{"id":66426,"date":"2026-11-14T15:10:35","date_gmt":"2026-11-14T07:10:35","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=66426"},"modified":"2026-11-14T15:10:35","modified_gmt":"2026-11-14T07:10:35","slug":"jiang-yizhou-breast-cancer-immunotherapy-resistance-2026","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/jiang-yizhou-breast-cancer-immunotherapy-resistance-2026\/","title":{"rendered":"\u6c5f\u4e00\u821f\u56e2\u961f\u8fd1\u671f\u5728\u7814\u7a76\u4ec0\u4e48\uff1f\u4ece\u57fa\u56e0\u7ec4\u3001\u4ee3\u8c22\u8bfb\u5230\u4e73\u817a\u764c\u514d\u75ab\u8010\u836f"},"content":{"rendered":"<div id=\"articleContent\" style=\"max-width:860px;margin:0 auto;color:#243b50;font-size:17px;line-height:1.95;overflow-wrap:break-word;\">\n<p class=\"ysx-kicker\" style=\"color:#587188;font-size:14px;line-height:1.8;border-left:4px solid #2563eb;padding:12px 16px;background:#f1f6ff;\">\u5b66\u8005\u7814\u7a76\u65b9\u5411\u89c2\u5bdf \u00b7 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18px;\">\u4ece\u6c5f\u4e00\u821f\u53ca\u5408\u4f5c\u8005\u4eca\u5e74\u53d1\u8868\u7684\u7814\u7a76\u4e2d\uff0c\u672c\u6587\u9009\u53d6\u4e09\u6761\u7ebf\u7d22\uff1a\u8f6c\u79fb\u7076\u7684\u57fa\u56e0\u7ec4\u53d8\u5316\u3001\u80bf\u7624\u4e0e\u9ad3\u7cfb\u7ec6\u80de\u7684\u4ee3\u8c22\u4e92\u4f5c\uff0c\u4ee5\u53ca\u611f\u89c9\u795e\u7ecf\u5bf9\u80bf\u7624\u57fa\u8d28\u7684\u5f71\u54cd\u3002\u8fd9\u662f\u5bf9\u516c\u5f00\u6587\u732e\u7684\u5f52\u7eb3\uff1b\u76f8\u5173\u5de5\u4f5c\u7531\u591a\u4f4d\u7814\u7a76\u8005\u5171\u540c\u5b8c\u6210\uff0c\u5177\u4f53\u8d21\u732e\u4ee5\u539f\u8bba\u6587\u4e3a\u51c6\u3002<a href=\"https:\/\/www.jci.org\/articles\/view\/188989\">1<\/a> <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC13006444\/\">2<\/a> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41650969\/\">3<\/a><\/p>\n<figure style=\"margin:28px 0;\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/11\/researcher-series-20261114-jiang-research-map.png?resize=1440%2C960&#038;ssl=1\" alt=\"\u6c5f\u4e00\u821f\u53ca\u5408\u4f5c\u8005\u7684\u4e73\u817a\u764c\u514d\u75ab\u8010\u836f\u7814\u7a76\u7ebf\u7d22\uff1a\u57fa\u56e0\u7ec4\u3001\u7ec6\u80de\u4ee3\u8c22\u4e0e\u795e\u7ecf\u5fae\u73af\u5883\uff0c\u4f9d\u636e\u6587\u732e1\u81f33\u7ed8\u5236\u7684\u9605\u8bfb\u793a\u610f\u56fe\" width=\"1440\" height=\"960\" style=\"display:block;width:100%;height:auto;border-radius:8px;\"><figcaption style=\"margin-top:9px;font-size:13px;line-height:1.7;color:#61758a;\">\u56fe\uff1a\u4f9d\u636e\u6587\u732e1\u20143\u6574\u7406\u7684\u9605\u8bfb\u793a\u610f\u56fe\uff1b\u4e0d\u540c\u7814\u7a76\u7684\u60a3\u8005\u5173\u8054\u3001\u529f\u80fd\u9a8c\u8bc1\u548c\u4e34\u5e8a\u8bc1\u636e\u9700\u5206\u522b\u5224\u65ad\uff0c\u975e\u5b9e\u9a8c\u7ed3\u679c\u6216\u8bca\u7597\u6d41\u7a0b\u3002<\/figcaption><\/figure>\n<h2 