{"id":72643,"date":"2026-11-15T08:31:06","date_gmt":"2026-11-15T00:31:06","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=72643"},"modified":"2026-11-15T08:31:06","modified_gmt":"2026-11-15T00:31:06","slug":"concoct-cutup-majority-merge-tie-chimera","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/concoct-cutup-majority-merge-tie-chimera\/","title":{"rendered":"CONCOCT \u7684\u5b50\u7247\u6bb5\u5206\u5bf9\u4e86\uff0c\u6574\u6761\u5e8f\u5217\u4e3a\u4ec0\u4e48\u8fd8\u4f1a\u8fdb\u9519\u7bb1\uff1f\u5b9e\u8dd1\u68c0\u67e5\u591a\u6570\u5408\u5e76\u4e0e\u5e73\u7968\u5f52\u5c5e"},"content":{"rendered":"
\n

\u5206\u7bb1\u7ed3\u679c\u4e2d\u7684\u4e00\u6761\u957f\u7247\u6bb5\uff0c\u770b\u8d77\u6765\u5c5e\u4e8e\u67d0\u4e2a\u57fa\u56e0\u7ec4\u7bb1\uff0c\u91cc\u9762\u5374\u51fa\u73b0\u4e0e\u5176\u4f59\u6210\u5458\u4e0d\u4e00\u81f4\u7684\u5206\u7c7b\u4fe1\u53f7\u3002\u6392\u67e5\u65f6\u9664\u4e86\u770b\u805a\u7c7b\u6a21\u578b\uff0c\u8fd8\u8981\u8ffd\u8e2a\u5b50\u7247\u6bb5\u6807\u7b7e\u5982\u4f55\u5408\u56de\u539f\u59cb\u5e8f\u5217\u3002CONCOCT \u7684\u5e38\u89c1\u6d41\u7a0b\u4f1a\u5148\u5207\u957f\u7247\u6bb5\uff0c\u8ba1\u7b97\u6bcf\u4e2a\u5b50\u7247\u6bb5\u7684\u7ec4\u6210\u4e0e\u8986\u76d6\uff0c\u518d\u628a\u6807\u7b7e\u5408\u56de\u53bb\u3002\u82e5\u539f\u59cb\u7247\u6bb5\u672c\u8eab\u8fde\u63a5\u4e86\u4e0d\u540c\u6765\u6e90\u7684\u533a\u6bb5\uff0c\u524d\u9762\u7684\u5c40\u90e8\u5206\u7ec4\u53ef\u80fd\u51c6\u786e\u63ed\u793a\u4e86\u77db\u76fe\uff0c\u540e\u9762\u7684\u5408\u5e76\u53c8\u4f1a\u628a\u6574\u6761\u7247\u6bb5\u4ea4\u7ed9\u5176\u4e2d\u4e00\u4e2a\u7bb1\u3002\u6211\u4eec\u7528\u4e24\u4e2a\u660e\u786e\u8bbe\u8ba1\u7684\u5d4c\u5408\u7247\u6bb5\uff0c\u5b9e\u9645\u8dd1\u5b8c\u5207\u7247\u3001\u805a\u7c7b\u3001\u5408\u5e76\u548c\u5e8f\u5217\u63d0\u53d6\uff0c\u89c2\u5bdf\u8fd9\u4e00\u6b65\u5230\u5e95\u53d1\u751f\u4e86\u4ec0\u4e48\u3002<\/p>\n

\u5207\u7247\u89e3\u51b3\u4e86\u4ec0\u4e48\u95ee\u9898\uff0c\u53c8\u7559\u4e0b\u4e86\u4ec0\u4e48\u95ee\u9898<\/h2>\n

