{"id":66428,"date":"2026-11-14T16:38:01","date_gmt":"2026-11-14T08:38:01","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=66428"},"modified":"2026-11-14T16:39:25","modified_gmt":"2026-11-14T08:39:25","slug":"spatialdwls-heart-slice","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/spatialdwls-heart-slice\/","title":{"rendered":"\u4e00\u5f20\u5fc3\u810f\u5207\u7247\u4e0a\u7684\u4e24\u79cd\u5fc3\u808c\u4fe1\u53f7\uff1a\u7a7a\u95f4\u89e3\u5377\u79ef\u80fd\u770b\u51fa\u4ec0\u4e48\uff1f"},"content":{"rendered":"

\u5728\u8fd9\u5f20\u53d1\u80b2\u4e2d\u4eba\u5fc3\u810f\u5207\u7247\u4e0a\uff0c\u6709\u4e00\u4e2a\u70b9\u4f4d\u5f88\u5bb9\u6613\u88ab\u4e00\u5f20\u914d\u8272\u56fe\u8bb2\u6f0f\u3002\u6309\u5360\u6bd4\u6700\u9ad8\u7684\u7c7b\u578b\u7ed9\u5b83\u4e0a\u8272\uff0c\u5b83\u4f1a\u88ab\u6807\u6210\u201c\u5fc3\u623f\u808c\u7ec6\u80de\u201d\uff1b\u6253\u5f00\u6bd4\u4f8b\u8868\uff0c\u540c\u4e00\u4e2a\u70b9\u8fd8\u6709 38.1% \u7684\u5fc3\u5ba4\u808c\u7ec6\u80de\u4f30\u8ba1\u5360\u6bd4<\/strong>\u3002\u4e00\u5f20\u56fe\u4e0a\u7684\u4e00\u79cd\u989c\u8272\uff0c\u538b\u7f29\u4e86\u591a\u5c11\u4fe1\u606f\uff1f\u6211\u4eec\u7528\u8fd9\u5f20\u5207\u7247\u7684\u771f\u5b9e\u7ed3\u679c\u6765\u770b\u3002<\/p>\n

\u60f3\u8fb9\u770b\u8fb9\u5bf9\u7167\uff0c\u53ef\u4ee5\u76f4\u63a5\u6253\u5f00\u5de5\u5177\uff0c\u9009\u300c\u516c\u5f00\u6837\u4f8b\u300d\uff0c\u70b9\u300c\u8fd0\u884c\u6837\u4f8b\u300d\u3002\u5728\u4e91\u751f\u4fe1\u8fd0\u884c\u8fd9\u5f20\u5fc3\u810f\u5207\u7247 \u2192<\/a><\/p>\n

\u540c\u4e00\u5f20\u5207\u7247\uff0c\u5fc3\u623f\u808c\u548c\u5fc3\u5ba4\u808c\u4fe1\u53f7\u96c6\u4e2d\u5728\u54ea\u91cc\uff1f<\/h2>\n

\u6837\u4f8b\u6765\u81ea SpatialDWLS \u4f5c\u8005\u516c\u5f00\u7684\u53d1\u80b2\u7b2c 6 \u5468\u4eba\u5fc3\u810f\u6837\u672c 10\uff0c\u5171\u6709 210 \u4e2a\u7a7a\u95f4\u70b9\u4f4d\u3002\u4e00\u4e2a\u70b9\u4f4d\u4f1a\u91c7\u5230\u5468\u56f4\u591a\u4e2a\u7ec6\u80de\u7684 RNA\u3002SpatialDWLS \u5229\u7528\u5355\u7ec6\u80de\u53c2\u8003\u8868\u8fbe\u8c31\uff0c\u4f30\u8ba1\u54ea\u4e9b\u7ec6\u80de\u7c7b\u578b\u7684\u7ec4\u5408\u80fd\u89e3\u91ca\u8fd9\u4e2a\u70b9\u4f4d\u7684\u8868\u8fbe\u3002\u672c\u6b21\u5206\u6790\u7528\u4e86 15 \u7c7b\u53c2\u8003\u7ec6\u80de\u548c 866 \u4e2a\u5171\u6709\u53c2\u8003\u57fa\u56e0\u3002\u65b9\u6cd5\u8bba\u6587<\/a> \u00b7 \u5fc3\u810f\u5207\u7247\u4e0e\u53c2\u8003\u6570\u636e<\/a><\/p>\n

