{"id":69471,"date":"2026-11-14T21:29:25","date_gmt":"2026-11-14T13:29:25","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=69471"},"modified":"2026-11-14T21:40:26","modified_gmt":"2026-11-14T13:40:26","slug":"card-spatial-deconvolution-shuffled-coordinates-boundaries","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/card-spatial-deconvolution-shuffled-coordinates-boundaries\/","title":{"rendered":"CARD \u753b\u51fa\u7684\u7ec4\u7ec7\u8fb9\u754c\u5f88\u5e73\u6ed1\uff0c\u600e\u4e48\u77e5\u9053\u8868\u8fbe\u6570\u636e\u771f\u7684\u652f\u6301\u5b83\uff1f"},"content":{"rendered":"<div class=\"ysx-method-guide\" style=\"max-width:820px;min-width:0;margin:0 auto;color:#26374a;line-height:1.86;overflow-wrap:anywhere\">\n<p>\u4e00\u5f20\u7ec4\u7ec7\u5207\u7247\u4e0a\uff0c\u67d0\u7c7b\u7ec6\u80de\u7684\u4e30\u5ea6\u4ece\u4e2d\u5fc3\u5411\u8fb9\u7f18\u5747\u5300\u964d\u4f4e\u3002\u5b83\u770b\u8d77\u6765\u5408\u4e4e\u76f4\u89c9\uff0c\u53ef\u662f\u5e73\u6ed1\u6070\u597d\u4e5f\u662f\u7a7a\u95f4\u6a21\u578b\u4e3b\u52a8\u5229\u7528\u7684\u6027\u8d28\u3002\u6211\u4eec\u600e\u6837\u5224\u65ad\u8fd9\u6761\u5e26\u72b6\u7ed3\u6784\u4e3b\u8981\u7531\u8868\u8fbe\u652f\u6301\uff0c\u8fd8\u662f\u5468\u56f4\u70b9\u4f4d\u4e00\u8d77\u628a\u5b83\u62c9\u6210\u4e86\u8fde\u7eed\u533a\u57df\uff1f\u4e00\u79cd\u53ef\u64cd\u4f5c\u7684\u529e\u6cd5\u662f\u4fdd\u5b58\u6bcf\u4e2a\u6761\u5f62\u7801\u5bf9\u5e94\u7684\u8868\u8fbe\uff0c\u56fa\u5b9a\u53c2\u8003\u4e0e\u6a21\u578b\u8bbe\u7f6e\uff0c\u53ea\u6253\u4e71\u5750\u6807\uff0c\u518d\u6bd4\u8f83\u4e30\u5ea6\u548c\u8fb9\u754c\u3002\u4e0b\u9762\u5148\u8bf4\u660e\u8fd9\u4e2a\u5bf9\u7167\u7a76\u7adf\u6539\u4e86\u4ec0\u4e48\uff0c\u518d\u770b\u4e3a\u4ec0\u4e48\u5728\u4e00\u4efd\u6709\u5f3a\u6807\u8bb0\u7684\u6a21\u62df\u7ec4\u7ec7\u4e2d\uff0c\u6539\u5750\u6807\u4e5f\u51e0\u4e4e\u4e0d\u52a8\u7ed3\u679c\u3002<\/p>\n<h2 style=\"font-size:1.38em;line-height:1.5;margin:1.55em 0 .55em;color:#182d43\">\u8868\u8fbe\u76f8\u8fd1\u4e0e\u5730\u7406\u76f8\u8fd1\u662f\u4e24\u4efd\u8bc1\u636e<\/h2>\n<p>CARD \u5229\u7528\u6709\u6807\u7b7e\u7684\u5355\u7ec6\u80de\u53c2\u8003\uff0c\u4f30\u8ba1\u7a7a\u95f4\u70b9\u4f4d\u4e2d\u7684\u7ec6\u80de\u7c7b\u578b\u7ec4\u6210\u3002\u5b83\u5141\u8bb8\u90bb\u8fd1\u4f4d\u7f6e\u7684\u7ec4\u6210\u5f7c\u6b64\u76f8\u5173\u3002\u5bf9\u4e8e\u8fde\u7eed\u5206\u5e03\u7684\u7ec4\u7ec7\uff0c\u53ea\u9760\u5355\u70b9\u7a00\u758f\u8ba1\u6570\u96be\u4ee5\u7a33\u5b9a\u786e\u5b9a\u7684\u6210\u5206\uff0c\u6709\u673a\u4f1a\u4ece\u5468\u56f4\u4f4d\u7f6e\u5f97\u5230\u652f\u6301\u3002\u6761\u4ef6\u662f\u6a21\u578b\u8ba4\u4e3a\u76f8\u4e92\u63a5\u8fd1\u7684\u5750\u6807\u5728\u7ec4\u7ec7\u4e2d\u4e5f\u786e\u5b9e\u53ef\u4ee5\u5171\u4eab\u4fe1\u606f\u3002\u4e00\u6761\u5f88\u7a84\u7684\u7a7a\u8154\u4e24\u4fa7\u5728\u5e73\u9762\u4e0a\u8ddd\u79bb\u5f88\u8fd1\uff0c\u7ec4\u7ec7\u4e0a\u5374\u53ef\u80fd\u5206\u5c5e\u4e24\u4e2a\u65b9\u5411\u76f8\u53cd\u7684\u4e0a\u76ae\u8868\u9762\u3002\u82e5\u628a\u5207\u7247\u4e0a\u7684\u4e24\u4e2a\u72ec\u7acb\u7ec4\u7ec7\u5757\u62fc\u6210\u4e00\u5f20\u56fe\uff0c\u7a7a\u767d\u88ab\u88c1\u6389\u540e\u672c\u6765\u79bb\u5f97\u5f88\u8fdc\u7684\u533a\u57df\u4e5f\u53ef\u80fd\u53d8\u6210\u90bb\u8fd1\u3002<a style=\"color:#3b6981;text-decoration:underline;text-underline-offset:2px\" href=\"https:\/\/www.nature.com\/articles\/s41587-022-01273-7\">CARD \u539f\u8bba\u6587\u5173\u4e8e\u7a7a\u95f4\u76f8\u5173\u6027\u4e0e\u672a\u6d4b\u4f4d\u7f6e\u63a8\u65ad\u7684\u8bf4\u660e<\/a><\/p>\n<p>\u4ece\u6700\u5bb9\u6613\u89e3\u91ca\u7684\u4f8b\u5b50\u60f3\u8d77\u3002\u4e00\u4e2a\u70b9\u7684\u90bb\u5c45\u4e2d\u4e5d\u4e2a\u5c5e\u4e8e\u4e0a\u76ae\uff0c\u4e00\u4e2a\u5c5e\u4e8e\u57fa\u8d28\u3002\u8be5\u70b9\u4f4d\u4e8e\u539a\u5b9e\u7684\u4e0a\u76ae\u5185\u90e8\u65f6\uff0c\u90bb\u91cc\u8bc1\u636e\u901a\u5e38\u4e0e\u5f62\u6001\u543b\u5408\u3002\u82e5\u5b83\u4f4d\u4e8e\u4e0a\u76ae\u548c\u57fa\u8d28\u4e4b\u95f4\u4e00\u6761\u53ea\u6709\u4e00\u4e2a\u70b9\u5bbd\u7684\u771f\u5b9e\u5206\u754c\u7ebf\u4e0a\uff0c\u540c\u6837\u7684\u4e5d\u6bd4\u4e00\u53ef\u80fd\u63a9\u76d6\u8fd9\u6761\u7a84\u5e26\u3002\u63a5\u4e0b\u6765\u5e94\u8be5\u627e\u5c40\u90e8\u72ec\u7acb\u8bc1\u636e\uff0c\u4f8b\u5982\u591a\u79cd\u57fa\u8d28\u6807\u8bb0\u80fd\u5426\u540c\u65f6\u68c0\u51fa\u3001\u5728\u8fde\u7eed\u5207\u7247\u4e0a\u80fd\u5426\u770b\u5230\u76f8\u5e94\u8d70\u5411\u3002\u53ea\u5728\u5df2\u7ecf\u753b\u51fa\u7684\u5e73\u6ed1\u4e30\u5ea6\u56fe\u4e0a\u6765\u56de\u7f29\u653e\uff0c\u5e76\u4e0d\u4f1a\u589e\u52a0\u9274\u522b\u80fd\u529b\u3002<\/p>\n<div class=\"guide-table\" style=\"max-width:100%;overflow-x:auto;margin:18px 0\">\n<table style=\"display:table;width:100%;max-width:100%;min-width:0;table-layout:fixed;border-collapse:collapse;font-size:.92em;line-height:1.6\">\n<thead>\n<tr>\n<th