style=\"margin:36px 0 18px;color:#17334e;font-size:25px;line-height:1.5;\">\u7ebf\u7d22\u4e00\uff1a\u4ece\u8f6c\u79fb\u7076\u7684\u57fa\u56e0\u7ec4\u91cc\u5bfb\u627e\u8010\u836f\u7ebf\u7d22<\/h2>\n<p style=\"margin:0 0 18px;\"><strong>\u4ee3\u8868\u8bba\u6587\uff1a\u300aJournal of Clinical Investigation\u300b\uff0c2026\u5e743\u67082\u65e5\u53d1\u8868\u3002<\/strong><a href=\"https:\/\/www.jci.org\/articles\/view\/188989\">1<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u8fd9\u9879\u7814\u7a76\u5bf9296\u4f4d\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u8f6c\u79fb\u7076\u6837\u672c\uff0c\u4f7f\u7528484\u57fa\u56e0\u68c0\u6d4b\u9762\u677f\u5f00\u5c55\u5206\u6790\uff0c\u5e76\u901a\u8fc7\u539f\u53d1\u7076\u4e0e\u8f6c\u79fb\u7076\u914d\u5bf9\u6837\u672c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002\u7814\u7a76\u53d1\u73b0\uff0cPKD1\u53d8\u5f02\u5728\u8f6c\u79fb\u7076\u4e2d\u5bcc\u96c6\uff0c\u5e76\u4e0e\u6297PD-1\u6cbb\u7597\u8010\u836f\u76f8\u5173\u3002\u8fd9\u91cc\u7684PKD1\u7f16\u7801\u591a\u56ca\u86cb\u767d1\u3002<a href=\"https:\/\/www.jci.org\/articles\/view\/188989\">1<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u4f5c\u8005\u8fd8\u7ed3\u5408\u591a\u7ec4\u5b66\u53ca\u7ec6\u80de\u3001\u52a8\u7269\u5b9e\u9a8c\uff0c\u7814\u7a76PKD1\u5982\u4f55\u901a\u8fc7\u8d8b\u5316\u56e0\u5b50CCL2\u5f71\u54cd\u514d\u75ab\u5fae\u73af\u5883\uff0c\u5e76\u63a2\u7d22\u9776\u5411CCL2\u9006\u8f6c\u8010\u836f\u7684\u53ef\u80fd\u6027\u3002<strong>\u60a3\u8005\u6837\u672c\u4e2d\u7684\u6cbb\u7597\u5173\u8054\uff0c\u4e0e\u6a21\u578b\u4e2d\u7684\u5e72\u9884\u6548\u679c\uff0c\u662f\u8fd9\u6761\u8bc1\u636e\u94fe\u4e2d\u4e0d\u540c\u7684\u73af\u8282\u3002<\/strong><a href=\"https:\/\/www.jci.org\/articles\/view\/188989\">1<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u8fd9\u7bc7\u8bba\u6587\u9002\u5408\u5e26\u7740\u4e00\u4e2a\u65b9\u6cd5\u95ee\u9898\u9605\u8bfb\uff1a\u600e\u6837\u4ece\u60a3\u8005\u6837\u672c\u4e2d\u7684\u5019\u9009\u53d8\u5316\uff0c\u8d70\u5230\u53ef\u4ee5\u63a5\u53d7\u5b9e\u9a8c\u68c0\u9a8c\u7684\u673a\u5236\u5047\u8bbe\uff1f\u5efa\u8bae\u5206\u522b\u68c0\u67e5\u6837\u672c\u6bd4\u8f83\u3001\u4e34\u5e8a\u5173\u8054\u3001\u72ec\u7acb\u9a8c\u8bc1\u548c\u529f\u80fd\u5e72\u9884\uff0c\u5224\u65ad\u6bcf\u4e00\u6b65\u652f\u6301\u4e86\u4ec0\u4e48\u7ed3\u8bba\u3002<\/p>\n<h2 style=\"margin:36px 0 18px;color:#17334e;font-size:25px;line-height:1.5;\">\u7ebf\u7d22\u4e8c\uff1a\u7ec6\u80de\u4e4b\u95f4\u7684\u4ee3\u8c22\u4e92\u4f5c\uff0c\u600e\u6837\u5f71\u54cd\u6cbb\u7597\u53cd\u5e94\uff1f<\/h2>\n<p style=\"margin:0 0 18px;\"><strong>\u4ee3\u8868\u8bba\u6587\uff1a\u300aCell Reports