{"id":73317,"date":"2026-11-15T16:20:12","date_gmt":"2026-11-15T08:20:12","guid":{"rendered":"https:\/\/www.biocloudservice.com\/wordpress\/?p=73317"},"modified":"2026-11-15T16:20:12","modified_gmt":"2026-11-15T08:20:12","slug":"hicexplorer-matrix-weights-kr-tad-window-cache-practice","status":"publish","type":"post","link":"https:\/\/www.biocloudservice.com\/wordpress\/hicexplorer-matrix-weights-kr-tad-window-cache-practice\/","title":{"rendered":"HiCExplorer \u5b9e\u8dd1\u6307\u5357\u2014\u2014\u77e9\u9635\u6743\u91cd\u3001\u6821\u6b63\u4e0e TAD \u7a97\u53e3\uff0c\u600e\u6837\u5224\u65ad\u8fb9\u754c\u53d8\u5316\u6765\u81ea\u54ea\u91cc"},"content":{"rendered":"
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\u672c\u6587\u5b9e\u9645\u5b89\u88c5\u5e76\u8fd0\u884c HiCExplorer 4.0.0\uff0c\u4f7f\u7528\u81ea\u5df1\u7f16\u5199\u7684\u4e00\u767e\u4e8c\u5341\u5206\u7bb1\u63a5\u89e6\u77e9\u9635\uff0c\u4f9d\u6b21\u68c0\u67e5\u683c\u5f0f\u8f6c\u6362\u3001\u77e9\u9635\u5e73\u8861\u3001\u7a97\u53e3\u8c03\u6574\u548c\u7f13\u5b58\u590d\u7528\u3002\u8f93\u5165\u5b8c\u5168\u662f\u4eba\u4e3a\u8bbe\u8ba1\u7684\u6570\u636e\uff0c\u6ca1\u6709\u771f\u5b9e\u7ec6\u80de\uff0c\u6ca1\u6709\u6d4b\u5e8f\u566a\u58f0\uff0c\u4e5f\u6ca1\u6709\u91cd\u590d\u6837\u672c\u3002\u672c\u6b21\u8fd0\u884c\u80fd\u591f\u8bf4\u660e\u7a0b\u5e8f\u600e\u6837\u5904\u7406\u8fd9\u4e9b\u8f93\u5165\uff0c\u4e0d\u80fd\u8bc4\u4ef7\u771f\u5b9e\u6837\u672c\u4e2d\u7684\u62d3\u6251\u7ed3\u6784\u57df\u8bc6\u522b\u51c6\u786e\u7387\uff0c\u66f4\u4e0d\u80fd\u628a\u547d\u4e2d\u7684\u8fb9\u754c\u5f53\u4f5c\u65b0\u7684\u751f\u7269\u5b66\u53d1\u73b0\u3002<\/p>\n

\"\u8fb9\u754c\u76f8\u540c\uff0c\u5206\u6570\u672a\u5fc5\u76f8\u540c\u3002120
120 \u4e2a\u4eba\u5de5\u5206\u7bb1\uff0c\u6838\u5bf9\u8f6c\u6362\u3001KR \u6821\u6b63\u4e0e\u7a97\u53e3\u7f13\u5b58<\/figcaption><\/figure>\n

\u4e00\u3001\u5148\u51b3\u5b9a\u4f60\u8981\u6bd4\u8f83\u54ea\u4e00\u5c42\u7ed3\u679c<\/h2>\n

\u63a5\u89e6\u77e9\u9635\u8bb0\u5f55\u5206\u7bb1\u4e4b\u95f4\u7684\u8054\u7cfb\uff0c\u884c\u5217\u8986\u76d6\u4e0d\u5747\u8861\u4f1a\u5f71\u54cd\u56fe\u50cf\u660e\u6697\u3002\u77e9\u9635\u5e73\u8861\u8bd5\u56fe\u5904\u7406\u5176\u4e2d\u4e00\u90e8\u5206\u7cfb\u7edf\u6027\u5dee\u5f02\uff0c\u5206\u79bb\u5206\u6570\u5219\u89c2\u5bdf\u67d0\u4e2a\u4f4d\u7f6e\u4e24\u4fa7\u7684\u63a5\u89e6\u5173\u7cfb\u3002\u8fb9\u754c\u8bc6\u522b\u8fd8\u4f1a\u589e\u52a0\u5c40\u90e8