{"id":72955,"date":"2026-11-15T12:50:54","date_gmt":"2026-11-15T04:50:54","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=72955"},"modified":"2026-11-15T12:52:41","modified_gmt":"2026-11-15T04:52:41","slug":"bioinformatics-multimodal-guide","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/bioinformatics-multimodal-guide\/","title":{"rendered":"\u751f\u7269\u4fe1\u606f\u5b66\u4e2d\u7684\u591a\u6a21\u6001\u662f\u4ec0\u4e48\uff1f\u4ece\u5355\u7ec6\u80de\u5230\u75c5\u7406\u56fe\u50cf\uff0c\u8bb2\u6e05\u7528\u9014\u3001\u4f18\u7f3a\u70b9\u4e0e\u5206\u6790\u8def\u7ebf"},"content":{"rendered":"

**\u6458\u8981\uff1a**\u591a\u6a21\u6001\u4e0d\u662f\u628a\u66f4\u591a\u6587\u4ef6\u653e\u5728\u4e00\u8d77\uff0c\u4e5f\u4e0d\u662f\u7ed9\u5206\u6790\u52a0\u4e0aAI\u6807\u7b7e\u3002\u672c\u6587\u4eceRNA\u3001\u86cb\u767d\u3001\u67d3\u8272\u8d28\u548c\u75c5\u7406\u56fe\u50cf\u51fa\u53d1\uff0c\u8bf4\u660e\u54ea\u4e9b\u6570\u636e\u80fd\u591f\u8054\u5408\u5206\u6790\u3001\u5e38\u7528\u65b9\u6cd5\u600e\u6837\u9009\u62e9\u3001\u4f55\u65f6\u503c\u5f97\u589e\u52a0\u6295\u5165\uff0c\u4ee5\u53ca\u5982\u4f55\u907f\u514d\u6837\u672c\u9519\u914d\u3001\u4fe1\u606f\u6cc4\u6f0f\u548c\u7ed3\u679c\u8fc7\u5ea6\u89e3\u91ca\u3002<\/p>\n

\u5148\u770b\u7ed3\u8bba<\/h2>\n

\u751f\u7269\u4fe1\u606f\u5b66\u4e2d\u7684\u591a\u6a21\u6001\uff0c\u5c31\u662f\u628a\u4e0d\u540c\u6d4b\u91cf\u65b9\u5f0f\u6216\u4e0d\u540c\u4fe1\u606f\u5c42\u9762\u7684\u6570\u636e\u8054\u7cfb\u8d77\u6765\uff0c\u5171\u540c\u56de\u7b54\u4e00\u4e2a\u660e\u786e\u7684\u7814\u7a76\u95ee\u9898\u3002<\/strong><\/p>\n

\u4f8b\u5982\uff0c\u7814\u7a76\u540c\u4e00\u4e2a\u80bf\u7624\uff0c\u53ef\u4ee5\u540c\u65f6\u770b\u57fa\u56e0\u8868\u8fbe\u3001\u86cb\u767d\u6807\u8bb0\u548c\u75c5\u7406\u5f62\u6001\u3002\u5b83\u4eec\u50cf\u51e0\u4f4d\u89c2\u5bdf\u89d2\u5ea6\u4e0d\u540c\u7684\u7814\u7a76\u8005\uff1a\u6709\u4eba\u89c2\u5bdf\u5206\u5b50\u6d3b\u52a8\uff0c\u6709\u4eba\u89c2\u5bdf\u7ec6\u80de\u8868\u9762\uff0c\u6709\u4eba\u89c2\u5bdf\u7ec4\u7ec7\u7ed3\u6784\u3002\u8054\u5408\u5206\u6790\u7684\u4ef7\u503c\uff0c\u662f\u8ba9\u8fd9\u4e9b\u4fe1\u606f\u4e92\u76f8\u8865\u5145\uff0c\u800c\u4e0d\u662f\u7b80\u5355\u6295\u7968\u3002<\/p>\n

\u4f46\u591a\u6a21\u6001\u4e0d\u4fdd\u8bc1\u6bd4\u5355\u6a21\u6001\u66f4\u51c6\u786e\u3002\u6570\u636e\u6ca1\u6709\u6b63\u786e\u5bf9\u5e94\u3001\u6837\u672c\u91cf\u4e0d\u8db3\u3001\u6279\u6b21\u4e0e\u75be\u75c5\u5206\u7ec4\u6df7\u5728\u4e00\u8d77\u65f6\uff0c\u589e\u52a0\u6570\u636e\u548c\u590d\u6742\u6a21\u578b\u53cd\u800c\u53ef\u80fd\u653e\u5927\u8bef\u5dee\u3002\u5f00\u59cb\u524d\uff0c\u5148\u95ee\u4e00\u53e5\uff1a\u65b0\u589e\u7684\u8fd9\u7c7b\u6570\u636e\uff0c\u51c6\u5907\u89e3\u51b3\u539f\u6765\u54ea\u4e2a\u5177\u4f53\u95ee\u9898\uff1f<\/strong><\/p>\n

\u4e00\u3001\u5148\u5206\u6e05\uff1a\u591a\u6a21\u6001\u3001\u591a\u7ec4\u5b66\u3001\u591a\u6570\u636e\u96c6\u6709\u4ec0\u4e48\u533a\u522b\uff1f<\/h2>\n

1. \u4ec0\u4e48\u662f\u201c\u6a21\u6001\u201d\uff1f<\/h3>\n

\u201c\u6a21\u6001\u201d\u901a\u5e38\u8868\u793a\u6570\u636e\u7684\u6d4b\u91cf\u5f62\u5f0f\u6216\u4fe1\u606f\u6765\u6e90\u3002\u5728\u751f\u4fe1\u7814\u7a76\u4e2d\uff0c\u5e38\u89c1\u6a21\u6001\u5305\u62ec\uff1a<\/p>\n\n\n\n\n\n\n\n\n\n\n
\u6570\u636e\u7c7b\u578b<\/th>\n\u4e3b\u8981\u63d0\u4f9b\u4ec0\u4e48\u4fe1\u606f<\/th>\n\u4e0d\u80fd\u76f4\u63a5\u66ff\u4ee3\u4ec0\u4e48<\/th>\n<\/tr>\n<\/thead>\n
\u8f6c\u5f55\u7ec4<\/td>\nRNA\u8868\u8fbe\u53ca\u5176\u53d8\u5316<\/td>\n\u4e0d\u7b49\u4e8e\u86cb\u767d\u4e30\u5ea6\u3001\u86cb\u767d\u6d3b\u6027\u6216\u7ec6\u80de\u529f\u80fd<\/td>\n<\/tr>\n
\u86cb\u767d\u8d28\u6216\u86cb\u767d\u6807\u8bb0<\/td>\n\u86cb\u767d\u6216\u6240\u9009\u6807\u8bb0\u7684\u4e30\u5ea6<\/td>\n\u4e0d\u80fd\u5355\u72ec\u8bf4\u660e\u6240\u6709\u4e0a\u6e38\u8c03\u63a7\u8fc7\u7a0b<\/td>\n<\/tr>\n
\u67d3\u8272\u8d28\u53ef\u53ca\u6027<\/td>\n\u54ea\u4e9b\u57fa\u56e0\u7ec4\u533a\u57df\u66f4\u6613\u88ab\u63a5\u8fd1<\/td>\n\u5f00\u653e\u533a\u57df\u4e0d\u7b49\u4e8e\u5bf9\u5e94\u57fa\u56e0\u4e00\u5b9a\u9ad8\u8868\u8fbe<\/td>\n<\/tr>\n
\u75c5\u7406\u3001\u663e\u5fae\u56fe\u50cf<\/td>\n\u5f62\u6001\u3001\u7ec4\u7ec7\u7ed3\u6784\u4e0e\u5c40\u90e8\u73af\u5883<\/td>\n\u4e0d\u80fd\u76f4\u63a5\u5f53\u4f5c\u5b8c\u6574\u7684\u5206\u5b50\u6d4b\u91cf<\/td>\n<\/tr>\n
\u7a7a\u95f4\u4f4d\u7f6e\u53ca\u76f8\u5173\u6d4b\u91cf<\/td>\n\u4fe1\u53f7\u5728\u54ea\u91cc\u3001\u4e0e\u54ea\u4e9b\u533a\u57df\u90bb\u8fd1<\/td>\n\u7a7a\u95f4\u76f8\u90bb\u4e0d\u81ea\u52a8\u7b49\u4e8e\u76f4\u63a5\u76f8\u4e92\u4f5c\u7528<\/td>\n<\/tr>\n
\u4e34\u5e8a\u6216\u8868\u578b\u4fe1\u606f<\/td>\n\u4e2a\u4f53\u80cc\u666f\u3001\u5904\u7406\u3001\u7597\u6548\u6216\u7ed3\u5c40<\/td>\n\u4e0d\u66ff\u4ee3\u5b9e\u9a8c\u8bbe\u8ba1\uff0c\u4e5f\u4e0d\u81ea\u52a8\u8bc1\u660e\u56e0\u679c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u8fd9\u4e9b\u6570\u636e\u4e4b\u95f4\u53ef\u80fd\u4e92\u8865\uff0c\u4e5f\u53ef\u80fd\u4e0d\u4e00\u81f4\u3002\u6bd4\u5982RNA\u5347\u9ad8\u800c\u86cb\u767d\u6ca1\u6709\u540c\u6b65\u5347\u9ad8\uff0c\u4e0d\u5fc5\u7acb\u523b\u8ba4\u5b9a\u5176\u4e2d\u4e00\u4efd\u6570\u636e\u9519\u4e86\uff0c\u8fd8\u8981\u8003\u8651\u6d4b\u91cf\u65f6\u95f4\u3001\u8c03\u63a7\u5c42\u6b21\u3001\u6280\u672f\u566a\u58f0\u548c\u6837\u672c\u7ec4\u6210\u3002<\/p>\n

