{"id":66357,"date":"2026-11-11T09:29:18","date_gmt":"2026-11-11T01:29:18","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=66357"},"modified":"2026-11-11T09:29:18","modified_gmt":"2026-11-11T01:29:18","slug":"single-cell-algorithm-boundaries-01-one-vs-one","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/single-cell-algorithm-boundaries-01-one-vs-one\/","title":{"rendered":"\u5ba2\u6237\u53ea\u67091v1\u5355\u7ec6\u80de\u6570\u636e\uff0c\u54ea\u4e9b\u5206\u6790\u80fd\u63a8\u8350\uff1f\uff08\u7b97\u6cd5\u8fb9\u754c1\/3\uff09"},"content":{"rendered":"<style>#articleContent{max-width:900px;margin:auto;color:#26364a;font-size:17px;line-height:1.85;overflow-wrap:anywhere}#articleContent p{margin:17px 0}#articleContent h2{font-size:25px;line-height:1.5;color:#0868dc;border-left:5px solid #ff9b32;padding-left:14px;margin:38px 0 18px}#articleContent h3{font-size:19px;color:#174c83;margin:25px 0 8px}#articleContent 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class=\"ref\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34584091\/\">[1]<\/a><a class=\"ref\" href=\"https:\/\/www.nature.com\/articles\/s41467-021-21038-1\">[2]<\/a><\/p>\n<p>\u4f46\u201c\u4e24\u4e2aSeurat\u5bf9\u8c61\u201d\u201c\u4e24\u4e2a\u6587\u5e93\u201d\u4e0d\u4e00\u5b9a\u7b49\u4e8e\u4e24\u4e2a\u4e2a\u4f53\u3002\u4e00\u4e2a\u5bf9\u8c61\u53ef\u80fd\u88c5\u6709\u591a\u4e2a\u53ef\u8ffd\u6eaf\u4f9b\u4f53\uff1b\u540c\u4e00\u4eba\u7684\u591a\u4efd\u6587\u5e93\u3001\u4e0d\u540c\u533a\u57df\u6216\u5927\u91cf\u7ec6\u80de\uff0c\u4e5f\u4e0d\u81ea\u52a8\u53d8\u6210\u591a\u4e2a\u72ec\u7acb\u4e2a\u4f53\u3002\u5148\u6838\u5bf9\u4f9b\u4f53ID\u3001\u5206\u7ec4\u3001\u53d6\u6837\u3001\u914d\u5bf9\u5173\u7cfb\u548c\u6279\u6b21\uff0c\u518d\u5224\u65ad\u8bbe\u8ba1\u3002<\/p>\n<p>\u5982\u679c\u662f\u540c\u4e00\u4eba\u7684\u5904\u7406\u524d\u540e\u5404\u4e00\u4efd\uff0c\u53ea\u80fd\u63cf\u8ff0\u8fd9\u4e00\u4f4d\u53d7\u8bd5\u5bf9\u8c61\u7684\u53d8\u5316\u3002\u914d\u5bf9\u6709\u52a9\u4e8e\u660e\u786e\u6bd4\u8f83\u5173\u7cfb\uff0c\u4f46\u4e00\u5bf9\u6837\u672c\u4ecd\u4e0d\u80fd\u4f30\u8ba1\u4e0d\u540c\u4e2a\u4f53\u4e4b\u95f4\u7684\u53d8\u5f02\u3002\u6df7\u6837\u540e\u82e5\u65e0\u6cd5\u533a\u5206\u4f9b\u4f53\uff0c\u4e5f\u4e0d\u80fd\u53ea\u6309\u6df7\u5165\u4eba\u6570\u8ba1\u7b97\u53ef\u7528\u4e8e\u7edf\u8ba1\u7684\u72ec\u7acb\u89c2\u6d4b\u3002<\/p>\n<h2>\u4e8c\u3001\u80fd\u505a\u4ec0\u4e48\uff0c\u8981\u6309\u7ed3\u8bba\u5c42\u7ea7\u8bf4\u660e<\/h2>\n<table 