{"id":73232,"date":"2026-11-15T15:18:36","date_gmt":"2026-11-15T07:18:36","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=73232"},"modified":"2026-11-15T15:20:02","modified_gmt":"2026-11-15T07:20:02","slug":"chromhmm-label-alignment-missing-zero-state-count-practice","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/chromhmm-label-alignment-missing-zero-state-count-practice\/","title":{"rendered":"ChromHMM \u5b9e\u8dd1\u590d\u76d8\uff0c\u72b6\u6001\u6807\u7b7e\u5168\u53d8\u4e86\uff0c\u67d3\u8272\u8d28\u5206\u6bb5\u5c31\u4e0d\u7a33\u5b9a\u5417"},"content":{"rendered":"
\n

\u7528 ChromHMM \u6bd4\u8f83\u4e24\u6b21\u5206\u6790\u65f6\uff0c\u5f88\u5bb9\u6613\u5148\u770b\u72b6\u6001\u7f16\u53f7\u3002\u4e00\u4efd\u7ed3\u679c\u7684\u67d0\u6bb5\u662f\u7b2c\u56db\u72b6\u6001\uff0c\u53e6\u4e00\u4efd\u53d8\u6210\u7b2c\u4e00\u72b6\u6001\uff0c\u770b\u8d77\u6765\u50cf\u5b8c\u5168\u53d8\u4e86\u3002\u4f46\u7f16\u53f7\u53ea\u662f\u6a21\u578b\u5185\u90e8\u7684\u540d\u79f0\uff0c\u6ca1\u6709\u8de8\u6a21\u578b\u56fa\u5b9a\u7684\u751f\u7269\u5b66\u8eab\u4efd\u3002\u672c\u6b21\u6559\u5b66\u5b9e\u9a8c\u6070\u597d\u5f97\u5230\u4e00\u4e2a\u5f88\u76f4\u89c2\u7684\u7ed3\u679c\uff0c\u4e24\u6b21\u56db\u72b6\u6001\u8bad\u7ec3\u7684\u9010\u683c\u539f\u59cb\u6807\u7b7e\u4e00\u81f4\u7387\u4e3a\u96f6\uff0c\u628a\u6807\u7b7e\u5bf9\u5e94\u5173\u7cfb\u5bf9\u9f50\u4ee5\u540e\uff0c\u4e00\u81f4\u7387\u5374\u4e3a\u767e\u5206\u4e4b\u767e\u3002\u771f\u6b63\u9700\u8981\u6bd4\u8f83\u7684\u662f\u6807\u8bb0\u7ec4\u5408\u548c\u533a\u95f4\u8fb9\u754c\uff0c\u800c\u4e0d\u662f\u989c\u8272\u6216\u8005\u7f16\u53f7\u662f\u5426\u76f8\u540c\u3002<\/p>\n

\u672c\u6587\u5b9e\u9645\u5b89\u88c5\u5e76\u8fd0\u884c ChromHMM 1.28\uff0c\u4f7f\u7528\u81ea\u884c\u6784\u9020\u7684\u4e09\u79cd\u533f\u540d\u6807\u8bb0\u3001\u4e00\u6761\u865a\u6784\u67d3\u8272\u4f53\uff0c\u5b8c\u6210\u8bad\u7ec3\u3001\u56fa\u5b9a\u6a21\u578b\u5206\u6bb5\u3001\u91cd\u547d\u540d\u53ca\u8ba1\u6570\u4e8c\u503c\u5316\u3002\u6240\u6709\u6570\u636e\u90fd\u4e0d\u662f\u5b9e\u9a8c\u6837\u672c\uff0c\u672c\u6587\u4e5f\u6ca1\u6709\u628a\u4efb\u4f55\u72b6\u6001\u547d\u540d\u4e3a\u542f\u52a8\u5b50\u6216\u589e\u5f3a\u5b50\u3002\u5c0f\u6570\u636e\u7684\u4f5c\u7528\u662f\u8ba9\u6bcf\u4e00\u6b21\u6539\u53d8\u90fd\u80fd\u8ffd\u6eaf\u539f\u56e0\uff0c\u4e0d\u7528\u4e8e\u8bc4\u4ef7\u771f\u5b9e\u6570\u636e\u7684\u6ce8\u91ca\u51c6\u786e\u7387\u3002\u8f6f\u4ef6\u5b9a\u4f4d\u548c\u5f53\u524d\u7248\u672c\u53ef\u4ee5\u5728\u5b98\u65b9\u9879\u76ee\u9875<\/a>\u6838\u67e5\u3002<\/p>\n