2. \u591a\u7ec4\u5b66\u662f\u591a\u6a21\u6001\u7684\u4e00\u79cd\u5e38\u89c1\u5f62\u5f0f<\/h3>\n

\u8f6c\u5f55\u7ec4\u4e0e\u86cb\u767d\u8d28\u7ec4\u8054\u5408\u5206\u6790\uff0c\u65e2\u53ef\u4ee5\u79f0\u4e3a\u591a\u7ec4\u5b66\uff0c\u4e5f\u53ef\u4ee5\u653e\u5728\u591a\u6a21\u6001\u6846\u67b6\u4e0b\u8ba8\u8bba\uff1b\u75c5\u7406\u56fe\u50cf\u4e0e\u8f6c\u5f55\u7ec4\u8054\u5408\u5206\u6790\uff0c\u5219\u8d85\u51fa\u4e86\u5355\u7eaf\u7ec4\u5b66\u6570\u636e\u7684\u8303\u56f4\u3002\u4e0d\u540c\u7814\u7a76\u9886\u57df\u7684\u7528\u8bcd\u5e76\u4e0d\u5b8c\u5168\u7edf\u4e00\uff0c\u9605\u8bfb\u8bba\u6587\u65f6\u5e94\u770b\u6e05\u4f5c\u8005\u5b9e\u9645\u7528\u4e86\u54ea\u4e9b\u6570\u636e\uff0c\u800c\u4e0d\u662f\u53ea\u770b\u6807\u9898\u4e2d\u7684\u201c\u591a\u6a21\u6001\u201d\u3002<\/p>\n

3. \u591a\u4e2a\u6587\u4ef6\uff0c\u4e0d\u4e00\u5b9a\u662f\u591a\u4e2a\u6a21\u6001<\/h3>\n

\u628a\u4e09\u4e2a\u533b\u9662\u7684RNA-seq\u6570\u636e\u6574\u5408\uff0c\u901a\u5e38\u4ecd\u662f\u540c\u4e00\u6a21\u6001\u7684\u8de8\u961f\u5217\u5206\u6790\u3002\u628a\u4e00\u4e2a\u8868\u8fbe\u77e9\u9635\u62c6\u6210\u8bad\u7ec3\u96c6\u3001\u9a8c\u8bc1\u96c6\u548c\u6d4b\u8bd5\u96c6\uff0c\u4e5f\u4e0d\u4f1a\u4ea7\u751f\u65b0\u7684\u6a21\u6001\u3002\u5224\u65ad\u6807\u51c6\u662f\u4fe1\u606f\u6765\u6e90\u548c\u6d4b\u91cf\u65b9\u5f0f\uff0c\u800c\u4e0d\u662f\u6587\u4ef6\u6570\u91cf\u6216\u5206\u6790\u56fe\u6570\u91cf\u3002<\/p>\n

\"\u591a\u6a21\u6001\u4fe1\u606f\u5730\u56fe\uff1aRNA\u3001\u86cb\u767d\u3001\u75c5\u7406\u5f71\u50cf\u4e0e\u4e34\u5e8a\u6570\u636e\u7684\u6574\u5408\"<\/figure>\n

\u56fe\u6ce8\uff1aRNA\u8868\u8fbe\u3001\u86cb\u767d\u6807\u8bb0\u3001\u67d3\u8272\u8d28\u53ef\u53ca\u6027\u3001\u75c5\u7406\u56fe\u50cf\u4e0e\u4e34\u5e8a\u4fe1\u606f\uff0c\u4ece\u4e0d\u540c\u5c42\u9762\u63cf\u8ff0\u7814\u7a76\u5bf9\u8c61\u3002\u662f\u5426\u53ef\u4ee5\u8054\u5408\u5206\u6790\uff0c\u53d6\u51b3\u4e8e\u6837\u672c\u5bf9\u5e94\u5173\u7cfb\u548c\u7814\u7a76\u76ee\u6807\u3002\u6982\u5ff5\u793a\u610f\uff0c\u975e\u771f\u5b9e\u5b9e\u9a8c\u6570\u636e\u3002<\/em><\/p>\n

\u4e8c\u3001\u6bd4\u9009\u7b97\u6cd5\u66f4\u91cd\u8981\uff1a\u8fd9\u4e9b\u6570\u636e\u7a76\u7adf\u5bf9\u5e94\u5230\u54ea\u4e00\u5c42\uff1f<\/h2>\n

\u540c\u4e00\u7ec6\u80de\u914d\u5bf9\uff1a\u80fd\u591f\u76f4\u63a5\u6bd4\u8f83\u540c\u4e00\u4e2a\u7ec6\u80de\u7684\u4e0d\u540c\u6d4b\u91cf<\/h3>\n

\u4f8b\u5982\uff0c\u4e00\u6b21\u5b9e\u9a8c\u5bf9\u540c\u4e00\u7ec6\u80de\u540c\u65f6\u6d4b\u91cfRNA\u4e0e\u86cb\u767d\u6807\u8bb0\u3002\u7ec6\u80de\u6761\u5f62\u7801\u63d0\u4f9b\u5bf9\u5e94\u5173\u7cfb\uff0c\u4f46\u4ecd\u8981\u68c0\u67e5\u6761\u5f62\u7801\u5904\u7406\u3001\u6837\u672c\u62c6\u5206\u4e0e\u8d28\u63a7\u7ed3\u679c\u3002\u4e0d\u80fd\u56e0\u4e3a\u4e24\u4efd\u77e9\u9635\u5217\u6570\u76f8\u540c\uff0c\u5c31\u8ba4\u4e3a\u6bcf\u5217\u90fd\u5bf9\u5e94\u540c\u4e00\u4e2a\u7ec6\u80de\u3002<\/p>\n

\u540c\u4e00\u6837\u672c\u6216\u60a3\u8005\u914d\u5bf9\uff1a\u80fd\u5bf9\u5e94\u4e2a\u4f53\uff0c\u4f46\u4e0d\u4e00\u5b9a\u80fd\u5bf9\u5e94\u7ec6\u80de<\/h3>\n

