{"id":73279,"date":"2026-11-15T15:51:02","date_gmt":"2026-11-15T07:51:02","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=73279"},"modified":"2026-11-15T15:51:02","modified_gmt":"2026-11-15T07:51:02","slug":"dss-smoothing-effect-threshold-dmr-merge-direction-practice","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/dss-smoothing-effect-threshold-dmr-merge-direction-practice\/","title":{"rendered":"DSS \u5b9e\u8dd1\u6307\u5357\u2014\u2014\u5dee\u5f02\u4f4d\u70b9\u3001\u6548\u5e94\u9608\u503c\u4e0e\u533a\u57df\u5408\u5e76\uff0c\u600e\u6837\u907f\u514d\u628a\u7ed3\u679c\u8bfb\u9519"},"content":{"rendered":"
\n

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bs <- makeBSseqData(dat, ids)\r\nplain <- DMLtest(\r\n  bs, group1 = ids[1:3], group2 = ids[4:6],\r\n  smoothing = FALSE, ncores = 1\r\n)\r\nsmooth <- DMLtest(\r\n  bs, group1 = ids[1:3], group2 = ids[4:6],\r\n  smoothing = TRUE, smoothing.span = 500, ncores = 1\r\n)\r\n<\/code><\/pre>\n
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dml_zero <- callDML(plain, delta = 0, p.threshold = 0.001)\r\ndml_effect <- callDML(plain, delta = 0.2, p.threshold = 0.05)\r\n<\/code><\/pre>\n
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\u56db\u3001\u5e73\u6ed1\u65e2\u53ef\u80fd\u589e\u5f3a\u8fde\u7eed\u4fe1\u53f7\uff0c\u4e5f\u53ef\u80fd\u6539\u53d8\u8fb9\u754c<\/h2>\n
\u4e0d\u5e73\u6ed1\u65f6\uff0c\u96f6\u5dee\u5f02\u68c0\u9a8c\u7b5b\u51fa\u4e03\u5341\u4e09\u4e2a\u4f4d\u70b9\uff0c\u5176\u4e2d\u4e03\u5341\u4e2a\u4f4d\u4e8e\u9884\u8bbe\u5927\u5e45\u53d8\u5316\u533a\u5757\uff0c\u53e6\u5916\u4e09\u4e2a\u5728\u8fd9\u4e9b\u533a\u5757\u4e4b\u5916\u3002\u5c0f\u5e45\u53d8\u5316\u533a\u5757\u6ca1\u6709\u4f4d\u70b9\u901a\u8fc7\u8be5\u95e8\u69db\u3002\u91c7\u7528\u4e8c\u5341\u4e2a\u767e\u5206\u70b9\u7684\u540e\u9a8c\u95e8\u69db\u65f6\uff0c\u7559\u4e0b\u4e03\u5341\u4e2a\u4f4d\u70b9\uff0c\u5747\u6765\u81ea\u4e24\u4e2a\u5927\u5e45\u53d8\u5316\u533a\u5757\u3002<\/p>\n