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\u4e8c\u503c\u6587\u4ef6\u524d\u4e24\u884c\u5206\u522b\u6807\u8bc6\u7ec6\u80de\u4e0e\u67d3\u8272\u4f53\u3001\u6807\u8bb0\u540d\u79f0\uff0c\u4e4b\u540e\u6bcf\u884c\u5bf9\u5e94\u4e00\u4e2a\u8fde\u7eed\u683c\u5b50\u3002\u4e0b\u9762\u7528 \\t<\/code> \u663e\u793a\u5236\u8868\u7b26\u7684\u4f4d\u7f6e\uff0c\u5b9e\u9645\u6587\u4ef6\u4f7f\u7528\u771f\u6b63\u7684\u5236\u8868\u7b26\uff0c\u7531\u590d\u73b0\u811a\u672c\u751f\u6210\uff0c\u4e0d\u5e94\u628a\u8fd9\u6bb5\u663e\u793a\u6587\u672c\u76f4\u63a5\u5b58\u6210\u8f93\u5165\u3002<\/p>\n

CellA\\tchrToy\r\nMarkA\\tMarkB\\tMarkC\r\n1\\t0\\t0\r\n1\\t0\\t0\r\n<\/code><\/pre>\n
\u5728\u8fd9\u91cc\uff0c\u96f6\u662f\u7ecf\u8fc7\u524d\u9762\u5904\u7406\u540e\u5224\u4e3a\u672a\u51fa\u73b0\uff0c\u4e00\u662f\u5224\u4e3a\u51fa\u73b0\uff0c\u4e8c\u624d\u8868\u793a\u7f3a\u5931\u3002\u7f3a\u5931\u610f\u5473\u7740\u8fd9\u4e2a\u4f4d\u7f6e\u7684\u89c2\u6d4b\u6ca1\u6709\u63d0\u4f9b\u76f8\u540c\u7684\u4fe1\u606f\uff0c\u4e0d\u80fd\u56e0\u4e3a\u8868\u683c\u9700\u8981\u586b\u6ee1\u5c31\u6539\u6210\u96f6\u3002\u6211\u4eec\u540e\u9762\u4e13\u95e8\u7528\u540c\u4e00\u4e2a\u8bad\u7ec3\u6a21\u578b\u9a8c\u8bc1\u8fd9\u4e2a\u5dee\u522b\u3002\u6587\u4ef6\u7ec4\u7ec7\u548c\u53d6\u503c\u5b9a\u4e49\u53ef\u6838\u5bf9\u5b98\u65b9\u624b\u518c<\/a>\uff0c\u4f46\u7406\u89e3\u5b9a\u4e49\u4e4b\u540e\uff0c\u4ecd\u5e94\u68c0\u67e5\u81ea\u5df1\u751f\u6210\u7684\u6587\u4ef6\u6709\u6ca1\u6709\u628a\u7f3a\u5931\u8bef\u5199\u6210\u9634\u6027\u3002<\/p>\n
\u4e8c\u3001\u4e24\u6b21\u8bad\u7ec3\u7684\u6807\u7b7e\u5168\u4e0d\u540c\uff0c\u8fb9\u754c\u5374\u5b8c\u5168\u76f8\u540c<\/h2>\n
\u5b9e\u9a8c\u5728\u56fa\u5b9a\u6458\u8981\u7684\u5bb9\u5668\u4e2d\u8fd0\u884c\uff0cJava \u7248\u672c\u4e3a 25.0.2-internal\u3002\u6bcf\u4e2a\u5bb9\u5668\u9650\u5236\u4e24\u6838\u3001\u56db GiB \u5185\u5b58\uff0cJava \u5806\u4e0a\u9650\u4e00 GiB\u3002\u8fd9\u4e9b\u662f\u672c\u4f8b\u7684\u73af\u5883\u8bb0\u5f55\uff0c\u4e0d\u662f\u5168\u57fa\u56e0\u7ec4\u4efb\u52a1\u7684\u8d44\u6e90\u5efa\u8bae\u3002\u4e0b\u9762\u5c55\u793a\u5176\u4e2d\u4e00\u6b21\u8bad\u7ec3\u547d\u4ee4\uff0c\u5176\u4ed6\u53c2\u6570\u76f8\u540c\u7684\u7b2c\u4e8c\u6b21\u8fd0\u884c\u53ea\u628a\u968f\u673a\u79cd\u5b50\u6539\u6210\u4e00\u767e\u516d\u5341\u516d\u3002<\/p>\n