\"\u540c\u4e00\u5fc3\u810f\u5207\u7247\u7684\u4e94\u5f20\u6bd4\u4f8b\u56fe\uff0c\u5fc3\u5ba4\u808c\u7ec6\u80de\u9ad8\u5360\u6bd4\u70b9\u4e3b\u8981\u5728\u56fe\u7684\u4e2d\u4e0b\u90e8\uff0c\u5fc3\u623f\u808c\u7ec6\u80de\u9ad8\u5360\u6bd4\u70b9\u4e3b\u8981\u5728\u4e0a\u90e8\u548c\u53f3\u4fa7\u5c40\u90e8\u3002\"<\/picture><\/a>
\u540c\u4e00\u7ec4\u70b9\u4f4d\uff0c\u5206\u5f00\u753b\u51fa\u4e94\u79cd\u7ec6\u80de\u7c7b\u578b\u3002\u4e0a\u6392\u4f9d\u6b21\u662f\u5fc3\u5ba4\u808c\u7ec6\u80de\u3001\u5fc3\u623f\u808c\u7ec6\u80de\u548c\u5e73\u6ed1\u808c\u7ec6\u80de\uff0c\u4e0b\u6392\u662f\u6bdb\u7ec6\u8840\u7ba1\u5185\u76ae\u548c\u5fc3\u5916\u819c\u7ec6\u80de\u3002\u5404\u56fe\u5171\u7528 0%\u2013100% \u7684\u8272\u6807\uff0c\u8d8a\u9ec4\u8868\u793a\u4f30\u8ba1\u5360\u6bd4\u8d8a\u9ad8\uff0c\u7070\u8272\u4ee3\u8868\u672a\u6c42\u89e3\u3002\u70b9\u51fb\u53ef\u770b\u5927\u56fe\u3002<\/figcaption><\/figure>\n

\u5148\u770b\u4e0a\u6392\u524d\u4e24\u5e45\u3002\u5728\u76f8\u540c\u7684\u5207\u7247\u5750\u6807\u4e0a\uff0c\u5fc3\u5ba4\u808c\u7ec6\u80de\u7684\u9ad8\u5360\u6bd4\u70b9\u5728\u56fe\u7684\u4e2d\u4e0b\u90e8\u8fde\u6210\u4e00\u7247\uff1b\u6362\u770b\u5fc3\u623f\u808c\u7ec6\u80de\uff0c\u540c\u4e00\u7247\u4f4d\u7f6e\u5927\u591a\u8f6c\u4e3a\u6df1\u8272\uff0c\u4e0a\u90e8\u548c\u53f3\u4fa7\u5c40\u90e8\u7684\u70b9\u53cd\u800c\u4eae\u8d77\u6765\u3002\u6cbf\u7740\u76f8\u90bb\u70b9\u770b\uff0c\u8fd9\u4e24\u7c7b\u53c2\u8003\u8868\u8fbe\u5448\u73b0\u51fa\u4e0d\u540c\u7684\u7a7a\u95f4\u5206\u5e03\u3002\u8981\u8fdb\u4e00\u6b65\u628a\u533a\u57df\u6807\u4e3a\u5177\u4f53\u89e3\u5256\u7ed3\u6784\uff0c\u8fd8\u9700\u5c06\u5750\u6807\u4e0e\u7ec4\u7ec7\u5b66\u5207\u7247\u914d\u51c6\u540e\u6838\u5bf9\u3002<\/p>\n