\u6781\u5c0f\u503c\u3001\u5dee\u5f02\u5e45\u5ea6\u548c\u7edf\u8ba1\u95e8\u69db\u7b49\u6761\u4ef6\u3002\u56e0\u6b64\uff0c\u6821\u6b63\u540e\u884c\u548c\u63a5\u8fd1\uff0c\u5e76\u4e0d\u610f\u5473\u7740\u6bcf\u4e2a\u5c40\u90e8\u533a\u57df\u7684\u63a5\u89e6\u6a21\u5f0f\u76f8\u540c\u3002\u8fb9\u754c\u6570\u91cf\u76f8\u540c\uff0c\u4e5f\u4e0d\u610f\u5473\u7740\u6bcf\u4e2a\u4f4d\u7f6e\u7684\u5206\u6570\u76f8\u540c\u3002<\/p>\n

\u5b9e\u9645\u9879\u76ee\u4e2d\uff0c\u6211\u5efa\u8bae\u5148\u5199\u4e0b\u6bd4\u8f83\u5bf9\u8c61\u3002\u5982\u679c\u95ee\u9898\u662f\u5904\u7406\u524d\u540e\u63a5\u89e6\u5206\u5e03\u6709\u6ca1\u6709\u6539\u53d8\uff0c\u5c31\u68c0\u67e5\u539f\u59cb\u4e0e\u6821\u6b63\u77e9\u9635\u3002\u5982\u679c\u95ee\u9898\u662f\u67d0\u4e2a\u5019\u9009\u8fb9\u754c\u662f\u5426\u53d8\u5f31\uff0c\u5c31\u6bd4\u8f83\u76f8\u540c\u7a97\u53e3\u4e0b\u7684\u5206\u79bb\u5206\u6570\u53ca\u9644\u8fd1\u8986\u76d6\u3002\u5982\u679c\u95ee\u9898\u662f\u4e0d\u540c\u6761\u4ef6\u7684\u7ed3\u6784\u57df\u6570\u91cf\u662f\u5426\u4e0d\u540c\uff0c\u8fd8\u8981\u63a7\u5236\u6709\u6548\u63a5\u89e6\u6570\u91cf\u3001\u5206\u8fa8\u7387\u3001\u63a9\u853d\u533a\u57df\u548c\u8c03\u7528\u95e8\u69db\u3002\u76f4\u63a5\u6bd4\u8f83\u4e24\u4e2a\u533a\u57df\u6587\u4ef6\u7684\u884c\u6570\uff0c\u8df3\u8fc7\u4e86\u4e2d\u95f4\u51e0\u5c42\u8bc1\u636e\u3002<\/p>\n

HiCExplorer \u7684\u5b9e\u7528\u4e4b\u5904\u5728\u4e8e\u8fd9\u4e9b\u6b65\u9aa4\u90fd\u6709\u72ec\u7acb\u5165\u53e3\uff0c\u65e2\u53ef\u4ee5\u7ec4\u7ec7\u6210\u6d41\u7a0b\uff0c\u4e5f\u53ef\u4ee5\u62c6\u5f00\u68c0\u67e5\u3002\u4ee3\u4ef7\u662f\u64cd\u4f5c\u8005\u5fc5\u987b\u8bb0\u4f4f\u6bcf\u4e2a\u6587\u4ef6\u7ecf\u8fc7\u4e86\u54ea\u4e9b\u53d8\u6362\u3002\u4e00\u4e2a\u6587\u4ef6\u540d\u91cc\u7684\u201c\u6821\u6b63\u201d\u4e8c\u5b57\u4e0d\u591f\uff0c\u81f3\u5c11\u8981\u8bb0\u5f55\u8f93\u5165\u5206\u8fa8\u7387\u3001\u6743\u91cd\u5217\u3001\u6821\u6b63\u65b9\u6cd5\u3001\u8fc7\u6ee4\u6761\u4ef6\u4ee5\u53ca\u662f\u5426\u53c8\u505a\u4e86\u5176\u4ed6\u53d8\u6362\u3002<\/p>\n

\u4e8c\u3001\u7528\u4e00\u4e2a\u53ef\u4ee5\u624b\u7b97\u5c40\u90e8\u7ed3\u679c\u7684\u77e9\u9635\u5f00\u59cb<\/h2>\n