Medicine\u300b\uff0c2026\u5e743\u670817\u65e5\u53d1\u8868\u3002<\/strong><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC13006444\/\">2<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u7814\u7a76\u5c06\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u4e0e\u4ee3\u8c22\u5206\u6790\u7ed3\u5408\uff0c\u89c2\u5bdf\u63a5\u53d7\u65b0\u8f85\u52a9\u5316\u7597\u6216\u5316\u7597\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7684\u65e9\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\u3002\u4f5c\u8005\u53d1\u73b0\uff0c\u80bf\u7624\u7ec6\u80de\u548c\u9ad3\u7cfb\u7ec6\u80de\u5728\u8461\u8404\u7cd6\u5229\u7528\u3001\u4e73\u9178\u4ea7\u751f\u4e0e\u518d\u5229\u7528\u65b9\u9762\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\uff1b\u6291\u5236\u4e73\u9178\u8f6c\u8fd0\u76f8\u5173\u86cb\u767dMCT1\uff0c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u589e\u5f3a\u4e86\u6297PD-1\u6216\u6297\u4f53\u5076\u8054\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\u3002<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC13006444\/\">2<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u9605\u8bfb\u65f6\u8fd8\u8981\u5206\u6e05\u5206\u6790\u4e0e\u6d4b\u91cf\uff1a\u8bba\u6587\u4f7f\u7528Compass\u63a8\u65ad\u4ee3\u8c22\u53cd\u5e94\u7684\u6f5c\u5728\u6d3b\u6027\uff0c\u4e5f\u8fdb\u884c\u4e86\u7a33\u5b9a\u540c\u4f4d\u7d20\u6807\u8bb0\u548c\u4ee3\u8c22\u5b9e\u9a8c\u3002<strong>\u8f6c\u5f55\u6570\u636e\u4e0a\u7684\u4ee3\u8c22\u63a8\u65ad\uff0c\u9700\u8981\u4e0e\u5b9e\u9a8c\u6d4b\u91cf\u5206\u522b\u89e3\u8bfb\u3002<\/strong>\u4f5c\u8005\u540c\u65f6\u6307\u51fa\uff0c\u751f\u5b58\u7ed3\u5c40\u53ca\u76f8\u5173\u8054\u5408\u6cbb\u7597\u7684\u6548\u679c\u4ecd\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC13006444\/\">2<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u8fd9\u6761\u7ebf\u7d22\u503c\u5f97\u501f\u9274\u7684\u7814\u7a76\u601d\u8def\u662f\uff1a\u5728\u63d0\u51fa\u4ee3\u8c22\u901a\u8def\u540e\uff0c\u7ee7\u7eed\u660e\u786e\u201c\u54ea\u7c7b\u7ec6\u80de\u4ea7\u751f\u3001\u54ea\u7c7b\u7ec6\u80de\u5229\u7528\u3001\u963b\u65ad\u54ea\u4e00\u6b65\u53ef\u4ee5\u6539\u53d8\u7ed3\u679c\u201d\uff0c\u518d\u68c0\u67e5\u662f\u5426\u5177\u5907\u652f\u6301\u8fd9\u4e9b\u5224\u65ad\u7684\u6570\u636e\u548c\u5b9e\u9a8c\u3002<\/p>\n<h2 style=\"margin:36px 0 18px;color:#17334e;font-size:25px;line-height:1.5;\">\u7ebf\u7d22\u4e09\uff1a\u611f\u89c9\u795e\u7ecf\u5982\u4f55\u53c2\u4e0e\u514d\u75ab\u6392\u65a5\uff1f<\/h2>\n<p style=\"margin:0 0 