\u5e73\u6ed1\u540e\uff0c\u96f6\u5dee\u5f02\u68c0\u9a8c\u7b5b\u51fa\u4e00\u767e\u4e09\u5341\u516b\u4e2a\u4f4d\u70b9\uff0c\u5305\u62ec\u4e03\u5341\u4e2a\u5927\u5e45\u53d8\u5316\u4f4d\u70b9\u3001\u4e09\u5341\u4e2a\u5c0f\u5e45\u53d8\u5316\u4f4d\u70b9\u4ee5\u53ca\u4e09\u5341\u516b\u4e2a\u5176\u4ed6\u4f4d\u7f6e\u3002\u540e\u9a8c\u6548\u5e94\u95e8\u69db\u5219\u7559\u4e0b\u4e03\u5341\u4e09\u4e2a\uff0c\u5176\u4e2d\u4e03\u5341\u4e2a\u6765\u81ea\u5927\u5e45\u53d8\u5316\u533a\u5757\uff0c\u53e6\u5916\u4e09\u4e2a\u4f4d\u4e8e\u5176\u4ed6\u4f4d\u7f6e\u3002\u5e73\u6ed1\u589e\u52a0\u7684\u4f4d\u70b9\u4e0d\u5e94\u5168\u90e8\u89e3\u91ca\u4e3a\u989d\u5916\u53d1\u73b0\uff0c\u90e8\u5206\u53d8\u5316\u4e0e\u90bb\u8fd1\u4f4d\u7f6e\u5171\u4eab\u4fe1\u606f\u6709\u5173\u3002<\/p>\n
\n\n\n\n\n\n\n\n\n
\u5206\u6790\u4e0e\u7b5b\u9009\u89c4\u5219<\/th>\n\u603b\u5165\u9009\u6570<\/th>\n\u5927\u5e45\u53d8\u5316\u533a\u5757\u5185<\/th>\n\u5c0f\u5e45\u53d8\u5316\u533a\u5757\u5185<\/th>\n<\/tr>\n<\/thead>\n
\u4e0d\u5e73\u6ed1\uff0c\u96f6\u5dee\u5f02\u68c0\u9a8c<\/td>\n73<\/td>\n70<\/td>\n0<\/td>\n<\/tr>\n
\u4e0d\u5e73\u6ed1\uff0c\u4e8c\u5341\u4e2a\u767e\u5206\u70b9\u540e\u9a8c\u95e8\u69db<\/td>\n70<\/td>\n70<\/td>\n0<\/td>\n<\/tr>\n
\u5e73\u6ed1\uff0c\u96f6\u5dee\u5f02\u68c0\u9a8c<\/td>\n138<\/td>\n70<\/td>\n30<\/td>\n<\/tr>\n
\u5e73\u6ed1\uff0c\u4e8c\u5341\u4e2a\u767e\u5206\u70b9\u540e\u9a8c\u95e8\u69db<\/td>\n73<\/td>\n70<\/td>\n0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\u8fd9\u4e2a\u5b9e\u9a8c\u63ed\u793a\u4e86\u4e00\u4e2a\u5bb9\u6613\u5ffd\u7565\u7684\u533a\u522b\u3002\u8fde\u7eed\u4f46\u5e45\u5ea6\u8f83\u5c0f\u7684\u53d8\u5316\uff0c\u53ef\u4ee5\u5728\u5e73\u6ed1\u540e\u83b7\u5f97\u8f83\u5f3a\u7684\u7edf\u8ba1\u8bc1\u636e\uff0c\u5374\u4ecd\u8fbe\u4e0d\u5230\u9884\u5148\u6307\u5b9a\u7684\u6548\u5e94\u5e45\u5ea6\u3002\u663e\u8457\u6027\u3001\u6548\u5e94\u5927\u5c0f\u548c\u7a7a\u95f4\u8fde\u7eed\u6027\u662f\u4e09\u4e2a\u7ef4\u5ea6\uff0c\u4e0d\u80fd\u7528\u5176\u4e2d\u4e00\u4e2a\u4ee3\u66ff\u53e6\u5916\u4e24\u4e2a\u3002<\/p>\n
\u5e73\u6ed1\u4e5f\u4f1a\u5c06\u533a\u5757\u5185\u90e8\u4e0e\u8fb9\u7f18\u7684\u4f30\u8ba1\u8054\u7cfb\u8d77\u6765\u3002\u672c\u4f8b\u7b2c\u4e00\u4e2a\u5927\u5e45\u53d8\u5316\u533a\u5757\u4f4d\u4e8e\u4e94\u5343\u96f6\u4e00\u5230\u4e94\u5343\u4e94\u767e\u516b\u5341\u4e00\uff0c\u672a\u5e73\u6ed1\u7684\u533a\u57df\u7ed3\u679c\u8986\u76d6\u8fd9\u4e2a\u8303\u56f4\u3002\u5e73\u6ed1\u540e\u6309\u96f6\u5dee\u5f02\u89c4\u5219\u8bc6\u522b\u7684\u76f8\u5e94\u533a\u57df\u6269\u5c55\u5230\u56db\u5343\u516b\u767e\u4e8c\u5341\u4e00\u81f3\u4e94\u5343\u4e03\u767e\u56db\u5341\u4e00\u3002\u8fb9\u754c\u8d8a\u5bbd\u5e76\u4e0d\u81ea\u52a8\u610f\u5473\u7740\u771f\u5b9e\u8c03\u63a7\u533a\u66f4\u957f\uff0c\u5b83\u4e5f\u53cd\u6620\u6240\u9009\u5e73\u6ed1\u4e0e\u533a\u57df\u8c03\u7528\u89c4\u5219\u7684\u5171\u540c\u4f5c\u7528\u3002<\/p>\n