\u672c\u6b21\u6784\u9020\u4e00\u6761\u957f\u5341\u4e8c\u4e07\u78b1\u57fa\u7684\u865a\u62df\u67d3\u8272\u4f53\uff0c\u6309\u4e00\u5343\u78b1\u57fa\u5206\u6210\u4e00\u767e\u4e8c\u5341\u4e2a\u5206\u7bb1\u3002\u6bcf\u56db\u5341\u4e2a\u5206\u7bb1\u8bbe\u4e3a\u4e00\u4e2a\u4eba\u5de5\u63a5\u89e6\u589e\u5f3a\u533a\uff0c\u533a\u5185\u8054\u7cfb\u4e58\u4ee5\u516b\uff0c\u533a\u95f4\u8054\u7cfb\u4e0d\u4e58\u3002\u518d\u52a0\u5165\u968f\u8ddd\u79bb\u8870\u51cf\u7684\u57fa\u7840\u503c\uff0c\u4ee5\u53ca\u6309\u56fa\u5b9a\u6a21\u5f0f\u91cd\u590d\u7684\u5206\u7bb1\u504f\u5dee\u3002\u8fd9\u6837\u65e2\u6709\u53ef\u9884\u671f\u7684\u533a\u5757\u4f4d\u7f6e\uff0c\u4e5f\u6709\u9700\u8981\u5904\u7406\u7684\u884c\u5217\u8986\u76d6\u5dee\u5f02\u3002<\/p>\n

\u8fd9\u662f\u4e00\u79cd\u6392\u67e5\u65b9\u6cd5\uff0c\u800c\u4e0d\u662f\u5bf9\u771f\u5b9e\u67d3\u8272\u8d28\u7684\u5b8c\u6574\u6a21\u62df\u3002\u4eba\u4e3a\u589e\u5f3a\u533a\u4e4b\u95f4\u6ca1\u6709\u771f\u5b9e\u7ec6\u80de\u7fa4\u4f53\u5f02\u8d28\u6027\uff0c\u8986\u76d6\u504f\u5dee\u4e5f\u53ea\u662f\u4e00\u4e2a\u7b80\u5355\u4e58\u6cd5\u56e0\u5b50\u3002\u5b83\u7684\u4ef7\u503c\u5728\u4e8e\uff0c\u5f53\u8f93\u51fa\u4e0d\u7b26\u5408\u9884\u671f\u65f6\uff0c\u53ef\u4ee5\u76f4\u63a5\u8ffd\u6eaf\u5230\u67d0\u4e00\u5bf9\u5206\u7bb1\uff0c\u4e0d\u5fc5\u540c\u65f6\u731c\u6d4b\u6bd4\u5bf9\u3001\u591a\u91cd\u5b9a\u4f4d\u3001\u5b9e\u9a8c\u6279\u6b21\u548c\u91cd\u590d\u5e8f\u5217\u7684\u5f71\u54cd\u3002<\/p>\n

\u6211\u4eec\u8fd8\u5728\u539f\u59cb\u6587\u4ef6\u4e2d\u5b58\u5165\u4eba\u4e3a\u6743\u91cd\uff0c\u503c\u662f\u5206\u7bb1\u504f\u5dee\u7684\u5012\u6570\u3002\u8fd9\u5217\u6743\u91cd\u4ec5\u7528\u4e8e\u68c0\u9a8c\u8f6c\u6362\u884c\u4e3a\uff0c\u5e76\u4e0d\u662f\u8f6f\u4ef6\u4ece\u771f\u5b9e\u6570\u636e\u4f30\u8ba1\u7684\u7ed3\u679c\u3002\u539f\u59cb\u8ba1\u6570\u548c\u4eba\u4e3a\u6743\u91cd\u540c\u65f6\u5b58\u5728\uff0c\u6b63\u597d\u53ef\u4ee5\u56de\u7b54\u4e00\u4e2a\u5e38\u88ab\u5ffd\u7565\u7684\u95ee\u9898\uff0c\u8f6c\u6362\u547d\u4ee4\u9ed8\u8ba4\u8bfb\u53d6\u7684\u5230\u5e95\u662f\u54ea\u4e00\u79cd\u6570\u503c\u3002<\/p>\n

\u56fa\u5b9a\u73af\u5883\u548c\u5b8c\u6574\u751f\u6210\u811a\u672c\u653e\u5728\u5b9e\u8dd1\u590d\u73b0\u5305<\/a>\u3002\u4e0b\u9762\u7684\u547d\u4ee4\u5c55\u793a\u5173\u952e\u6b65\u9aa4\uff0c\u590d\u73b0\u5305\u91cc\u7684\u8fd0\u884c\u5668\u4f1a\u51c6\u5907\u8f93\u5165\uff0c\u5e76\u5728\u9694\u79bb\u7684\u5bb9\u5668\u76ee\u5f55\u5185\u6267\u884c\u3002<\/p>\n

IMAGE=quay.io\/biocontainers\/hicexplorer@sha256:868b27997ec40d1f656d472d4ed6a914b2145fd7decf1dc75af32f6b8e9e0cca\r\ndocker pull "$IMAGE"\r\npython3 run.py .\/hicexplorer_practice\r\n<\/code><\/pre>\n
