{"id":68110,"date":"2026-11-14T20:18:35","date_gmt":"2026-11-14T12:18:35","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=68110"},"modified":"2026-11-14T20:18:35","modified_gmt":"2026-11-14T12:18:35","slug":"pyscenic-regulon-aucell-motif-target-evidence","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/pyscenic-regulon-aucell-motif-target-evidence\/","title":{"rendered":"pySCENIC \u7ed9\u4e00\u4e2a\u8f6c\u5f55\u56e0\u5b50\u6253\u51fa\u9ad8\u5206\uff0c\u7a76\u7adf\u662f\u54ea\u4e00\u6b65\u63d0\u4f9b\u7684\u8bc1\u636e\uff1f"},"content":{"rendered":"<div class=\"ysx-method-guide\" style=\"max-width:820px;min-width:0;margin:0 auto;color:#26374a;line-height:1.86;overflow-wrap:anywhere\">\n<p>\u5355\u7ec6\u80de\u70ed\u56fe\u4e0a\u67d0\u4e2a\u8f6c\u5f55\u56e0\u5b50\u7684\u8c03\u63a7\u5b50\u5f88\u4eae\uff0c\u53ef\u4e00\u67e5\u8868\u8fbe\uff0c\u5b83\u81ea\u5df1\u7684\u8f6c\u5f55\u672c\u5e76\u4e0d\u591a\u3002\u5f88\u591a\u4eba\u4ece\u8fd9\u91cc\u5f00\u59cb\u6000\u7591\u8f93\u5165\u51fa\u4e86\u9519\u3002\u770b\u6e05 pySCENIC 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style=\"color:#765237;text-decoration:underline;text-underline-offset:2px\" href=\"https:\/\/pyscenic.readthedocs.io\/en\/latest\/tutorial.html\">pySCENIC \u7684\u5efa\u7f51\u5b9e\u4f8b<\/a><\/p>\n<p>\u63a5\u4e0b\u6765\u6309\u8c03\u63a7\u56e0\u5b50\u53ca\u5176\u5019\u9009\u76ee\u6807\u7ec4\u6210\u6a21\u5757\uff0c\u68c0\u67e5\u5bf9\u5e94\u987a\u5f0f\u533a\u57df\u7684\u57fa\u5e8f\u6392\u540d\u662f\u5426\u5bcc\u96c6\uff0c\u518d\u636e\u6b64\u4fdd\u7559\u8f83\u6709\u4f9d\u636e\u7684\u9776\u57fa\u56e0\u3002\u8fd9\u91cc\u6709\u4e24\u4e2a\u5bb9\u6613\u6f0f\u67e5\u7684\u4ea4\u96c6\u3002\u7b2c\u4e00\u662f\u8868\u8fbe\u77e9\u9635\u7684\u57fa\u56e0\u547d\u540d\u4e0e\u8f6c\u5f55\u56e0\u5b50\u540d\u5355\u7684\u4ea4\u96c6\uff0c\u7b2c\u4e8c\u662f\u8868\u8fbe\u57fa\u56e0\u4e0e\u6392\u540d\u6570\u636e\u5e93\u53ef\u8bc6\u522b\u57fa\u56e0\u7684\u4ea4\u96c6\u3002\u82e5\u5b9e\u9a8c\u5bf9\u8c61\u662f\u5c0f\u9f20\uff0c\u5374\u6df7\u7528\u4eba\u7c7b\u7684\u7f16\u53f7\u3001\u6ce8\u91ca\u8868\u548c\u6392\u540d\u5e93\uff0c\u5373\u4fbf\u8fd0\u884c\u7ed3\u675f\uff0c\u7559\u4e0b\u7684\u7f51\u7edc\u4e5f\u53ef\u80fd\u53ea\u8986\u76d6\u5f88\u504f\u7684\u4e00\u90e8\u5206\u57fa\u56e0\u3002\u8bb0\u5f55\u4ea4\u96c6\u5927\u5c0f\u3001\u672a\u5339\u914d\u57fa\u56e0\u53ca\u4f7f\u7528\u7684\u6570\u636e\u5e93\u7248\u672c\uff0c\u80fd\u5e2e\u52a9\u5b9a\u4f4d\u4e3a\u4ec0\u4e48\u719f\u6089\u7684\u56e0\u5b50\u4ece\u7ed3\u679c\u91cc\u6d88\u5931\u3002<a style=\"color:#765237;text-decoration:underline;text-underline-offset:2px\" href=\"https:\/\/pyscenic.readthedocs.io\/en\/latest\/\">\u8f6f\u4ef6\u4e0e\u6392\u540d\u5e93\u683c\u5f0f\u8bf4\u660e<\/a><\/p>\n<h2 style=\"font-size:1.38em;line-height:1.5;margin:1.55em 0 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style=\"display:table;width:100%;max-width:100%;min-width:0;table-layout:fixed;border-collapse:collapse;font-size:.92em;line-height:1.6\">\n<thead>\n<tr>\n<th scope=\"col\" style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;background:#fff4e9;color:#1e293b;vertical-align:top;text-align:right;padding:6px;border:1px solid #c4cfdb\">\u57fa\u56e0\u5728\u672c\u7ec6\u80de\u5185\u7684\u540d\u6b21<\/th>\n<th scope=\"col\" style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;background:#fff4e9;color:#1e293b;vertical-align:top;text-align:left;padding:6px;border:1px solid #c4cfdb\">\u7ec6\u80de\u4e00<\/th>\n<th