\u4e00\u4e2a\u60a3\u8005\u7684\u75c5\u7406\u5207\u7247\u548c\u80bf\u7624\u8f6c\u5f55\u7ec4\u53ef\u4ee5\u5728\u60a3\u8005\u5c42\u9762\u5efa\u7acb\u5173\u8054\u3002\u4f46\u4e24\u4efd\u6750\u6599\u53ef\u80fd\u6765\u81ea\u4e0d\u540c\u53d6\u6837\u533a\u57df\uff0c\u4e0d\u4e00\u5b9a\u5177\u6709\u5b8c\u5168\u76f8\u540c\u7684\u7ec6\u80de\u7ec4\u6210\uff1b\u6cbb\u7597\u524d\u540e\u7684\u6750\u6599\u4e5f\u4e0d\u80fd\u76f4\u63a5\u5f53\u4f5c\u540c\u4e00\u65f6\u95f4\u7684\u6d4b\u91cf\u3002\u5206\u6790\u8868\u5e94\u540c\u65f6\u4fdd\u7559\u4e2a\u4f53\u3001\u6837\u672c\u3001\u7ec4\u7ec7\u90e8\u4f4d\u3001\u65f6\u95f4\u548c\u6279\u6b21\u4fe1\u606f\u3002<\/p>\n

\u975e\u914d\u5bf9\u6216\u90e8\u5206\u914d\u5bf9\uff1a\u53ef\u4ee5\u7814\u7a76\uff0c\u4f46\u5047\u8bbe\u66f4\u591a<\/h3>\n

\u6709\u4e9b\u7ec6\u80de\u53ea\u6709RNA\uff0c\u6709\u4e9b\u53ea\u6709ATAC\uff0c\u8fd8\u6709\u4e00\u90e8\u5206\u540c\u65f6\u5177\u5907\u4e24\u7c7b\u6d4b\u91cf\u3002\u6b64\u65f6\u9700\u8981\u652f\u6301\u76f8\u5e94\u6570\u636e\u7ed3\u6784\u7684\u65b9\u6cd5\uff0c\u800c\u4e0d\u662f\u5f3a\u884c\u628a\u77e9\u9635\u62fc\u8d77\u6765\u3002\u8de8\u6a21\u6001\u6620\u5c04\u4f9d\u8d56\u5171\u540c\u7ed3\u6784\u548c\u6a21\u578b\u5047\u8bbe\uff0c\u6574\u5408\u540e\u770b\u8d77\u6765\u6df7\u5408\uff0c\u5e76\u4e0d\u8bc1\u660e\u6bcf\u4e2a\u7ec6\u80de\u90fd\u88ab\u6b63\u786e\u5339\u914d\u3002<\/p>\n

**\u4e00\u4e2a\u5e38\u89c1\u9519\u8bef\uff1a**\u628a\u7532\u961f\u5217\u7684RNA\u4e0e\u4e59\u961f\u5217\u7684\u86cb\u767d\u6570\u636e\u6309\u884c\u53f7\u6216\u6837\u672c\u6570\u91cf\u5bf9\u9f50\u3002\u5b83\u4eec\u5373\u4f7f\u7814\u7a76\u540c\u4e00\u79cd\u75be\u75c5\uff0c\u4e5f\u4e0d\u80fd\u51ed\u7a7a\u6210\u4e3a\u201c\u540c\u4e00\u6279\u6837\u672c\u201d\u3002\u8fd9\u7c7b\u9879\u76ee\u5e94\u660e\u786e\u662f\u8de8\u961f\u5217\u8bc1\u636e\u6574\u5408\uff0c\u800c\u975e\u4e2a\u4f53\u7ea7\u914d\u5bf9\u5206\u6790\u3002<\/p>\n

\u4e09\u3001\u591a\u6a21\u6001\u80fd\u7528\u6765\u89e3\u51b3\u54ea\u4e9b\u5b9e\u9645\u95ee\u9898\uff1f<\/h2>\n

\u573a\u666f1\uff1a\u5355\u7ec6\u80deRNA\u4e0e\u86cb\u767d\u6807\u8bb0\u4e00\u8d77\u5e2e\u52a9\u8bc6\u522b\u7ec6\u80de<\/h3>\n

CITE-seq\u4f7f\u7528\u5e26\u6709\u5be1\u6838\u82f7\u9178\u6807\u7b7e\u7684\u6297\u4f53\uff0c\u5c06\u7279\u5b9a\u86cb\u767d\u6807\u8bb0\u68c0\u6d4b\u4e0e\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u91cf\u7ed3\u5408\u8d77\u6765\u3002\u5b83\u63d0\u4f9b\u540c\u4e00\u7ec6\u80de\u7684\u4e24\u7c7b\u4fe1\u606f\uff0c\u53ef\u7528\u4e8e\u7ec6\u80de\u8bc6\u522b\u4e0e\u72b6\u6001\u7814\u7a76\u3002\u4f46\u68c0\u6d4b\u8303\u56f4\u53d6\u51b3\u4e8e\u6297\u4f53\u9762\u677f\uff0c\u4e0d\u80fd\u5199\u6210\u201c\u83b7\u5f97\u4e86\u5168\u90e8\u86cb\u767d\u8d28\u7ec4\u201d\u3002[1]<\/p>\n

\u8fd9\u4e2a\u4f8b\u5b50\u7684\u542f\u53d1\u662f\uff1a\u5982\u679cRNA\u5bf9\u67d0\u4e9b\u7ec6\u80de\u7fa4\u7684\u533a\u5206\u4e0d\u5145\u5206\uff0c\u800c\u5df2\u6709\u53ef\u9760\u7684\u86cb\u767d\u6807\u8bb0\uff0c\u589e\u52a0\u76f8\u5e94\u6d4b\u91cf\u53ef\u80fd\u6709\u5b9e\u9645\u4ef7\u503c\u3002\u53cd\u8fc7\u6765\uff0c\u5982\u679c\u6297\u4f53\u80cc\u666f\u9ad8\u6216\u76ee\u6807\u6807\u8bb0\u9009\u5f97\u4e0d\u5408\u9002\uff0c\u6570\u636e\u591a\u4e00\u5c42\u4e0d\u7b49\u4e8e\u8bc1\u636e\u5f3a\u4e00\u5c42\u3002<\/p>\n

\u573a\u666f2\uff1aRNA\u4e0e\u67d3\u8272\u8d28\u6570\u636e\u4e00\u8d77\u7814\u7a76\u7ec6\u80de\u72b6\u6001<\/h3>\n

RNA\u66f4\u63a5\u8fd1\u8868\u8fbe\u8f93\u51fa\uff0c\u67d3\u8272\u8d28\u53ef\u53ca\u6027\u63d0\u4f9b\u8c03\u63a7\u72b6\u6001\u7684\u53e6\u4e00\u79cd\u7ebf\u7d22\u3002\u8054\u5408\u5206\u6790\u53ef\u4ee5\u5e2e\u52a9\u7814\u7a76\u8005\u628a\u7ec6\u80de\u72b6\u6001\u4e0e\u5019\u9009\u8c03\u63a7\u533a\u57df\u8054\u7cfb\u8d77\u6765\u3002\u4e0d\u8fc7\uff0c\u4ece\u5f00\u653e\u533a\u57df\u5230\u76ee\u6807\u57fa\u56e0\uff0c\u518d\u5230\u529f\u80fd\u673a\u5236\uff0c\u4e2d\u95f4\u4ecd\u6709\u591a\u5c42\u63a8\u65ad\u3002\u4e00\u4e2a\u533a\u57df\u5f00\u653e\u3001\u9644\u8fd1\u57fa\u56e0\u8868\u8fbe\u53d8\u5316\uff0c\u4e0d\u8db3\u4ee5\u5355\u72ec\u8bc1\u660e\u76f4\u63a5\u8c03\u63a7\u5173\u7cfb\u3002<\/p>\n

