4f46AFDB50\u9ed8\u8ba4\u4ecd\u9700151GB\u5185\u5b58\u3002\u672c\u6587\u62c6\u89e335GB\u964d\u914d\u4ee3\u4ef7\u3001CPU\/GPU\u8def\u5f84\u3001\u7d22\u5f15\u4e0e\u6279\u91cf\u5e76\u53d1\u89c4\u5212\u3002<\/p>\n","protected":false},"author":1,"featured_media":66293,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1,75],"tags":[424,423,340,275,409,426,425,341],"class_list":["post-66294","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-part","category-compute-environment","tag-alphafold-db","tag-foldseek","tag-gpu","tag-275","tag-ai","tag-426","tag-425","tag-341"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/10\/daily-bio-blog-20261026-foldseek-search-foldseek-poster.png?fit=1080%2C1350&ssl=1","_links":{"self":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/comments?post=66294"}],"version-history":[{"count":1,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66294\/revisions"}],"predecessor-version":[{"id":66295,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66294\/revisions\/66295"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media\/66293"}],"wp:attachment":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media?parent=66294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/categories?post=66294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/tags?post=66294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}