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data-label=\"\u5efa\u8bae\u63aa\u65bd\">\u533a\u5206\u6c47\u603b\u8868\u8fbe\u3001\u7f51\u7edc\u4f30\u8ba1\u4e0e\u7ec4\u95f4\u63a8\u65ad\u3002\u7f3a\u5c11\u91cd\u590d\u65f6\u964d\u4f4e\u7ed3\u8bba\u5c42\u7ea7\u3002<\/td>\n<\/tr>\n<tr>\n<td data-label=\"\u5e38\u89c1\u8bf4\u6cd5\u6216\u95ee\u9898\">\u201c\u6279\u6b21\u6821\u6b63\u5b8c\uff0c\u5c31\u80fd\u786e\u5b9a\u662f\u75be\u75c5\u6548\u5e94\u3002\u201d<\/td>\n<td data-label=\"\u4e3a\u4ec0\u4e48\u4e0d\u591f\">\u5f53\u7ec4\u522b\u548c\u6279\u6b21\u3001\u4f9b\u4f53\u5b8c\u5168\u6df7\u6742\u65f6\uff0c\u8f6f\u4ef6\u65e0\u6cd5\u51ed\u7a7a\u8fa8\u8ba4\u5404\u81ea\u8d21\u732e\u3002<\/td>\n<td data-label=\"\u5efa\u8bae\u63aa\u65bd\">\u56de\u770b\u8bbe\u8ba1\u4e0e\u8d28\u63a7\uff1b\u5fc5\u8981\u65f6\u8865\u6837\u672c\u6216\u505a\u72ec\u7acb\u9a8c\u8bc1\uff0c\u4e0d\u627f\u8bfa\u7b97\u6cd5\u6d88\u9664\u5168\u90e8\u6df7\u6742\u3002<\/td>\n<\/tr>\n<tr>\n<td data-label=\"\u5e38\u89c1\u8bf4\u6cd5\u6216\u95ee\u9898\">\u201c\u52a0\u5165\u516c\u5171\u6570\u636e\uff0c\u5c31\u7b97\u628a\u5ba2\u6237\u6837\u672c\u8865\u9f50\u4e86\u3002\u201d<\/td>\n<td data-label=\"\u4e3a\u4ec0\u4e48\u4e0d\u591f\">\u6765\u6e90\u3001\u7ec4\u7ec7\u3001\u5904\u7406\u548c\u5e73\u53f0\u5dee\u5f02\u53ef\u80fd\u5f15\u5165\u65b0\u6df7\u6742\u3002<\/td>\n<td data-label=\"\u5efa\u8bae\u63aa\u65bd\">\u5148\u8bc4\u4f30\u53ef\u6bd4\u6027\uff1b\u9002\u5408\u65f6\u4f5c\u4e3a\u5916\u90e8\u9a8c\u8bc1\u6216\u660e\u786e\u7684\u8054\u5408\u5206\u6790\uff0c\u4e0d\u80fd\u81ea\u52a8\u7b97\u4f5c\u540c\u4e00\u8bbe\u8ba1\u7684\u91cd\u590d\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>\u56db\u3001\u524d\u7aef\u5148\u95ee\u8fd96\u9879\uff0c\u518d\u51b3\u5b9a\u63a8\u8350\u8303\u56f4<\/h2>\n<p>1. \u6bcf\u7ec4\u7a76\u7adf\u6709\u591a\u5c11\u72ec\u7acb\u4e2a\u4f53\uff1f\u4f9b\u4f53ID\u80fd\u5426\u8ffd\u6eaf\uff1f<br \/>2. 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\u80fd\u5426\u8865\u72ec\u7acb\u6837\u672c\u3001\u67e5\u627e\u53ef\u6bd4\u516c\u5f00\u6570\u636e\uff0c\u6216\u505a\u540e\u7eed\u5b9e\u9a8c\u9a8c\u8bc1\uff1f<\/p>\n<p><strong>\u4e0d\u8981\u53ea\u95ee\u201c\u603b\u5171\u591a\u5c11\u7ec6\u80de\u201d\u3002<\/strong>\u5047\u8bbe\u4e24\u4efd\u6570\u636e\u4e00\u51712\u4e07\u7ec6\u80de\uff0c\u4f46\u76ee\u6807\u4e9a\u7fa4\u5728\u5176\u4e2d\u4e00\u4efd\u4ec5\u6709\u51e0\u5341\u4e2a\uff0c\u7f51\u7edc\u5206\u6790\u4ecd\u53ef\u80fd\u4e0d\u7a33\u5b9a\uff1b\u8fd9\u91cc\u7684\u6570\u