ChromHMM.sh -Xmx1g -Djava.awt.headless=true LearnModel \\\r\n  -b 200 -l genome.txt -init random -s 165 -p 2 -r 100 \\\r\n  -noautoopen -nobrowser -noenrich -noimage \\\r\n  -printposterior -printstatebyline \\\r\n  binary learn4 4 toy\r\n<\/code><\/pre>\n
\u7b2c\u4e00\u8f6e\u56db\u72b6\u6001\u8bad\u7ec3\u5f97\u5230\u4e8c\u5341\u56db\u6bb5\uff0c\u7b2c\u4e8c\u8f6e\u4e5f\u662f\u4e8c\u5341\u56db\u6bb5\u3002\u7a0b\u5e8f\u6309\u6bcf\u4e2a\u683c\u5b50\u7684\u72b6\u6001\u68c0\u67e5\uff0c\u53d1\u73b0\u5bf9\u5e94\u4f4d\u7f6e\u7684\u6570\u5b57\u6807\u7b7e\u4e00\u4e2a\u90fd\u4e0d\u76f8\u540c\u3002\u4f46\u628a\u7b2c\u4e8c\u8f6e\u7684\u4e00\u3001\u4e8c\u3001\u4e09\u3001\u56db\u72b6\u6001\u5206\u522b\u6620\u5c04\u5230\u7b2c\u4e00\u8f6e\u7684\u56db\u3001\u4e09\u3001\u4e8c\u3001\u4e00\u4ee5\u540e\uff0c\u6240\u6709\u683c\u5b50\u7684\u5206\u6bb5\u72b6\u6001\u90fd\u4e00\u81f4\u3002\u6b64\u65f6\u5982\u679c\u76f4\u63a5\u7edf\u8ba1\u6570\u5b57\u76f8\u7b49\u7387\uff0c\u5c31\u4f1a\u9519\u8bef\u5730\u628a\u4e00\u6b21\u6807\u7b7e\u7f6e\u6362\u63cf\u8ff0\u4e3a\u6a21\u578b\u4e0d\u7a33\u5b9a\u3002<\/p>\n
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\n\n\n\n\n\n\n\n\n
\u68c0\u67e5\u9879<\/th>\n\u672c\u6b21\u7ed3\u679c<\/th>\n\u6b63\u786e\u7406\u89e3<\/th>\n<\/tr>\n<\/thead>\n
\u4e24\u8f6e\u56db\u72b6\u6001\u7684\u533a\u95f4\u6570<\/td>\n\u5747\u4e3a 24<\/td>\n\u8fd8\u9700\u68c0\u67e5\u5177\u4f53\u8fb9\u754c<\/td>\n<\/tr>\n
\u539f\u59cb\u6570\u5b57\u6807\u7b7e\u4e00\u81f4\u7387<\/td>\n0<\/td>\n\u6807\u7b7e\u6ca1\u6709\u76f4\u63a5\u53ef\u6bd4\u6027<\/td>\n<\/tr>\n
\u5bf9\u9f50\u6807\u7b7e\u540e\u7684\u4e00\u81f4\u7387<\/td>\n1<\/td>\n\u672c\u4f8b\u5206\u6bb5\u5b8c\u5168\u4e00\u81f4<\/td>\n<\/tr>\n
Reorder \u540e\u7684\u533a\u95f4\u6570<\/td>\n24<\/td>\n\u6539\u540d\u6ca1\u6709\u6539\u53d8\u8fb9\u754c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