\u4e94\u3001\u533a\u57df\u7ed3\u679c\u9700\u8981\u4e0e\u4f4d\u70b9\u7ed3\u679c\u5206\u522b\u5ba1\u9605<\/h2>\n
\u5728\u672a\u5e73\u6ed1\u7ed3\u679c\u4e0a\uff0c\u6211\u4eec\u4f7f\u7528\u6700\u5c0f\u957f\u5ea6\u4e94\u5341\u3001\u4f4d\u70b9\u6570\u95e8\u69db\u4e09\u3001\u5408\u5e76\u8ddd\u79bb\u4e00\u767e\u548c\u663e\u8457\u6bd4\u4f8b\u95e8\u69db\u96f6\u70b9\u4e94\u8fdb\u884c\u533a\u57df\u8c03\u7528\u3002\u96f6\u5dee\u5f02\u89c4\u5219\u4e0e\u4e8c\u5341\u4e2a\u767e\u5206\u70b9\u89c4\u5219\u90fd\u5f97\u5230\u4e24\u4e2a\u533a\u57df\uff0c\u5206\u522b\u5305\u542b\u4e09\u5341\u548c\u56db\u5341\u4e2a CpG\u3002\u8fd9\u4e0e\u672c\u6b21\u6784\u9020\u7684\u4e24\u4e2a\u5927\u5e45\u53d8\u5316\u533a\u5757\u5bf9\u5e94\uff0c\u4f46\u4e0d\u80fd\u636e\u6b64\u63a8\u65ad\u771f\u5b9e\u6837\u672c\u4e5f\u4f1a\u5982\u6b64\u6574\u9f50\u3002<\/p>\n
dmr <- callDMR(\r\n  plain, delta = 0, p.threshold = 0.001,\r\n  minlen = 50, minCG = 3,\r\n  dis.merge = 100, pct.sig = 0.5\r\n)\r\n<\/code><\/pre>\n
\u533a\u57df\u8868\u5305\u542b\u8d77\u6b62\u4f4d\u7f6e\u3001\u957f\u5ea6\u3001\u4f4d\u70b9\u6570\u91cf\u3001\u4e24\u7ec4\u5747\u503c\u3001\u5dee\u5f02\u4ee5\u53ca\u533a\u57df\u7edf\u8ba1\u91cf\u3002\u672c\u6b21\u8f93\u51fa\u7684\u957f\u5ea6\u6309\u7ec8\u70b9\u51cf\u8d77\u70b9\u518d\u52a0\u4e00\u8ba1\u7b97\u3002\u4f8b\u5982\u4e94\u5343\u96f6\u4e00\u5230\u4e94\u5343\u4e94\u767e\u516b\u5341\u4e00\u5bf9\u5e94\u4e94\u767e\u516b\u5341\u4e00\u78b1\u57fa\u3002\u82e5\u8981\u8f6c\u6362\u4e3a\u96f6\u8d77\u70b9\u3001\u53f3\u4fa7\u5f00\u653e\u7684 BED \u533a\u95f4\uff0c\u5e94\u5bf9\u8d77\u70b9\u505a\u76f8\u5e94\u8f6c\u6362\uff0c\u800c\u4e0d\u662f\u53ea\u5c06\u4e24\u5217\u590d\u5236\u8fc7\u53bb\u3002<\/p>\n
\u533a\u57df\u5185\u5747\u503c\u4e0e\u4f4d\u70b9\u5e73\u5747\u6709\u5173\uff0c\u4e0d\u80fd\u81ea\u52a8\u7406\u89e3\u4e3a\u628a\u5168\u90e8\u6837\u672c\u8bfb\u6bb5\u6c47\u603b\u540e\u5f97\u5230\u7684\u8986\u76d6\u52a0\u6743\u6bd4\u4f8b\u3002\u533a\u57df\u7edf\u8ba1\u91cf\u4e5f\u4e0d\u662f\u663e\u8457\u6027\u6982\u7387\u3002\u672c\u6b21\u8f93\u51fa\u4e2d\u6ca1\u6709\u533a\u57df\u5c42\u9762\u7684 FDR \u5217\uff0c\u4e0d\u80fd\u56e0\u4e3a\u8f93\u5165\u4f4d\u70b9\u8868\u6709\u6821\u6b63\u503c\uff0c\u5c31\u628a\u7ed3\u679c\u6587\u4ef6\u6807\u9898\u5199\u6210\u201c\u533a\u57df FDR \u5c0f\u4e8e\u67d0\u503c\u201d\u3002<\/p>\n
