{"id":72718,"date":"2026-11-15T10:11:56","date_gmt":"2026-11-15T02:11:56","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=72718"},"modified":"2026-11-15T10:11:56","modified_gmt":"2026-11-15T02:11:56","slug":"virtual-cell-piano-unseen-interventions-20261115","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/virtual-cell-piano-unseen-interventions-20261115\/","title":{"rendered":"PIANO\u4e4b\u540e\uff1a\u865a\u62df\u7ec6\u80de\u600e\u6837\u8bc1\u660e\u81ea\u5df1\u9884\u6d4b\u4e86\u201c\u672a\u77e5\u5e72\u9884\u201d\uff1f"},"content":{"rendered":"<div id=\"articleContent\" style=\"max-width:860px;margin:0 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href=\"https:\/\/github.com\/NingWang1729\/piano\/blob\/ed35eb3575c00acc17f3598a7f5af06d0fa72278\/piano\/models\/base_models.py\">\u56fa\u5b9a\u7248\u672c\u7684\u7f16\u7801\u4e0e\u89e3\u7801\u5b9e\u73b0<\/a><\/p>\n<figure style=\"margin:28px 0;\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/11\/virtual-cell-daily-20261115-piano-unseen-interventions-piano-intervention-evidence.png?resize=1080%2C1440&#038;ssl=1\" alt=\"\u865a\u62df\u7ec6\u80de\u672a\u77e5\u5e72\u9884\u9a8c\u8bc1\u6d77\u62a5\uff1aPIANO\u4f5c\u8005\u62a5\u544a\u4ebf\u7ea7\u6574\u5408\uff1b\u533a\u5206\u5df2\u77e5\u54cd\u5e94\u6062\u590d\u4e0e\u672a\u89c1\u6761\u4ef6\u9884\u6d4b\uff0c\u5148\u7559\u51fa\u5b8c\u6574\u6761\u4ef6\uff0c\u53ea\u7528\u5141\u8bb8\u8f93\u5165\uff0c\u518d\u7528\u54cd\u5e94\u53d8\u5316\u548c\u7b80\u5355\u57fa\u7ebf\u68c0\u9a8c\u589e\u91cf\" 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href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.08.06.743394v1.full\">\u4f5c\u8005\u9884\u5370\u672c\uff1a\u836f\u7269\u5efa\u6a21\u65b9\u6cd5<\/a><\/p>\n<p>\u5173\u952e\u95ee\u9898\u8fd8\u6709\u6f5c\u5728\u72b6\u6001\u6765\u81ea\u54ea\u91cc\u3002\u5982\u679c\u76ee\u6807\u662f\u201c\u5c1a\u672a\u7ed9\u836f\u65f6\u9884\u6d4b\u7ed9\u836f\u7ed3\u679c\u201d\uff0c\u8bc4\u4f30\u8f93\u5165\u539f\u5219\u4e0a\u5e94\u9650\u4e8e\u90a3\u65f6\u53ef\u83b7\u5f97\u7684\u4fe1\u606f\u3002\u82e5\u6f5c\u5728\u72b6\u6001\u5df2\u7ecf\u7531\u76ee\u6807\u6761\u4ef6\u4e0b\u7684\u5904\u7406\u540e\u8868\u8fbe\u63a8\u65ad\u51fa\u6765\uff0c\u4efb\u52a1\u5c31\u53d8\u6210\u5229\u7528\u90e8\u5206\u7ed3\u679c\u6062\u590d\u54cd\u5e94\uff1b\u8fd9\u4ecd\u53ef\u80fd\u6709\u5206\u6790\u4ef7\u503c\uff0c\u4f46\u7528\u9014\u9700\u8981\u53e6\u884c\u8bf4\u660e\u3002<\/p>\n<p>\u63a5\u53e3\u540d\u4e5f\u4e0d\u80fd\u66ff\u4ee3\u5b9e\u9a8c\u5b9a\u4e49\u3002PIANO\u7684get_counterfactual\u652f\u6301\u66f4\u6362\u534f\u53d8\u91cf\uff0c\u9ed8\u8ba4\u8bbe\u7f6e\u4f1a\u5e73\u5747\u7c7b\u522b\u534f\u53d8\u91cf\u7f16\u7801\u5e76\u4fdd\u7559\u8fde\u7eed\u503c\u3002\u7531\u6b64\u751f\u6210\u7684\u8868\u8fbe\uff0c\u662f\u5426\u5bf9\u5e94\u67d0\u4e2a\u771f\u5b9e\u5e72\u9884\uff0c\u9700\u8981\u7ed3\u5408\u6761\u4ef6\u8986\u76d6\u3001\u6df7\u6742\u56e0\u7d20\u4e0e\u5b9e\u9a8c\u5bf9\u7167\u5224\u65ad\uff1b\u4e0d\u80fd\u4ec5\u56e0\u51fd\u6570\u540d\u542b\u6709\u201c\u53cd\u4e8b\u5b9e\u201d\u5c31\u8ba4\u5b9a\u56e0\u679c\u6548\u5e94\u5df2\u88ab\u8bc6\u522b\u3002<a 