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\u8fd9\u4e00\u7ed3\u679c\u7ed9\u6bd4\u8f83\u5de5\u4f5c\u4e00\u4e2a\u5f88\u5b9e\u7528\u7684\u6b21\u5e8f\uff0c\u5148\u786e\u8ba4\u8f93\u5165\u77e9\u9635\u548c\u683c\u5b50\u5bbd\u5ea6\u4e00\u81f4\uff0c\u518d\u6bd4\u8f83\u53d1\u5c04\u6a21\u5f0f\uff0c\u6700\u540e\u624d\u6bd4\u8f83\u91cd\u547d\u540d\u540e\u7684\u5206\u6bb5\u3002\u5982\u679c\u76f4\u63a5\u7528\u72b6\u6001\u7f16\u53f7\u8fde\u63a5\u4e24\u4efd\u8868\uff0c\u5f88\u53ef\u80fd\u5728\u6ca1\u6709\u62a5\u9519\u7684\u60c5\u51b5\u4e0b\u5f97\u5230\u4e00\u4efd\u903b\u8f91\u9519\u8bef\u7684\u53d8\u5316\u77e9\u9635\u3002\u683c\u5f0f\u6b63\u786e\u5e76\u4e0d\u80fd\u4fdd\u8bc1\u6bd4\u8f83\u5bf9\u8c61\u6b63\u786e\u3002<\/p>\n
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\u4e94\u3001\u540e\u9a8c\u66f4\u63a5\u8fd1\u4e00\uff0c\u4e0d\u4ee3\u8868\u72b6\u6001\u6570\u91cf\u9009\u5f97\u66f4\u597d<\/h2>\n
\u672c\u6b21\u53e6\u5916\u8bad\u7ec3\u4e86\u4e00\u4e2a\u4e24\u72b6\u6001\u6a21\u578b\uff0c\u4f7f\u7528\u540c\u4e00\u4efd\u8f93\u5165\u548c\u76f8\u540c\u7684\u521d\u59cb\u5316\u79cd\u5b50\u3002\u56db\u72b6\u6001\u6a21\u578b\u53ef\u4ee5\u5206\u522b\u6982\u62ec\u4e09\u79cd\u5355\u6807\u8bb0\u6a21\u5f0f\u4e0e\u5168\u90e8\u4f4e\u7684\u6a21\u5f0f\uff0c\u4e24\u72b6\u6001\u6a21\u578b\u5219\u53ea\u80fd\u538b\u7f29\u8fd9\u4e9b\u533a\u522b\u3002\u8f93\u51fa\u7ed3\u679c\u91cc\uff0c\u4e00\u79cd\u72b6\u6001\u4e3b\u8981\u4fdd\u7559\u4e19\u9ad8\u7684\u7279\u5f81\uff0c\u53e6\u4e00\u79cd\u628a\u7532\u9ad8\u3001\u4e59\u9ad8\u548c\u5168\u90e8\u4f4e\u7b49\u60c5\u51b5\u6df7\u5728\u4e86\u4e00\u8d77\u3002<\/p>\n
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\n\n\n\n\n\n\n
\u6a21\u578b<\/th>\n\u5206\u6bb5\u6570<\/th>\n\u5e73\u5747\u6700\u5927\u540e\u9a8c\u6982\u7387<\/th>\n\u672c\u4f8b\u4e2d\u7684\u4ee3\u4ef7<\/th>\n<\/tr>\n<\/thead>\n
\u56db\u72b6\u6001<\/td>\n24<\/td>\n\u7ea6 0.99725<\/td>\n\u4fdd\u7559\u4e86\u66f4\u591a\u6807\u8bb0\u7ec4\u5408<\/td>\n<\/tr>\n
\u4e24\u72b6\u6001<\/td>\n13<\/td>\n\u7ea6 0.99755<\/td>\n\u591a\u79cd\u7ec4\u5408\u88ab\u5f52\u5230\u540c\u4e00\u72b6\u6001<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\u56e0\u6b64\uff0c\u9009\u62e9\u72b6\u6001\u6570\u4e0d\u80fd\u53ea\u8ffd\u6c42\u6700\u6e05\u6670\u7684\u70ed\u56fe\u3001\u6700\u9ad8\u7684\u540e\u9a8c\u503c\u6216\u8005\u6700\u5c11\u7684\u533a\u95f4\u6570\u3002\u5e94\u5148\u8bf4\u660e\u7814\u7a76\u9700\u8981\u533a