\u516d\u3001\u7528\u4eba\u5de5\u7ed3\u679c\u8868\u770b\u6e05\u5408\u5e76\u89c4\u5219<\/h2>\n
\u4e3a\u4e86\u5c06\u533a\u57df\u89c4\u5219\u4e0e\u524d\u9762\u7684\u6a21\u578b\u4f30\u8ba1\u5206\u5f00\uff0c\u6211\u4eec\u53e6\u5199\u4e00\u5f20\u5341\u4e03\u4e2a\u4f4d\u70b9\u7684\u7ed3\u679c\u8868\uff0c\u4f4d\u7f6e\u4ece\u4e00\u767e\u5230\u4e8c\u767e\u516d\u5341\uff0c\u6bcf\u5341\u4e2a\u78b1\u57fa\u4e00\u4e2a\u3002\u524d\u4e24\u6bb5\u5404\u56db\u4e2a\u4f4d\u70b9\u4e3a\u6b63\u5411\u5dee\u5f02\uff0c\u6700\u540e\u4e00\u6bb5\u56db\u4e2a\u4f4d\u70b9\u4e3a\u8d1f\u5411\u5dee\u5f02\uff0c\u6bb5\u95f4\u4e94\u4e2a\u4f4d\u70b9\u53ea\u6709\u5f88\u5f31\u7684\u7edf\u8ba1\u8bc1\u636e\u3002\u8fd9\u91cc\u7684\u5747\u503c\u3001\u5dee\u5f02\u548c\u7edf\u8ba1\u91cf\u662f\u4eba\u5de5\u6307\u5b9a\u7684\uff0c\u4e0d\u662f\u524d\u9762\u516d\u4e2a\u6837\u672c\u62df\u5408\u5f97\u5230\u7684\u8f93\u51fa\u3002<\/p>\n
\u5f53\u6700\u5c0f\u957f\u5ea6\u4e3a\u4e09\u5341\u3001\u5408\u5e76\u8ddd\u79bb\u4e3a\u4e8c\u5341\u65f6\uff0c\u4e09\u4e2a\u533a\u6bb5\u5206\u522b\u4fdd\u7559\uff0c\u8303\u56f4\u662f\u4e00\u767e\u5230\u4e00\u767e\u4e09\u5341\u3001\u4e00\u767e\u516d\u5341\u5230\u4e00\u767e\u4e5d\u5341\uff0c\u4ee5\u53ca\u4e8c\u767e\u4e09\u5341\u5230\u4e8c\u767e\u516d\u5341\u3002\u6bcf\u4e2a\u533a\u57df\u5305\u542b\u56db\u4e2a\u4f4d\u70b9\uff0c\u957f\u5ea6\u4e09\u5341\u4e00\u3002\u628a\u5408\u5e76\u8ddd\u79bb\u6539\u4e3a\u4e09\u5341\u540e\uff0c\u524d\u4e24\u6bb5\u8fde\u63a5\u6210\u4e00\u767e\u5230\u4e00\u767e\u4e5d\u5341\uff0c\u8fde\u540c\u4e2d\u95f4\u4e24\u4e2a\u5f31\u4f4d\u70b9\u5171\u5341\u4e2a\u4f4d\u70b9\u3002<\/p>\n
\u672c\u6b21\u8fd8\u53d1\u73b0\u4e00\u4e2a\u4e0d\u80fd\u53ea\u770b\u53c2\u6570\u540d\u731c\u6d4b\u7684\u7ec6\u8282\u3002\u4fdd\u6301\u6700\u5c0f\u957f\u5ea6\u4e09\u5341\uff0c\u5c06\u5408\u5e76\u8ddd\u79bb\u6539\u6210\u4e00\u767e\uff0c\u7ed3\u679c\u4ecd\u4e0e\u5408\u5e76\u8ddd\u79bb\u4e09\u5341\u5b8c\u5168\u76f8\u540c\u3002\u68c0\u67e5\u5b89\u88c5\u7248\u51fd\u6570\u5