\u4e09\u3001\u683c\u5f0f\u8f6c\u6362\u53ef\u80fd\u540c\u65f6\u5e94\u7528\u6743\u91cd<\/h2>\n
\u6211\u4eec\u5206\u522b\u8fd0\u884c\u4e00\u6b21\u9ed8\u8ba4\u8f6c\u6362\u548c\u4e00\u6b21\u663e\u5f0f\u8bfb\u53d6\u539f\u59cb\u503c\u7684\u8f6c\u6362\u3002\u4e24\u6b21\u8f93\u51fa\u683c\u5f0f\u90fd\u662f\u5c42\u6b21\u5316\u77e9\u9635\u6587\u4ef6\uff0c\u4f46\u7b2c\u96f6\u53f7\u4e0e\u7b2c\u4e00\u53f7\u5206\u7bb1\u4e4b\u95f4\u7684\u6570\u503c\uff0c\u524d\u8005\u4e3a\u56db\u767e\u516b\u5341\uff0c\u540e\u8005\u4e3a\u4e5d\u767e\u516d\u5341\u3002\u8fd9\u4e2a\u53d8\u5316\u4e0e\u4eba\u4e3a\u6743\u91cd\u76f8\u4e58\u7684\u7ed3\u679c\u5b8c\u5168\u4e00\u81f4\uff0c\u8bf4\u660e\u672c\u6b21\u9ed8\u8ba4\u8f6c\u6362\u786e\u5b9e\u5e94\u7528\u4e86\u5df2\u6709\u6743\u91cd\u3002<\/p>\n
hicConvertFormat -m toy.cool \\\r\n  --inputFormat cool --outputFormat h5 \\\r\n  -o weighted.h5\r\n\r\nhicConvertFormat -m toy.cool \\\r\n  --inputFormat cool --outputFormat h5 \\\r\n  --load_raw_values -o raw.h5\r\n<\/code><\/pre>\n
\n\n\n\n\n\n\n\n
\u672c\u6b21\u68c0\u67e5\u5bf9\u8c61<\/th>\n\u8bfb\u53d6\u539f\u59cb\u503c<\/th>\n\u9ed8\u8ba4\u8f6c\u6362<\/th>\n<\/tr>\n<\/thead>\n
\u5206\u7bb1\u96f6\u4e0e\u4e00\u4e4b\u95f4\u7684\u6570\u503c<\/td>\n960<\/td>\n480<\/td>\n<\/tr>\n
\u5b8c\u6574\u5bf9\u79f0\u77e9\u9635\u6570\u503c\u603b\u548c<\/td>\n2286458<\/td>\n694234<\/td>\n<\/tr>\n
\u4e0e\u76f8\u5e94\u8bfb\u53d6\u65b9\u5f0f\u9010\u5143\u7d20\u6838\u5bf9<\/td>\n\u4e00\u81f4<\/td>\n\u4e00\u81f4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\u8868\u4e2d\u603b\u548c\u662f\u5c55\u5f00\u540e\u7684\u5b8c\u6574\u5bf9\u79f0\u77e9\u9635\u6c42\u548c\uff0c\u975e\u5bf9\u89d2\u7ebf\u8054\u7cfb\u5728\u4e24\u4e2a\u65b9\u5411\u51fa\u73b0\uff0c\u4e0d\u80fd\u76f4\u63a5\u5f53\u4f5c\u72ec\u7acb\u63a5\u89e6\u5206\u5b50\u603b\u6570\u3002\u8fd9\u91cc\u4f7f\u7528\u5b83\u53ea\u662f\u68c0\u67e5\u540c\u4e00\u8868\u793a\u65b9\u5f0f\u4e0b\u7684\u6570\u503c\u53d8\u5316\uff0c\u771f\u6b63\u6bd4\u8f83\u6709\u6548\u63a5\u89e6\u91cf\u65f6\uff0c\u5e94\u56de\u5230\u539f\u59cb\u63a5\u89e6\u5217\u8868\u6216\u6309\u5b58\u50a8\u7ea6\u5b9a\u7edf\u8ba1\u3002<\/p>\n