18px;\"><strong>\u4ee3\u8868\u8bba\u6587\uff1a\u300aCell\u300b\uff0c2026\u5e742\u6708\u5728\u7ebf\u53d1\u8868\u3002<\/strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41650969\/\">3<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u7814\u7a76\u63d0\u51fa\u4e86\u4e00\u6761\u611f\u89c9\u795e\u7ecf\u2014\u6210\u7ea4\u7ef4\u7ec6\u80de\u8054\u7cfb\uff1a\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u795e\u7ecf\u751f\u957f\u56e0\u5b50NGF\u4fc3\u4f7f\u611f\u89c9\u795e\u7ecf\u91ca\u653eCGRP\uff0c\u540e\u8005\u4f5c\u7528\u4e8e\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e0a\u7684\u53d7\u4f53\u590d\u5408\u7269\uff0c\u4fc3\u8fdb\u80f6\u539f\u6c89\u79ef\uff0c\u5f62\u6210\u514d\u75ab\u6392\u65a5\u7684\u5fae\u73af\u5883\u3002\u8bba\u6587\u7531\u6c5f\u4e00\u821f\u3001\u90b5\u5fd7\u654f\u3001\u8096\u6bc5\u3001\u502a\u91d1\u98de\u7b49\u7814\u7a76\u8005\u5408\u4f5c\u5b8c\u6210\u3002<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867426000486\">3<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u7814\u7a76\u8fd8\u63a2\u7d22\u4e86\u963b\u65ad\u8fd9\u4e00\u4fe1\u53f7\u8f74\u7684\u589e\u654f\u6f5c\u529b\u3002\u533b\u9662\u5bf9\u8be5\u7814\u7a76\u7684\u4ecb\u7ecd\u660e\u786e\u6307\u51fa\uff0crimegepant\u4e0e\u514d\u75ab\u6cbb\u7597\u7684\u589e\u6548\u9a8c\u8bc1\u6765\u81ea\u52a8\u7269\u6a21\u578b\u3002\u56e0\u6b64\uff0c\u5e94\u5c06\u5176\u7406\u89e3\u4e3a\u503c\u5f97\u8fdb\u4e00\u6b65\u7814\u7a76\u7684\u8f6c\u5316\u7ebf\u7d22\uff0c\u4e0d\u80fd\u5199\u6210\u5df2\u7ecf\u786e\u7acb\u7684\u4e73\u817a\u764c\u5e38\u89c4\u6cbb\u7597\u65b9\u6848\u3002<a href=\"https:\/\/www.shca.org.cn\/english\/channel\/detail\/27368.shtml\">3<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u7531\u6b64\u53ef\u4ee5\u8fdb\u4e00\u6b65\u63d0\u51fa\u4e00\u4e2a\u7814\u7a76\u95ee\u9898\uff1a\u5728\u5206\u6790\u514d\u75ab\u7ec6\u80de\u4e4b\u5916\uff0c\u795e\u7ecf\u4fe1\u53f7\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u548c\u7ec4\u7ec7\u57fa\u8d28\u4e4b\u95f4\u7684\u8054\u7cfb\uff0c\u662f\u5426\u4e5f\u503c\u5f97\u7eb3\u5165\u9a8c\u8bc1\u8303\u56f4\uff1f\u8fd9\u662f\u672c\u6587\u57fa\u4e8e\u8be5\u7814\u7a76\u63d0\u51fa\u7684\u9605\u8bfb\u5efa\u8bae\u3002<\/p>\n<h2 style=\"margin:36px 0 18px;color:#17334e;font-size:25px;line-height:1.5;\">\u4e00\u7bc711\u6708\u7684\u65b0\u968f\u8bbf\uff1a\u4e34\u5e8a\u8bc1\u636e\u8fd8\u9700\u8981\u65f6\u95f4\u68c0\u9a8c<\/h2>\n<p style=\"margin:0 0 18px;\"><strong>\u6c5f\u4e00\u821f\u53c2\u4e0e\u7f72\u540d\u7684NeoTENNIS\u968f\u8bbf\u8bba\u6587\uff0c\u4e8e2026\u5e7411\u67085\u65e5\u5728\u300aCancer Letters\u300b\u5728\u7ebf\u53d1\u8868\u3002<\/strong>\u8fd9\u662f\u4e00\u987970\u4f8b\u2161\u2014\u2162\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u5355\u81c2\u2161\u671f\u7814\u7a76\uff0c\u63a2\u7d22\u4e0d\u542b\u94c2\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u7b56\u7565\uff1b\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u4e3a\u9884\u8bbe\u6b21\u8981\u7ec8\u70b9\u3002<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42