\u957f\u7247\u6bb5\u5305\u542b\u7684\u78b1\u57fa\u66f4\u591a\uff0c\u5e8f\u5217\u7ec4\u6210\u4f30\u8ba1\u901a\u5e38\u66f4\u7a33\u5b9a\uff0c\u4f46\u957f\u5ea6\u5dee\u5f02\u5f88\u5927\u7684\u7247\u6bb5\u653e\u5728\u540c\u4e00\u805a\u7c7b\u6d41\u7a0b\u4e2d\uff0c\u4e5f\u53ef\u80fd\u8ba9\u4fe1\u606f\u5c3a\u5ea6\u4e0d\u4e00\u81f4\u3002CONCOCT \u7684\u6807\u51c6\u7528\u6cd5\u5305\u542b\u6309\u56fa\u5b9a\u957f\u5ea6\u5207\u7247\uff0c\u518d\u4e3a\u8fd9\u4e9b\u5b50\u7247\u6bb5\u751f\u6210\u6837\u672c\u8986\u76d6\u8868\u3002\u8fd9\u6837\u53ef\u4ee5\u7528\u5c40\u90e8\u7ec4\u6210\u548c\u5c40\u90e8\u8986\u76d6\u63cf\u8ff0\u4e00\u6761\u957f\u5e8f\u5217\u7684\u4e0d\u540c\u533a\u6bb5\u3002\u5b9e\u9645\u5de5\u4f5c\u4e2d\u5c24\u5176\u5e94\u68c0\u67e5\u5b50\u7247\u6bb5\u4e4b\u95f4\u662f\u5426\u5177\u6709\u4e00\u81f4\u4fe1\u53f7\u3002\u82e5\u540c\u4e00\u539f\u59cb\u5e8f\u5217\u7684\u524d\u540e\u533a\u6bb5\u88ab\u5206\u5230\u4e0d\u540c\u7c07\uff0c\u53ef\u80fd\u6d89\u53ca\u7ec4\u88c5\u5d4c\u5408\u3001\u91cd\u590d\u3001\u62f7\u8d1d\u6570\u5dee\u5f02\u3001\u6c34\u5e73\u8f6c\u79fb\u533a\u57df\uff0c\u6216\u8005\u5f53\u524d\u6a21\u578b\u5728\u8be5\u5904\u7684\u533a\u5206\u4e0d\u786e\u5b9a\u6027\u3002\u4f5c\u8005\u5de5\u4f5c\u6d41\u7a0b<\/a> \u00b7 CONCOCT \u9879\u76ee\u4ee3\u7801<\/a><\/p>\n

\u89c2\u5bdf\u5230\u5206\u6bb5\u6807\u7b7e\u4e0d\u4e00\u81f4\u4ee5\u540e\uff0c\u4e0b\u4e00\u6b65\u9700\u8981\u5224\u65ad\u8fd9\u4e2a\u4e0d\u4e00\u81f4\u7684\u6765\u6e90\u3002\u5c40\u90e8\u6807\u7b7e\u63d0\u4f9b\u4e86\u68c0\u67e5\u4f4d\u7f6e\uff0c\u4ecd\u8981\u56de\u5230\u539f\u59cb\u8bfb\u6bb5\u3001\u7ec4\u88c5\u56fe\u548c\u6ce8\u91ca\u8bc1\u636e\u5224\u65ad\u662f\u5426\u5b58\u5728\u9519\u8bef\u8fde\u63a5\u3002\u67d0\u4e2a\u57fa\u56e0\u7ec4\u91cc\u7684\u771f\u5b9e\u5916\u6e90\u533a\u6bb5\uff0c\u4e5f\u53ef\u80fd\u5728\u7ec4\u6210\u4e0a\u504f\u79bb\u4e3b\u4f53\u3002\u76f8\u53cd\uff0c\u4e00\u6bb5\u4eba\u5de5\u8bef\u62fc\u63a5\u5728\u6574\u4f53\u957f\u5ea6\u4e0e\u5e73\u5747\u6df1\u5ea6\u4e0a\u4e5f\u53ef\u80fd\u770b\u8d77\u6765\u6b63\u5e38\u3002\u4fdd\u5b58\u6bcf\u4e2a\u5b50\u7247\u6bb5\u7684\u539f\u59cb\u5750\u6807\u3001\u8986\u76d6\u548c\u805a\u7c7b\u6807\u7b7e\uff0c\u80fd\u8ba9\u8fd9\u4e9b\u4e0d\u540c\u89e3\u91ca\u6709\u673a\u4f1a\u63a5\u53d7\u68c0\u9a8c\u3002<\/p>\n