\u628a\u540c\u4e00\u4e2a\u70b9\u7684\u4e24\u5217\u6bd4\u4f8b\u653e\u5728\u4e00\u8d77\u8bfb<\/h2>\n

\u4e0b\u9762\u56db\u884c\u6765\u81ea\u5de5\u5177\u8f93\u51fa\u7684\u5b8c\u6574\u6bd4\u4f8b\u8868\u3002\u8bfb\u7b2c\u4e00\u884c\u65f6\u7559\u610f\u54ea\u4e00\u7c7b\u5360\u4e3b\u5bfc\uff1b\u8bfb\u7b2c\u4e09\u884c\u65f6\uff0c\u7559\u610f\u4e3b\u5bfc\u7c7b\u578b\u4ee5\u5916\u8fd8\u5269\u4e0b\u591a\u5c11\u4fe1\u53f7\u3002<\/p>\n

\n\n\n\n\n\n\n\n\n
\u70b9\u4f4d ID<\/th>\n\u5fc3\u5ba4\u808c\u7ec6\u80de<\/th>\n\u5fc3\u623f\u808c\u7ec6\u80de<\/th>\n<\/tr>\n<\/thead>\n
10x9x7<\/td>\n99.1%<\/td>\n0.9%<\/td>\n<\/tr>\n
10x8x20<\/td>\n0.0%<\/td>\n100.0%<\/td>\n<\/tr>\n
10x12x19<\/td>\n38.1%<\/td>\n53.7%<\/td>\n<\/tr>\n
10x19x21<\/td>\nNA<\/td>\nNA<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n

\u6700\u503c\u5f97\u56de\u770b\u7684\u662f\u7b2c\u4e09\u884c\u3002<\/strong>\u5728 10x12x19<\/code>\uff0c\u8fd9\u4e24\u7c7b\u52a0\u8d77\u6765\u7ea6\u5360 91.8%\uff0c\u5176\u4f59\u7ea6 8.2% \u5206\u7ed9\u4e86\u5176\u4ed6\u53c2\u8003\u7c7b\u578b\u3002\u53ea\u770b\u4e3b\u5bfc\u7c7b\u578b\u56fe\uff0c\u8fd9\u4e2a\u70b9\u4e0e\u7b2c\u4e8c\u884c\u90fd\u4f1a\u663e\u793a\u4e3a\u5fc3\u623f\u808c\u7ec6\u80de\u5360\u4f18\uff1b\u770b\u5b8c\u6574\u6bd4\u4f8b\uff0c\u5c31\u77e5\u9053\u54ea\u4e00\u4e2a\u70b9\u66f4\u503c\u5f97\u653e\u5927\uff0c\u53bb\u6838\u5bf9\u5468\u56f4\u70b9\u4f4d\u3001\u7ec4\u7ec7\u56fe\u50cf\u548c\u6807\u5fd7\u57fa\u56e0\u3002\u4e24\u7c7b\u4fe1\u53f7\u5171\u540c\u51fa\u73b0\u5728\u4e00\u4e2a\u91c7\u6837\u70b9\uff0c\u53ef\u4ee5\u63d0\u793a\u5c40\u90e8\u6df7\u5408\uff1b\u8981\u5224\u65ad\u7ec6\u80de\u662f\u5426\u5f7c\u6b64\u63a5\u89e6\uff0c\u8fd8\u9700\u8981\u66f4\u9ad8\u7a7a\u95f4\u5206\u8fa8\u7387\u7684\u8bc1\u636e\u3002<\/p>\n