982408\/\">4<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u4e2d\u4f4d\u968f\u8bbf44.7\u4e2a\u6708\u65f6\uff0c\u4f30\u8ba1\u76843\u5e74EFS\u7387\u4e3a80.6%\uff0895%\u7f6e\u4fe1\u533a\u95f468.9%\u201488.3%\uff09\u3002\u4f5c\u8005\u660e\u786e\u63d0\u51fa\uff0c\u4ecd\u9700\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u4e00\u6b65\u8bc4\u4ef7\u8fd9\u4e00\u7b56\u7565\u3002\u8fd9\u9879\u7814\u7a76\u5e76\u975e\u524d\u8ff0\u4e09\u4e2a\u673a\u5236\u65b9\u5411\u7684\u4e34\u5e8a\u9a8c\u8bc1\uff0c\u4e5f\u4e0d\u80fd\u7528\u5355\u81c2\u7ed3\u679c\u8bc1\u660e\u65b9\u6848\u4f18\u4e8e\u73b0\u6709\u6cbb\u7597\u3002<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42982408\/\">4<\/a><\/p>\n<p style=\"margin:0 0 18px;\">\u628a\u8fd9\u7bc7\u968f\u8bbf\u653e\u5728\u4e00\u8d77\u9605\u8bfb\uff0c\u662f\u4e3a\u4e86\u63d0\u9192\u81ea\u5df1\u533a\u5206\u4e24\u4e2a\u95ee\u9898\uff1a<strong>\u673a\u5236\u4e0a\u662f\u5426\u6709\u5e72\u9884\u4f9d\u636e\uff0c\u4e34\u5e8a\u4e0a\u662f\u5426\u5df2\u7ecf\u8bc1\u660e\u60a3\u8005\u83b7\u76ca\u3002<\/strong>\u4e24\u8005\u90fd\u9700\u8981\u5404\u81ea\u5408\u9002\u7684\u9a8c\u8bc1\u3002<\/p>\n<h2 style=\"margin:36px 0 18px;color:#17334e;font-size:25px;line-height:1.5;\">\u628a\u56db\u7bc7\u8bba\u6587\u6574\u7406\u6210\u4e00\u5f20\u8bc1\u636e\u9605\u8bfb\u8868<\/h2>\n<p style=\"margin:0 0 18px;\">\u4e0b\u9762\u662f\u672c\u6587\u63d0\u51fa\u7684\u9605\u8bfb\u5efa\u8bae\uff0c\u53ef\u7528\u4e8e\u68b3\u7406\u7814\u7a76\u8bbe\u8ba1\u548c\u51c6\u5907\u7ec4\u4f1a\u8ba8\u8bba\u3002<\/p>\n<div style=\"overflow-x:auto;margin:22px 0 28px;-webkit-overflow-scrolling:touch;\">\n<table style=\"width:100%;min-width:620px;border-collapse:collapse;font-size:15px;line-height:1.75;\">\n<thead style=\"background:#eaf2ff;color:#17334e;\">\n<tr>\n<th style=\"padding:12px;border:1px solid #dbe5f1;text-align:left;\">\u7814\u7a76\u5c42\u9762<\/th>\n<th style=\"padding:12px;border:1px solid #dbe5f1;text-align:left;\">\u5bf9\u5e94\u8bba\u6587<\/th>\n<th style=\"padding:12px;border:1px solid #dbe5f1;text-align:left;\">\u9605\u8bfb\u65f6\u4f18\u5148\u6838\u5bf9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">\u57fa\u56e0\u7ec4\u4e0e\u514d\u75ab\u5fae\u73af\u5883<\/td>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">PKD1\u4e0e\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c[1]<\/td>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">\u539f\u53d1\u7076\u4e0e\u8f6c\u79fb\u7076\u5982\u4f55\u6bd4\u8f83\uff1f\u6cbb\u7597\u5173\u8054\u600e\u6837\u8fde\u63a5\u529f\u80fd\u5b9e\u9a8c\uff1f<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">\u7ec6\u80de\u4ee3\u8c22\u4e92\u4f5c<\/td>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">\u5355\u7ec6\u80de\u4ee3\u8c22\u4e0eMCT1[2]<\/td>