\"\u5c40\u90e8\u5206\u5bf9\uff0c\u6574\u4f53\u4ecd\u53ef\u80fd\u6df7\u5165\u3002\u540c\u4e00\u4efd\u805a\u7c7b\u8868\u5012\u5e8f\u540e\uff0c\u5e73\u7968\u7247\u6bb5\u6362\u4e86\u5f52\u5c5e\u3002\u5b50\u7247\u6bb5\u805a\u7c7b\uff0c\u7532
\u540c\u4e00\u4efd\u805a\u7c7b\u8868\u5012\u5e8f\u540e\uff0c\u5e73\u7968\u7247\u6bb5\u6362\u4e86\u5f52\u5c5e<\/figcaption><\/figure>\n

\u5b9e\u8dd1\u7ecf\u9a8c \u00b7 \u516d\u5341\u6761\u6b63\u5e38\u7247\u6bb5\u52a0\u4e24\u6761\u6709\u610f\u8bbe\u8ba1\u7684\u5d4c\u5408\u5e8f\u5217<\/h2>\n

\u5b9e\u9a8c\u4f7f\u7528 CONCOCT 1.1.0\uff0c\u4ee5\u56fa\u5b9a\u968f\u673a\u79cd\u5b50\u751f\u6210\u4e24\u7c7b\u4eba\u5de5\u5e8f\u5217\u3002\u6bcf\u7c7b\u6709\u4e09\u5341\u6761\u4e24\u4e07\u78b1\u57fa\u7684\u6b63\u5e38\u7247\u6bb5\uff0c\u4e24\u7c7b\u7684\u78b1\u57fa\u7ec4\u6210\u4e0d\u540c\uff0c\u5728\u56db\u4e2a\u8bbe\u8ba1\u6837\u672c\u4e2d\u4e5f\u6709\u76f8\u53cd\u7684\u6df1\u5ea6\u53d8\u5316\u3002\u518d\u52a0\u5165\u4e24\u6761\u5d4c\u5408\u5e8f\u5217\u3002\u7b2c\u4e00\u6761\u957f\u4e09\u4e07\u78b1\u57fa\uff0c\u524d\u4e00\u4e07\u6765\u81ea\u7532\u7c7b\uff0c\u540e\u4e24\u4e07\u6765\u81ea\u4e59\u7c7b\u3002\u7b2c\u4e8c\u6761\u957f\u4e24\u4e07\uff0c\u524d\u540e\u5404\u4e00\u4e07\u6765\u81ea\u7532\u4e59\u4e24\u7c7b\u3002\u5b83\u4eec\u662f\u4e3a\u4e86\u68c0\u9a8c\u540e\u5904\u7406\u800c\u660e\u786e\u6784\u9020\u7684\u53cd\u4f8b\uff0c\u6765\u6e90\u6807\u7b7e\u5728\u751f\u6210\u65f6\u5df2\u7ecf\u77e5\u9053\uff0c\u4e0d\u80fd\u7528\u6b64\u6f14\u793a\u7684\u5206\u79bb\u7a0b\u5ea6\u4f30\u8ba1\u81ea\u7136\u7fa4\u843d\u7684\u51c6\u786e\u7387\u3002<\/p>\n

