{"id":66408,"date":"2026-11-12T22:53:06","date_gmt":"2026-11-12T14:53:06","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=66408"},"modified":"2026-11-12T22:53:06","modified_gmt":"2026-11-12T14:53:06","slug":"shao-zhimin-breast-cancer-multiomics-research-2026","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/shao-zhimin-breast-cancer-multiomics-research-2026\/","title":{"rendered":"\u90b5\u5fd7\u654f\u56e2\u961f\u8fd1\u671f\u5728\u7814\u7a76\u4ec0\u4e48\uff1f\u4ece\u4e73\u817a\u764c\u5206\u578b\u8bfb\u5230AI\u75c5\u7406\u4e0e\u7a7a\u95f4\u514d\u75ab"},"content":{"rendered":"
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\u56fe\uff1a\u4f9d\u636e\u6587\u732e2\u30014\u20146\u6574\u7406\u7684\u9605\u8bfb\u793a\u610f\u56fe\uff0c\u975e\u5b9e\u9a8c\u7ed3\u679c\u6216\u8bca\u7597\u6d41\u7a0b\uff1bLINUX\u6807\u6ce8\u4e3a2026\u5e74\u89c1\u520a\u5e74\u4efd\uff0c\u5728\u7ebf\u53d1\u8868\u65f6\u95f4\u4e3a2025\u5e7412\u6708\u3002<\/figcaption><\/figure>\n

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2019\u5e74\u7684\u300aCancer Cell\u300b\u8bba\u6587\u5206\u6790\u4e86465\u4f8b\u539f\u53d1\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u4e34\u5e8a\u3001\u57fa\u56e0\u7ec4\u548c\u8f6c\u5f55\u7ec4\u8d44\u6599\uff0c\u63d0\u51fa\u56db\u4e2a\u57fa\u4e8e\u8f6c\u5f55\u7ec4\u7684\u4e9a\u578b\uff1a\u8154\u9762\u96c4\u6fc0\u7d20\u53d7\u4f53\u578b\u3001\u514d\u75ab\u8c03\u8282\u578b\u3001\u57fa\u5e95\u6837\u514d\u75ab\u6291\u5236\u578b\u548c\u95f4\u8d28\u6837\u578b\u3002\u8fd9\u662f\u7406\u89e3\u56e2\u961f\u4e09\u9634\u6027\u4e73\u817a\u764c\u7814\u7a76\u7684\u4e00\u7bc7\u57fa\u7840\u6587\u732e\u30021<\/a><\/p>\n

2023\u5e74\u7684\u300aNature Genetics\u300b\u8bba\u6587\u5219\u9762\u5411\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001HER2\u9634\u6027\uff08HR+\/HER2\u2212\uff09\u4e73\u817a\u764c<\/strong>\uff0c\u5efa\u7acb579\u4f8b\u60a3\u8005\u7684\u591a\u7ec4\u5b66\u961f\u5217\uff0c\u63d0\u51fa\u7ecf\u5178\u8154\u9762\u578b\u3001\u514d\u75ab\u578b\u3001\u589e\u6b96\u578b\u548c\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff08RTK\uff09\u9a71\u52a8\u578b\u56db\u4e2a\u4e9a\u578b\uff1b\u540e\u7eed\u7814\u7a76\u5206\u522b\u5c06\u5176\u6807\u4e3aSNF1\u81f3SNF4\u3002\u56e0\u6b64\uff0c\u9605\u8bfb\u65f6\u5e94\u5148\u770b\u75be\u75c5\u4eba\u7fa4\uff0c\u518d\u770b\u5206\u578b\u540d\u79f0\uff0c\u907f\u514d\u628a\u4e24\u5957\u201c\u56db\u5206\u578b\u201d\u6df7\u7528\u30022<\/a> 5<\/a><\/p>\n