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">\u54ea\u4e9b\u6765\u81ea\u8ba1\u7b97\u63a8\u65ad\uff1f\u54ea\u4e9b\u7ecf\u8fc7\u4ee3\u8c22\u6d4b\u91cf\u6216\u6a21\u578b\u5e72\u9884\uff1f<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">\u795e\u7ecf\u4e0e\u7ec4\u7ec7\u57fa\u8d28<\/td>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">\u611f\u89c9\u795e\u7ecf\u2014\u6210\u7ea4\u7ef4\u7ec6\u80de\u7814\u7a76[3]<\/td>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">\u7ec6\u80de\u95f4\u4fe1\u53f7\u5982\u4f55\u9a8c\u8bc1\uff1f\u5e72\u9884\u6548\u679c\u5728\u54ea\u79cd\u6a21\u578b\u4e2d\u6210\u7acb\uff1f<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">\u4e34\u5e8a\u968f\u8bbf<\/td>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">NeoTENNIS\u66f4\u65b0\u5206\u6790[4]<\/td>\n<td style=\"padding:12px;border:1px solid #dbe5f1;vertical-align:top;\">\u4eba\u7fa4\u3001\u6cbb\u7597\u65b9\u6848\u3001\u968f\u8bbf\u65f6\u95f4\u548c\u7ec8\u70b9\u662f\u4ec0\u4e48\uff1f\u6709\u6ca1\u6709\u968f\u673a\u5bf9\u7167\uff1f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h2 style=\"margin:36px 0 18px;color:#17334e;font-size:25px;line-height:1.5;\">\u8ba9\u81ea\u5df1\u7684\u7814\u7a76\u95ee\u9898\u518d\u5177\u4f53\u4e00\u70b9<\/h2>\n<p style=\"margin:0 0 18px;\">\u5982\u679c\u60f3\u501f\u9274\u8fd9\u4e9b\u7814\u7a76\uff0c\u5efa\u8bae\u5148\u628a\u95ee\u9898\u5199\u6210\u4e00\u53e5\u53ef\u4ee5\u68c0\u9a8c\u7684\u8bdd\uff0c\u4f8b\u5982\u201c\u67d0\u79cd\u57fa\u56e0\u53d8\u5f02\u662f\u5426\u4e0e\u514d\u75ab\u6392\u65a5\u76f8\u5173\u201d\uff0c\u6216\u201c\u80bf\u7624\u4e0e\u9ad3\u7cfb\u7ec6\u80de\u7684\u4e73\u9178\u4e92\u4f5c\u80fd\u5426\u5f97\u5230\u72ec\u7acb\u9a8c\u8bc1\u201d\u3002\u7136\u540e\u5217\u6e05\u53ef\u7528\u6570\u636e\u3001\u6837\u672c\u5206\u7ec4\u3001\u6cbb\u7597\u4e0e\u968f\u8bbf\u4fe1\u606f\uff0c\u4ee5\u53ca\u80fd\u591f\u5f00\u5c55\u7684\u9a8c\u8bc1\u6761\u4ef6\u3002<\/p>\n<p style=\"margin:0 0 18px;\">\u9700\u8981\u4e91\u751f\u4fe1\u534f\u52a9\u68b3\u7406\u5206\u6790\u8def\u5f84\u65f6\uff0c\u53ef\u5148\u63d0\u4f9b\u8bba\u6587DOI\u3001\u6570\u636e\u7f16\u53f7\u6216\u6570\u636e\u6982\u51b5\uff0c\u4ee5\u53ca\u5e0c\u671b\u56de\u7b54\u7684\u4e00\u4e2a\u95ee\u9898\u3002\u6c9f\u901a\u65f6\u5148\u786e\u8ba4\u6570\u636e\u53ef\u83b7\u5f97\u6027\u4e0e\u5206\u6790\u8303\u56f4\uff0c\u518d\u8ba8\u8bba\u9002\u5408\u7684\u652f\u6301\u65b9\u5f0f\u3002<\/p>\n<p style=\"margin:0 0 18px;\"><a href=\"https:\/\/work.weixin.qq.com\/kfid\/kfcb05492f29d4d6064\" data-ysx-event=\"contact_click\" style=\"display:inline-block;background:#2563eb;color:#fff;padding:12px 18px;border-radius:7px;font-weight:700;text-decoration:none;\">\u8054\u7cfb\u4e91\u751f\u4fe1\uff0c\u6c9f\u901a\u514d\u75ab\u5fae\u73af\u5883\u5206\u6790\u4e0e\u9a8c\u8bc1\u9700\u6c42<\/a><\/p>\n<h2 