\u8fd9\u4e00\u6b65\u7684\u7ecf\u9a8c\u5f88\u660e\u786e\uff0c\u683c\u5f0f\u8f6c\u6362\u524d\u5148\u770b\u6743\u91cd\u5217\uff0c\u8f6c\u6362\u540e\u62bd\u67e5\u51e0\u4e2a\u975e\u96f6\u5355\u5143\u3002\u5df2\u7ecf\u5e94\u7528\u8fc7\u6743\u91cd\u7684\u77e9\u9635\u5982\u679c\u53c8\u88ab\u5f53\u4f5c\u539f\u59cb\u8ba1\u6570\u9001\u53bb\u6821\u6b63\uff0c\u5206\u6790\u7684\u8d77\u70b9\u5c31\u53d8\u4e86\u3002\u8f6f\u4ef6\u4e0d\u4f1a\u7406\u89e3\u4f60\u7684\u6587\u4ef6\u547d\u540d\u610f\u56fe\uff0c\u53ea\u4f1a\u6309\u8f93\u5165\u7ed3\u6784\u548c\u53c2\u6570\u6267\u884c\u3002\u9ed8\u8ba4\u6743\u91cd\u5217\u3001\u539f\u59cb\u8bfb\u53d6\u9009\u9879\u53ca\u6743\u91cd\u7684\u5e94\u7528\u65b9\u5f0f\u89c1\u683c\u5f0f\u8f6c\u6362\u5b98\u65b9\u8bf4\u660e<\/a>\u3002<\/p>\n
\u56db\u3001\u6821\u6b63\u65b9\u6cd5\u4e0d\u540c\uff0c\u540c\u540d\u8fc7\u6ee4\u53c2\u6570\u672a\u5fc5\u751f\u6548<\/h2>\n
\u63a5\u4e0b\u6765\u5bf9\u660e\u786e\u4fdd\u7559\u539f\u59cb\u503c\u7684\u77e9\u9635\u6267\u884c KR \u5e73\u8861\u3002\u6821\u6b63\u524d\uff0c\u5404\u884c\u6570\u503c\u603b\u548c\u7684\u53d8\u5f02\u7cfb\u6570\u7ea6\u4e3a\u96f6\u70b9\u56db\u516d\u4e8c\u3002\u6821\u6b63\u540e\u7ea6\u4e3a\u4e8c\u70b9\u4e8c\u56db\u4e58\u5341\u7684\u8d1f\u516b\u6b21\u65b9\uff0c\u5404\u884c\u603b\u548c\u90fd\u63a5\u8fd1\u4e00\u4e07\u4e5d\u5343\u96f6\u4e94\u5341\u4e09\u70b9\u516b\u3002\u8fd9\u4e2a\u7ed3\u679c\u8bf4\u660e\u672c\u4f8b\u7684\u884c\u548c\u5747\u8861\u76ee\u6807\u5f97\u5230\u4e86\u6ee1\u8db3\uff0c\u5e76\u4e0d\u8bf4\u660e\u6240\u6709\u5b9e\u9a8c\u504f\u5dee\u90fd\u5df2\u6d88\u5931\u3002<\/p>\n
hicCorrectMatrix correct \\\r\n  --matrix raw.h5 --outFileName kr.h5 \\\r\n  --correctionMethod KR --threads 1\r\n<\/code><\/pre>\n
\u6211\u4eec\u8fd8\u505a\u4e86\u4e00\u4e2a\u6545\u610f\u8bbe\u7f6e\u6781\u7aef\u8fc7\u6ee4\u9608\u503c\u7684\u5bf9\u7167\uff0c\u4ecd\u4f7f\u7528 KR \u65b9\u6cd5\uff0c\u989d\u5916\u4f20\u5165 --filterThreshold 100 101<\/code>\u3002\u4e24\u6b21\u8f93\u51fa\u9010\u5143\u7d20\u6700\u5927\u5dee\u5f02\u4e3a\u96f6\u3002\u539f\u56e0\u4e0d\u662f\u8fd9\u4e9b\u9608\u503c\u201c\u6070\u597d\u6ca1\u8fc7\u6ee4\u6389\u4efb\u4f55\u5f02\u5e38\u70b9\u201d\uff0c\u800c\u662f\u8be5\u53c2\u6570\u5728\u672c\u6b21\u7248\u672c\u4e2d\u9002\u7528\u4e8e ICE \u6821\u6b63\u3002\u628a\u53e6\u4e00\u79cd\u7b97\u6cd5\u7684\u53c2\u6570\u653e\u8fdb\u547d\u4ee4\uff0c\u4e0d\u7b49\u4e8e\u5df2\u7ecf\u5b8c\u6210\u90a3\u9879\u8fc7\u6ee4\u3002<\/p>\n