\u56e2\u961f\u53c2\u4e0e\u76842024\u5e74\u300aNature Cancer\u300b\u7814\u7a76\u8fdb\u4e00\u6b65\u6574\u5408\u4e86773\u4f8b\u4e2d\u56fd\u4e73\u817a\u764c\u60a3\u8005\u7684\u57fa\u56e0\u7ec4\u3001\u8f6c\u5f55\u7ec4\u3001\u86cb\u767d\u7ec4\u3001\u4ee3\u8c22\u7ec4\u3001\u5f71\u50cf\u7ec4\u53ca\u6570\u5b57\u75c5\u7406\u7279\u5f81\u3002\u5b83\u63d0\u4f9b\u4e86\u4e00\u4e2a\u89c2\u5bdf\u591a\u5c42\u6570\u636e\u5982\u4f55\u5171\u540c\u652f\u6301\u60a3\u8005\u5206\u5c42\u7684\u4f8b\u5b50\uff1b\u961f\u5217\u603b\u4eba\u6570\u5e76\u4e0d\u8868\u793a\u6bcf\u4e00\u79cd\u68c0\u6d4b\u90fd\u6709773\u4efd\u6837\u672c\u30023<\/a><\/p>\n

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\u4ee3\u8868\u8bba\u6587\uff1aLINUX\u8bd5\u9a8c\uff0c\u300aCancer Cell\u300b\uff0c2025\u5e7412\u67084\u65e5\u5728\u7ebf\u53d1\u8868\uff0c2026\u5e742\u6708\u89c1\u520a\u3002<\/strong>4<\/a><\/p>\n

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\u4ee3\u8868\u8bba\u6587\uff1aMultimodal assessment of exceptional responders\u2026\uff0c\u300aJournal of Clinical Investigation\u300b\uff0c2026\u5e7410\u670815\u65e5\u53d1\u8868\u3002<\/strong>5<\/a><\/p>\n

\u8fd9\u9879\u5de5\u4f5c\u6765\u81eaFASCINATE-N\u8bd5\u9a8c\u7684HR+\/HER2\u2212\u4e73\u817a\u764c\u8f6c\u5316\u7814\u7a76\uff0c\u6574\u5408\u8f6c\u5f55\u7ec4\u3001\u57fa\u56e0\u7ec4\u3001\u6570\u5b57\u75c5\u7406\u548c\u4e34\u5e8a\u8d44\u6599\uff0c\u5173\u6ce8\u7597\u6548\u7279\u522b\u597d\u6216\u7279\u522b\u5dee\u7684\u60a3\u8005\u3002\u7eb3\u5165\u7684230\u4f4d\u60a3\u8005\u81f3\u5c11\u5177\u6709\u4e00\u4e2a\u7ec4\u5b66\u7ef4\u5ea6\u7684\u6570\u636e\uff0c\u5e76\u975e\u4eba\u4eba\u90fd\u6709\u5168\u5957\u591a\u7ec4\u5b66\u68c0\u6d4b\u30025<\/a><\/p>\n

\u8bba\u6587\u5728SNF1\u4e2d\u89c2\u5bdf\u5230\u795e\u7ecf\u5468\u56f4\u4fb5\u72af\u4e0e\u5185\u5206\u6ccc\u6cbb\u7597\u6548\u679c\u7684\u8054\u7cfb\uff1b\u5728SNF4\u4e2d\uff0c\u6570\u5b57\u75c5\u7406\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5206\u6790\u63d0\u793a\uff0c\u80bf\u7624\u2014\u95f4\u8d28\u2014\u514d\u75ab\u754c\u9762\u7684\u7a7a\u95f4\u7ed3\u6784\u4e0e\u963f\u5e15\u66ff\u5c3c\u7597\u6548\u6709\u5173\u3002\u7531\u6b64\u53ef\u4ee5\u8fdb\u4e00\u6b65\u8ffd\u95ee\uff1a\u5206\u578b\u4e4b\u5916\uff0c\u7ec4\u7ec7\u7ed3\u6784\u662f\u5426\u8fd8\u80fd\u63d0\u4f9b\u89e3\u91ca\u7597\u6548\u7684\u4fe1\u606f\uff1f<\/strong>5<\/a><\/p>\n