MultiVI\u9488\u5bf9\u591a\u7ec4\u5b66\u53ca\u5355\u6a21\u6001\u5355\u7ec6\u80de\u6570\u636e\u5b66\u4e60\u8054\u5408\u8868\u793a\uff0c\u4e5f\u80fd\u5bf9\u672a\u6d4b\u6a21\u6001\u8fdb\u884c\u63a8\u65ad\u3002[4] **\u63a8\u65ad\u51fa\u6765\u7684RNA\u6216\u53ef\u53ca\u6027\u6570\u503c\u662f\u6a21\u578b\u4f30\u8ba1\uff0c\u4e0d\u662f\u8865\u505a\u4e86\u4e00\u6b21\u5b9e\u9a8c\u3002**\u7528\u4e8e\u540e\u7eed\u7814\u7a76\u65f6\uff0c\u5e94\u6807\u8bb0\u6765\u6e90\uff0c\u8bc4\u4f30\u4e0d\u786e\u5b9a\u6027\uff0c\u5e76\u907f\u514d\u7528\u6a21\u578b\u81ea\u5df1\u751f\u6210\u7684\u6570\u636e\u201c\u9a8c\u8bc1\u201d\u6a21\u578b\u81ea\u5df1\u63d0\u51fa\u7684\u7ed3\u8bba\u3002<\/p>\n

\u573a\u666f3\uff1a\u75c5\u7406\u56fe\u50cf\u4e0e\u5206\u5b50\u6570\u636e\u5171\u540c\u7814\u7a76\u60a3\u8005\u7ed3\u5c40<\/h3>\n

\u75c5\u7406\u56fe\u50cf\u5305\u542b\u7ec4\u7ec7\u7ed3\u6784\u548c\u5f62\u6001\u7279\u5f81\uff0c\u5206\u5b50\u6570\u636e\u63d0\u4f9b\u53e6\u4e00\u5c42\u4fe1\u606f\u3002Chen\u7b49\u4eba\u7684\u539f\u59cb\u7814\u7a76\u572814\u79cd\u764c\u75c7\u4e2d\u5f00\u5c55\u75c5\u7406\u2014\u7ec4\u5b66\u878d\u5408\u4e0e\u9884\u540e\u7814\u7a76\uff0c\u5c55\u793a\u4e86\u8fd9\u4e00\u7814\u7a76\u8def\u5f84\u3002[5] \u8fd9\u4e0d\u662f\u201c\u6240\u6709\u80bf\u7624\u90fd\u5e94\u8be5\u4e0a\u591a\u6a21\u6001\u201d\u7684\u8bc1\u636e\uff0c\u4e5f\u4e0d\u610f\u5473\u7740\u76f8\u5173\u6a21\u578b\u53ef\u4ee5\u76f4\u63a5\u7528\u4e8e\u4e34\u5e8a\u51b3\u7b56\u3002<\/p>\n

\u771f\u6b63\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff1a\u5728\u540c\u6837\u7684\u60a3\u8005\u5212\u5206\u4e0b\uff0c\u8054\u5408\u6a21\u578b\u662f\u5426\u6bd4\u56fe\u50cf\u6a21\u578b\u3001\u5206\u5b50\u6a21\u578b\uff0c\u4ee5\u53ca\u5fc5\u8981\u7684\u4e34\u5e8a\u57fa\u7ebf\u66f4\u6709\u7528\uff1b\u6362\u5230\u4e0d\u540c\u4e2d\u5fc3\u3001\u4e0d\u540c\u626b\u63cf\u548c\u68c0\u6d4b\u6761\u4ef6\u540e\uff0c\u6548\u679c\u662f\u5426\u4ecd\u7136\u4fdd\u6301\u3002<\/p>\n

\u56db\u3001\u5e38\u7528\u5206\u6790\u601d\u8def\u6709\u54ea\u4e9b\uff1f\u4e0d\u8981\u628a\u5de5\u5177\u5f53\u6210\u4e07\u80fd\u7b54\u6848<\/h2>\n

1. \u7279\u5f81\u5c42\u878d\u5408\uff1a\u5148\u6574\u7406\u7279\u5f81\uff0c\u518d\u5408\u5e76\u5206\u6790<\/h3>\n

\u76f4\u89c2\u505a\u6cd5\u662f\u5c06\u4e0d\u540c\u6a21\u6001\u7684\u7279\u5f81\u6574\u7406\u540e\u5408\u5e76\uff0c\u7528\u4e8e\u540e\u7eed\u5efa\u6a21\u3002\u4f18\u70b9\u662f\u5bb9\u6613\u7406\u89e3\u548c\u5efa\u7acb\u57fa\u7ebf\uff1b\u96be\u70b9\u662f\u4e0d\u540c\u6570\u636e\u7684\u91cf\u7eb2\u3001\u7a00\u758f\u6027\u548c\u7279\u5f81\u6570\u91cf\u53ef\u80fd\u76f8\u5dee\u5f88\u5927\u3002\u4e00\u4e2a\u6a21\u6001\u6709\u51e0\u4e07\u4e2a\u7279\u5f81\uff0c\u53e6\u4e00\u4e2a\u53ea\u6709\u51e0\u5341\u4e2a\u6307\u6807\uff0c\u76f4\u63a5\u62fc\u63a5\u53ef\u80fd\u8ba9\u6a21\u578b\u504f\u5411\u67d0\u4e00\u4fa7\u3002<\/p>\n

\u5b9e\u8df5\u4e2d\u9700\u8981\u8003\u8651\u6807\u51c6\u5316\u3001\u7279\u5f81\u9009\u62e9\u548c\u6b63\u5219\u5316\uff0c\u5e76\u786e\u4fdd\u8fd9\u4e9b\u6b65\u9aa4\u6ca1\u6709\u63d0\u524d\u4f7f\u7528\u6d4b\u8bd5\u6570\u636e\u3002\u4e0d\u662f\u628a\u77e9\u9635\u201c\u5408\u5e76\u6210\u529f\u201d\uff0c\u5c31\u5b8c\u6210\u4e86\u5408\u7406\u878d\u5408\u3002<\/p>\n

2. \u8868\u793a\u5c42\u878d\u5408\uff1a\u63d0\u70bc\u5171\u540c\u7ed3\u6784\uff0c\u4e5f\u4fdd\u7559\u5dee\u5f02<\/h3>\n

MOFA+\u901a\u8fc7\u6f5c\u5728\u56e0\u5b50\u523b\u753b\u591a\u6a21\u6001\u6570\u636e\u7684\u4e3b\u8981\u53d8\u5316\uff0c\u5e2e\u52a9\u63a2\u7d22\u54ea\u4e9b\u53d8\u5316\u8de8\u6a21\u6001\u5171\u4eab\uff0c\u54ea\u4e9b\u66f4\u5177\u6709\u6a21\u6001\u7279\u5f02\u6027\u3002[3] \u6f5c\u5728\u56e0\u5b50\u53ef\u4ee5\u7406\u89e3\u4e3a\u82e5\u5e72\u4e3b\u8981\u53d8\u5316\u65b9\u5411\uff0c\u4f46\u4e0d\u80fd\u4ec5\u51ed\u4e00\u4e2a\u56e0\u5b50\u4e0e\u75be\u75c5\u5206\u7ec4\u76f8\u5173\uff0c\u5c31\u628a\u5b83\u547d\u540d\u4e3a\u67d0\u6761\u786e\u5b9a\u673a\u5236\u3002<\/p>\n

\u89e3\u91ca\u65f6\u5e94\u540c\u65f6\u68c0\u67e5\u56e0\u5b50\u4e0e\u6279\u6b21\u3001\u6837\u672c\u8d28\u91cf\u548c\u5176\u4ed6\u80cc\u666f\u53d8\u91cf\u7684\u5173\u7cfb\uff0c\u518d\u770b\u5bf9\u5e94\u7279\u5f81\u662f\u5426\u652f\u6301\u751f\u7269\u5b66\u89e3\u91ca\u3002<\/p>\n

3. \u90bb\u57df\u878d\u5408\uff1a\u7efc\u5408\u4e0d\u540c\u6a21\u6001\u5bf9\u7ec6\u80de\u5173\u7cfb\u7684\u63cf\u8ff0<\/h3>\n