style=\"margin:36px 0 18px;color:#17334e;font-size:25px;line-height:1.5;\">\u53c2\u8003\u6587\u732e\u4e0e\u6838\u5bf9\u8bf4\u660e<\/h2>\n<ol style=\"padding-left:24px;font-size:14px;line-height:1.85;overflow-wrap:anywhere;\">\n<li style=\"margin:0 0 17px;\">Zhu XZ, Zhou YF, Ying XH, et al. <strong>Comprehensive genomic profiling of triple-negative breast cancer metastases identifies role of PKD1 in immunotherapy resistance.<\/strong> <em>Journal of Clinical Investigation<\/em>. 2026;136(5):e188989. DOI\uff1a<a href=\"https:\/\/doi.org\/10.1172\/JCI188989\">10.1172\/JCI188989<\/a>\u3002<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41766665\/\">PubMed\uff1a41766665<\/a>\uff1b<a href=\"https:\/\/www.jci.org\/articles\/view\/188989\">\u5f00\u653e\u5168\u6587<\/a>\u3002<\/li>\n<li style=\"margin:0 0 17px;\">Xu Y, Liu XY, Zhang H, et al. <strong>Comprehensive single-cell metabolic profiling identifies targets to sensitize triple-negative breast cancer to chemo-immunotherapy.<\/strong> <em>Cell Reports Medicine<\/em>. 2026;7(3):102659. DOI\uff1a<a href=\"https:\/\/doi.org\/10.1016\/j.xcrm.2026.102659\">10.1016\/j.xcrm.2026.102659<\/a>\u3002<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41850242\/\">PubMed\uff1a41850242<\/a>\uff1b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC13006444\/\">\u5f00\u653e\u5168\u6587<\/a>\u3002<\/li>\n<li style=\"margin:0 0 17px;\">Zhang SW, Wang H, Xiao Y, et al. <strong>Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment.<\/strong> <em>Cell<\/em>. 2026. 2\u67085\u65e5\u5728\u7ebf\u53d1\u8868\uff0c2\u670819\u65e5\u89c1\u520a\u3002DOI\uff1a<a href=\"https:\/\/doi.org\/10.1016\/j.cell.2026.01.001\">10.1016\/j.cell.2026.01.001<\/a>\u3002<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41650969\/\">PubMed\uff1a41650969<\/a>\uff1b<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867426000486\">\u671f\u520a\u9875\u9762<\/a>\uff1b<a href=\"https:\/\/www.shca.org.cn\/english\/channel\/detail\/27368.shtml\">\u533b\u9662\u7814\u7a76\u4ecb\u7ecd<\/a>\u3002<\/li>\n<li style=\"margin:0 0 17px;\">Hao S, Wang X, Ma LX, et al. <strong>Event-free survival in patients with early triple-negative breast cancer receiving platinum-free, de-escalated anti-PD-1 neoadjuvant therapy: an updated analysis of the NeoTENNIS trial.<\/strong> <em>Cancer Letters<\/em>. 