\u5206\u5230\u4ec0\u4e48\u7a0b\u5ea6\uff0c\u518d\u68c0\u67e5\u589e\u52a0\u72b6\u6001\u662f\u5426\u5f62\u6210\u53ef\u89e3\u91ca\u3001\u53ef\u91cd\u590d\u7684\u7ec6\u5206\u3002\u4e00\u4e2a\u72b6\u6001\u88ab\u62c6\u6210\u4e24\u4e2a\u4f46\u6807\u8bb0\u7ec4\u5408\u51e0\u4e4e\u76f8\u540c\uff0c\u548c\u539f\u672c\u6df7\u5728\u4e00\u8d77\u7684\u4e24\u79cd\u7ec4\u5408\u88ab\u5206\u5f00\uff0c\u662f\u4e0d\u540c\u7684\u7ed3\u679c\u3002\u5916\u90e8\u6ce8\u91ca\u53ef\u4ee5\u5e2e\u52a9\u8bc4\u4ef7\uff0c\u4f46\u4e5f\u8981\u907f\u514d\u4e00\u8fb9\u53cd\u590d\u8c03\u6574\u6a21\u578b\uff0c\u4e00\u8fb9\u628a\u540c\u4e00\u4efd\u6ce8\u91ca\u5f53\u6210\u72ec\u7acb\u9a8c\u8bc1\u3002<\/p>\n
\u672c\u4f8b\u63d0\u4f9b\u7684\u662f\u6982\u5ff5\u4e0a\u7684\u53cd\u4f8b\uff0c\u6ca1\u6709\u8fdb\u884c\u5168\u8303\u56f4\u72b6\u6001\u6570\u641c\u7d22\uff0c\u4e5f\u6ca1\u6709\u5efa\u7acb\u771f\u5b9e\u6570\u636e\u4e0a\u7684\u6700\u4f18\u6a21\u578b\u3002\u5c06\u6a21\u62df\u4e2d\u7684\u56db\u72b6\u6001\u539f\u6837\u63a8\u8350\u7ed9\u5176\u4ed6\u7814\u7a76\uff0c\u6070\u597d\u8fdd\u80cc\u4e86\u8fd9\u4e2a\u5b9e\u9a8c\u60f3\u8bf4\u660e\u7684\u4e8b\u60c5\u3002\u6a21\u578b\u590d\u6742\u5ea6\u9700\u8981\u8ddf\u8f93\u5165\u4fe1\u606f\u548c\u5206\u6790\u76ee\u6807\u5bf9\u5e94\uff0c\u4e0d\u80fd\u8ddf\u4e00\u7bc7\u6559\u7a0b\u7684\u6f14\u793a\u53c2\u6570\u7ed1\u5b9a\u3002<\/p>\n
\u516d\u3001\u4e8c\u503c\u5316\u662f\u4e0a\u6e38\u51b3\u7b56\uff0c\u4e0d\u80fd\u5f53\u4f5c\u65e0\u635f\u8f6c\u6362<\/h2>\n
\u4e3a\u72ec\u7acb\u68c0\u67e5\u4e8c\u503c\u5316\uff0c\u6211\u4eec\u53e6\u5efa\u4e86\u4e00\u767e\u683c\u3001\u4e24\u79cd\u6807\u8bb0\u7684\u8ba1\u6570\u8f93\u5165\u3002\u7b2c\u4e00\u79cd\u53ea\u5728\u5176\u4e2d\u4e8c\u5341\u683c\u5199\u5165\u4e8c\u5341\u4e2a\u8ba1\u6570\uff0c\u5176\u4f59\u4e3a\u96f6\u3002\u7b2c\u4e8c\u79cd\u5728\u5168\u90e8\u683c\u5b50\u5199\u8d1f\u4e00\uff0c\u8868\u793a\u8be5\u8ba1\u6570\u8f93\u5165\u4e2d\u7684\u7f3a\u5931\u3002\u6ce8\u610f\u8fd9\u91cc\u8ba1\u6570\u6587\u4ef6\u7684\u7f3a\u5931\u5199\u6cd5\u4e0e\u8bad\u7ec3\u7528\u4e8c\u503c\u6587\u4ef6\u4e0d\u540c\uff0c\u4e0d\u80fd\u4e92\u6362\u6587\u4ef6\u683c\u5f0f\u3002<\/p>\n