Seurat\u7684\u52a0\u6743\u6700\u8fd1\u90bb\u601d\u8def\uff0c\u5373WNN\uff0c\u9488\u5bf9\u540c\u4e00\u7ec6\u80de\u7684\u591a\u6a21\u6001\u6d4b\u91cf\uff0c\u5b66\u4e60\u4e0d\u540c\u6a21\u6001\u5bf9\u5c40\u90e8\u7ec6\u80de\u5173\u7cfb\u7684\u76f8\u5bf9\u8d21\u732e\uff0c\u800c\u4e0d\u662f\u7b80\u5355\u7b49\u6743\u76f8\u52a0\u3002[2] \u5b83\u9002\u5408\u7684\u95ee\u9898\u548c\u8f93\u5165\u7ed3\u6784\u90fd\u6709\u8fb9\u754c\uff0c\u4e0d\u80fd\u628a\u6765\u81ea\u4e0d\u540c\u4e2a\u4f53\u3001\u6ca1\u6709\u7ec6\u80de\u5bf9\u5e94\u5173\u7cfb\u7684\u6570\u636e\u76f4\u63a5\u89c6\u4e3a\u6807\u51c6\u914d\u5bf9\u8f93\u5165\u3002<\/p>\n

4. \u9884\u6d4b\u5c42\u878d\u5408\uff1a\u5148\u5206\u522b\u5efa\u6a21\uff0c\u518d\u7ec4\u5408\u7ed3\u679c<\/h3>\n

\u4e0d\u540c\u6a21\u6001\u53ef\u4ee5\u5148\u5404\u81ea\u5efa\u7acb\u6a21\u578b\uff0c\u518d\u7ec4\u5408\u9884\u6d4b\u3002\u8fd9\u6837\u4fbf\u4e8e\u89c2\u5bdf\u5355\u6a21\u6001\u8868\u73b0\uff0c\u4f46\u7ec4\u5408\u6743\u91cd\u4e5f\u9700\u8981\u5728\u5f00\u53d1\u6570\u636e\u4e2d\u786e\u5b9a\uff0c\u4e0d\u80fd\u53cd\u590d\u67e5\u770b\u6d4b\u8bd5\u96c6\u540e\u8c03\u6574\u3002\u5b9e\u9645\u4f7f\u7528\u65f6\u5982\u679c\u67d0\u79cd\u6a21\u6001\u62ff\u4e0d\u5230\uff0c\u7cfb\u7edf\u600e\u6837\u5904\u7406\uff0c\u5e94\u5728\u65b9\u6848\u9636\u6bb5\u5c31\u8003\u8651\uff0c\u800c\u4e0d\u662f\u7b49\u6a21\u578b\u4e0a\u7ebf\u624d\u53d1\u73b0\u7f3a\u6570\u636e\u3002<\/p>\n

\u4e0a\u8ff0\u51e0\u7c7b\u662f\u7406\u89e3\u65b9\u6cd5\u7684\u6846\u67b6\uff0c\u5e76\u975e\u4e92\u65a5\u5206\u7c7b\u3002\u590d\u6742\u65b9\u6cd5\u53ef\u80fd\u540c\u65f6\u5305\u542b\u591a\u79cd\u7b56\u7565\u3002\u9009\u5de5\u5177\u65f6\uff0c\u4f18\u5148\u6838\u5bf9\u7814\u7a76\u76ee\u6807\u3001\u914d\u5bf9\u7ed3\u6784\u3001\u8f93\u5165\u683c\u5f0f\u548c\u9a8c\u8bc1\u65b9\u5f0f\uff0c\u4e0d\u5b9c\u5355\u51ed\u201c\u7528\u4e86\u6df1\u5ea6\u5b66\u4e60\u201d\u5224\u65ad\u5148\u8fdb\u7a0b\u5ea6\u3002<\/p>\n

\u4e94\u3001\u591a\u6a21\u6001\u7684\u4f18\u70b9\uff1a\u4ec0\u4e48\u65f6\u5019\u589e\u52a0\u6570\u636e\u771f\u7684\u503c\u5f97\uff1f<\/h2>\n

**\u8865\u5145\u4fe1\u606f\u76f2\u533a\u3002**\u5f53\u539f\u6709\u6570\u636e\u7f3a\u5c11\u67d0\u4e2a\u5173\u952e\u7ef4\u5ea6\u65f6\uff0c\u65b0\u589e\u6d4b\u91cf\u53ef\u80fd\u63d0\u4f9b\u771f\u6b63\u7684\u65b0\u4fe1\u606f\u3002\u4f8b\u5982\u5f62\u6001\u53d8\u5316\u4e0e\u5206\u5b50\u53d8\u5316\u7ed3\u5408\uff0c\u6709\u52a9\u4e8e\u628a\u7ec4\u7ec7\u8868\u73b0\u548c\u5206\u5b50\u7ebf\u7d22\u8054\u7cfb\u8d77\u6765\u3002<\/p>\n

**\u63d0\u4f9b\u8de8\u5c42\u9762\u7684\u652f\u6301\u3002**\u4e00\u4e2a\u5019\u9009\u73b0\u8c61\u540c\u65f6\u5f97\u5230\u4e0d\u540c\u6d4b\u91cf\u7684\u652f\u6301\uff0c\u53ef\u80fd\u66f4\u503c\u5f97\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002\u4f46\u4e0d\u540c\u6a21\u6001\u4e5f\u53ef\u80fd\u53d7\u540c\u4e00\u6df7\u6742\u56e0\u7d20\u5f71\u54cd\uff0c\u4e0d\u80fd\u628a\u201c\u591a\u4efd\u652f\u6301\u201d\u76f4\u63a5\u5f53\u4f5c\u72ec\u7acb\u8bc1\u636e\u6216\u56e0\u679c\u8bc1\u660e\u3002<\/p>\n

**\u5e2e\u52a9\u8bc6\u522b\u5f02\u8d28\u6027\u3002**\u540c\u4e00\u75be\u75c5\u540d\u79f0\u4e0b\u53ef\u80fd\u5b58\u5728\u4e0d\u540c\u7ec6\u80de\u72b6\u6001\u6216\u7ec4\u7ec7\u7279\u5f81\u3002\u8054\u5408\u4fe1\u606f\u6709\u673a\u4f1a\u7ec6\u5316\u63cf\u8ff0\uff0c\u4f46\u65b0\u5206\u51fa\u7684\u4e9a\u7fa4\u5fc5\u987b\u68c0\u67e5\u7a33\u5b9a\u6027\uff0c\u4e0d\u80fd\u53ea\u51ed\u805a\u7c7b\u56fe\u5c31\u5ba3\u5e03\u53d1\u73b0\u65b0\u4e9a\u578b\u3002<\/p>\n

**\u6539\u5584\u67d0\u4e9b\u9884\u6d4b\u4efb\u52a1\u3002**\u5982\u679c\u65b0\u589e\u6a21\u6001\u63d0\u4f9b\u539f\u6709\u6570\u636e\u6ca1\u6709\u7684\u4fe1\u606f\uff0c\u8054\u5408\u6a21\u578b\u53ef\u80fd\u6539\u5584\u8868\u73b0\u3002\u4f46\u5e94\u62a5\u544a\u6539\u5584\u5e45\u5ea6\u3001\u6ce2\u52a8\u548c\u4f7f\u7528\u6210\u672c\uff0c\u800c\u4e0d\u662f\u53ea\u6311\u6700\u597d\u7684\u4e00\u6b21\u7ed3\u679c\u3002\u82e5\u589e\u52a0\u6602\u8d35\u68c0\u6d4b\u540e\u6536\u76ca\u5f88\u5c0f\uff0c\u7b80\u5355\u6a21\u578b\u53cd\u800c\u53ef\u80fd\u66f4\u9002\u5408\u5b9e\u9645\u4efb\u52a1\u3002<\/p>\n