\u8fd9\u7c7b\u95ee\u9898\u9002\u5408\u5728\u6b63\u5f0f\u5206\u6790\u524d\u7528\u5c0f\u8f93\u5165\u68c0\u67e5\u3002\u5148\u8bbe\u7f6e\u4e00\u4e2a\u5e94\u8be5\u660e\u663e\u5f71\u54cd\u7ed3\u679c\u7684\u6781\u7aef\u6761\u4ef6\uff0c\u518d\u6bd4\u8f83\u63a9\u853d\u6570\u91cf\u6216\u8f93\u51fa\u77e9\u9635\u3002\u5982\u679c\u5b8c\u5168\u6ca1\u6709\u53d8\u5316\uff0c\u5148\u6838\u5bf9\u53c2\u6570\u9002\u7528\u8303\u56f4\uff0c\u800c\u4e0d\u662f\u7acb\u5373\u89e3\u91ca\u4e3a\u6570\u636e\u975e\u5e38\u7a33\u5b9a\u3002\u4e24\u79cd\u6821\u6b63\u65b9\u6cd5\u53ca\u4e13\u7528\u8fc7\u6ee4\u53c2\u6570\u53ef\u4ee5\u5bf9\u7167\u5b98\u65b9\u6821\u6b63\u5de5\u5177\u8bf4\u660e<\/a>\u3002<\/p>\n
\u884c\u548c\u5e73\u8861\u4e5f\u6709\u4f7f\u7528\u524d\u63d0\u3002\u8986\u76d6\u6781\u4f4e\u7684\u5206\u7bb1\u5373\u4f7f\u88ab\u653e\u5927\uff0c\u4e5f\u4e0d\u4f1a\u51ed\u7a7a\u589e\u52a0\u4fe1\u606f\u3002\u7f3a\u5931\u533a\u3001\u7ec4\u88c5\u7a7a\u6d1e\u548c\u4e0d\u53ef\u9760\u5206\u7bb1\u5e94\u8be5\u6709\u6e05\u695a\u7684\u5904\u7406\u8bb0\u5f55\u3002\u5bf9\u4e8e\u62f7\u8d1d\u6570\u6539\u53d8\u660e\u663e\u6216\u8de8\u6837\u672c\u6df1\u5ea6\u4e0d\u5747\u7684\u7814\u7a76\uff0c\u66f4\u4e0d\u80fd\u628a\u201c\u5df2\u7ecf\u6821\u6b63\u201d\u89c6\u4e3a\u6d88\u9664\u6240\u6709\u53ef\u6bd4\u6027\u95ee\u9898\u7684\u8bc1\u660e\u3002<\/p>\n
\u4e94\u3001\u6539\u53d8\u7a97\u53e3\u540e\uff0c\u5148\u770b\u5206\u6570\uff0c\u518d\u770b\u8fb9\u754c\u6570\u91cf<\/h2>\n
\u7b2c\u4e00\u6b21\u8c03\u7528\u4f7f\u7528\u6700\u5c0f\u7a97\u53e3\u4e09\u5343\u78b1\u57fa\u3001\u6700\u5927\u7a97\u53e3\u4e5d\u5343\u78b1\u57fa\uff0c\u7b2c\u4e8c\u6b21\u4f7f\u7528\u516d\u5343\u81f3\u4e00\u4e07\u516b\u5343\u78b1\u57fa\u3002\u4e24\u6b21\u90fd\u91c7\u7528\u76f8\u540c\u7684\u7edf\u8ba1\u95e8\u69db\u3001\u5dee\u5f02\u5e45\u5ea6\u95e8\u69db\u548c\u6700\u5c0f\u8fb9\u754c\u95f4\u8ddd\u3002\u7a97\u53e3\u662f\u5728\u89c2\u5bdf\u5c3a\u5ea6\u4e0a\u4f5c\u8c03\u6574\uff0c\u4e0d\u662f\u6539\u53d8\u8f93\u5165\u77e9\u9635\u7684\u5206\u7bb1\u5927\u5c0f\u3002<\/p>\n
hicFindTADs -m kr.h5 --outPrefix small \\\r\n  --minDepth 3000 --maxDepth 9000 --step 1000 \\\r\n  --correctForMultipleTesting fdr \\\r\n  --thresholdComparisons 0.05 --delta 0.01 \\\r\n  --minBoundaryDistance 4000 -p 1\r\n<\/code><\/pre>\n
\n\n\n\n\n\n\n\n\n
\u672c\u6b21\u8c03\u7528<\/th>\n\u8fb9\u754c\u9644\u8fd1\u5206\u6570<\/th>\n\u8fb9\u754c\u6570\u91cf<\/th>\n\u533a\u57df\u6587\u4ef6\u4e2d\u7684\u533a\u95f4<\/th>\n<\/tr>\n<\/thead>\n
\u4e09\u5343\u81f3\u4e5d\u5343\u78b1\u57fa\u7a97\u53e3<\/td>\n\u7ea6 \u22123.199<\/td>\n2<\/td>\n\u56db\u4e07\u81f3\u516b\u4e07\u78b1\u57fa<\/td>\n<\/tr>\n
\u516d\u5343\u81f3\u4e00\u4e07\u516b\u5343\u78b1\u57fa\u7a97\u53e3<\/td>\n\u7ea6 \u22122.276<\/td>\n2<\/td>\n\u56db\u4e07\u81f3\u516b\u4e07\u78b1\u57fa<\/td>\n<\/tr>\n