b9e\u73b0\u53ef\u89c1\uff0c\u5b83\u4f1a\u5728\u5408\u5e76\u8ddd\u79bb\u8d85\u8fc7\u6700\u5c0f\u957f\u5ea6\u65f6\uff0c\u5c06\u524d\u8005\u9650\u5236\u5230\u540e\u8005\u3002\u56e0\u6b64\uff0c\u540d\u4e49\u4e0a\u628a\u8ddd\u79bb\u8c03\u5927\uff0c\u5e76\u4e0d\u603b\u610f\u5473\u7740\u5b9e\u9645\u5141\u8bb8\u66f4\u8fdc\u7684\u533a\u57df\u8fde\u63a5\u3002<\/p>\n
\n\n\n\n\n\n\n\n\n
\u6700\u5c0f\u957f\u5ea6\u4e0e\u5408\u5e76\u8ddd\u79bb<\/th>\n\u5b9e\u9645\u533a\u57df\u7ed3\u679c<\/th>\n\u9700\u8981\u5173\u6ce8\u7684\u53d8\u5316<\/th>\n<\/tr>\n<\/thead>\n
\u957f\u5ea6 30\uff0c\u8ddd\u79bb 20<\/td>\n\u4e09\u4e2a\u533a\u57df<\/td>\n\u5206\u522b\u4fdd\u7559\u4e09\u4e2a\u65b9\u5411\u533a\u6bb5<\/td>\n<\/tr>\n
\u957f\u5ea6 30\uff0c\u8ddd\u79bb 30<\/td>\n\u4e24\u4e2a\u533a\u57df<\/td>\n\u524d\u4e24\u6bb5\u8fde\u540c\u5f31\u4f4d\u70b9\u5408\u5e76<\/td>\n<\/tr>\n
\u957f\u5ea6 30\uff0c\u8ddd\u79bb 100<\/td>\n\u4ecd\u4e3a\u4e24\u4e2a\u533a\u57df<\/td>\n\u5408\u5e76\u8ddd\u79bb\u88ab\u9650\u5236<\/td>\n<\/tr>\n
\u957f\u5ea6 100\uff0c\u8ddd\u79bb 100<\/td>\n\u4e00\u4e2a\u533a\u57df<\/td>\n\u6b63\u8d1f\u65b9\u5411\u4e0e\u5f31\u4f4d\u70b9\u540c\u65f6\u8fdb\u5165<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\u8fd9\u91cc\u6700\u540e\u4e00\u884c\u540c\u65f6\u6539\u53d8\u4e86\u4e24\u4e2a\u53c2\u6570\uff0c\u4e0d\u80fd\u628a\u5168\u90e8\u53d8\u5316\u5355\u72ec\u5f52\u56e0\u4e8e\u5408\u5e76\u8ddd\u79bb\u3002\u5b83\u7684\u4f5c\u7528\u662f\u5c55\u793a\u4e00\u7ec4\u8f83\u5bbd\u677e\u8fde\u63a5\u89c4\u5219\u7684\u5b9e\u9645\u540e\u679c\u3002\u67e5\u770b\u51fd\u6570\u5b9e\u73b0\u8fd8\u53d1\u73b0\uff0c\u8be5\u7248\u672c\u6700\u7ec8\u957f\u5ea6\u548c\u4f4d\u70b9\u6570\u7684\u5224\u65ad\u4f7f\u7528\u4e25\u683c\u5927\u4e8e\u95e8\u69db\u3002\u56e0\u6b64\uff0c\u4e34\u754c\u4f4d\u7f6e\u662f\u5426\u4fdd\u7559\uff0c\u5e94\u6838\u5bf9\u5b89\u88c5\u7248\u5b9e\u73b0\u5e76\u7528\u5c0f\u4f8b\u5b50\u9a8c\u8bc1\uff0c\u4e0d\u80fd\u53ea\u6309\u53c2\u6570\u540d\u5b57\u63a8\u65ad\u3002<\/p>\n
\u4e03\u3001\u4e00\u4e2a\u533a\u57df\u4e5f\u53ef\u80fd\u542b\u6709\u76f8\u53cd\u65b9\u5411\u7684\u4f4d\u70b9<\/h2>\n