\u516d\u3001\u591a\u6a21\u6001\u7684\u7f3a\u70b9\uff1a\u6700\u5bb9\u6613\u5728\u54ea\u4e9b\u5730\u65b9\u51fa\u95ee\u9898\uff1f<\/h2>\n

1. \u8d39\u7528\u589e\u52a0\uff0c\u4f46\u6709\u6548\u6837\u672c\u53ef\u80fd\u51cf\u5c11<\/h3>\n

\u6709100\u4f4d\u53d7\u8bd5\u8005\u7684RNA\u6570\u636e\uff0c\u4e0d\u610f\u5473\u7740\u5c31\u6709100\u4f4d\u53d7\u8bd5\u8005\u7684\u5b8c\u6574\u591a\u6a21\u6001\u6570\u636e\u3002\u5982\u679c\u53ea\u670940\u4f4d\u540c\u65f6\u5177\u6709\u53e6\u4e00\u79cd\u6d4b\u91cf\uff0c\u9650\u5236\u5728\u5b8c\u6574\u914d\u5bf9\u6837\u672c\u4e0a\u5206\u6790\u65f6\uff0c\u53ef\u7528\u6837\u672c\u4f1a\u51cf\u5c11\uff1b\u6539\u7528\u7f3a\u5931\u6a21\u6001\u65b9\u6cd5\uff0c\u4e5f\u9700\u8981\u68c0\u67e5\u7f3a\u5931\u539f\u56e0\u548c\u76f8\u5173\u5047\u8bbe\u3002<\/p>\n

\u4f8b\u5982\uff0c\u53ea\u6709\u75c5\u60c5\u8f83\u91cd\u7684\u4eba\u63a5\u53d7\u67d0\u9879\u68c0\u6d4b\uff0c\u7f3a\u5931\u5c31\u4e0d\u662f\u7b80\u5355\u968f\u673a\u7684\u3002\u6a21\u578b\u53ef\u80fd\u5229\u7528\u68c0\u6d4b\u662f\u5426\u5b58\u5728\u6765\u5224\u65ad\u5206\u7ec4\uff0c\u800c\u975e\u5b66\u5230\u5e0c\u671b\u7814\u7a76\u7684\u751f\u7269\u5b66\u5173\u7cfb\u3002<\/p>\n

2. \u6279\u6b21\u6821\u6b63\u53ef\u80fd\u4e0d\u8db3\uff0c\u4e5f\u53ef\u80fd\u8fc7\u5ea6<\/h3>\n

\u4e0d\u5904\u7406\u6280\u672f\u5dee\u5f02\uff0c\u6a21\u578b\u53ef\u80fd\u5b66\u5230\u5e73\u53f0\u7279\u5f81\uff1b\u8fc7\u5ea6\u8ffd\u6c42\u4e0d\u540c\u6279\u6b21\u5b8c\u5168\u6df7\u5408\uff0c\u53c8\u53ef\u80fd\u62b9\u53bb\u771f\u5b9e\u751f\u7269\u5b66\u5dee\u5f02\u3002\u5e94\u7ed3\u5408\u5b9e\u9a8c\u8bbe\u8ba1\u68c0\u67e5\u6574\u5408\u524d\u540e\u7ed3\u679c\uff0c\u65e2\u770b\u6280\u672f\u56e0\u7d20\u662f\u5426\u51cf\u5f31\uff0c\u4e5f\u770b\u5df2\u77e5\u751f\u7269\u7ed3\u6784\u662f\u5426\u4fdd\u7559\u3002\u4e0d\u80fd\u4ee5\u201cUMAP\u6df7\u5f97\u8d8a\u5747\u5300\u8d8a\u597d\u201d\u4f5c\u4e3a\u552f\u4e00\u6807\u51c6\u3002<\/p>\n

3. \u4fe1\u606f\u6cc4\u6f0f\u4f1a\u5236\u9020\u865a\u5047\u7684\u9ad8\u51c6\u786e\u7387<\/h3>\n

\u540c\u4e00\u4e2a\u60a3\u8005\u6709\u591a\u5f20\u5207\u7247\u3001\u591a\u4e2a\u65f6\u95f4\u70b9\u6216\u8bb8\u591a\u7ec6\u80de\uff0c\u5982\u679c\u8fd9\u4e9b\u76f8\u5173\u6570\u636e\u540c\u65f6\u8fdb\u5165\u8bad\u7ec3\u96c6\u548c\u6d4b\u8bd5\u96c6\uff0c\u6a21\u578b\u53ef\u80fd\u5df2\u7ecf\u89c1\u8fc7\u8be5\u60a3\u8005\u7684\u4fe1\u606f\u3002\u9884\u6d4b\u4efb\u52a1\u5e94\u6309\u771f\u6b63\u72ec\u7acb\u7684\u5355\u4f4d\u5212\u5206\u6570\u636e\u3002\u82e5\u76ee\u6807\u662f\u63a8\u5e7f\u5230\u65b0\u60a3\u8005\uff0c\u5c31\u4e0d\u80fd\u628a\u540c\u4e00\u60a3\u8005\u7684\u4e0d\u540c\u7ec6\u80de\u5f53\u4f5c\u4e92\u4e0d\u76f8\u5173\u7684\u72ec\u7acb\u6d4b\u8bd5\u4e2a\u4f53\u3002<\/p>\n

\u540c\u6837\uff0c\u5148\u7528\u5168\u90e8\u6570\u636e\u7b5b\u9009\u4e0e\u7ed3\u5c40\u76f8\u5173\u7684\u7279\u5f81\uff0c\u518d\u5212\u5206\u8bad\u7ec3\u6d4b\u8bd5\uff0c\u4e5f\u4f1a\u8ba9\u6d4b\u8bd5\u4fe1\u606f\u63d0\u524d\u53c2\u4e0e\u5f00\u53d1\u3002\u7279\u5f81\u7b5b\u9009\u3001\u53c2\u6570\u9009\u62e9\u548c\u9608\u503c\u8c03\u6574\uff0c\u5e94\u7eb3\u5165\u6b63\u786e\u7684\u8bad\u7ec3\u4e0e\u9a8c\u8bc1\u6d41\u7a0b\u3002<\/p>\n

4. \u53ef\u89e3\u91ca\u4e0d\u7b49\u4e8e\u6709\u56e0\u679c\u8bc1\u636e<\/h3>\n

\u6a21\u578b\u7ed9\u67d0\u4e2a\u57fa\u56e0\u3001\u533a\u57df\u6216\u56fe\u50cf\u5757\u8f83\u9ad8\u6743\u91cd\uff0c\u53ea\u8bf4\u660e\u5b83\u5728\u5f53\u524d\u6a21\u578b\u4e2d\u6709\u8d21\u732e\uff0c\u4e0d\u80fd\u76f4\u63a5\u8bc1\u660e\u5b83\u5bfc\u81f4\u75be\u75c5\u3002\u91cd\u8981\u6027\u8fd8\u53ef\u80fd\u53d7\u76f8\u5173\u7279\u5f81\u3001\u6570\u636e\u5206\u5e03\u548c\u6a21\u578b\u7ed3\u6784\u5f71\u54cd\u3002\u673a\u5236\u4e3b\u5f20\u9700\u8981\u4e0e\u7814\u7a76\u8bbe\u8ba1\u53ca\u72ec\u7acb\u5b9e\u9a8c\u76f8\u5339\u914d\u3002<\/p>\n

5. \u6570\u636e\u3001\u7b97\u529b\u548c\u7ef4\u62a4\u590d\u6742\u5ea6\u4e00\u8d77\u4e0a\u5347<\/h3>\n

\u591a\u6a21\u6001\u9879\u76ee\u4e0d\u4ec5\u591a\u51e0\u4e2a\u8f93\u5165\u6587\u4ef6\uff0c\u8fd8\u589e\u52a0\u5339\u914d\u3001\u8d28\u63a7\u3001\u7248\u672c\u7ba1\u7406\u3001\u8ba1\u7b97\u548c\u89e3\u91ca\u5de5\u4f5c\u3002\u6a21\u578b\u5347\u7ea7\u3001\u6ce8\u91ca\u7248\u672c\u53d8\u5316\u6216\u65b0\u589e\u6570\u636e\u540e\uff0c\u65e7\u6d41\u7a0b\u80fd\u5426\u91cd\u590d\u8fd0\u884c\uff0c\u4e5f\u662f\u9879\u76ee\u6210\u672c\u7684\u4e00\u90e8\u5206\u3002<\/p>\n