\u590d\u7528\u7b2c\u4e00\u7ec4\u7f13\u5b58\u5e76\u6539\u53d8\u7a97\u53e3\u53c2\u6570<\/td>\n\u7ea6 \u22123.199<\/td>\n2<\/td>\n\u56db\u4e07\u81f3\u516b\u4e07\u78b1\u57fa<\/td>\n<\/tr>\n
\u590d\u7528\u7f13\u5b58\uff0c\u5dee\u5f02\u5e45\u5ea6\u95e8\u69db\u8bbe\u4e3a 100<\/td>\n\u65e0\u4fdd\u7559\u8fb9\u754c<\/td>\n0<\/td>\n\u7a7a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\u4e24\u7ec4\u91cd\u65b0\u8ba1\u7b97\u7684\u5206\u6570\u660e\u663e\u4e0d\u540c\uff0c\u4f46\u4e24\u4e2a\u4e3b\u8981\u8fb9\u754c\u4ecd\u4f4d\u4e8e\u4eba\u5de5\u533a\u5757\u8fde\u63a5\u5904\u3002\u56e0\u6b64\uff0c\u201c\u8fb9\u754c\u6ca1\u53d8\u201d\u53ea\u80fd\u8bf4\u660e\u672c\u4f8b\u8fd9\u4e9b\u79bb\u6563\u8fb9\u754c\u5bf9\u8fd9\u4e24\u7ec4\u7a97\u53e3\u8f83\u7a33\u5b9a\uff0c\u4e0d\u80fd\u8bf4\u7a97\u53e3\u6ca1\u6709\u5f71\u54cd\u7ed3\u679c\u3002\u82e5\u7814\u7a76\u5173\u6ce8\u7684\u662f\u8fb9\u754c\u5f3a\u5ea6\uff0c\u5206\u6570\u53d8\u5316\u672c\u8eab\u5c31\u4e0d\u80fd\u7565\u8fc7\u3002<\/p>\n
\u53e6\u4e00\u4e2a\u9700\u8981\u6ce8\u610f\u7684\u7ec6\u8282\u662f\uff0c\u4eba\u5de5\u8f93\u5165\u6709\u4e09\u4e2a\u589e\u5f3a\u533a\uff0c\u533a\u57df\u6587\u4ef6\u5374\u53ea\u7ed9\u51fa\u56db\u4e07\u81f3\u516b\u4e07\u78b1\u57fa\u4e4b\u95f4\u7684\u4e00\u4e2a\u533a\u95f4\u3002\u8f93\u51fa\u89c4\u5219\u6839\u636e\u76f8\u90bb\u4fdd\u7559\u8fb9\u754c\u5f62\u6210\u533a\u57df\uff0c\u4e0d\u4f1a\u4e3a\u4e86\u5bf9\u5e94\u6211\u4eec\u8bbe\u8ba1\u7684\u533a\u5757\u6570\uff0c\u81ea\u52a8\u628a\u67d3\u8272\u4f53\u4e24\u7aef\u4e5f\u8865\u6210\u5b8c\u6574\u533a\u57df\u3002\u62ff\u8f93\u51fa\u884c\u6570\u53bb\u8ba1\u7b97\u201c\u627e\u56de\u4e86\u51e0\u4e2a\u771f\u5b9e\u7ed3\u6784\u57df\u201d\uff0c\u5728\u8fd9\u4e2a\u4f8b\u5b50\u91cc\u4ece\u5b9a\u4e49\u4e0a\u5c31\u4e0d\u5408\u9002\u3002<\/p>\n
\u8fb9\u754c\u6587\u4ef6\u628a\u56db\u4e07\u9644\u8fd1\u62a5\u544a\u4e3a\u4e09\u4e07\u4e5d\u5343\u4e94\u767e\u81f3\u56db\u4e07\u96f6\u4e94\u767e\u7684\u533a\u95f4\uff0c\u533a\u57df\u6587\u4ef6\u5219\u4f7f\u7528\u56db\u4e07\u4f5c\u4e3a\u8fde\u63a5\u5750\u6807\u3002\u9605\u8bfb\u7ed3\u679c\u65f6\u8981\u4fdd\u7559\u533a\u95f4\u548c\u5206\u8fa8\u7387\u4fe1\u606f\uff0c\u907f\u514d\u628a\u6587\u4ef6\u7684\u8d77\u70b9\u8bef\u79f0\u4e3a\u7cbe\u786e\u5230\u5355\u78b1\u57fa\u7684\u7269\u7406\u8fb9\u754c\u3002\u5b98\u65b9\u5bf9\u8f93\u51fa\u7c7b\u578b\u548c\u8fb9\u754c\u5224\u5b9a\u6b65\u9aa4\u7684\u8bf4\u660e\u89c1\u8fb9\u754c\u8bc6\u522b\u6587\u6863<\/a>\u3002<\/p>\n