\u9996\u5148\u6267\u884c\u4f5c\u8005\u7684\u5207\u7247\u7a0b\u5e8f\uff0c\u7247\u6bb5\u957f\u5ea6\u4e00\u4e07\u3001\u91cd\u53e0\u957f\u5ea6\u96f6\uff0c\u5e76\u542f\u7528\u5408\u5e76\u672b\u5c3e\u77ed\u7247\u6bb5\u7684\u9009\u9879\u3002\u516d\u5341\u4e8c\u6761\u539f\u59cb\u5e8f\u5217\u5f97\u5230\u4e00\u767e\u4e8c\u5341\u4e94\u4e2a\u5b50\u7247\u6bb5\uff0c\u518d\u6309\u6bcf\u6bb5\u5df2\u77e5\u6765\u6e90\u751f\u6210\u56db\u5217\u8bbe\u8ba1\u8986\u76d6\u3002\u968f\u540e\u8c03\u7528\u5b8c\u6574\u805a\u7c7b\u5165\u53e3\uff0c\u56fa\u5b9a\u79cd\u5b50\u4e09\u5341\u4e03\u3001\u4e24\u4e2a\u7ebf\u7a0b\u3001\u56db\u4e2a\u521d\u59cb\u7c07\u4e0e\u6700\u591a\u4e24\u767e\u6b21\u8fed\u4ee3\u3002\u6700\u7ec8\u7532\u7c7b\u7684\u516d\u5341\u4e8c\u4e2a\u5b50\u7247\u6bb5\u5168\u90e8\u5728\u672c\u6b21\u7f16\u53f7\u4e3a\u96f6\u7684\u7c07\uff0c\u4e59\u7c7b\u516d\u5341\u4e09\u4e2a\u5168\u90e8\u5728\u7f16\u53f7\u4e3a\u4e00\u7684\u7c07\u3002\u4e24\u4e2a\u5d4c\u5408\u7247\u6bb5\u5185\u90e8\u7684\u4e0d\u540c\u533a\u6bb5\uff0c\u4e5f\u5206\u522b\u843d\u5230\u5bf9\u5e94\u6765\u6e90\u7684\u7c07\u3002\u8f93\u5165\u751f\u6210\u5668\u3001\u5b8c\u6574\u8c03\u7528\u4e0e\u5b9e\u6d4b\u7ed3\u679c<\/a><\/p>\n