\u4e03\u3001\u4e00\u4e2a\u53ef\u4ee5\u7167\u7740\u8ba8\u8bba\u7684\u9879\u76ee\u793a\u4f8b<\/h2>\n

\u4ee5\u4e0b\u4e3a\u6559\u5b66\u8bbe\u8ba1\u793a\u4f8b\uff0c\u4e0d\u662f\u4e91\u751f\u4fe1\u5df2\u5b8c\u6210\u9879\u76ee\uff0c\u4e5f\u4e0d\u4ee3\u8868\u5df2\u53d6\u5f97\u4efb\u4f55\u6548\u679c\u3002<\/strong><\/p>\n

\u5047\u8bbe\u8bfe\u9898\u7ec4\u6709\u4e00\u6279\u60a3\u8005\u7684\u75c5\u7406\u5207\u7247\u3001\u80bf\u7624RNA\u6570\u636e\u548c\u968f\u8bbf\u8bb0\u5f55\uff0c\u60f3\u7814\u7a76\u8054\u5408\u4fe1\u606f\u662f\u5426\u6709\u52a9\u4e8e\u9884\u540e\u9884\u6d4b\u3002<\/p>\n

**\u7b2c\u4e00\u6b65\uff0c\u660e\u786e\u9884\u6d4b\u53d1\u751f\u5728\u4ec0\u4e48\u65f6\u5019\u3002**\u4f8b\u5982\u4f7f\u7528\u6cbb\u7597\u524d\u80fd\u83b7\u5f97\u7684\u4fe1\u606f\u9884\u6d4b\u4e4b\u540e\u7684\u7ed3\u5c40\uff0c\u5c31\u4e0d\u80fd\u628a\u540e\u7eed\u6cbb\u7597\u53cd\u5e94\u6216\u968f\u8bbf\u4e2d\u624d\u51fa\u73b0\u7684\u53d8\u91cf\u4f5c\u4e3a\u5f53\u65f6\u7684\u8f93\u5165\u3002\u5426\u5219\u5373\u4f7f\u6a21\u578b\u5206\u6570\u5f88\u9ad8\uff0c\u4e5f\u6ca1\u6709\u5bf9\u5e94\u7684\u771f\u5b9e\u4f7f\u7528\u573a\u666f\u3002<\/p>\n

**\u7b2c\u4e8c\u6b65\uff0c\u5efa\u7acb\u60a3\u8005\u7ea7\u6570\u636e\u6e05\u5355\u3002**\u4e00\u884c\u8bb0\u5f55\u4e00\u4efd\u6837\u672c\uff0c\u901a\u8fc7\u60a3\u8005\u7f16\u53f7\u5173\u8054\u5207\u7247\u3001RNA\u4e0e\u7ed3\u5c40\uff1b\u8bb0\u5f55\u91c7\u6837\u65f6\u95f4\u3001\u7ec4\u7ec7\u6765\u6e90\u3001\u68c0\u6d4b\u6279\u6b21\u3001\u7f3a\u5931\u539f\u56e0\u548c\u53ef\u7528\u6587\u4ef6\u3002\u591a\u4e2a\u5207\u7247\u5c5e\u4e8e\u540c\u4e00\u60a3\u8005\u65f6\uff0c\u4e0d\u80fd\u64c5\u81ea\u589e\u52a0\u72ec\u7acb\u60a3\u8005\u6570\u3002<\/p>\n

**\u7b2c\u4e09\u6b65\uff0c\u5206\u522b\u68c0\u67e5\u8d28\u91cf\u3002**\u56fe\u50cf\u68c0\u67e5\u7ec4\u7ec7\u533a\u57df\u4e0e\u660e\u663e\u4f2a\u5f71\uff1bRNA\u68c0\u67e5\u6837\u672c\u8d28\u91cf\u53ca\u5f02\u5e38\uff1b\u968f\u8bbf\u6838\u5bf9\u65f6\u95f4\u8d77\u70b9\u3001\u4e8b\u4ef6\u7f16\u7801\u548c\u5220\u5931\u542b\u4e49\u3002\u5148\u5904\u7406\u660e\u663e\u95ee\u9898\uff0c\u518d\u8ba8\u8bba\u590d\u6742\u878d\u5408\u3002<\/p>\n

**\u7b2c\u56db\u6b65\uff0c\u7528\u540c\u6837\u7684\u6570\u636e\u5212\u5206\u6bd4\u8f83\u3002**\u81f3\u5c11\u5efa\u7acb\u4e0e\u76ee\u6807\u76f8\u7b26\u7684\u5355\u6a21\u6001\u57fa\u7ebf\u548c\u8054\u5408\u6a21\u578b\u3002\u82e5\u4e34\u5e8a\u4fe1\u606f\u672c\u8eab\u5f88\u6709\u9884\u6d4b\u529b\uff0c\u4e5f\u8981\u8003\u8651\u76f8\u5e94\u57fa\u7ebf\uff0c\u907f\u514d\u628a\u5df2\u6709\u4fe1\u606f\u7684\u8d21\u732e\u8bef\u7b97\u5230\u65b0\u589e\u6a21\u6001\u4e0a\u3002<\/p>\n

**\u7b2c\u4e94\u6b65\uff0c\u533a\u5206\u201c\u5206\u5f97\u5f00\u201d\u548c\u201c\u4f30\u5f97\u51c6\u201d\u3002**\u4f8b\u5982\u6a21\u578b\u80fd\u591f\u8f83\u597d\u533a\u5206\u98ce\u9669\u9ad8\u4f4e\uff0c\u5e76\u4e0d\u7b49\u4e8e\u7ed9\u51fa\u7684\u98ce\u9669\u6982\u7387\u51c6\u786e\u3002\u9884\u540e\u4efb\u52a1\u9700\u8981\u7ed3\u5408\u65f6\u95f4\u4e0e\u5220\u5931\u9009\u62e9\u6307\u6807\uff1b\u8fd8\u5e94\u8003\u8651\u6821\u51c6\u3001\u7f6e\u4fe1\u533a\u95f4\u4ee5\u53ca\u4e0d\u540c\u4e9a\u7ec4\u7684\u7a33\u5b9a\u6027\u3002<\/p>\n

**\u7b2c\u516d\u6b65\uff0c\u4f5c\u51fa\u660e\u786e\u7684\u4e0b\u4e00\u6b65\u5224\u65ad\u3002**\u8054\u5408\u6a21\u578b\u7a33\u5b9a\u4f18\u4e8e\u57fa\u7ebf\uff0c\u53ef\u4ee5\u7ee7\u7eed\u5916\u90e8\u9a8c\u8bc1\uff1b\u53ea\u5728\u8bad\u7ec3\u6570\u636e\u66f4\u597d\uff0c\u5c31\u5148\u67e5\u8fc7\u62df\u5408\u548c\u6cc4\u6f0f\uff1b\u589e\u76ca\u5f88\u5c0f\u4e14\u6210\u672c\u660e\u663e\u589e\u52a0\uff0c\u5219\u4fdd\u7559\u7b80\u5355\u65b9\u6848\u3002\u7ed3\u679c\u4e0d\u652f\u6301\u590d\u6742\u6a21\u578b\uff0c\u4e5f\u662f\u4e00\u9879\u6709\u4ef7\u503c\u7684\u7ed3\u8bba\u3002<\/p>\n

\"\u591a\u6a21\u6001\u5206\u6790\u4ece\u7814\u7a76\u95ee\u9898\u5230\u72ec\u7acb\u9a8c\u8bc1\u7684\u6d41\u7a0b\"<\/figure>\n