\u4f5c\u8005\u5728\u8ba8\u8bba\u4e2d\u6307\u51fa\u4e86\u5355\u4e2d\u5fc3\u3001\u6837\u672c\u91cf\u548c\u6781\u7aef\u53cd\u5e94\u8005\u5206\u6790\u7684\u9650\u5236\uff0c\u5e76\u5f3a\u8c03\u957f\u671f\u968f\u8bbf\u7684\u5fc5\u8981\u6027\u3002\u9002\u5408\u4ece\u8fd9\u7bc7\u8bba\u6587\u5b66\u4e60\u5982\u4f55\u63d0\u51fa\u3001\u9a8c\u8bc1\u65b0\u7684\u7814\u7a76\u5047\u8bbe\uff1b\u5176\u4e2d\u7684\u63a2\u7d22\u6027\u53d1\u73b0\u4ecd\u9700\u6269\u5927\u9a8c\u8bc1\u30025<\/a><\/p>\n

\u8fd1\u671f\u7ebf\u7d22\u4e09\uff1a\u514d\u75ab\u7ec6\u80de\u201c\u5728\u4ec0\u4e48\u4f4d\u7f6e\u201d\uff0c\u4e5f\u503c\u5f97\u7814\u7a76<\/h2>\n

\u4ee3\u8868\u8bba\u6587\uff1aDecoding neutrophil spatial heterogeneity\u2026\uff0c\u300aCancer Cell\u300b\uff0c2026\u5e7411\u67089\u65e5\u53d1\u8868\u3002<\/strong>6<\/a><\/p>\n

\u8fd9\u662f\u672c\u6b21\u68c0\u7d22\u91cd\u70b9\u5173\u6ce8\u7684\u4e00\u7bc7\u65b0\u8bba\u6587\u3002\u7814\u7a76\u6574\u5408AI\u8ba1\u7b97\u75c5\u7406\uff08n=1,113\uff09\u548c\u5355\u7ec6\u80de\u7a7a\u95f4\u7ec4\u5b66\uff08n=104\uff09\uff0c\u5206\u6790\u4e73\u817a\u764c\u4e2d\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u7a7a\u95f4\u5206\u5e03\u53ca\u5176\u4e34\u5e8a\u610f\u4e49\uff1b\u8fd9\u4e24\u7ec4\u89c4\u6a21\u5bf9\u5e94\u4e0d\u540c\u7684\u6570\u636e\u5c42\u7ea7\uff0c\u4e0d\u80fd\u76f4\u63a5\u76f8\u52a0\u5f53\u4f5c\u72ec\u7acb\u60a3\u8005\u603b\u6570\u30026<\/a><\/p>\n

\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c\u4e2d\uff0c\u7814\u7a76\u53d1\u73b0\uff1a\u4e2d\u6027\u7c92\u7ec6\u80de\u9760\u8fd1\u80bf\u7624\u7ec6\u80de\uff0c\u4e0e\u8f83\u597d\u7684\u9884\u540e\u76f8\u5173\uff1b\u9760\u8fd1\u514d\u75ab\u7ec6\u80de\uff0c\u5219\u4e0e\u66f4\u597d\u7684\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u76f8\u5173\u3002<\/strong>\u8bba\u6587\u8fd8\u7ed3\u5408\u7a7a\u95f4\u7ec4\u5b66\u4e0e\u5b9e\u9a8c\u9a8c\u8bc1\u63a2\u7d22\u5176\u751f\u7269\u5b66\u89e3\u91ca\u30026<\/a><\/p>\n