\u516d\u3001\u590d\u7528\u7f13\u5b58\u65f6\uff0c\u547d\u4ee4\u91cc\u5199\u4e86\u65b0\u7a97\u53e3\u4e5f\u53ef\u80fd\u6ca1\u6709\u91cd\u7b97<\/h2>\n
\u7b2c\u4e09\u6b21\u8c03\u7528\u590d\u7528\u7b2c\u4e00\u7ec4\u7684\u5206\u79bb\u5206\u6570\u7f13\u5b58\uff0c\u540c\u65f6\u5728\u547d\u4ee4\u4e2d\u5199\u5165\u7b2c\u4e8c\u7ec4\u7a97\u53e3\u53c2\u6570\u3002\u5f97\u5230\u7684\u4ecd\u662f\u7b2c\u4e00\u7ec4\u5206\u6570\uff0c\u800c\u4e0d\u662f\u7b2c\u4e8c\u7ec4\u91cd\u65b0\u8ba1\u7b97\u7684\u7ed3\u679c\u3002\u8fd9\u4e2a\u64cd\u4f5c\u9002\u5408\u8c03\u6574\u57fa\u4e8e\u540c\u4e00\u5206\u6570\u7684\u7b5b\u9009\u95e8\u69db\uff0c\u4e0d\u80fd\u5f53\u4f5c\u65b0\u7a97\u53e3\u5b9e\u9a8c\u3002<\/p>\n
\u7f13\u5b58\u8bfb\u5199\u5e26\u6765\u7ea6\u767e\u4e07\u5206\u4e4b\u4e00\u4ee5\u5185\u7684\u6d6e\u70b9\u5dee\u5f02\uff0c\u56e0\u6b64\u590d\u73b0\u811a\u672c\u6bd4\u8f83\u6570\u503c\u5bb9\u5dee\u53ca\u8fb9\u754c\u5750\u6807\uff0c\u6ca1\u6709\u8981\u6c42\u6587\u672c\u6587\u4ef6\u6bcf\u4e00\u4e2a\u5b57\u7b26\u5b8c\u5168\u76f8\u540c\u3002\u8fd9\u4e5f\u662f\u5b9e\u9645\u6838\u9a8c\u65f6\u5e94\u533a\u5206\u7684\u4e24\u4ef6\u4e8b\uff0c\u6570\u503c\u4e0a\u7684\u540c\u4e00\u7ed3\u679c\u4e0d\u4e00\u5b9a\u5177\u6709\u9010\u5b57\u8282\u4e00\u81f4\u7684\u6587\u672c\u8868\u793a\uff0c\u53cd\u8fc7\u6765\uff0c\u6587\u4ef6\u540d\u53d8\u5316\u4e5f\u4e0d\u8bc1\u660e\u8ba1\u7b97\u5185\u5bb9\u53d8\u5316\u3002<\/p>\n
\u5982\u679c\u8981\u6539\u53d8\u89c2\u5bdf\u5c3a\u5ea6\uff0c\u5e94\u4f7f\u7528\u65b0\u7684\u8f93\u51fa\u524d\u7f00\u91cd\u65b0\u8ba1\u7b97\u5206\u6570\u3002\u82e5\u53ea\u662f\u6bd4\u8f83\u4e0d\u540c\u663e\u8457\u6027\u95e8\u69db\u6216\u5dee\u5f02\u5e45\u5ea6\u95e8\u69db\uff0c\u53ef\u4ee5\u590d\u7528\u540c\u4e00\u7f13\u5b58\uff0c\u5e76\u5728\u8bb0\u5f55\u4e2d\u660e\u786e\u7f13\u5b58\u6765\u6e90\u3002\u5426\u5219\u4e00\u4e2a\u770b\u8d77\u6765\u5305\u542b\u65b0\u53c2\u6570\u7684\u547d\u4ee4\u4f1a\u7559\u4e0b\u9519\u8bef\u5370\u8c61\uff0c\u8ba9\u540e\u7eed\u5206\u6790\u8005\u4ee5\u4e3a\u6240\u6709\u7ec4\u5408\u90fd\u72ec\u7acb\u8ba1\u7b97\u8fc7\u3002<\/p>\n
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\u4e03\u3001\u771f\u6b63\u6bd4\u8f83\u6837\u672c\u65f6\uff0c\u600e\u6837\u628a\u8fd9\u5957\u68c0\u67e5\u7528\u8d77\u6765<\/h2>\n
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