\u9ed8\u8ba4\u8fd0\u884c\u540e\uff0c\u7b2c\u4e00\u79cd\u6807\u8bb0\u6709\u4e8c\u5341\u683c\u88ab\u5224\u4e3a\u51fa\u73b0\uff0c\u7b2c\u4e8c\u79cd\u7684\u4e00\u767e\u683c\u90fd\u8f6c\u4e3a\u4e8c\u503c\u7f3a\u5931\u3002\u518d\u589e\u52a0\u4e00\u4e2a\u4e09\u5341\u7684\u7edd\u5bf9\u8ba1\u6570\u95e8\u69db\u540e\uff0c\u7b2c\u4e00\u79cd\u6ca1\u6709\u4efb\u4f55\u683c\u5b50\u88ab\u5224\u4e3a\u51fa\u73b0\uff0c\u800c\u7b2c\u4e8c\u79cd\u4ecd\u7136\u5168\u90e8\u4fdd\u6301\u7f3a\u5931\u3002\u8fd9\u4e24\u6b21\u8fd0\u884c\u4f7f\u7528\u7684\u539f\u59cb\u8ba1\u6570\u5b8c\u5168\u76f8\u540c\uff0c\u53d8\u5316\u6765\u81ea\u5224\u5b9a\u6761\u4ef6\uff0c\u800c\u4e0d\u662f\u6837\u672c\u751f\u7269\u5b66\u53d1\u751f\u53d8\u5316\u3002<\/p>\n
ChromHMM.sh BinarizeSignal signal binarize_default\r\nChromHMM.sh BinarizeSignal -g 30 signal binarize_high\r\n<\/code><\/pre>\n
\u8fd9\u4e5f\u63d0\u9192\u6211\u4eec\uff0c\u4e0d\u5e94\u628a\u4efb\u610f\u5f52\u4e00\u5316\u540e\u7684\u8fde\u7eed\u8f68\u9053\u76f4\u63a5\u5f53\u6210\u539f\u59cb\u8ba1\u6570\u8f93\u5165\u3002\u5df2\u7ecf\u8fdb\u884c\u5bf9\u6570\u8f6c\u6362\u3001\u6bd4\u4f8b\u7f29\u653e\u6216\u8005\u5176\u4ed6\u6821\u6b63\u7684\u6570\u503c\uff0c\u4e0e\u4e00\u4e2a\u683c\u5b50\u91cc\u89c2\u5bdf\u5230\u591a\u5c11\u6761\u7247\u6bb5\u4e0d\u662f\u540c\u4e00\u5bf9\u8c61\u3002\u5373\u4f7f\u8f6f\u4ef6\u63a5\u53d7\u4e86\u6570\u5b57\u6587\u4ef6\uff0c\u540e\u7eed\u9608\u503c\u7684\u7edf\u8ba1\u542b\u4e49\u4e5f\u53ef\u80fd\u5df2\u7ecf\u6539\u53d8\u3002\u5206\u6790\u8bb0\u5f55\u5e94\u8be5\u4fdd\u7559\u8f93\u5165\u5355\u4f4d\u3001\u4e8c\u503c\u5316\u65b9\u6cd5\u3001\u63a7\u5236\u6570\u636e\u548c\u9608\u503c\uff0c\u800c\u4e0d\u53ea\u662f\u6700\u540e\u7684\u96f6\u4e00\u77e9\u9635\u3002<\/p>\n
\u672c\u6b21\u5b89\u88c5\u4e0e\u8fd0\u884c\u8fd8\u7559\u4e0b\u4e24\u4e2a\u590d\u73b0\u7ecf\u9a8c\u3002\u7b2c\u4e00\uff0c\u8bbe\u7f6e\u4e86\u968f\u673a\u79cd\u5b50\u540e\uff0c\u6a21\u578b\u6587\u4ef6\u540d\u542b\u79cd\u5b50\u6807\u8bc6\uff0c\u4e0d\u80fd\u5728\u540e\u7eed\u547d\u4ee4\u4e2d\u76f2\u5199\u4e00\u4e2a\u4e0d\u5b58\u5728\u7684\u56fa\u5b9a\u6587\u4ef6\u540d\uff0c\u5e94\u8bfb\u53d6\u5b9e\u9645\u4ea7\u7269\u5e76\u786e\u8ba4\u552f\u4e00\u6027\u3002\u7b2c\u4e8c\uff0c\u867d\u7136\u4f20\u5165\u4e24\u7ebf\u7a0b\u4e0a\u9650\uff0c\u672c\u4f8b\u53ea\u6709\u4e00\u4e2a\u8f93\u5165\u5e8f\u5217\uff0c\u8bad\u7ec3\u65e5\u5fd7\u5b9e\u9645\u62a5\u544a\u4f7f\u7528\u4e00\u4e2a\u7ebf\u7a0b\u3002\u7ebf\u7a0b\u53c2\u6570\u4e0d\u662f\u5df2\u7ecf\u83b7\u5f97\u76f8\u5e94\u52a0\u901f\u7684\u8bc1\u636e\uff0c\u8fd9\u4e2a\u5c0f\u5b9e\u9a8c\u4e5f\u6ca1\u6709\u6d4b\u91cf\u5e76\u884c\u6027\u80fd\u3002<\/p>\n