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#dce6f3;vertical-align:top;\">\u9700\u8981\u5339\u914d\u5bf9\u7167\u3001\u91cd\u590d\u548c\u6d4b\u91cf\u6761\u4ef6\u8bb0\u5f55<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u5168\u65b0\u836f\u7269\u53c8\u662f\u53e6\u4e00\u9879\u4efb\u52a1\u3002\u5982\u679c\u65b9\u6cd5\u53ea\u7528\u8bad\u7ec3\u4e2d\u51fa\u73b0\u8fc7\u7684\u7c7b\u522b\u7f16\u7801\u8868\u793a\u836f\u7269\uff0c\u5c31\u8981\u5148\u8bf4\u660e\u600e\u6837\u8868\u5f81\u65b0\u836f\uff0c\u6216\u660e\u786e\u5f53\u524d\u63a5\u53e3\u4e0d\u652f\u6301\u8be5\u95ee\u9898\u3002\u80fd\u586b\u5199\u4e00\u4e2a\u6761\u4ef6\u5b57\u5178\uff0c\u4e0d\u4ee3\u8868\u6a21\u578b\u62e5\u6709\u76f8\u5e94\u7684\u96f6\u6837\u672c\u9884\u6d4b\u80fd\u529b\u3002<\/p>\n<h2 style=\"margin-top:34px;color:#173b6a;font-size:25px;line-height:1.5;\">\u8bc4\u4ef7\u54cd\u5e94\u53d8\u5316\uff0c\u624d\u80fd\u770b\u51fa\u6a21\u578b\u589e\u52a0\u4e86\u4ec0\u4e48<\/h2>\n<p>\u5982\u679c\u53ea\u6bd4\u8f83\u7ed9\u836f\u540e\u8868\u8fbe\u4e0e\u9884\u6d4b\u8868\u8fbe\u7684\u6574\u4f53\u76f8\u5173\u6027\uff0c\u7ec6\u80de\u8eab\u4efd\u548c\u539f\u6709\u9ad8\u8868\u8fbe\u57fa\u56e0\u53ef\u80fd\u8d21\u732e\u5927\u90e8\u5206\u76f8\u4f3c\u5ea6\u3002\u6211\u4eec\u5efa\u8bae\u628a\u4e3b\u8981\u76ee\u6807\u5199\u6210\u201c\u76f8\u5bf9\u4e8e\u5339\u914d\u5bf9\u7167\u7684\u53d8\u5316\u201d\uff0c\u540c\u65f6\u62a5\u544a\u7edd\u5bf9\u8868\u8fbe\u62df\u5408\uff0c\u8ba9\u8bfb\u8005\u770b\u89c1\u6a21\u578b\u6062\u590d\u7684\u662f\u57fa\u7ebf\u8fd8\u662f\u5904\u7406\u6548\u5e94\u3002<\/p>\n<p>\u5177\u4f53\u53ef\u6bd4\u8f83\u54cd\u5e94\u65b9\u5411\u3001\u6548\u5e94\u5927\u5c0f\u3001\u9884\u5148\u786e\u5b9a\u57fa\u56e0\u96c6\u7684\u6392\u5e8f\uff0c\u4ee5\u53ca\u4e0d\u540c\u91cd\u590d\u4e4b\u95f4\u7684\u4e00\u81f4\u6027\u3002\u57fa\u56e0\u96c6\u4e0e\u8bc4\u4ef7\u89c4\u5219\u5e94\u5728\u5f00\u53d1\u9636\u6bb5\u786e\u5b9a\uff1b\u4e0d\u80fd\u770b\u5b8c\u6d4b\u8bd5\u7ed3\u679c\uff0c\u518d\u53ea\u6311\u8868\u73b0\u597d\u7684\u57fa\u56e0\u3002\u7b80\u5355\u57fa\u7ebf\u4e5f\u5e94\u4f7f\u7528\u540c\u6837\u5141\u8bb8\u83b7\u5f97\u7684\u4fe1\u606f\uff0c\u4f8b\u5982\u76f4\u63a5\u6cbf\u7528\u5bf9\u7167\u8868\u8fbe\uff0c\u6216\u91c7\u7528\u8bad\u7ec3\u6570\u636e\u4e2d\u53ef\u5f97\u5230\u7684\u5e73\u5747\u54cd\u5e94\u3002<\/p>\n<