\u8fd9\u5f20\u8868\u8bb0\u5f55\u7684\u662f\u6a21\u578b\u4f30\u8ba1\u3002\u7b2c\u4e8c\u884c\u7684 100% \u8868\u793a\u5728\u7ed9\u5b9a\u53c2\u8003\u8c31\u548c\u53c2\u6570\u4e0b\uff0c\u6a21\u578b\u5c06\u8be5\u70b9\u7684\u7ec4\u6210\u5168\u90e8\u5206\u7ed9\u5fc3\u623f\u808c\u7ec6\u80de\u3002\u6700\u540e\u4e00\u884c\u7684 NA<\/code> \u5219\u8868\u793a\u6ca1\u6709\u5f97\u5230\u53ef\u7528\u7684\u6bd4\u4f8b\uff0c\u8bfb\u8868\u65f6\u5e94\u4fdd\u7559\u7f3a\u5931\u3002\u672c\u6b21 210 \u4e2a\u70b9\u4f4d\u4e2d\uff0c209 \u4e2a\u5f97\u5230\u4f30\u8ba1\uff0c1 \u4e2a\u672a\u6c42\u89e3\u3002<\/p>\n

\u81ea\u5df1\u8dd1\u4e00\u6b21\uff0c\u627e\u56de\u90a3\u4e2a\u6df7\u5408\u70b9\u4f4d<\/h2>\n

\u8fdb\u5165\u5de5\u5177\u540e\u70b9\u51fb\u300c\u8fd0\u884c\u6837\u4f8b\u300d\uff0c\u5148\u770b\u9875\u9762\u6309\u4e3b\u5bfc\u7ec6\u80de\u7c7b\u578b\u7740\u8272\u7684\u7a7a\u95f4\u56fe\uff0c\u518d\u70b9\u300c\u4e0b\u8f7d\u5b8c\u6574\u6bd4\u4f8b\u8868 TSV\u300d\uff0c\u641c\u7d22 10x12x19<\/code>\u3002\u5bf9\u7167 Atrial_cardiomyocytes<\/code> \u548c Ventricular_cardiomyocytes<\/code> \u4e24\u5217\uff0c\u5c31\u80fd\u4ece\u56fe\u4e0a\u7684\u4e00\u4e2a\u989c\u8272\u8bfb\u56de\u4e24\u79cd\u7ec6\u80de\u7684\u4f30\u8ba1\u5360\u6bd4\u3002\u672c\u6587\u7684\u4e94\u5e45\u5206\u56fe\uff0c\u4e5f\u6765\u81ea\u540c\u4e00\u5f20\u6bd4\u4f8b\u8868\u3002\u6253\u5f00 SpatialDWLS\uff0c\u76f4\u63a5\u8fd0\u884c\u5fc3\u810f\u5207\u7247\u6837\u4f8b \u2192<\/strong><\/a><\/p>\n

\u6362\u81ea\u5df1\u7684\u5207\u7247\u65f6\uff0c\u51c6\u5907\u7a7a\u95f4\u8868\u8fbe\u77e9\u9635\u3001\u540c\u7269\u79cd\u4e14\u4e0e\u7ec4\u7ec7\u5339\u914d\u7684\u7ec6\u80de\u7c7b\u578b\u53c2\u8003\u8868\u8fbe\u8c31\uff0c\u4ee5\u53ca\u70b9\u4f4d\u5206\u7ec4\u8868\u3002\u7a7a\u95f4\u77e9\u9635\u4f7f\u7528\u5f52\u4e00\u5316\u540e\u53d6\u5bf9\u6570\u7684\u6570\u503c\uff0c\u53c2\u8003\u8c31\u4f7f\u7528\u5f52\u4e00\u5316\u540e\u3001\u53d6\u5bf9\u6570\u524d\u7684\u5e73\u5747\u8868\u8fbe\u3002\u70b9\u4f4d\u8868\u518d\u52a0\u4e0a x<\/code>\u3001y<\/code> \u4e24\u5217\uff0c\u5c31\u80fd\u628a\u4f30\u8ba1\u6bd4\u4f8b\u653e\u56de\u7ec4\u7ec7\u5750\u6807\u3002\u672c\u6587\u4f7f\u7528\u4e91\u751f\u4fe1\u6837\u4f8b\u7684\u56db\u7ec4\u70b9\u4f4d\u5206\u7ec4\uff1b\u539f\u8bba\u6587\u6559\u7a0b\u91c7\u7528 Leiden \u5206\u7ec4\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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