scope=\"col\" style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;background:#edf7fc;color:#1e293b;vertical-align:top;text-align:left;padding:6px;border:1px solid #c4cfdb\">\u8981\u533a\u5206\u7684\u95ee\u9898<\/th>\n<th scope=\"col\" style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;background:#edf7fc;color:#1e293b;vertical-align:top;text-align:left;padding:6px;border:1px solid #c4cfdb\">\u4fdd\u6301\u4e00\u81f4\u7684\u8f93\u5165<\/th>\n<th scope=\"col\" style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;background:#edf7fc;color:#1e293b;vertical-align:top;text-align:left;padding:6px;border:1px solid #c4cfdb\">\u6539\u53d8\u6216\u53e6\u67e5\u7684\u8bc1\u636e<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u8868\u8fbe\u5f3a\u5230\u8db3\u4ee5\u5355\u72ec\u786e\u5b9a\u4e3b\u5bfc\u7c7b\u578b\u5417<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u540c\u4e00\u53c2\u8003\u3001\u8ba1\u6570\u548c\u6761\u5f62\u7801<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u968f\u673a\u91cd\u914d\u5750\u6807\uff0c\u518d\u6838\u4e3b\u5bfc\u6807\u7b7e\u548c\u8fde\u7eed\u6743\u91cd<\/td>\n<\/tr>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u4e00\u6761\u7a84\u8fb9\u754c\u662f\u5426\u53d7\u9644\u8fd1\u70b9\u7275\u5f15<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u539f\u59cb\u7ec4\u7ec7\u56fe\u53ca\u6355\u83b7\u8303\u56f4<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u5206\u522b\u62bd\u53d6\u7ec4\u7ec7\u5185\u90e8\u3001\u8fb9\u754c\u548c\u7a7a\u8154\u5bf9\u5cb8\u7684\u70b9<\/td>\n<\/tr>\n<tr>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u65b0\u7f51\u683c\u4e0a\u7684\u6570\u662f\u600e\u6837\u5f97\u5230\u7684<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u539f\u59cb\u6d4b\u91cf\u4f4d\u7f6e\u548c\u5df2\u62df\u5408\u6a21\u578b<\/td>\n<td style=\"white-space:normal;overflow-wrap:anywhere;word-break:normal;padding:6px;vertical-align:top;border:1px solid #c4cfdb\">\u6807\u8bb0\u63d2\u503c\u4f4d\u7f6e\uff0c\u7528\u771f\u5b9e\u906e\u76d6\u70b9\u4f5c\u9a8c\u8bc1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<figure class=\"guide-figure\" style=\"margin:24px 0 28px\"><img