\u5728\u6700\u5c0f\u957f\u5ea6\u548c\u5408\u5e76\u8ddd\u79bb\u5747\u4e3a\u4e00\u767e\u65f6\uff0c\u4eba\u5de5\u8868\u4e2d\u7684\u5341\u4e03\u4e2a\u4f4d\u70b9\u5408\u6210\u4e00\u4e2a\u957f\u4e00\u767e\u516d\u5341\u4e00\u78b1\u57fa\u7684\u533a\u57df\u3002\u533a\u57df\u5185\u65e2\u6709\u516b\u4e2a\u6b63\u5411\u663e\u8457\u4f4d\u70b9\uff0c\u4e5f\u6709\u56db\u4e2a\u8d1f\u5411\u663e\u8457\u4f4d\u70b9\uff0c\u8fd8\u5305\u542b\u4e94\u4e2a\u5f31\u4f4d\u70b9\u3002\u533a\u57df\u5e73\u5747\u5dee\u5f02\u53ea\u6709\u7ea6\u516d\u70b9\u4e00\u516b\u4e2a\u767e\u5206\u70b9\uff0c\u660e\u663e\u5c0f\u4e8e\u5404\u663e\u8457\u533a\u6bb5\u5206\u522b\u8bbe\u5b9a\u7684\u4e8c\u5341\u4e94\u4e2a\u767e\u5206\u70b9\u3002<\/p>\n
\u533a\u57df\u7edf\u8ba1\u91cf\u4e5f\u53d7\u5230\u65b9\u5411\u62b5\u6d88\u5f71\u54cd\u3002\u516b\u4e2a\u6b63\u5411\u4f4d\u70b9\u5404\u8d21\u732e\u4e94\uff0c\u56db\u4e2a\u8d1f\u5411\u4f4d\u70b9\u5404\u8d21\u732e\u8d1f\u4e94\uff0c\u518d\u52a0\u4e0a\u4e94\u4e2a\u5f31\u4f4d\u70b9\u5404\u96f6\u70b9\u4e8c\uff0c\u5408\u8ba1\u4e3a\u4e8c\u5341\u4e00\u3002\u82e5\u53ea\u770b\u533a\u57df\u7edf\u8ba1\u91cf\u6392\u5e8f\uff0c\u5f88\u96be\u76f4\u63a5\u77e5\u9053\u5185\u90e8\u6709\u8fd9\u6837\u660e\u663e\u7684\u65b9\u5411\u5206\u88c2\u3002\u56e0\u6b64\uff0c\u5bf9\u5019\u9009\u533a\u57df\u5e94\u540c\u65f6\u67e5\u770b\u4f4d\u70b9\u65b9\u5411\u3001\u5404\u6837\u672c\u6bd4\u4f8b\u548c\u8986\u76d6\u5206\u5e03\u3002<\/p>\n
\u5c06\u663e\u8457\u4f4d\u70b9\u6bd4\u4f8b\u95e8\u69db\u63d0\u9ad8\u5230\u96f6\u70b9\u516b\u540e\uff0c\u8fd9\u4e2a\u5408\u5e76\u533a\u57df\u4e0d\u518d\u8f93\u51fa\u3002\u56e0\u4e3a\u5341\u4e03\u4e2a\u4f4d\u70b9\u4e2d\u53ea\u6709\u5341\u4e8c\u4e2a\u8fbe\u5230\u8bbe\u5b9a\u7684\u4f4d\u70b9\u8bc1\u636e\u95e8\u69db\uff0c\u6bd4\u4f8b\u7ea6\u4e3a\u767e\u5206\u4e4b\u4e03\u5341\u70b9\u516d\u3002\u8fd9\u4e2a\u6bd4\u4f8b\u9650\u5236\u662f\u5bf9\u533a\u57df\u5185\u90e8\u7ec4\u6210\u7684\u8981\u6c42\uff0c\u5e76\u4e0d\u662f\u533a\u57df\u5c42\u9762\u7684\u9519\u8bef\u53d1\u73b0\u7387\u63a7\u5236\uff0c\u4e24\u8005\u4e0d\u80fd\u6df7\u7528\u540d\u79f0\u3002<\/p>\n
\u8fd9\u4e5f\u662f\u4e3a\u4ec0\u4e48\u533a\u57df\u6ce8\u91ca\u4e0d\u5e94\u7acb\u5373\u7b49\u540c\u4e8e\u673a\u5236\u7ed3\u8bba\u3002\u4e00\u4e2a\u533a\u57df\u4e0e\u542f\u52a8\u5b50\u91cd\u53e0\uff0c\u53ea\u8bf4\u660e\u7a7a\u95f4\u5173\u7cfb\u3002\u533a\u57df\u662f\u5426\u65b9\u5411\u4e00\u81f4\u3001\u662f\u5426\u7531\u5c11\u6570\u79bb\u7fa4\u6837\u672c\u9a71\u52a8\u3001\u4e0d\u540c