\u4e03\u3001\u62ff\u5230\u7ed3\u679c\u4ee5\u540e\u600e\u6837\u9010\u5c42\u68c0\u67e5<\/h2>\n
\u5efa\u8bae\u5148\u68c0\u67e5\u4e09\u4ef6\u53ef\u4ee5\u76f4\u63a5\u8ba1\u6570\u7684\u4e8b\u60c5\uff0c\u4e8c\u503c\u77e9\u9635\u884c\u6570\u662f\u5426\u5bf9\u5e94\u67d3\u8272\u4f53\u957f\u5ea6\u3001\u5206\u6bb5\u662f\u5426\u843d\u5728\u9884\u671f\u683c\u5b50\u8fb9\u754c\u3001\u6bcf\u4e2a\u72b6\u6001\u7d2f\u8ba1\u957f\u5ea6\u662f\u5426\u4e0e\u603b\u8986\u76d6\u957f\u5ea6\u76f8\u7b26\u3002\u63a5\u7740\u68c0\u67e5\u6807\u8bb0\u8868\u5934\u4e0e\u53d1\u5c04\u53c2\u6570\uff0c\u518d\u68c0\u67e5\u7f3a\u5931\u4f4d\u7f6e\u53ca\u540e\u9a8c\u5206\u5e03\u3002\u53ea\u6709\u8fd9\u4e9b\u57fa\u7840\u5173\u7cfb\u4e00\u81f4\uff0c\u624d\u9002\u5408\u7ee7\u7eed\u505a\u529f\u80fd\u547d\u540d\u548c\u6761\u4ef6\u4e4b\u95f4\u7684\u6bd4\u8f83\u3002<\/p>\n
ChromHMM \u7684\u4f18\u70b9\u662f\u80fd\u591f\u628a\u591a\u79cd\u6807\u8bb0\u7684\u7ec4\u5408\u4e0e\u7a7a\u95f4\u8fde\u7eed\u6027\u653e\u5728\u540c\u4e00\u6a21\u578b\u4e2d\uff0c\u5e76\u4fdd\u7559\u53ef\u4ee5\u5ba1\u9605\u7684\u53c2\u6570\u4e0e\u5206\u6bb5\u3002\u9650\u5236\u4e5f\u5f88\u660e\u786e\uff0c\u4e8c\u503c\u5316\u4f1a\u538b\u7f29\u5f3a\u5ea6\u4fe1\u606f\uff0c\u72b6\u6001\u7f16\u53f7\u4e0d\u80fd\u8de8\u6a21\u578b\u76f4\u63a5\u6bd4\u8f83\uff0c\u529f\u80fd\u6807\u7b7e\u9700\u8981\u989d\u5916\u8bc1\u636e\u3002\u5b83\u9002\u5408\u7528\u6765\u63d0\u51fa\u548c\u7ec4\u7ec7\u67d3\u8272\u8d28\u72b6\u6001\u7684\u5047\u8bbe\uff0c\u4e0d\u4f1a\u66ff\u4ee3\u539f\u59cb\u5b9e\u9a8c\u8d28\u91cf\u63a7\u5236\uff0c\u4e5f\u4e0d\u4f1a\u628a\u7f3a\u5931\u6570\u636e\u53d8\u6210\u771f\u5b9e\u89c2\u6d4b\u3002<\/p>\n
\u4e0b\u8f7d\u672c\u7ec4\u811a\u672c\u4e0e\u672c\u6b21\u7ed3\u679c\u8bb0\u5f55<\/a>\uff0c\u89e3\u538b\u540e\u5728\u672c\u7bc7\u76ee\u5f55\u6267\u884c\u4e0b\u9762\u547d\u4ee4\u5373\u53ef\u91cd\u5efa\u5168\u90e8\u6a21\u62df\u8f93\u5165\u3002\u811a\u672c\u56fa\u5b9a\u955c\u50cf\u6458\u8981\uff0c\u8bb0\u5f55\u547d\u4ee4\u3001\u9000\u51fa\u7801\u3001\u6a21\u578b\u3001\u540e\u9a8c\u548c\u6bd4\u8f83\u7ed3\u679c\uff0c\u65e2\u80fd\u6838\u5bf9\u672c\u6587\u6570\u5b57\uff0c\u4e5f\u80fd\u4fee\u6539\u7ffb\u8f6c\u6bd4\u4f8b\u6216\u7f3a\u5931\u4f4d\u7f6e\u7ee7\u7eed\u7ec3\u4e60\u3002\u5efa\u8bae\u6bcf\u6b21\u4f7f\u7528\u65b0\u7684\u8f93\u51fa\u76ee\u5f55\uff0c\u907f\u514d\u628a\u65e7\u6a21\u578b\u8bef\u8ba4\u4e3a\u5f53\u524d\u7ed3\u679c\u3002<\/p>\n