loading=\"lazy\" decoding=\"async\" src=\"\/wordpress\/wp-content\/uploads\/2026\/11\/card-spatial-deconvolution-shuffled-coordinates-boundaries-guide.png\" alt=\"\u4ea4\u6362\u5750\u6807\uff0c\u4e30\u5ea6\u4f1a\u8ddf\u7740\u8d70\u5417\u3002\u6a21\u62df\u5b9e\u8dd1\uff5c\u56fa\u5b9a\u8ba1\u6570\u548c\u53c2\u8003\uff0c\u6bd4\u8f83\u540c\u4e00\u70b9\u7684\u4e24\u6b21\u6743\u91cd\u3002\u539f\u56fe\uff0c48 \u4e2a\u70b9\uff0c\u4e09\u79cd\u7c7b\u578b\u7684\u6807\u8bb0\u6e05\u695a\uff0c\u53d6\u5404\u70b9\u4e3b\u5bfc\u7c7b\u578b\u3002\u6253\u4e71\uff0c48 \u4e2a\u4ecd\u4e00\u81f4\uff0c\u7ec6\u80de\u7c7b\u578b\u548c\u6761\u5f62\u7801\u4fdd\u6301\u5bf9\u5e94\uff0c\u53ea\u91cd\u914d\u5750\u6807\u3002\u9010\u683c\uff0c\u6700\u5927\u5dee\u7ea6 0.00017\uff0c\u6807\u7b7e\u90fd\u4e00\u81f4\uff0c\u4ecd\u80fd\u6d4b\u51fa\u8fde\u7eed\u6743\u91cd\u7684\u5c0f\u53d8\u5316\u3002\" width=\"1200\" height=\"840\" style=\"display:block;width:100%;height:auto;border-radius:10px\"><figcaption style=\"font-size:14px;line-height:1.6;margin:9px 2px 0;color:#475569\">\u6a21\u62df\u5b9e\u8dd1\uff5c\u56fa\u5b9a\u8ba1\u6570\u548c\u53c2\u8003\uff0c\u6bd4\u8f83\u540c\u4e00\u70b9\u7684\u4e24\u6b21\u6743\u91cd\u3002<\/figcaption><\/figure>\n<h2 style=\"font-size:1.38em;line-height:1.5;margin:1.55em 0 .55em;color:#182d43\">\u7ed9\u539f\u59cb\u6761\u5f62\u7801\u6362\u5750\u6807\uff0c\u522b\u628a\u77e9\u9635\u548c\u5750\u6807\u4e00\u8d77\u6d17\u724c<\/h2>\n<p>\u5f88\u591a\u5bf9\u7167\u5b9e\u9a8c\u5931\u8d25\u5728\u4e00\u4e2a\u770b\u4e0d\u89c1\u7684\u5730\u65b9\u3002\u5982\u679c\u628a\u7a7a\u95f4\u8868\u8fbe\u77e9\u9635\u7684\u5217\u4e0e\u5750\u6807\u8868\u7684\u884c\u7528\u540c\u4e00\u4e2a\u6392\u5217\u540c\u65f6\u632a\u52a8\uff0c\u518d\u8fde\u540c\u6761\u5f62\u7801\u4e00\u8d77\u4fdd\u5b58\uff0c\u53ea\u662f\u6539\u53d8\u4e86\u6587\u4ef6\u7684\u884c\u5217\u987a\u5e8f\uff0c\u6bcf\u4e2a\u70b9\u548c\u81ea\u5df1\u7684\u7ec4\u7ec7\u4f4d\u7f6e\u4ecd\u7136\u7ed1\u5728\u4e00\u8d77\u3002\u6b63\u786e\u7684\u64cd\u4f5c\u662f\u56fa\u5b9a\u8868\u8fbe\u548c\u6761\u5f62\u7801\uff0c\u91cd\u65b0\u7ed9\u8fd9\u4e9b\u6761\u5f62\u7801\u5206\u914d\u4e00\u7ec4\u6253\u4e71\u7684\u5750\u6807\u3002\u8fd8\u8981\u9632\u6b62\u5bf9\u8c61\u6784\u9020\u51fd\u6570\u6309\u884c\u540d\u91cd\u6392\u65f6\uff0c\u53c8\u628a\u5750\u6807\u6062\u590d\u6210\u539f\u914d\u5bf9\u3002\u5b9e\u8df5\u4e2d\u53ef\u4ee5\u62bd\u4e09\u679a\u76f8\u8ddd\u8f83\u8fdc\u7684\u6761\u5f62\u7801\uff0c\u5728\u8f93\u5165\u539f\u7248\u548c\u5bf9\u7167\u7248\u4e2d\u6253\u5370\u5b83\u4eec\u7684\u8ba1\u6570\u603b\u548c\u3001\u6a2a\u7eb5\u5750\u6807\u548c\u90bb\u8fd1\u6761\u5f62\u7801\u3002\u8ba1\u6570\u503c\u5e94\u4e0d\u53d8\uff0c\u5c40\u90e8\u90bb\u5c45\u5e94\u6539\u53d8\u3002<\/p>\n<pre