\u56fe\u6ce8\uff1a\u7814\u7a76\u95ee\u9898\u2192\u6837\u672c\u5bf9\u5e94\u2192\u5206\u6a21\u6001\u8d28\u63a7\u2192\u5355\u6a21\u6001\u57fa\u7ebf\u2192\u8054\u5408\u5206\u6790\u2192\u72ec\u7acb\u9a8c\u8bc1\u2192\u51b3\u5b9a\u662f\u5426\u7ee7\u7eed\u3002\u6a21\u578b\u63a8\u65ad\u4e0e\u5b9e\u6d4b\u6570\u636e\u5206\u5f00\u6807\u8bb0\uff1b\u8054\u5408\u5206\u6790\u6ca1\u6709\u7a33\u5b9a\u589e\u76ca\u65f6\uff0c\u4e0d\u5fc5\u7ee7\u7eed\u589e\u52a0\u590d\u6742\u5ea6\u3002\u6d41\u7a0b\u793a\u610f\uff0c\u975e\u5b9e\u6d4b\u6027\u80fd\u7ed3\u679c\u3002<\/em><\/p>\n

\u516b\u3001\u5f00\u59cb\u524d\u51c6\u5907\u4ec0\u4e48\uff1f\u5b8c\u6210\u540e\u600e\u6837\u9a8c\u6536\uff1f<\/h2>\n

\u5f00\u59cb\u524d\uff1a\u4e00\u4efd\u8bf4\u660e\u3001\u4e00\u5f20\u5bf9\u5e94\u8868\u3001\u4e00\u4efd\u6587\u4ef6\u6e05\u5355<\/h3>\n

\u9879\u76ee\u8bf4\u660e\u81f3\u5c11\u56de\u7b54\uff1a\u7814\u7a76\u5bf9\u8c61\u662f\u4ec0\u4e48\u3001\u6838\u5fc3\u95ee\u9898\u662f\u4ec0\u4e48\u3001\u5df2\u6709\u54ea\u51e0\u7c7b\u6570\u636e\u3001\u662f\u5426\u5b58\u5728\u914d\u5bf9\u3001\u6700\u7ec8\u5e0c\u671b\u5f97\u5230\u89e3\u91ca\u8fd8\u662f\u9884\u6d4b\u5de5\u5177\u3002<\/p>\n

\u6837\u672c\u5bf9\u5e94\u8868\u5efa\u8bae\u4fdd\u7559\uff1a\u4e2a\u4f53\u7f16\u53f7\u3001\u6837\u672c\u7f16\u53f7\u3001\u6a21\u6001\u7c7b\u578b\u3001\u7ec4\u7ec7\u90e8\u4f4d\u3001\u91c7\u6837\u65f6\u95f4\u3001\u5206\u7ec4\u3001\u6279\u6b21\u3001\u7f3a\u5931\u60c5\u51b5\u4e0e\u6587\u4ef6\u8def\u5f84\u3002\u6d89\u53ca\u4eba\u5458\u4fe1\u606f\u65f6\u4f7f\u7528\u5408\u9002\u7684\u7814\u7a76\u7f16\u53f7\uff0c\u4e0d\u628a\u4e0e\u5206\u6790\u65e0\u5173\u7684\u8eab\u4efd\u8d44\u6599\u6df7\u5165\u6587\u4ef6\u3002<\/p>\n

\u6587\u4ef6\u6e05\u5355\u5e94\u8bf4\u660e\u8f93\u5165\u662f\u539f\u59cb\u6d4b\u5e8f\u6587\u4ef6\u3001\u8ba1\u6570\u77e9\u9635\u3001\u6807\u51c6\u5316\u77e9\u9635\u3001\u56fe\u50cf\u8fd8\u662f\u5df2\u5904\u7406\u5bf9\u8c61\uff0c\u5e76\u4fdd\u7559\u53c2\u8003\u57fa\u56e0\u7ec4\u3001\u6ce8\u91ca\u548c\u8f6f\u4ef6\u7248\u672c\u3002\u53ea\u6709\u51e0\u5f20\u7ed3\u679c\u622a\u56fe\uff0c\u901a\u5e38\u4e0d\u8db3\u4ee5\u91cd\u65b0\u8fdb\u884c\u53ef\u9760\u6574\u5408\u3002\u8d44\u6599\u51c6\u5907\u53ef\u53c2\u8003\u4e91\u751f\u4fe1\u7684\u751f\u4fe1\u5206\u6790\u6570\u636e\u4e0e\u5206\u7ec4\u4fe1\u606f\u6e05\u5355<\/a>\u3002<\/p>\n

\u5b8c\u6210\u540e\uff1a\u4e0d\u8981\u53ea\u9a8c\u6536\u56fe\u7247\u662f\u5426\u6f02\u4eae<\/h3>\n

\u5efa\u8bae\u68c0\u67e5\u516d\u9879\u4ea4\u4ed8\uff1a<\/p>\n

    \n
  1. **\u6570\u636e\u53bb\u5411\u6e05\u695a\u3002**\u54ea\u4e9b\u6837\u672c\u7eb3\u5165\u3001\u54ea\u4e9b\u6392\u9664\u3001\u4e3a\u4ec0\u4e48\u6392\u9664\uff0c\u662f\u5426\u6539\u53d8\u4e86\u7ec4\u95f4\u6784\u6210\u3002<\/li>\n
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    \u53c2\u8003\u6587\u732e<\/h2>\n

    [1] Stoeckius M, et al. Simultaneous epitope and transcriptome measurement in single cells.<\/strong> Nature Methods<\/em>. 2017;14:865\u2013868. DOI: 10.1038\/nmeth.4380<\/a>\u3002\u7528\u9014\uff1a\u4e86\u89e3CITE-seq\u5982\u4f55\u8fde\u63a5RNA\u4e0e\u7279\u5b9a\u86cb\u767d\u6807\u8bb0\u6d4b\u91cf\u3002<\/p>\n

    [2] Hao Y, et al. Integrated analysis of multimodal single-cell data.<\/strong> Cell<\/em>. 2021;184:3573\u20133587.e29. DOI: 10.1016\/j.cell.2021.04.048<\/a>\u3002\u7528\u9014\uff1a\u4e86\u89e3WNN\u53ca\u540c\u4e00\u7ec6\u80de\u591a\u6a21\u6001\u4fe1\u606f\u7684\u6574\u5408\u601d\u8def\u3002<\/p>\n

    [3] Argelaguet R, et al. MOFA+: a statistical framework for comprehensive integration of multi-modal single-cell data.<\/strong> Genome Biology<\/em>. 2020;21:111. DOI: 10.1186\/s13059-020-02015-1<\/a>\u3002\u7528\u9014\uff1a\u4e86\u89e3\u591a\u6a21\u6001\u6570\u636e\u4e2d\u7684\u6f5c\u5728\u56e0\u5b50\u4e0e\u53d8\u5316\u6765\u6e90\u3002<\/p>\n

    [4] Ashuach T, et al. MultiVI: deep generative model for the integration of multimodal data.<\/strong> Nature Methods<\/em>. 2023;20:1222\u20131231. DOI: 10.1038\/s41592-023-01909-9<\/a>\u3002\u7528\u9014\uff1a\u4e86\u89e3\u914d\u5bf9\u3001\u5355\u6a21\u6001\u6570\u636e\u6574\u5408\u53ca\u7f3a\u5931\u6a21\u6001\u63a8\u65ad\u7684\u80fd\u529b\u548c\u8fb9\u754c\u3002<\/p>\n

    [5] Chen RJ, et al. Pan-cancer integrative histology-genomic analysis via multimodal deep learning.<\/strong> Cancer Cell<\/em>. 2022;40:865\u2013878.e6. DOI: 10.1016\/j.ccell.2022.07.004<\/a>\u3002\u7528\u9014\uff1a\u4e86\u89e3\u75c5\u7406\u56fe\u50cf\u4e0e\u5206\u5b50\u6570\u636e\u8054\u5408\u5f00\u5c55\u9884\u540e\u7814\u7a76\u7684\u5b9e\u4f8b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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