CpG \u7684\u8986\u76d6\u662f\u5426\u53ef\u6bd4\uff0c\u90fd\u9700\u8981\u7ee7\u7eed\u68c0\u67e5\u3002\u628a\u533a\u57df\u5148\u8d34\u5230\u57fa\u56e0\u540d\u4e0a\uff0c\u518d\u5ffd\u7565\u5185\u90e8\u4f4d\u70b9\u7ed3\u6784\uff0c\u5bb9\u6613\u8ba9\u4e00\u4e2a\u590d\u6742\u7ed3\u679c\u770b\u8d77\u6765\u8fc7\u4e8e\u6574\u9f50\u3002<\/p>\n
\u516b\u3001DSS \u7684\u4f18\u52bf\u4e0e\u9002\u7528\u8fb9\u754c<\/h2>\n
DSS \u7684\u4f18\u52bf\u662f\u5c06\u8ba1\u6570\u6df1\u5ea6\u3001\u91cd\u590d\u95f4\u53d8\u5316\u548c\u5dee\u5f02\u4f30\u8ba1\u7ed3\u5408\u8d77\u6765\uff0c\u5e76\u63d0\u4f9b\u4ece\u4f4d\u70b9\u5230\u533a\u57df\u7684\u64cd\u4f5c\u63a5\u53e3\u3002\u5e73\u6ed1\u5bf9\u8fde\u7eed\u53d8\u5316\u7684\u5206\u6790\u4e5f\u5f88\u5b9e\u7528\u3002\u5176\u4f7f\u7528\u4ee3\u4ef7\u662f\u7528\u6237\u5fc5\u987b\u5206\u6e05\u6a21\u578b\u8f93\u51fa\u3001\u4f4d\u70b9\u7b5b\u9009\u548c\u533a\u57df\u6784\u9020\u4e09\u4e2a\u9636\u6bb5\uff0c\u5c24\u5176\u4e0d\u80fd\u628a\u5e73\u6ed1\u540e\u7684\u66f4\u591a\u4f4d\u70b9\u81ea\u52a8\u89c6\u4e3a\u66f4\u597d\u7684\u7ed3\u679c\u3002<\/p>\n
\u590d\u6742\u5b9e\u9a8c\u8bbe\u8ba1\u8fd8\u9700\u8981\u8003\u8651\u6279\u6b21\u3001\u914d\u5bf9\u5173\u7cfb\u548c\u5176\u4ed6\u534f\u53d8\u91cf\u3002\u672c\u6587\u53ea\u8fd0\u884c\u4e86\u7b80\u5355\u4e24\u7ec4\u6bd4\u8f83\uff0c\u6ca1\u6709\u9a8c\u8bc1\u591a\u56e0\u7d20\u6a21\u578b\uff0c\u4e5f\u6ca1\u6709\u9a8c\u8bc1\u65e0\u751f\u7269\u5b66\u91cd\u590d\u7684\u5206\u6790\u3002\u5982\u679c\u7814\u7a76\u95ee\u9898\u9700\u8981\u8fd9\u4e9b\u529f\u80fd\uff0c\u5e94\u91cd\u65b0\u6838\u5bf9\u76f8\u5e94\u6a21\u578b\u7684\u8f93\u5165\u548c\u652f\u6301\u8303\u56f4\uff0c\u4e0d\u80fd\u76f4\u63a5\u628a\u4e24\u7ec4\u6bd4\u8f83\u7684\u53c2\u6570\u89e3\u91ca\u590d\u5236\u8fc7\u53bb\u3002<\/p>\n
\u5bf9\u4e8e\u6b63\u5f0f\u7814\u7a76\uff0c\u5efa\u8bae\u9884\u5148\u5199\u660e\u7ec4\u522b\u65b9\u5411\u3001\u662f\u5426\u5e73\u6ed1\u3001\u6548\u5e94\u95e8\u69db\u3001\u4f4d\u70b9\u7b5b\u9009\u89c4\u5219\u53ca\u533a\u57df\u53c2\u6570\uff0c\u518d\u68c0\u67e5\u5408\u7406\u53c2\u6570\u8303\u56f4\u5185\u7ed3\u8bba\u662f\u5426\u7a33\u5b9a\u3002\u7a33\u5b9a\u6027\u68c0\u67e5\u7684\u76ee\u6807\u662f\u8fa8\u8ba4\u54ea\u4e9b\u7ed3\u8bba\u4f9d\u8d56\u7279\u5b9a\u8bbe\u5b9a\uff0c\u800c\u4e0d\u662f\u4e0d\u65ad\u4fee\u6539\u9608\u503c\u76f4\u5230\u5f97\u5230\u6ee1\u610f\u7684\u533a\u57df\u6570\u91cf\u3002<\/p>\n