style=\"max-width:100%;box-sizing:border-box;overflow-x:auto;margin:18px 0;padding:14px 16px;background:#f3f6fa;color:#1a293c;border:1px solid #d8e1ea;border-radius:8px;line-height:1.55;white-space:pre;overflow-wrap:normal;word-break:normal\"><code class=\"language-r\"># \u884c\u540d\u662f\u552f\u4e00\u70b9\u4f4d\u6761\u5f62\u7801\uff0cxy \u662f\u539f\u59cb\u4e8c\u7ef4\u5750\u6807\u77e9\u9635\r\nset.seed(73)\r\nshuffled_xy &lt;- xy[sample(nrow(xy)), , drop = FALSE]\r\nrownames(shuffled_xy) &lt;- rownames(xy)\r\nstopifnot(identical(rownames(shuffled_xy), rownames(xy)))\r\nhead(cbind(xy, shuffled_xy))\r\n<\/code><\/pre>\n<p>\u5982\u679c\u9879\u76ee\u6709\u591a\u5f20\u5207\u7247\uff0c\u5e94\u5728\u6bcf\u5f20\u5207\u7247\u5185\u90e8\u8003\u8651\u8fd9\u4e2a\u5bf9\u7167\uff0c\u5e76\u6309\u539f\u5b9e\u9a8c\u8bbe\u8ba1\u51b3\u5b9a\u54ea\u4e9b\u4f4d\u7f6e\u53ef\u4ee5\u4e92\u6362\u3002\u5168\u7247\u6253\u4e71\u80fd\u7834\u574f\u5927\u5c3a\u5ea6\u7ec4\u7ec7\u5206\u533a\uff0c\u9002\u5408\u63a2\u67e5\u603b\u4f53\u7a7a\u95f4\u4f9d\u8d56\u3002\u82e5\u95ee\u9898\u662f\u540c\u4e00\u7ec4\u7ec7\u533a\u5185\u90e8\u662f\u5426\u4ecd\u6709\u5c40\u90e8\u5206\u5e03\uff0c\u5219\u53ef\u4ee5\u53ea\u5728\u540c\u7c7b\u7ec4\u7ec7\u533a\u57df\u5185\u6253\u4e71\u3002\u4e24\u79cd\u505a\u6cd5\u4fdd\u7559\u7684\u7ed3\u6784\u4e0d\u540c\uff0c\u5e94\u5206\u522b\u7ed9\u7ed3\u679c\u8d77\u6e05\u695a\u7684\u540d\u79f0\u3002\u628a\u6240\u6709\u75c5\u4eba\u3001\u5207\u7247\u548c\u7269\u7406\u5355\u4f4d\u6df7\u5728\u4e00\u8d77\u968f\u673a\uff0c\u968f\u540e\u5f97\u51fa\u7684\u53d8\u5316\u51e0\u4e4e\u65e0\u6cd5\u5f52\u56e0\u3002\u8fd9\u4e2a\u5bf9\u7167\u7528\u4e8e\u8bca\u65ad\u7ed3\u679c\u5bf9\u5750\u6807\u7684\u654f\u611f\u7a0b\u5ea6\uff0c\u672c\u8eab\u4e0d\u4f1a\u63d0\u4f9b\u6a21\u578b\u6b63\u786e\u4e0e\u5426\u7684\u75c5\u7406\u771f\u503c\u3002<\/p>\n<h2 style=\"font-size:1.38em;line-height:1.5;margin:1.55em 0 .55em;color:#182d43\">\u5b9e\u8dd1\u7ecf\u9a8c\uff5c\u8fd9\u6b21\u5750\u6807\u6362\u4e86\uff0c\u56db\u5341\u516b\u4e2a\u4e3b\u5bfc\u6807\u7b7e\u4e00\u4e2a\u4e5f\u6ca1\u6709\u6362<\/h2>\n<p>\u6211\u4eec\u5728 R 4.5.2 \u5b89\u88c5 Bioconductor \u7248 CARDspa 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