python3 109-concoct\/run.py "$(command -v concoct)" \\\r\n  "$(dirname "$(command -v cut_up_fasta.py)")" work109\r\n\r\n# \u5355\u72ec\u68c0\u67e5\u6807\u7b7e\u5408\u5e76\u65f6\uff0c\u4e00\u5e76\u4fdd\u5b58\u8b66\u544a\r\nmerge_cutup_clustering.py work109\/model\/clustering_gt1000.csv \\\r\n  > merged.csv 2> merged.warnings.txt\r\n<\/code><\/pre>\n
\u8fd0\u884c\u73af\u5883\u9700\u8981\u4e00\u8d77\u4fdd\u7559\u3002\u672c\u6b21\u4f7f\u7528 Python 3.11\u3001NumPy 1.26.4\u3001pandas 1.5.3\u3001SciPy 1.13.1 \u4e0e scikit-learn 1.1.3\u3002\u5f00\u59cb\u4f7f\u7528\u8f83\u65b0\u7684 scikit-learn 1.8.0 \u65f6\uff0c\u539f\u7248\u5165\u53e3\u5728\u4e3b\u6210\u5206\u5206\u6790\u4e4b\u524d\u56e0\u6df7\u5408\u5217\u540d\u7c7b\u578b\u800c\u62a5\u9519\u3002\u56fa\u5b9a\u517c\u5bb9\u4f9d\u8d56\u540e\u5b8c\u6210\u4e86\u5168\u6d41\u7a0b\u3002\u8fd9\u4e2a\u9519\u8bef\u53d1\u751f\u5728\u7279\u5f81\u8f93\u5165\u68c0\u67e5\u9636\u6bb5\uff0c\u4e0d\u80fd\u636e\u6b64\u8bc4\u4ef7\u6570\u636e\u80fd\u5426\u5206\u7bb1\u3002\u590d\u8dd1\u65f6\u5148\u8ba9\u540c\u4e00\u4efd\u5c0f\u4f8b\u5b50\u901a\u8fc7\u5e76\u786e\u8ba4\u8f93\u51fa\u5b57\u6bb5\uff0c\u518d\u66ff\u6362\u81ea\u5df1\u7684\u8f93\u5165\uff0c\u53ef\u4ee5\u51cf\u5c11\u73af\u5883\u5dee\u5f02\u4e0e\u751f\u7269\u5b66\u5dee\u5f02\u6df7\u5728\u4e00\u8d77\u7684\u60c5\u51b5\u3002<\/p>\n
\n\n\n\n\n\n\n
\u539f\u59cb\u7247\u6bb5<\/th>\n\u5b50\u7247\u6bb5\u5b9e\u9645\u6807\u7b7e<\/th>\n\u539f\u987a\u5e8f\u5408\u56de\u540e\u7684\u6807\u7b7e<\/th>\n\u5012\u5e8f\u8bb0\u5f55\u518d\u5408\u56de\u540e\u7684\u6807\u7b7e<\/th>\n<\/tr>\n<\/thead>\n
\u4e09\u4e07\u78b1\u57fa\u5d4c\u5408\u7247\u6bb5<\/td>\n\u7532\u3001\u4e59\u3001\u4e59<\/td>\n\u4e59<\/td>\n\u4e59<\/td>\n<\/tr>\n
\u4e24\u4e07\u78b1\u57fa\u5d4c\u5408\u7247\u6bb5<\/td>\n\u7532\u3001\u4e59<\/td>\n\u7532<\/td>\n\u4e59<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\u7b2c\u4e8c\u6b21\u5408\u5e76\u6cbf\u7528\u5df2\u7ecf\u8ba1\u7b97\u597d\u7684\u805a\u7c7b\u8868\uff0c\u53ea\u628a\u8bb0\u5f55\u884c\u987a\u5e8f\u5012\u7f6e\u3002\u539f\u59cb\u5e8f\u5217\u3001\u5b50\u7247\u6bb5\u6807\u7b7e\u548c\u6a21\u578b\u90fd\u6ca1\u6709\u91cd\u65b0\u8ba1\u7b97\u3002\u5bf9\u4e8e\u4e24\u7968\u5bf9\u4e00\u7968\u7684\u7247\u6bb5\uff0c\u5408\u5e76\u4ecd\u9009\u4e59\u3002\u5bf9\u4e8e\u4e00\u7968\u5bf9\u4e00\u7968\u7684\u7247\u6bb5\uff0c\u5408\u5e76\u7ed3\u679c\u4ece\u7532\u53d8\u6210\u4e59\u3002\u4e24\u6b21\u90fd\u771f\u6b63\u8c03\u7528\u4e86\u539f\u4f5c\u8005\u7684\u5408\u5e76\u811a\u672c\uff0c\u4e4b\u540e\u53c8\u8c03\u7528\u5e8f\u5217\u63d0\u53d6\u811a\u672c\uff0c\u4ece\u539f\u59cb FASTA \u751f\u6210\u5bf9\u5e94\u7bb1\u6587\u4ef6\u3002\u7b2c\u4e00\u6b21\u5b8c\u6574\u7684\u5e73\u7968\u7247\u6bb5\u8fdb\u5165\u7532\u7bb1\uff0c\u7b2c\u4e8c\u6b21\u5219\u5b8c\u6574\u8fdb\u5165\u4e59\u7bb1\u3002<\/p>\n
\u4e3a\u4ec0\u4e48\u770b\u5230\u8b66\u544a\u4ee5\u540e\u4ecd\u7136\u4f1a\u5f97\u5230\u4e00\u4e2a\u6807\u7b7e<\/h2>\n
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