\u4e5d\u3001\u600e\u6837\u590d\u73b0\u5b9e\u8dd1\u5e76\u68c0\u67e5\u81ea\u5df1\u7684\u7ed3\u679c<\/h2>\n
\u4e0b\u8f7d\u672c\u7ec4\u5b8c\u6574\u811a\u672c\u4e0e\u5b9e\u8dd1\u8bb0\u5f55<\/a>\uff0c\u5728\u672c\u7bc7\u76ee\u5f55\u6267\u884c\u4e0b\u9762\u547d\u4ee4\uff0c\u53ef\u91cd\u65b0\u751f\u6210\u516d\u4e2a\u8ba1\u6570\u6587\u4ef6\u3001\u4e24\u79cd\u6a21\u578b\u7ed3\u679c\u53ca\u4eba\u5de5\u533a\u57df\u7ec3\u4e60\u3002\u811a\u672c\u56fa\u5b9a\u968f\u673a\u79cd\u5b50\u548c\u5bb9\u5668\u6458\u8981\uff0c\u4fdd\u7559\u5b89\u88c5\u7248\u672c\u3001\u5206\u7ec4\u4ea4\u6362\u68c0\u67e5\u3001\u533a\u57df\u8868\u3001\u51fd\u6570\u5b9e\u73b0\u4e0e\u65e5\u5fd7\u3002\u5bb9\u5668\u9650\u5236\u4e3a\u4e24\u6838\u3001\u56db GiB \u5185\u5b58\uff0c\u6ca1\u6709\u8fdb\u884c\u5927\u89c4\u6a21\u8017\u65f6\u6216\u5185\u5b58\u57fa\u51c6\u6d4b\u8bd5\u3002<\/p>\n
python3 run.py output\r\n<\/code><\/pre>\n
\u8fd0\u884c\u540e\u53ef\u4ee5\u5148\u786e\u8ba4\u4ea4\u6362\u7ec4\u522b\u662f\u5426\u53ea\u6539\u53d8\u5dee\u5f02\u65b9\u5411\uff0c\u518d\u5bf9\u7167\u96f6\u5dee\u5f02\u4e0e\u6548\u5e94\u95e8\u69db\u7684\u5165\u9009\u6570\u91cf\uff0c\u6700\u540e\u68c0\u67e5\u4eba\u5de5\u533a\u57df\u5185\u90e8\u7684\u5341\u4e03\u4e2a\u4f4d\u70b9\u3002\u628a\u8fd9\u4e09\u6b65\u5e94\u7528\u5230\u81ea\u5df1\u7684\u9879\u76ee\uff0c\u80fd\u591f\u5206\u522b\u53d1\u73b0\u65b9\u5411\u9519\u8bef\u3001\u7b5b\u9009\u542b\u4e49\u6df7\u6dc6\u548c\u533a\u57df\u5185\u90e8\u4e0d\u4e00\u81f4\u7684\u95ee\u9898\u3002\u5b83\u4eec\u6bd4\u5355\u72ec\u8f93\u51fa\u4e00\u4e2a\u5dee\u5f02\u533a\u57df\u603b\u6570\uff0c\u66f4\u80fd\u5e2e\u52a9\u8bfb\u8005\u5224\u65ad\u7ed3\u679c\u662f\u5426\u503c\u5f97\u7ee7\u7eed\u7814\u7a76\u3002<\/p>\n
\u5f53\u5206\u6790\u6269\u5c55\u5230\u66f4\u591a\u6837\u672c\u548c\u5168\u57fa\u56e0\u7ec4\u533a\u57df\uff0c\u9700\u8981\u4fdd\u7559\u6a21\u578b\u3001\u53c2\u6570\u4e0e\u4f4d\u70b9\u5ba1\u9605\u8bb0\u5f55\u65f6\uff0c\u53ef\u901a\u8fc7\u4e91\u751f\u4fe1\u751f\u7269\u5206\u6790\u670d\u52a1\u5668\u670d\u52a1<\/a>\u5f00\u5c55\u7edf\u4e00\u7684\u6279\u91cf\u5206\u6790\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"
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