5b57\u662f\u60c5\u666f\u793a\u4f8b\uff0c\u4e0d\u662f\u67d0\u4e2a\u7b97\u6cd5\u7684\u7edf\u4e00\u95e8\u69db\u3002<\/p>\n<h2>\u4e94\u3001\u600e\u6837\u5411\u5ba2\u6237\u8bf4\uff0c\u65e2\u8bb2\u6e05\u4ef7\u503c\uff0c\u53c8\u4e0d\u5938\u5927\uff1f<\/h2>\n<blockquote><p>\u201c\u8fd9\u4e24\u4efd\u6570\u636e\u53ef\u4ee5\u5148\u505a\u8d28\u91cf\u8bc4\u4f30\u3001\u7ec6\u80de\u56fe\u8c31\u548c\u5019\u9009\u63a2\u7d22\u3002\u8fdb\u4e00\u6b65\u5206\u6790\u8981\u770b\u76ee\u6807\u7ec6\u80de\u548c\u57fa\u56e0\u4fe1\u53f7\u662f\u5426\u652f\u6301\u3002\u56e0\u4e3a\u76ee\u524d\u6bcf\u7ec4\u53ea\u6709\u4e00\u4e2a\u72ec\u7acb\u6837\u672c\uff0c\u7ed3\u679c\u66f4\u9002\u5408\u7528\u4e8e\u9009\u62e9\u540e\u7eed\u9a8c\u8bc1\u65b9\u5411\uff0c\u4e0d\u80fd\u4ec5\u51ed\u7ec6\u80de\u6570\u91cf\u5c31\u63a8\u5e7f\u6210\u7a33\u5b9a\u7684\u7ec4\u95f4\u7ed3\u8bba\u3002\u6211\u4eec\u53ef\u4ee5\u5148\u628a\u6700\u503c\u5f97\u505a\u7684\u95ee\u9898\u7f29\u5c0f\uff0c\u518d\u8ba8\u8bba\u9700\u8981\u8865\u54ea\u4e9b\u8bc1\u636e\u3002\u201d<\/p><\/blockquote>\n<p>\u9047\u5230\u201c\u4e09\u865a\u62df\u201d\u8fd9\u7c7b\u670d\u52a1\u7b80\u79f0\uff0c\u524d\u7aef\u8fd8\u5e94\u8ffd\u95ee\u5bf9\u5e94\u7684\u5177\u4f53\u7b97\u6cd5\u3001\u6570\u636e\u5e93\u3001\u8f93\u5165\u4e0e\u8f93\u51fa\u3002\u4e0d\u540c\u865a\u62df\u65b9\u6cd5\u5e76\u975e\u4e92\u76f8\u66ff\u4ee3\uff0c\u4e5f\u4e0d\u80fd\u56e0\u4e3a\u540d\u5b57\u76f8\u8fd1\u5c31\u6253\u5305\u63a8\u8350\u3002\u4e0b\u4e00\u7bc7\u4f1a\u5206\u522b\u8bf4\u660e\u865a\u62df\u6572\u9664\u3001\u8f6c\u5f55\u56e0\u5b50\u6270\u52a8\u548c\u836f\u7269\u5019\u9009\u7b5b\u9009\u7684\u6761\u4ef6\u3002<\/p>\n<h2>\u8d44\u6599\u4f9d\u636e<\/h2>\n<p>\u5b98\u65b9\u53c2\u6570\u4e0e\u63a5\u53e3\u53ef\u80fd\u66f4\u65b0\uff1b\u5b9e\u9645\u627f\u63a5\u65f6\u9700\u6838\u5bf9\u91c7\u7528\u7248\u672c\u3002\u6587\u4e2d\u7684\u9879\u76ee\u5206\u7ea7\u548c\u5904\u7406\u987a\u5e8f\u4e3a\u6c9f\u901a\u5efa\u8bae\u3002<\/p>\n<ol>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34584091\/\">\u5355\u7ec6\u80de\u5dee\u5f02\u5206\u6790\u4e0e\u751f\u7269\u5b66\u91cd\u590d\uff1aSquair \u7b49\u539f\u59cb\u7814\u7a76<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-021-21038-1\">\u5355\u7ec6\u80de\u4f2a\u91cd\u590d\u95ee\u9898\uff1aZimmerman \u7b49\u539f\u59cb\u7814\u7a76<\/a><\/li>\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9058914\/\">scTenifoldKnk \u539f\u59cb\u8bba\u6587\uff1a\u8bbe\u8ba1\u3001\u7269\u79cd\u4e0e\u5c40\u9650<\/a><\/li>\n<li><a