p>\u8fd9\u4e0d\u662f\u8981\u6c42\u6240\u6709\u4efb\u52a1\u4f7f\u7528\u540c\u4e00\u4e2a\u5206\u6570\u3002\u5f3a\u6548\u836f\u7269\u4e0e\u5f31\u6548\u836f\u7269\u3001\u4e0d\u540c\u7ec6\u80de\u7cfb\u53ca\u4e0d\u540c\u5242\u91cf\u7684\u96be\u5ea6\u53ef\u80fd\u4e0d\u540c\uff0c\u5e94\u5206\u522b\u5c55\u793a\u7ed3\u679c\uff0c\u5e76\u6309\u72ec\u7acb\u751f\u7269\u5b66\u91cd\u590d\u4f30\u8ba1\u4e0d\u786e\u5b9a\u6027\u3002\u6a21\u578b\u5728\u90e8\u5206\u6761\u4ef6\u6709\u589e\u91cf\uff0c\u4e5f\u5e94\u5199\u6e05\u8fd9\u4e9b\u6761\u4ef6\uff1b\u4e00\u4e2a\u603b\u5e73\u5747\u503c\u4e0d\u8db3\u4ee5\u652f\u6491\u6240\u6709\u7528\u9014\u3002<\/p>\n<h2 style=\"margin-top:34px;color:#173b6a;font-size:25px;line-height:1.5;\">\u4ea7\u4e1a\u5408\u4f5c\u4e3a\u4f55\u8ba9\u9a8c\u6536\u66f4\u91cd\u8981<\/h2>\n<p>11\u67089\u65e5\uff0cDeepLife\u7f72\u540d\u516c\u544a\u5ba3\u5e03\u4e0e3billion\u5408\u4f5c\uff0c\u628aTwinCell\u865a\u62df\u7ec6\u80de\u5e73\u53f0\u4e0e\u60a3\u8005\u57fa\u56e0\u7ec4\u5b66\u3001\u836f\u7269\u5316\u5b66\u80fd\u529b\u8fde\u63a5\uff0c\u7528\u4e8e\u9057\u4f20\u4fee\u9970\u9776\u70b9\u548c\u5c0f\u5206\u5b50\u53d1\u73b0\u3002\u516c\u544a\u7684\u62a5\u9053\u65e5\u671f\u4e0e\u6240\u8ff0\u5408\u4f5c\u5ba3\u5e03\u65e5\u671f\u5747\u4e3a11\u67089\u65e5\uff0c\u5904\u4e8e\u672c\u671f\u8fd1\u4e03\u5929\u7a97\u53e3\u3002\u5b83\u8bf4\u660e\u4ea7\u4e1a\u6b63\u5728\u63a8\u52a8\u201c\u6a21\u578b\u2014\u9776\u70b9\u2014\u5316\u5408\u7269\u201d\u7684\u8854\u63a5\uff0c\u4f46\u516c\u544a\u6ca1\u6709\u63d0\u4f9b\u53ef\u4f9b\u672c\u6587\u72ec\u7acb\u6838\u9a8c\u7684\u524d\u77bb\u6027\u80fd\u6bd4\u8f83\uff0c\u4e0d\u80fd\u636e\u6b64\u8ba4\u5b9a\u76ee\u6807\u5df2\u7ecf\u5b9e\u73b0\u3002<a style=\"overflow-wrap:anywhere;\" href=\"https:\/\/www.globenewswire.com\/news-release\/2026\/11\/09\/3398157\/0\/en\/deeplife-and-3billion-partner-to-discover-small-molecule-therapeutics-against-genetic-modifier-targets-across-multiple-diseases.html\">\u516c\u53f8\u539f\u59cb\u5408\u4f5c\u516c\u544a<\/a><\/p>\n<p>\u5f53\u6a21\u578b\u7528\u4e8e\u5b89\u6392\u5b9e\u9a8c\uff0c\u6700\u91cd\u8981\u7684\u4ea4\u4ed8\u5c31\u5305\u62ec\uff1a\u54ea\u4e9b\u6761\u4ef6\u503c\u5f97\u4f18\u5148\u6d4b\u8bd5\uff0c\u9884\u6d4b\u6765\u81ea\u54ea\u4e9b\u5141\u8bb8\u4f7f\u7528\u7684\u6570\u636e\uff0c\u4ee5\u53ca\u5b9e\u9a8c\u5931\u8d25\u65f6\u5e94\u5f53\u4fee\u6539\u54ea\u9879\u5047\u8bbe\u3002PIANO\u4e0eTwinCell\u5c5e\u4e8e\u4e0d\u540c\u6846\u67b6\uff1b\u8fd9\u91cc\u628a\u5b83\u4eec\u653e\u5728\u540c\u4e00\u79d1\u7814\u95ee\u9898\u4e0b\u8ba8\u8bba\uff0c\u4e0d\u628a\u4e8c\u8005\u5f53\u6210\u5df2\u7ecf\u5b8c\u6210\u7edf\u4e00\u6bd4\u8f83\u7684\u6a21\u578b\u3002<\/p>\n<h2 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