python3 run.py output\r\n<\/code><\/pre>\n
\u5f53\u6d41\u7a0b\u6269\u5c55\u5230\u591a\u7ec6\u80de\u7c7b\u578b\u3001\u591a\u5957\u6807\u8bb0\u548c\u591a\u8f6e\u6a21\u578b\u6bd4\u8f83\u65f6\uff0c\u53ef\u901a\u8fc7\u4e91\u751f\u4fe1\u751f\u7269\u5206\u6790\u670d\u52a1\u5668\u670d\u52a1<\/a>\u7ec4\u7ec7\u73af\u5883\u3001\u6570\u636e\u4e0e\u53ef\u8ffd\u6eaf\u7684\u5206\u6790\u4efb\u52a1\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"
\u5b9e\u9645\u8fd0\u884c ChromHMM 1.28\uff0c\u4ee5\u4eba\u5de5\u6807\u8bb0\u9a8c\u8bc1\u6807\u7b7e\u7f6e\u6362\u3001\u7f3a\u5931\u4e0e\u96f6\u503c\u3001\u72b6\u6001\u6570\u91cf\u548c\u8ba1\u6570\u4e8c\u503c\u5316\u7684\u5f71\u54cd\u3002<\/p>\n","protected":false},"author":1,"featured_media":73231,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[49],"tags":[1406,1407,591,1408],"class_list":["post-73232","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-software","tag-chromhmm","tag-1407","tag-591","tag-1408"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.biocloudservice.com\/wordpress\/wp-content\/uploads\/2026\/11\/chromhmm-label-alignment-missing-zero-state-count-practice-guide.png?fit=1200%2C840&ssl=1","_links":{"self":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/73232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/comments?post=73232"}],"version-history":[{"count":2,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/73232\/revisions"}],"predecessor-version":[{"id":73240,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/posts\/73232\/revisions\/73240"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media\/73231"}],"wp:attachment":[{"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/media?parent=73232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/categories?post=73232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biocloudservice.com\/wordpress\/wp-json\/wp\/v2\/tags?post=73232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}