href=\"https:\/\/github.com\/sulab-wmu\/scPagwas\">scPagwas \u5b98\u65b9\u4ed3\u5e93\uff1aGWAS \u4e0e\u5355\u7ec6\u80de\u6574\u5408\u3001\u7248\u672c\u8bf4\u660e<\/a><\/li>\n<li><a href=\"https:\/\/smorabit.github.io\/hdWGCNA\/articles\/basic_tutorial.html\">hdWGCNA \u5b98\u65b9\u5355\u7ec6\u80de\u6559\u7a0b\uff1a\u6309\u6837\u672c\u548c\u7ec6\u80de\u7c7b\u578b\u6784\u5efa metacell<\/a><\/li>\n<\/ol>\n<p>\u5982\u9700\u5224\u65ad\u73b0\u6709\u6570\u636e\u9002\u5408\u54ea\u4e9b\u5206\u6790\uff0c\u53ef\u5148\u5411\u4e91\u751f\u4fe1\u63d0\u4f9b\u7814\u7a76\u95ee\u9898\u3001\u7269\u79cd\u3001\u6837\u672c\u5206\u7ec4\u4e0e\u76ee\u6807\u7ec6\u80de\u7684\u6570\u636e\u6982\u51b5\u3002<\/p>\n<p><a class=\"cta\" data-ysx-event=\"contact_click\" href=\"https:\/\/work.weixin.qq.com\/kfid\/kfcb05492f29d4d6064\">\u8054\u7cfb\u4e91\u751f\u4fe1\uff0c\u8bc4\u4f30\u5206\u6790\u524d\u63d0\u4e0e\u8303\u56f4<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7ed9\u552e\u524d\u6280\u672f\u8001\u5e08\u76841v1\u5355\u7ec6\u80de\u9879\u76ee\u5224\u65ad\u6307\u5357\uff1a\u5148\u6570\u72ec\u7acb\u751f\u7269\u5b66\u6837\u672c\uff0c\u518d\u533a\u5206\u63a2\u7d22\u5206\u6790\u3001\u6761\u4ef6\u6027\u8fdb\u9636\u5206\u6790\u4e0e\u7ec4\u95f4\u63a8\u65ad\u3002\u9644\u5e38\u89c1\u8bef\u533a\u3001\u89e3\u51b3\u63aa\u65bd\u548c\u5ba2\u6237\u6c9f\u901a\u8bdd\u672f\u3002<\/p>\n","protected":false},"author":1,"featured_media":66356,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1,71],"tags":[90,477,174,478],"class_list":["post-66357","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-part","category-single-cell","tag-90","tag-477","tag-174","tag-478"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/11\/algorithm-presales-series-20261105-part-01-algorithm-poster.png?fit=1200%2C680&ssl=1","_links":{"self":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/comments?post=66357"}],"version-history":[{"count":1,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66357\/revisions"}],"predecessor-version":[{"id":66390,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66357\/revisions\/66390"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media\/66356"}],"wp:attachment":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media?parent=66357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/categories?post=66357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/tags?post=66357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}