scope=\"col\" style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;background:#fff4e9;color:#1e293b;vertical-align:top;text-align:left;padding:6px;border:1px solid #c4cfdb\">\u7ec6\u80de\u4e8c<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb;text-align:right\">\u7b2c\u4e00<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u7532\u4e00<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u5176\u4ed6\u7532<\/td>\n<\/tr>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb;text-align:right\">\u7b2c\u4e8c<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u7532\u4e8c<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u5176\u4ed6\u4e59<\/td>\n<\/tr>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb;text-align:right\">\u7b2c\u4e09<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u5176\u4ed6\u7532<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u5176\u4ed6\u4e19<\/td>\n<\/tr>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb;text-align:right\">\u7b2c\u56db<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u7532\u4e09<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u7532\u4e00<\/td>\n<\/tr>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb;text-align:right\">\u7b2c\u4e94<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u5176\u4ed6\u4e59<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u7532\u4e8c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<figure class=\"guide-figure\" style=\"margin:24px 0 28px\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/11\/pyscenic-regulon-aucell-motif-target-evidence-guide.png?resize=1200%2C840&#038;ssl=1\" alt=\"\u70ed\u56fe\u4e0a\u7684\u9ad8\u5206\u6765\u81ea\u54ea\u7ec4\u57fa\u56e0\u3002\u4ece\u70ed\u56fe\u5f80\u56de\u67e5\uff0c\u4e09\u4e2a\u6b65\u9aa4\u7559\u4e0b\u4e09\u79cd\u4e0d\u540c\u8bc1\u636e\u3002\u5019\u9009\u8fb9\uff0c\u591a\u4e2a\u57fa\u56e0\u662f\u5426\u4e00\u8d77\u53d8\u5316\uff0c\u56de\u5230\u540c\u4e00\u8c31\u7cfb\uff0c\u68c0\u67e5\u5171\u8868\u8fbe\u5173\u7cfb\u662f\u5426\u8fd8\u5b58\u5728\u3002\u57fa\u5e8f\uff0c\u5019\u9009\u9776\u70b9\u6709\u54ea\u4e9b\u987a\u5f0f\u7ebf\u7d22\uff0c\u6838\u5bf9\u7269\u79cd\u3001\u6392\u540d\u5e93\u548c\u57fa\u56e0\u6807\u8bc6\u7684\u4ea4\u96c6\u3002\u6d3b\u6027\uff0c\u9776\u57fa\u56e0\u5728\u672c\u7ec6\u80de\u7684\u6392\u540d\uff0c\u628a\u9776\u70b9\u7684\u6392\u540d\u4e0e\u56e0\u5b50\u81ea\u8eab\u8868\u8fbe\u5206\u522b\u67e5\u770b\u3002\" width=\"1200\" height=\"840\" style=\"display:block;width:100%;height:auto;border-radius:10px\"><figcaption style=\"font-size:14px;line-height:1.6;margin:9px 2px 0;color:#475569\">\u4ece\u70ed\u56fe\u5f80\u56de\u67e5\uff0c\u4e09\u4e2a\u6b65\u9aa4\u7559\u4e0b\u4e09\u79cd\u4e0d\u540c\u8bc1\u636e\u3002<\/figcaption><\/figure>\n<p>\u5728\u7b2c\u4e00\u679a\u7ec6\u80de\u4e2d\uff0c\u4ece\u7b2c\u4e00\u540d\u5f00\u59cb\u9010\u4e2a\u5f80\u4e0b\u626b\uff0c\u7d2f\u8ba1\u547d\u4e2d\u6570\u4f9d\u6b21\u662f\u4e00\u3001\u4e8c\u3001\u4e8c\u3001\u4e09\u3001\u4e09\u3002\u7b2c\u4e8c\u679a\u4e3a\u96f6\u3001\u96f6\u3001\u96f6\u3001\u4e00\u3001\u4e8c\u3002\u54ea\u4e00\u679a\u5bcc\u96c6\u66f4\u65e9\uff0c\u8bfb\u8005\u53ef\u4ee5\u76f4\u63a5\u770b\u51fa\u6765\u3002AUCell 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style=\"color:#765237;text-decoration:underline;text-underline-offset:2px\" href=\"https:\/\/bioconductor.org\/packages\/release\/bioc\/vignettes\/AUCell\/inst\/doc\/AUCell.html\">AUCell 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