2026\u5e7411\u67085\u65e5\u5728\u7ebf\u53d1\u8868\u3002DOI\uff1a<a href=\"https:\/\/doi.org\/10.1016\/j.canlet.2026.218953\">10.1016\/j.canlet.2026.218953<\/a>\u3002<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42982408\/\">PubMed\uff1a42982408<\/a>\u3002<\/li>\n<\/ol>\n<p class=\"ysx-source-note\" style=\"color:#586b7d;font-size:14px;line-height:1.85;border-top:1px solid #dbe5f1;padding-top:18px;\">\u6838\u5bf9\u8bf4\u660e\uff1a\u672c\u7bc7\u4f9d\u636e\u516c\u5f00\u6587\u732e\u6574\u7406\uff0c\u7814\u7a76\u65b9\u5411\u6982\u62ec\u548c\u9605\u8bfb\u5efa\u8bae\u5c5e\u4e8e\u7f16\u8f91\u5f52\u7eb3\uff0c\u5e76\u975e\u8bfe\u9898\u7ec4\u6210\u679c\u5168\u96c6\u6216\u672a\u516c\u5f00\u8ba1\u5212\u3002\u6587\u732e1\u6838\u5bf9\u5f00\u653e\u6b63\u6587\uff0c\u6587\u732e2\u6838\u5bf9\u5f00\u653e\u5168\u6587\u4e2d\u7684\u65b9\u6cd5\u3001\u5c40\u9650\u4e0e\u4f5c\u8005\u8d21\u732e\uff1b\u6587\u732e3\u4f9d\u636ePubMed\u8bb0\u5f55\u3001\u671f\u520a\u53ef\u8bfb\u5185\u5bb9\u53ca\u533b\u9662\u4ecb\u7ecd\uff0c\u6587\u732e4\u4f9d\u636ePubMed\u8bb0\u5f55\u4e0e\u6458\u8981\uff0c\u89e3\u8bfb\u9650\u4e8e\u5df2\u6838\u5b9e\u8303\u56f4\u3002\u914d\u56fe\u4e3a\u6587\u732e\u9605\u8bfb\u793a\u610f\u56fe\u3002\u672c\u6587\u7531\u4e91\u751f\u4fe1\u72ec\u7acb\u6574\u7406\uff0c\u5f15\u7528\u4e0d\u8868\u793a\u76f8\u5173\u5b66\u8005\u6216\u673a\u6784\u4e0e\u4e91\u751f\u4fe1\u5b58\u5728\u5408\u4f5c\u6216\u80cc\u4e66\u5173\u7cfb\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u56f4\u7ed5\u6c5f\u4e00\u821f\u53ca\u5408\u4f5c\u80052026\u5e74\u7684\u516c\u5f00\u8bba\u6587\uff0c\u68b3\u7406\u8f6c\u79fb\u7076PKD1\u53d8\u5f02\u3001\u5355\u7ec6\u80de\u4ee3\u8c22\u4e0eMCT1\u3001\u611f\u89c9\u795e\u7ecf\u4e0e\u80bf\u7624\u57fa\u8d28\u4e09\u6761\u7814\u7a76\u7ebf\u7d22\uff0c\u5e76\u7ed3\u540811\u6708NeoTENNIS\u968f\u8bbf\u8bf4\u660e\u673a\u5236\u4e0e\u4e34\u5e8a\u8bc1\u636e\u7684\u533a\u522b\uff0c\u9644\u539f\u6587\u3001PMID\u53caDOI\u3002<\/p>\n","protected":false},"author":1,"featured_media":66425,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1,76],"tags":[543,544,545,546,517,520,542,547],"class_list":["post-66426","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-part","category-survival-oncology","tag-543","tag-544","tag-545","tag-546","tag-517","tag-520","tag-542","tag-547"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/11\/researcher-series-20261114-jiang-research-map.png?fit=1440%2C960&ssl=1","_links":{"self":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/comments?post=66426"}],"version-history":[{"count":1,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66426\/revisions"}],"predecessor-version":[{"id":66427,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/66426\/revisions\/66427"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media\/66425"}],"wp:attachment":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media?parent=66426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/categories?post=66426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/tags?post=66426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}