\u8fd9\u7bc7\u8bba\u6587\u63d0\u4f9b\u7684\u9605\u8bfb\u542f\u53d1\u662f\uff1a\u7814\u7a76\u514d\u75ab\u5fae\u73af\u5883\u65f6\uff0c\u53ef\u4ee5\u540c\u65f6\u95ee\u201c\u6709\u54ea\u4e9b\u7ec6\u80de\u201d\u548c\u201c\u5b83\u4eec\u4e0e\u8c01\u76f8\u90bb\u201d\u3002\u4e34\u5e8a\u961f\u5217\u4e2d\u7684\u76f8\u5173\u6027\u3001\u5b9e\u9a8c\u4e2d\u7684\u673a\u5236\u8bc1\u636e\u4ee5\u53ca\u5b9e\u9645\u6cbb\u7597\u5e94\u7528\uff0c\u5e94\u5206\u522b\u5224\u65ad\uff0c\u4e0d\u80fd\u76f4\u63a5\u4e92\u76f8\u66ff\u4ee3\u3002<\/p>\n

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\n\n\n\n\n\n\n\n\n
\u5f53\u524d\u60f3\u5f04\u6e05\u7684\u95ee\u9898<\/th>\n\u5efa\u8bae\u5148\u8bfb<\/th>\n\u8bfb\u5b8c\u5c1d\u8bd5\u56de\u7b54<\/th>\n<\/tr>\n<\/thead>\n
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    \n
  1. Jiang YZ, Ma D, Suo C, et al. Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.<\/strong> Cancer Cell<\/em>. 2019;35(3):428\u2013440.e5. DOI\uff1a10.1016\/j.ccell.2019.02.001<\/a>\u3002PubMed\uff1a30853353<\/a>\u3002<\/li>\n
  2. Jin X, Zhou YF, Ma D, et al. Molecular classification of hormone receptor-positive HER2-negative breast cancer.<\/strong> Nature Genetics<\/em>. 2023;55:1696\u20131708. DOI\uff1a10.1038\/s41588-023-01507-7<\/a>\u3002PubMed\uff1a37770634<\/a>\u3002<\/li>\n
  3. Jiang YZ, Ma D, Jin X, et al. Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities.<\/strong> Nature Cancer<\/em>. 2024;5:673\u2013690. DOI\uff1a10.1038\/s43018-024-00725-0<\/a>\u3002PubMed\uff1a38347143<\/a>\u3002<\/li>\n
  4. Fan L, Zhang WJ, Li HP, et al. Precision treatment with artificial intelligence assisted subtyping enhances therapeutic efficacy in HR+\/HER2\u2212 breast cancer: The LINUXtrial.<\/strong> Cancer Cell<\/em>. 2026;44(2):355\u2013365.e3. 2025\u5e7412\u67084\u65e5\u5728\u7ebf\u53d1\u8868\u3002DOI\uff1a10.1016\/j.ccell.2025.11.003<\/a>\u3002PubMed\uff1a41349543<\/a>\u3002<\/li>\n
  5. Xiao Y, Yang F, Qi YJ, et al. Multimodal assessment of exceptional responders refines subtyping-directed precision treatment in HR+\/HER2\u2212 breast cancer.<\/strong> Journal of Clinical Investigation<\/em>. 2026;136(20):e202305. DOI\uff1a10.1172\/JCI202305<\/a>\u3002PubMed\uff1a42878074<\/a>\uff1b\u5f00\u653e\u5168\u6587<\/a>\u3002<\/li>\n
  6. Xu YZ, Wu XR, Qiu ZY, et al. Decoding neutrophil spatial heterogeneity and clinical implications in breast cancer.<\/strong> Cancer Cell<\/em>. 2026;44(11):2249\u20132266.e9. DOI\uff1a10.1016\/j.ccell.2026.10.005<\/a>\u3002PubMed\uff1a43003078<\/a>\uff1b\u671f\u520a\u9875\u9762<\/a>\u3002<\/li>\n<\/ol>\n

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